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31. 发明授权

US5693772A Desalaninebenanomicin A derivatives and processes for the preparation thereof 失效
标题翻译：脱氨基苯丙氨酸A衍生物及其制备方法
公开(公告)号：US5693772A
公开(公告)日：1997-12-02
申请号：US492007
申请日：1995-08-15
申请人： Tomio Takeuchi , Shinichi Kondo , Daishiro Ikeda , Toshio Nishizuka
发明人： Tomio Takeuchi , Shinichi Kondo , Daishiro Ikeda , Toshio Nishizuka
IPC分类号： C07H15/24 , A01N43/16 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61P31/04 , A61P31/10 , C07H1/00 , C07H15/244
CPC分类号： C07H15/244 , A01N43/16 , C07H15/24 , Y02P20/55
摘要： Desalaninebenanomicin A has been synthesized by chemical conversion of benanomicin A. Amino acid derivatives of desalaninebenanomicin A having the general formula (Ia): ##STR1## where R.sup.a represents a hyhrogen atom, a C.sub.1-5 alkyl group, a C.sub.1-5 hydroxyalkyl group, carboxyl group or a lower alkoxycarbonyl group have been synthesized by condensing the 2-carboxyl group of desalaninebenanomicin A with a variety of amino acids. Among the derivatives of the formula (Ia) having antifungal activities, such desalaninebenanomicin A derivatives in which R.sup.a is a C.sub.2-5 alkyl group, a C.sub.2-5 hydroxyalkyl group, carboxyl group or a lower alkoxycarbonyl group are novel semi-synthetic antibiotics having antifungal activities.
摘要翻译： PCT No.PCT / JP93 / 00082 Sec。 371日期1995年8月15日 102（e）日期1995年8月15日PCT提交1993年1月22日PCT公布。出版物WO94 / 17085 日期1994年8月4日通过苯那霉素A的化学转化已经合成了西丹西南贝那霉素A.具有通式（Ia）的脱氨基苯乙胺素A的氨基酸衍生物：其中R a表示氢原子，C 1-5烷基已经通过将脱氨基苯丙氨酸A的2-羧基与各种氨基酸缩合来合成C1-5羟基烷基，羧基或低级烷氧基羰基。在具有抗真菌活性的式（Ia）的衍生物中，其中Ra为C2-5烷基，C2-5羟基烷基，羧基或低级烷氧基羰基的脱氨基苯乙胺丙氨酸衍生物是具有抗真菌剂的新型半合成抗生素活动

32. 发明授权

US5536094A Protective ink ribbon unit holder 失效
标题翻译：保护色带单元座
公开(公告)号：US5536094A
公开(公告)日：1996-07-16
申请号：US489212
申请日：1995-06-09
申请人： Shinichi Kondo
发明人： Shinichi Kondo
IPC分类号： B41J32/00 , B41J17/32 , B65D85/672 , B41J35/28
CPC分类号： B41J17/32 , B65D85/672
摘要： An ink ribbon unit has supply and take-up spools which are fastened securely and locked against free rotation inexpensively and reliably in a manner not to impair the quality of an ink ribbon thereof. The supply and take-up spools are fastened securely and locked against free rotation by an elastic sheet-like holder which is formed by vacuum forming and has a fixed shape. The holder has a first holding portion for holding the take-up spool and a pair of second holding portions for holding diametrically opposite surfaces of the ink ribbon wound on the supply spool. The holder has free ends extending from the respective second holding portions and secured to each other by an adhesive tape.
摘要翻译：色带单元具有供应和卷取线轴，其以不损害其墨带的质量的方式可靠地紧固并且以可靠的方式被锁定抵抗自由旋转。供给卷取卷轴被牢固地固定并且通过由真空成形而形成的弹性片状保持器而被自由旋转锁定，并具有固定的形状。保持器具有用于保持卷取卷轴的第一保持部和用于保持缠绕在供给卷轴上的墨带的径向相对的表面的一对第二保持部。保持器具有从相应的第二保持部分延伸并且通过胶带彼此固定的自由端。

