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31. 发明申请

US20080102473A1 Method and system to improve contrast in lateral flow assay 审中-公开
标题翻译：提高侧流测定对比度的方法和系统
公开(公告)号：US20080102473A1
公开(公告)日：2008-05-01
申请号：US11591647
申请日：2006-10-31
申请人： Julie E. Fouquet , Daniel B. Roitman
发明人： Julie E. Fouquet , Daniel B. Roitman
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/558 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786
摘要： A lateral flow assay includes one or more optically-reactive test regions that are examined using light propagating at a wavelength that matches or nearly matches an absorption wavelength associated with each optically-reactive test region. The presence or absence of a color or absorption in each optically-reactive test region may be determined by an individual examining each optically-reactive test region or by one or more detectors that detect fluorescence from one or more optically-reactive test regions or detect light transmitted through or reflected off one or more optically-reactive test regions.
摘要翻译：侧流测定包括使用在与每个光学反应性测试区域相关联的吸收波长匹配或接近匹配的波长传播的光来检查的一个或多个光学反应性测试区域。在每个光学反应性测试区域中存在或不存在颜色或吸收可以由个体检查每个光学反应性测试区域或由检测来自一个或多个光学反应性测试区域的荧光或检测光的一个或多个检测器来确定透射通过或反射出一个或多个光学反应性测试区域。

32. 发明授权

US06927029B2 Surface with tethered polymeric species for binding biomolecules 失效
标题翻译：具有束缚聚合物的表面用于结合生物分子
公开(公告)号：US06927029B2
公开(公告)日：2005-08-09
申请号：US10005577
申请日：2001-12-03
申请人： Steven M. Lefkowitz , Daniel B. Roitman , Nelson R. Holcomb
发明人： Steven M. Lefkowitz , Daniel B. Roitman , Nelson R. Holcomb
IPC分类号： G01N33/543 , G01N33/545 , C12Q1/68 , C07H21/04 , C12M1/36 , C12N11/16
CPC分类号： G01N33/545 , G01N33/54393
摘要： The invention provides a solid support for adsorbing a biomolecule. The support comprises a surface coating having a non-nucleotidic polymer tethered to a surface reactive site. The polymer comprises a backbone, terminus, and adsorbing moieties covalently attached to the backbone and capable of adsorbing a biomolecule that can assume a plurality of conformations. The polymer is generally tethered to the surface at its terminus and the backbone exhibits sufficient mobility and flexibility such that a biomolecule adsorbed by the adsorbing moieties can assume a desired conformation for hybridization. Also provided is a process for preparing a surface coating having a functionalized surface.
摘要翻译：本发明提供了用于吸附生物分子的固体支持物。载体包括具有与表面反应性位点连接的非核酸聚合物的表面涂层。聚合物包含主链，末端和吸附部分，其共价连接到骨架上并且能够吸附可呈现多个构象的生物分子。聚合物通常在其末端处连接到表面，并且主链显示出足够的迁移率和柔性，使得被吸附部分吸附的生物分子可以呈现出期望的构象用于杂交。还提供了制备具有官能化表面的表面涂层的方法。

33. 发明授权

US06803097B2 Composite film made of particles embedded in a polymer matrix 失效
标题翻译：由嵌入聚合物基质中的颗粒制成的复合膜
公开(公告)号：US06803097B2
公开(公告)日：2004-10-12
申请号：US10327285
申请日：2002-12-19
申请人： Daniel B. Roitman , Seiji Inaoka
发明人： Daniel B. Roitman , Seiji Inaoka
IPC分类号： B32B516
CPC分类号： C08J5/18 , Y10T428/25 , Y10T428/254 , Y10T428/256 , Y10T428/259 , Y10T428/2982 , Y10T428/2987
摘要： The present invention is a film and method for making the same. The film includes a plurality of particles having a desired film property that are entrapped in a matrix of linkage polymer molecules. The linkage polymer molecules ionically bind to the particles. The linkage polymer molecules are electrochemically polymerizable in a solvent. The particles are insoluble in the solvent. The film is prepared by providing an electrode and a solution of the linkage polymer molecules in which the particles are suspended. An electrical potential is provided between the solution and the electrode in temporal sequence that causes the linkage polymer molecules to polymerize in the vicinity of the electrode thereby entrapping the particles.
摘要翻译：本发明是其制造方法及其制造方法。膜包括多个具有期望的膜性质的颗粒，其被捕获在连接聚合物分子的基质中。连接聚合物分子与颗粒离子结合。连接聚合物分子在溶剂中可电化学聚合。颗粒不溶于溶剂。通过提供悬浮颗粒的连接聚合物分子的电极和溶液来制备膜。以时间顺序在溶液和电极之间提供电位，使得连接聚合物分子在电极附近聚合，从而截留颗粒。

