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31. 发明授权

US06749736B1 Electrode arrangement for the dielectrophoretic diversion of particles 有权
标题翻译：用于介电电泳转移颗粒的电极布置
公开(公告)号：US06749736B1
公开(公告)日：2004-06-15
申请号：US09720222
申请日：2001-02-22
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27453
CPC分类号： B03C5/026 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0825 , B01L2400/0409 , B01L2400/0415 , B01L2400/0424 , B01L2400/0457 , B03C5/005 , B03C2201/26 , C12M33/00 , C12M35/02 , C12M47/04
摘要： Electrode arrangement (10) in a microsystem adapted for dielectrophoretic manipulation of particles (30) in a suspension fluid in a channel (21), wherein at least one electrode (11, 11a, 11b, 12) is arranged on a lateral wall of the channel (21), the electrode (11, 11a, 11b, 12) consisting of a plurality of electrode segments adapted to generate at least one field gradient for influencing the movement paths of the particles (30) in the channel (21). In one embodiment of the invention, the particles are moved in the microsystem by exposure to centrifugal and/or gravitational forces.
摘要翻译：在微系统中的电极装置（10），其适用于在通道（21）中的悬浮液中的颗粒（30）的介电电泳操作，其中至少一个电极（11,11a，11b，12）布置在所述通道通道（21），由多个电极段组成的电极（11,11a，11b，12），其适于产生用于影响通道（21）中的颗粒（30）的运动路径的至少一个场梯度。在本发明的一个实施方案中，颗粒通过暴露于离心和/或重力而在微系统中移动。

32. 发明授权

US09149813B2 Methods and devices for separating particles in a liquid flow 有权
标题翻译：用于分离液体流中的颗粒的方法和装置
公开(公告)号：US09149813B2
公开(公告)日：2015-10-06
申请号：US13586988
申请日：2012-08-16
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： G01N27/447 , B03C5/00
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

33. 发明申请

US20090008254A1 Microfluidic System and Corresponding Control Method 审中-公开
标题翻译：微流控系统及相应的控制方法
公开(公告)号：US20090008254A1
公开(公告)日：2009-01-08
申请号：US11908605
申请日：2006-03-16
申请人： Torsten Müller , Thomas Schnelle
发明人： Torsten Müller , Thomas Schnelle
IPC分类号： B01D57/02 , C25B11/00
CPC分类号： B03C5/026 , B03C5/005
摘要： The invention relates to a microfluidic system containing a carrier current channel (1) for receiving a carrier current containing particles suspended therein, and at least one electrode arrangement (3) which is arranged in the carrier current channel and used to manipulate the suspended particles (2), the electrode arrangement (3) containing two manipulation electrodes (4, 5). According to the invention, the electrode arrangement (3) contains two centering electrodes (6, 7), in addition to the two manipulation electrodes (4, 5), for centering the particles, the two centering electrodes (6, 7) being arranged in the carrier current channel (1) respectively upstream of one of the two manipulation electrodes (4, 5). The invention also relates to a corresponding control method.
摘要翻译：本发明涉及一种微流体系统，其包含用于接收载流子电流的载流子流道（1），所述载流子流包含悬浮在其中的颗粒;以及至少一个电极装置（3），其布置在所述载流子通道中并用于操纵所述悬浮颗粒 2），电极装置（3）包含两个操纵电极（4,5）。根据本发明，电极装置（3）除了两个操作电极（4,5）之外还包含两个定心电极（6,7），用于使颗粒居中，两个定心电极（6,7）被布置分别位于两个操作电极（4,5）中的一个的上游的载波电流通道（1）中。本发明还涉及相应的控制方法。

34. 发明授权

US06991906B1 Method and device for measuring, calibrating and using laser tweezers 失效
标题翻译：用于测量，校准和使用激光镊子的方法和装置
公开(公告)号：US06991906B1
公开(公告)日：2006-01-31
申请号：US09582609
申请日：1998-12-21
申请人： Günter Fuhr , Thomas Schnelle , Torsten Müller , Hermine Hitzler , Karl-Otto Greulich , Shamoi Monajembashi
发明人： Günter Fuhr , Thomas Schnelle , Torsten Müller , Hermine Hitzler , Karl-Otto Greulich , Shamoi Monajembashi
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： H05H3/04 , G21K1/006
摘要： To measure or exert optically-induced forces on at least one particle in the focus of an optical cage, the following steps are taken: a) the focus is positioned in a microelectrode arrangement with a three-dimensional electrical field that has a field gradient which forms an electrical capture area, and the focus is at a distance from the capture are and b) the amplitude of the electrical field, the light power of the light beam forming the optical cage, and/or the distance of the capture area from the focus are varied to detect which varied field property moves the particle from the focus to the capture area or vice versa, or at least to temporarily move the particle into the capture area.
摘要翻译：为了在光学保持架的焦点的至少一个颗粒上测量或施加光学诱导的力，采取以下步骤：a）焦点位于具有场梯度的三维电场的微电极布置中，形成电捕获区域，并且聚焦距离捕获的距离为b）电场的幅度，形成光学笼的光束的光功率和/或捕获区域距离改变焦点以检测哪个变化的场性质将粒子从焦点移动到捕获区域，反之亦然，或至少临时将颗粒移动到捕获区域中。

