专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明专利

IE920828A1 PROCESS FOR THE DIASTEREOSELECTIVE REDUCTIVE PINACOL¹COUPLING OF HOMOCHIRAL Ó-AMINOALDEHYDES 未知
公开(公告)号：IE920828A1
公开(公告)日：1992-09-23
申请号：IE920828
申请日：1992-03-13
申请人： HOECHST AG
发明人： JENDRALLA JOACHIM-HEINER , JACOBI DETLEF , KAMMERMEIER BERNHARD
IPC分类号： C07C229/00 , C07C269/06 , C07C271/20 , C07C271/22 , C07C315/04 , C07C317/44 , C07D217/16 , C07C271/00 , C07C309/00 , C07D217/00
摘要： A method is described for the preparation of optically pure symmetric compounds of the formula I in which R , R and R are described in the description, with the simultaneous control of the four centres of chirality identified with .

32. 发明专利

AU1284092A PROCESS FOR THE DIASTEREOSELECTIVE REDUCTIVE PINACOL COUPLING OF HOMOCHIRAL ALPHA-AMINOALDEHYDES 未知
公开(公告)号：AU1284092A
公开(公告)日：1992-09-17
申请号：AU1284092
申请日：1992-03-13
申请人： HOECHST AG
发明人： JENDRALLA JOACHIM-HEINER , JACOBI DETLEF , KAMMERMEIER BERNHARD
IPC分类号： C07C229/00 , C07C269/06 , C07C271/20 , C07C271/22 , C07C315/04 , C07C317/44 , C07D217/16 , C07C215/20 , C07C237/10 , C07C213/00 , C07C215/28 , C07C271/16
摘要： A method is described for the preparation of optically pure symmetric compounds of the formula I in which R , R and R are described in the description, with the simultaneous control of the four centres of chirality identified with .

33. 发明专利

FI921069A 未知
公开(公告)号：FI921069A
公开(公告)日：1992-09-16
申请号：FI921069
申请日：1992-03-12
申请人： HOECHST AG
发明人： JENDRALLA JOACHIM-HEINER , JACOBI DETLEF , KAMMERMEIER BERNHARD
IPC分类号： C07C229/00 , C07C269/06 , C07C271/20 , C07C271/22 , C07C315/04 , C07C317/44 , C07D217/16
摘要： A method is described for the preparation of optically pure symmetric compounds of the formula I in which R , R and R are described in the description, with the simultaneous control of the four centres of chirality identified with .

34. 发明专利

CA2208129C PROCESS FOR THE PREPARATION OF CHIRAL, NONRACEMIC (4-ARYL-2,5-DIOXOIMIDAZO-LIDIN-1-YL)ACETIC ACIDS 未知
公开(公告)号：CA2208129C
公开(公告)日：2007-01-02
申请号：CA2208129
申请日：1997-06-19
申请人： HOECHST AG
发明人： KULITZSCHER BERNDT , HOLLA WOLFGANG , KAMMERMEIER BERNHARD , BECK GERHARD , MICHALOWSKY JURGEN
IPC分类号： C07D233/72 , A61K31/415 , A61K31/4166 , A61P7/02 , C07D233/74 , C07D233/76 , C07D233/78 , C07D233/80
摘要： Process for the preparation of chiral, nonracemic (4-aryl-2,5-dioxoimidazo- lidin- 1-yl)acetic acids The present invention relates to a process for the preparation of chira l, nonracemic compounds of the formula I in which R1 and R2 have the meanings indicated in claim 1 and which are useful intermediates for the preparation of pharmaceutical active compounds in which, for resolution, a salt is formed from the racemic compound of the formula I and a chiral, nonracemic amino compound. It furthermore relates to compounds of the formula I and esters thereof.

35. 发明专利

ES2137268T3 未知
公开(公告)号：ES2137268T3
公开(公告)日：1999-12-16
申请号：ES93921894
申请日：1993-09-30
申请人： HOECHST AG
发明人： BECK GERHARD , JENDRALLA JOACHIM-HEINER , KAMMERMEIER BERNHARD
IPC分类号： C07B53/00 , C07C315/00 , C07C315/02 , C07C315/04 , C07C317/44 , C07C319/14 , C07C323/51 , C07C323/52 , C07C323/56
摘要： PCT No. PCT/EP93/02674 Sec. 371 Date Mar. 30, 1995 Sec. 102(e) Date Mar. 30, 1995 PCT Filed Sep. 30, 1993 PCT Pub. No. WO94/07850 PCT Pub. Date Apr. 14, 1994Compounds of the formula I I can be prepared in a multi-day process starting from the compounds of the formulae II and III R1-SH, II III where the substituents R1, R2 and R3 have the meanings given.

36. 发明专利

IE74136B1 Process for the preparation of racemic and optically active 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its precursors 未知
公开(公告)号：IE74136B1
公开(公告)日：1997-07-02
申请号：IE920207
申请日：1992-01-23
申请人： HOECHST AG
发明人： KAMMERMEIER BERNHARD , LERCH ULRICH
IPC分类号： C07D217/26
摘要： A process for the preparation of racemic and optically active 1,2.3,4-tetrahydroisoquinoline-3-carboxylic acid is described, in which dihalo-o-xylylenes are cyclized to dicarboxylic acid esters in basic medium using dialkyl N-acylamidomalonates of the formula (CO2R1)2CHNHCOR2, in which R1 is (C1-C4)-alkyl and R2 is H, (C1-C4)-alkyl or (C6-C12)-aryl, decarboxylated by basic hydrolysis and subsequent acid work-up and then reacted in acid medium to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or dihalo-o-xylylenes are cyclized in basic medium to give the dicarboxylic acid esters and these are reacted directly without isolation in a one-pot process to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, if desired the racemic 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is reacted with (-)menthol and p-toluenesulfonic acid to give (-)menthyl (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate, then the diastereomers are separated by column chromatography and subjected to basic hydrolysis to give (D)-or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is esterified by means of benzyl alcohol and p-toluenesulfonic acid, reacted with D(-)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate or with L(+)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and then the compounds obtained are separated into the optical antipodes by fractional crystallization in an inert solvent and the enantiomers (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid are liberated by basic hydrolysis, the chiral auxiliary reagent being recovered.