33. 发明授权

US5278052A Process for the simultaneous production of benanomicins A and B 失效
标题翻译：同时生产苯那霉素A和B的方法
公开(公告)号：US5278052A
公开(公告)日：1994-01-11
申请号：US715770
申请日：1991-06-14
申请人： Tomio Takeuchi , Takeshi Hara , Masa Hamada , Shinichi Kondo , Masaji Sezaki , Haruo Yamamoto , Shuichi Gomi
发明人： Tomio Takeuchi , Takeshi Hara , Masa Hamada , Shinichi Kondo , Masaji Sezaki , Haruo Yamamoto , Shuichi Gomi
IPC分类号： C07H15/24 , C12P19/56 , C12P19/12
CPC分类号： C12R1/01 , C07H15/24 , C12P19/56 , Y10S435/826
摘要： Benanomicin A and Benanomicin B are fermentatively produced by the cultivation of a new microorganism Actinomadura spadix, designated as MH193-16F4 strain.
摘要翻译：通过培养命名为MH193-16F4菌株的新的微生物Actinomadura spadix发酵生产贝那霉素A和Benanomicin B。

34. 发明授权

US4994578A Certain anti-tumor duocarmycin antibiotics from streptomyces 失效
标题翻译：某些来自链霉菌的抗肿瘤双卡霉素抗生素
公开(公告)号：US4994578A
公开(公告)日：1991-02-19
申请号：US344738
申请日：1989-04-28
申请人： Kazunori Ohba , Hiroomi Watabe , Mieko Nagasawa , Shiro Sakakibara , Takashi Shomura , Masaji Sezaki , Shinichi Kondo , Masao Koyama , Tadashi Nakazawa , Haruo Yamamoto
发明人： Kazunori Ohba , Hiroomi Watabe , Mieko Nagasawa , Shiro Sakakibara , Takashi Shomura , Masaji Sezaki , Shinichi Kondo , Masao Koyama , Tadashi Nakazawa , Haruo Yamamoto
IPC分类号： C07D471/04 , C07D487/04 , C12P17/18
CPC分类号： C07D471/04 , C07D487/04 , C12P17/182
摘要： Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.
摘要翻译：具有抗微生物活性和抗肿瘤活性的新型物质，通过培养属于链霉菌属的微生物并能够生产它们和这些物质的衍生物的方法。

35. 发明授权

US4938788A Method of producing uniform silica glass block 失效
标题翻译：均匀二氧化硅玻璃块的制造方法
公开(公告)号：US4938788A
公开(公告)日：1990-07-03
申请号：US291258
申请日：1988-12-28
申请人： Hideaki Segawa , Koji Tsukuma , Shinichi Kondo , Keishi Honta
发明人： Hideaki Segawa , Koji Tsukuma , Shinichi Kondo , Keishi Honta
IPC分类号： C03B20/00 , C03B19/06 , C03B19/09 , C03B32/00 , C03B37/012
CPC分类号： C03B37/01297 , C03B19/06 , C03B19/066 , C03B19/09 , C03B20/00 , C03B32/00 , C03B37/01282 , C03B2201/04 , Y10S65/90
摘要： A method of producing a uniform silica glass block comprising using silica powder as a raw material, and treating it at high temperature and pressure by a hot press and/or a hot isostatic press in vacuum or in an inert gas atmosphere, preferably with a capsule of silica glass or a high-melting point metal. By conducting calcination in fluorine, chlorine or their compound gas and then in oxygen, the OH group content of the silica glass can be reduced dramatically.