34. 发明授权

US06533918B2 Method for depositing electrically conducting polymer films via electrochemical deposition of precursor polymers 有权
标题翻译：通过前体聚合物的电化学沉积沉积导电聚合物膜的方法
公开(公告)号：US06533918B2
公开(公告)日：2003-03-18
申请号：US09919072
申请日：2001-09-11
申请人： Daniel B. Roitman , Seiji Inaoka , Riogoberto C. Advincula
发明人： Daniel B. Roitman , Seiji Inaoka , Riogoberto C. Advincula
IPC分类号： C25B300
CPC分类号： C08G61/02 , C08G61/10 , C08G61/123 , Y10T428/24942
摘要： A method for depositing an electrically conducting film on an electrode and the film resulting from that method. An electrically conducting film according to the present invention is deposited by immersing the electrode in a solution of a precursor polymer in a predetermined solvent. The precursor polymer includes a plurality of electrochemical polymerizable monomers. Each monomer has first and second polymer-forming active sites that can be joined by electrochemical polymerization and third and fourth polymer-forming active sites that can be joined chemically in solution. The precursor polymer is constructed from the monomers joined by the third and fourth polymer-forming active sites. The precursor polymer is soluble in the solvent whereas a polymer formed by electrochemical polymerization of the first and second polymer-forming active sites is insoluble in the solvent. An electrical potential is applied to the electrode to cause monomers of the precursor polymer molecules to be joined electrochemically by their first and second polymer-forming active sites.
摘要翻译：用于在电极上沉积导电膜的方法和由该方法得到的膜。通过将电极浸入前体聚合物在预定溶剂中的溶液中来沉积根据本发明的导电膜。前体聚合物包括多个电化学可聚合单体。每个单体具有可以通过电化学聚合连接的第一和第二聚合物形成活性位点和可以在溶液中化学连接的第三和第四聚合物形成活性位点。前体聚合物由由第三和第四聚合物形成活性位点连接的单体构成。前体聚合物可溶于溶剂，而由第一和第二聚合物形成活性位点的电化学聚合形成的聚合物不溶于溶剂。对电极施加电位，使前体聚合物分子的单体通过其第一和第二聚合物形成活性位点电化学连接。

35. 发明授权

US06294245B1 Method for depositing electrically conducting polymer films via electrochemical deposition of precursor polymers 有权
标题翻译：通过前体聚合物的电化学沉积沉积导电聚合物膜的方法
公开(公告)号：US06294245B1
公开(公告)日：2001-09-25
申请号：US09401666
申请日：1999-09-22
申请人： Daniel B. Roitman , Seiji Inaoka , Riogoberto C. Advincula
发明人： Daniel B. Roitman , Seiji Inaoka , Riogoberto C. Advincula
IPC分类号： B41M520
CPC分类号： C08G61/02 , C08G61/10 , C08G61/123 , Y10T428/24942
摘要： A method for depositing an electrically conducting film on an electrode and the film resulting from that method. An electrically conducting film according to the present invention is deposited by immersing the electrode in a solution of a precursor polymer in a predetermined solvent. The precursor polymer includes a plurality of electrochemical polymerizable monomers. Each monomer has first and second polymer-forming active sites that can be joined by electrochemical polymerization and third and fourth polymer-forming active sites that can be joined chemically in solution. The precursor polymer is constructed from the monomers joined by the third and fourth polymer-forming active sites. The precursor polymer is soluble in the solvent whereas a polymer formed by electrochemical polymerization of the first and second polymer-forming active sites is insoluble in the solvent.
摘要翻译：用于在电极上沉积导电膜的方法和由该方法得到的膜。通过将电极浸入前体聚合物在预定溶剂中的溶液中来沉积根据本发明的导电膜。前体聚合物包括多个电化学可聚合单体。每个单体具有可以通过电化学聚合连接的第一和第二聚合物形成活性位点和可以在溶液中化学连接的第三和第四聚合物形成活性位点。前体聚合物由由第三和第四聚合物形成活性位点连接的单体构成。前体聚合物可溶于溶剂，而由第一和第二聚合物形成活性位点的电化学聚合形成的聚合物不溶于溶剂。