37. 发明专利

HUT70583A PROCESS FOR THE STEREOSELECTIVE SYNTHESIS OF 3-SUBSTITUTED 2-THIOMETHYL PROPIONIC ACIDS 未知
公开(公告)号：HUT70583A
公开(公告)日：1995-10-30
申请号：HU9500953
申请日：1993-09-30
申请人： HOECHST AG
发明人： BECK GERHARD , KAMMERMEIER BERNHARD , HOLLA WOLFGANG
IPC分类号： C07D277/14 , B01J31/02 , C07B53/00 , C07B61/00 , C07C315/00 , C07C315/02 , C07C315/04 , C07C317/44 , C07D263/16 , C07D263/22 , C07D263/26 , C07D277/16
摘要： PCT No. PCT/EP93/02673 Sec. 371 Date May 15, 1995 Sec. 102(e) Date May 15, 1995 PCT Filed Sep. 30, 1993 PCT Pub. No. WO94/00789 PCT Pub. Date Apr. 14, 1994Process for the stereoselective synthesis of 3-substituted 2-thiomethylpropionic acids Compounds of the formula I I in which R1 and R2 are as defined can be prepared stereoselectively by reaction of acrylic acid or derivatives thereof or propionic acid or derivatives thereof with a chiral auxiliary, reaction with a mercaptan, stereoselective alkylation and subsequent hydrolysis and oxidation.

38. 发明专利

HU9500953D0 PROCESS FOR THE STEREOSELECTIVE SYNTHESIS OF 3-SUBSTITUTED 2-THIOMETHYL PROPIONIC ACIDS 未知
公开(公告)号：HU9500953D0
公开(公告)日：1995-05-29
申请号：HU9500953
申请日：1993-09-30
申请人： HOECHST AG
发明人： BECK GERHARD , KAMMERMEIER BERNHARD , HOLLA WOLFGANG
IPC分类号： C07D277/14 , B01J31/02 , C07B53/00 , C07B61/00 , C07C315/00 , C07C315/02 , C07C315/04 , C07C317/44 , C07D263/16 , C07D263/22 , C07D263/26 , C07D277/16
摘要： PCT No. PCT/EP93/02673 Sec. 371 Date May 15, 1995 Sec. 102(e) Date May 15, 1995 PCT Filed Sep. 30, 1993 PCT Pub. No. WO94/00789 PCT Pub. Date Apr. 14, 1994Process for the stereoselective synthesis of 3-substituted 2-thiomethylpropionic acids Compounds of the formula I I in which R1 and R2 are as defined can be prepared stereoselectively by reaction of acrylic acid or derivatives thereof or propionic acid or derivatives thereof with a chiral auxiliary, reaction with a mercaptan, stereoselective alkylation and subsequent hydrolysis and oxidation.

39. 发明专利

AU645654B2 Process for the preparation of racemic and optically active 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and its precursors 未知
公开(公告)号：AU645654B2
公开(公告)日：1994-01-20
申请号：AU1039492
申请日：1992-01-23
申请人： HOECHST AG
发明人： KAMMERMEIER BERNHARD , LERCH ULRICH
IPC分类号： C07D217/26
摘要： A process for the preparation of racemic and optically active 1,2.3,4-tetrahydroisoquinoline-3-carboxylic acid is described, in which dihalo-o-xylylenes are cyclized to dicarboxylic acid esters in basic medium using dialkyl N-acylamidomalonates of the formula (CO2R1)2CHNHCOR2, in which R1 is (C1-C4)-alkyl and R2 is H, (C1-C4)-alkyl or (C6-C12)-aryl, decarboxylated by basic hydrolysis and subsequent acid work-up and then reacted in acid medium to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or dihalo-o-xylylenes are cyclized in basic medium to give the dicarboxylic acid esters and these are reacted directly without isolation in a one-pot process to give (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, if desired the racemic 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is reacted with (-)menthol and p-toluenesulfonic acid to give (-)menthyl (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate, then the diastereomers are separated by column chromatography and subjected to basic hydrolysis to give (D)-or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, or (D,L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is esterified by means of benzyl alcohol and p-toluenesulfonic acid, reacted with D(-)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (D)-mandelate or with L(+)mandelic acid to give benzyl (D)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and benzyl (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (L)-mandelate and then the compounds obtained are separated into the optical antipodes by fractional crystallization in an inert solvent and the enantiomers (D)- or (L)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid are liberated by basic hydrolysis, the chiral auxiliary reagent being recovered.

40. 发明专利

NO923879D0 未知
公开(公告)号：NO923879D0
公开(公告)日：1992-10-06
申请号：NO923879
申请日：1992-10-06
申请人： HOECHST AG
发明人： JACOBI DETLEF , JENDRALLA JOACHIM-HEINER , KAMMERMEIER BERNHARD
IPC分类号： C07C229/00 , C07C213/00 , C07C215/18 , C07C269/00 , C07C269/06 , C07C271/16 , C07C271/20 , C07C271/22 , C07C315/04 , C07C317/44 , C07C317/50 , C07D217/12 , C07D217/16 , C07D217/18 , C07H15/04 , C07C
摘要： A process for the preparation of optically pure symmetrical compounds of the formula I is described, in which R , R and R are explained in the description, with simultaneous control of the four centres of chirality marked by *.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式