36. 发明授权

US4898858A Cephalosporin derivatives and antibiotics containing the same 失效
标题翻译：头孢菌素衍生物和含有相同的抗生素
公开(公告)号：US4898858A
公开(公告)日：1990-02-06
申请号：US928955
申请日：1986-11-10
申请人： Seiji Shibahara , Tsuneo Okonogi , Yasushi Murai , Toshiaki Kudo , Takashi Yoshida , Ken Nishihata , Shinichi Kondo
发明人： Seiji Shibahara , Tsuneo Okonogi , Yasushi Murai , Toshiaki Kudo , Takashi Yoshida , Ken Nishihata , Shinichi Kondo
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/36
CPC分类号： C07D501/00
摘要： New cephalosporin derivatives of a general formula (I) and non-toxic salts and non-toxic esters thereof are provided: ##STR1## (wherein R represents an acyclic or cyclic lower alkyl group having 1-6 carbon atoms, which may optionally be substituted by a halogen atom; the steric configuration as asterisked (*) includes an optical-active (R)-form or (S)-form or an optical-inactive (RS)-form; n is 0 or 1, n.sup.1 is 0 to 3, n.sup.2 is 0 to 3; and when n.sup.1 is 0, n.sup.2 is 3; when n.sup.1 is 1, n.sup.2 is 2; when n.sup.1 is 2, n.sup.2 is 1; when n.sup.1 is 3, n.sup.2 is 0).The new derivatives of the formula (I) and non-toxic salts and esters thereof have high bactericidal activity with broad antibacterial spectra, and these are useful as active ingredients in bactericides.
摘要翻译：提供了通式（I）的新型头孢菌素衍生物及其无毒盐和无毒酯：其中R表示具有1-6个碳原子的无环或环状低级烷基，其可以任选地被卤素原子取代;星号（*）的空间构型包括光学活性（R）形式或（S）形式或光学非活性（RS）形式; n是0或 1，n1为0〜3，n2为0〜3，n2为0时，n2为3，n1为1时n2为2，n1为2时，n2为1，n1为3时，n2为0 ）。式（I）的新衍生物及其无毒盐和酯具有广泛的抗菌谱具有高杀菌活性，可用作杀菌剂中的活性成分。

37. 发明授权

US4793184A Ultrasonic imaging apparatus and method of forming an ultrasonic image of an object 失效
标题翻译：超声波成像装置和形成物体的超声波图像的方法
公开(公告)号：US4793184A
公开(公告)日：1988-12-27
申请号：US898518
申请日：1986-08-21
申请人： Hiroshi Ikeda , Kageyoshi Katakura , Toshio Ogawa , Shin'ichiro Umemura , Shinichi Kondo
发明人： Hiroshi Ikeda , Kageyoshi Katakura , Toshio Ogawa , Shin'ichiro Umemura , Shinichi Kondo
IPC分类号： G01S7/52 , G01S15/89 , G01N29/04
CPC分类号： G01S7/52046 , G01S15/8918 , G01S7/52085
摘要： An ultrasonic imaging apparatus and method of forming an image of an acoustic image of an object employing the aperture synthesis technique, in which at least one partial aperture for accommodating a predetermined number of successive transducers is established and applied to a transducer array to select the predetermined number of successive transducers accommodated in the partial aperture so that the selected transducers serve to transmit ultrasonic acoustic signals to an object and receive signals reflected from the object, and the at least one partial aperture is specifically moved along the arrayed transducers for similar signal transmission to and/or signal reception from the object, whereby the apparatus and the method do not suffer substantial noise caused during changeover between transmitting and receiving operation modes and/or enjoy and enlarged aperture for signal transmission or enlarged aperture for signal reception with a suppressed decrease of the frame rate.
摘要翻译：一种使用孔径合成技术形成对象的声像的图像的超声波成像装置和方法，其中建立用于容纳预定数量的连续换能器的至少一个部分孔径并将其应用于换能器阵列以选择预定的容纳在部分孔径中的连续换能器的数量，使得所选择的换能器用于向对象发射超声波信号并接收从物体反射的信号，并且至少一个部分孔径被特别地沿着阵列换能器移动以用于类似的信号传输和/或来自对象的信号接收，由此该装置和方法不会在发送和接收操作模式之间切换期间产生实质的噪声和/或用于信号传输的享受和扩大的孔径或用于信号接收的扩大的孔径，帧速率。