36. 发明授权

US5972419A Electroluminescent display and method for making the same 失效
标题翻译：电致发光显示及其制作方法
公开(公告)号：US5972419A
公开(公告)日：1999-10-26
申请号：US874693
申请日：1997-06-13
申请人： Daniel B. Roitman
发明人： Daniel B. Roitman
IPC分类号： H05B33/10 , G09F9/30 , H01L27/32 , H01L51/50 , H05B33/12 , H05B33/14 , B05D5/06
CPC分类号： H01L27/3239 , H01L27/3206 , H01L51/5036 , H01L51/0005 , Y10S428/917
摘要： A method for constructing an electroluminescent display and a novel display constructed thereby. In the method of the present invention, a bottom electrode having a planar sheet of conducting material is first deposited on a substrate. A mask is then deposited on the bottom electrode to define wells. For at least first and second ones of the wells defined by the mask, an electroluminescent material is dispensed into the wells. The electroluminescent material dispensed into the first well emits a different spectrum of light from the electroluminescent material dispensed into the second well. In one embodiment of the invention, an isolation layer is deposited over the electroluminescent material after the electroluminescent material has dried. A top electrode is then deposited over the isolation layer. In a display according to the present invention, a plurality of pixels are deposited on a bottom electrode and then a top electrode is provided for energizing the pixels. The plurality of pixels includes first and second pixels, the first pixel having a first mixture of at least two electroluminescent dyes and the second pixel having a second mixture of the electroluminescent dyes. The first mixture differs in the ratios of the electroluminescent dyes from the second mixture.
摘要翻译：一种用于构造电致发光显示器的方法和由此构成的新型显示器。在本发明的方法中，首先将具有导电材料的平板的底电极沉积在基板上。然后将掩模沉积在底部电极上以限定孔。对于由掩模限定的至少第一和第二阱，将电致发光材料分配到孔中。分配到第一阱中的电致发光材料从分配到第二阱中的电致发光材料发射不同光谱的光。在本发明的一个实施例中，在电致发光材料干燥之后，在电致发光材料上沉积隔离层。然后将顶部电极沉积在隔离层上。在根据本发明的显示器中，多个像素沉积在底部电极上，然后提供顶部电极用于激励像素。多个像素包括第一和第二像素，第一像素具有至少两个电致发光染料的第一混合物，第二像素具有电致发光染料的第二混合物。第一混合物的电致发光染料与第二混合物的比例不同。