38. 发明授权

US4758557A Cephalosporin derivatives and bactericides containing the same 失效
标题翻译：头孢菌素衍生物和含有相同的杀菌剂
公开(公告)号：US4758557A
公开(公告)日：1988-07-19
申请号：US872316
申请日：1986-06-09
申请人： Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Hiroko Ogino , Ryoichi Okamoto , Takashi Yoshida , Masaji Sezaki , Fumio Kai , Shigeharu Inoue , Shinichi Kondo
发明人： Takashi Tsuruoka , Katsuyoshi Iwamatsu , Kiyoaki Katano , Hiroko Ogino , Ryoichi Okamoto , Takashi Yoshida , Masaji Sezaki , Fumio Kai , Shigeharu Inoue , Shinichi Kondo
IPC分类号： A61K31/545 , C07D501/24 , C07D501/36 , C07D501/46
CPC分类号： C07D501/24
摘要： Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: ##STR1## wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); ##STR2## or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): ##STR3## or an unsubstituted or substituted pyridinium group of a formula (I-3); ##STR4## or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):--S--Het (I-4).
摘要翻译：由下式（I）表示的头孢菌素化合物及其药学上可接受的盐对各种致病细菌（包括铜绿假单胞菌）具有广泛的杀菌谱，并且可用作人和动物的致病性疾病的杀菌剂：其中A代表式（I-1）的未取代或取代的吡啶硫基; （I-1）或式（I-2）的未取代或取代的吡啶硫基：式（I-2）或未取代或取代的式（I-3）吡啶鎓基; （I-3）或式（I-4）的5-或6-元杂环硫或二环杂环硫基：-S-Het（I-4）。

39. 发明授权

US4658058A 11-O-methylspergualin 失效
标题翻译： 11-O-甲基精氨酸
公开(公告)号：US4658058A
公开(公告)日：1987-04-14
申请号：US723169
申请日：1985-04-15
申请人： Hamao Umezawa , Tomio Takeuchi , Shinichi Kondo , Hironobu Iinuma , Daishiro Ikeda , Teruya Nakamura , Akio Fujii
发明人： Hamao Umezawa , Tomio Takeuchi , Shinichi Kondo , Hironobu Iinuma , Daishiro Ikeda , Teruya Nakamura , Akio Fujii
IPC分类号： A61K31/16 , A61P35/00 , C07C67/00 , C07C239/00 , C07C279/14 , C07D209/48 , C12P13/02 , C07C129/12
CPC分类号： C07D209/48 , C07C279/14 , C12P13/02 , Y10S514/908
摘要： The novel compound N-[(3-aminoproypl)aminobutyl]-Z-(F-guandino-3-hydroxyheptanamido)-2-methoxyethanamide or a pharmaceutically acceptable salt thereof which has antitumor activity in experimental animals.
摘要翻译：在实验动物中具有抗肿瘤活性的新化合物N - [（3-氨基嘌呤）氨基丁基] -Z-（F-胍基-3-羟基庚氨酰）-2-甲氧基乙酰胺或其药学上可接受的盐。

40. 发明授权

US4525299A (-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same 失效
标题翻译：（ - ） - 15-脱氧精球蛋白，其制备方法及其中间体
公开(公告)号：US4525299A
公开(公告)日：1985-06-25
申请号：US493209
申请日：1983-05-10
申请人： Hamao Umezawa , Tomio Takeuchi , Shinichi Kondo
发明人： Hamao Umezawa , Tomio Takeuchi , Shinichi Kondo
IPC分类号： C07C279/14 , C07D309/12 , C07C103/52
CPC分类号： C07D309/12 , C07C279/14
摘要： (-)-15-Deoxyspergualin represented by the following formula ##STR1## a salt thereof having antitumor activity, process for the preparation thereof and intermediate thereof.
摘要翻译：（ - ） - 15-以下式表示的脱氧胆固醇：＆lt; IMAGE＆gt; + TR 2 CH 2 CH 2 NHCH 2 CH 2 CH 2 NH 2; 其具有抗肿瘤活性的盐，其制备方法及其中间体。

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