37. 发明授权

US5629389A Polymer-based electroluminescent device with improved stability 失效
标题翻译：基于聚合物的电致发光器件具有改进的稳定性
公开(公告)号：US5629389A
公开(公告)日：1997-05-13
申请号：US463141
申请日：1995-06-06
申请人： Daniel B. Roitman , James R. Sheats , Mark R. Hueschen
发明人： Daniel B. Roitman , James R. Sheats , Mark R. Hueschen
IPC分类号： H05B33/20 , C09K11/02 , C09K11/06 , H01L51/00 , H01L51/30 , H01L51/50 , H05B33/12 , H05B33/14 , C08F283/00 , H01B1/00 , H01L27/15 , H01L31/12
CPC分类号： H01L51/5012 , C09K11/025 , C09K11/06 , H05B33/14 , H01L51/0038 , Y10S362/80
摘要： An improved electroluminescent device which includes a hole injection electrode, an electron injection electrode, and an electroluminescent layer located between the hole and electron injection electrodes. The electroluminescent layer includes an organic polymer and a hindered phenolic additive in a concentration greater than 4% by weight. The preferred organic polymer is a derivative of PPV. The preferred hindered phenolic additives are and 2,4,6 tri-tert-butyl phenol 2,6 di-tert-butyl-methylphenol. The device has higher efficiency and a slower rate of degradation than devices lacking the hindered phenolic additive.
摘要翻译：一种改进的电致发光器件，其包括位于空穴和电子注入电极之间的空穴注入电极，电子注入电极和电致发光层。电致发光层包括浓度大于4重量％的有机聚合物和受阻酚类添加剂。优选的有机聚合物是PPV的衍生物。优选的受阻酚添加剂是2,4,6-三叔丁基苯酚2,6-二叔丁基 - 甲基苯酚。该装置具有比缺乏受阻酚添加剂的装置更高的效率和更低的降解速率。

38. 发明授权

US5552221A Polybenzazole fibers having improved tensile strength retention 失效
标题翻译：具有改善拉伸强度保持性的聚吲哚纤维
公开(公告)号：US5552221A
公开(公告)日：1996-09-03
申请号：US366346
申请日：1994-12-29
申请人： Ying H. So , Steven J. Martin , Chieh-Chun Chau , Ritchie A. Wessling , Ashish Sen , Katsuhiko Kato , Daniel B. Roitman , Willie E. Rochefort
发明人： Ying H. So , Steven J. Martin , Chieh-Chun Chau , Ritchie A. Wessling , Ashish Sen , Katsuhiko Kato , Daniel B. Roitman , Willie E. Rochefort
IPC分类号： D06P3/00 , D01F6/74 , D01F6/94 , D01F11/08 , D06M13/02 , D06M13/50 , B32B5/02 , C08G73/22
CPC分类号： D01F6/74 , Y10T428/2929
摘要： Described is a method for preparing a polybenzazole filament which comprises extruding a polybenzazole dope filament, drawing the filament across an air gap, coagulating and washing the filament, and drying the filament, characterized in that a solution of a compound selected from the group consisting of ferrocenes, ruthocene, iodide-, cobalt-, and copper-containing compounds, dyes, and mixtures thereof is contacted with a filament subsequent to the washing step and prior to the drying step. This method provides a means to improve the tensile strength retention of damaged polybenzazole filaments following exposure to sunlight.
摘要翻译：描述了一种制备聚苯并唑丝的方法，该方法包括挤出聚吲哚染料丝，拉伸细丝穿过气隙，凝结和洗涤细丝，干燥长丝，其特征在于，将选自以下的化合物的溶液二茂铁，钌菁，碘化物，钴和含铜化合物，染料及其混合物在洗涤步骤之后和干燥步骤之前与细丝接触。该方法提供了一种改善受暴露于阳光下的受损聚吲哚长丝的拉伸强度保留的方法。

39. 发明授权

US10753931B2 Assay test strips with multiple labels and reading same 有权
公开(公告)号：US10753931B2
公开(公告)日：2020-08-25
申请号：US12410182
申请日：2009-03-24
申请人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
发明人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
IPC分类号： G01N33/558 , G01N33/58 , G01N21/77 , G01N35/00
摘要： In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.

40. 发明授权

US09891217B2 Assay test strips with multiple labels and reading same 有权
公开(公告)号：US09891217B2
公开(公告)日：2018-02-13
申请号：US12410167
申请日：2009-03-24
申请人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
发明人： Patrick T. Petruno , John F. Petrilla , Michael J. Brosnan , Rong Zhou , Daniel B. Roitman
IPC分类号： G01N33/558 , G01N33/58 , G01N21/77 , G01N35/00
CPC分类号： G01N33/558 , G01N33/582 , G01N2021/7786 , G01N2035/00108
摘要： In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip includes a test label that specifically binds a target analyte and at least one non-specific-binding label that is free of any specific binding affinity for the target analyte. Systems and methods of reading assay test strips also are described.

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