35. 发明授权

US06727451B1 Method and device for manipulating microparticles in fluid flows 有权
标题翻译：用于操纵流体流中微粒的方法和装置
公开(公告)号：US06727451B1
公开(公告)日：2004-04-27
申请号：US09673034
申请日：2000-11-30
申请人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
发明人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
IPC分类号： B01D5702
CPC分类号： B03C5/026 , C12M47/04
摘要： To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.
摘要翻译：为了操纵在与第一通道或多个第一通道相交的流体中的微粒作为流，一个或多个微粒暴露于电场屏障，其将其方向从流动方向朝向流动边缘改变为侧向（17）。结果，微粒可以在流动流体之间来回移动。优选的应用包括处理，分离，分选或限制程序。

36. 发明申请

US20090148937A1 MICRO-FLUIDIC SYSTEM COMPRISING AN EXPANDED CHANNEL 审中-公开
标题翻译：包含扩展通道的微流体系统
公开(公告)号：US20090148937A1
公开(公告)日：2009-06-11
申请号：US11719618
申请日：2005-11-17
申请人： Thomas Schnelle , Torsten Müller , Annette Pfennig
发明人： Thomas Schnelle , Torsten Müller , Annette Pfennig
IPC分类号： C12N5/06 , G01N15/00 , G01N27/26 , B03B5/00
CPC分类号： G01N15/1056 , B01L3/502753 , B01L2200/0647 , B01L2300/0864 , B01L2400/0424 , B03C5/026 , B03C2201/26 , G01N15/1404 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/1236 , G01N2015/149
摘要： The invention relates to a micro-fluidic system including a fluid medium channel that holds a fluid medium containing particles in suspension. According to the invention, the fluid medium channel has an expanded section with an enlarged cross-section along part of its length, in order to reduce the flow speed to allow the analysis of the particles.
摘要翻译：本发明涉及一种微流体系统，其包括流体介质通道，其保持含有悬浮液中的颗粒的流体介质。根据本发明，流体介质通道具有沿其长度的一部分具有放大横截面的膨胀部分，以便减小流速以允许分析颗粒。

37. 发明申请

US20070020767A1 Processes and devices for the liquid treatment of suspended particles 审中-公开
标题翻译：用于液体处理悬浮颗粒的方法和装置
公开(公告)号：US20070020767A1
公开(公告)日：2007-01-25
申请号：US10556239
申请日：2004-05-10
申请人： Thomas Schnelle
发明人： Thomas Schnelle
IPC分类号： G01N1/10
CPC分类号： B01L3/502784 , B01J19/0093 , B01J2219/00788 , B01J2219/00853 , B01J2219/00858 , B01J2219/0086 , B01J2219/0097 , B01L3/502761 , B01L2200/0668 , B01L2200/0673 , B01L2400/0415 , B01L2400/0436 , B01L2400/0454 , B03C5/026 , G01N2015/1081 , G01N2015/149 , Y10T436/2575
摘要： Processes are described for the treatment of at least one particle (10-13) with at least one reaction liquid (20) in a main channel (30) of a fluidic microsystem (100) with the following steps: movement of the at least one particle (10-13) with a carrier liquid (40) flowing in a longitudinal direction of the main channel (30) up to a holding device (50), at least a temporary holding of the at least one particle (13) under the action of a holding force exerted by the holding device (50), and supplying of the reaction liquid (20) from at least one lateral channel (31) into the main channel (30) so that the at least one held particle (13) is rinsed by the reaction liquid (20), the holding device (50) being arranged downstream after a mouth (32) of the lateral channel (31) in the main channel (30) and the reaction liquid (20) flowing through the holding device (50) with a direction of flow running in the longitudinal direction of the main channel (30). Fluidic microsystems and electrode arrangements for realizing the processes are also described.
摘要翻译：描述了用于在流体微系统（100）的主通道（30）中用至少一个反应液体（20）处理至少一个颗粒（10-13）的方法，其具有以下步骤：至少一个颗粒（10-13）与载液（40）沿着主通道（30）的纵向方向流动到保持装置（50），至少暂时保持至少一个颗粒（13）由保持装置（50）施加的保持力的作用，以及将反应液体（20）从至少一个横向通道（31）供应到主通道（30）中，使得至少一个保持的颗粒（13）由反应液（20）冲洗，保持装置（50）在主通道（30）中的侧通道（31）的口（32）之后并且反应液（20）流过保持件装置（50），其沿着主通道的纵向方向流动 el（30）。还描述了用于实现该过程的流体微系统和电极装置。

38. 发明授权

US07070684B1 Electrode arrangement for generating functional field barriers in microsystems 失效
标题翻译：用于在微系统中产生功能场屏障的电极装置
公开(公告)号：US07070684B1
公开(公告)日：2006-07-04
申请号：US09720275
申请日：1999-06-28
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01F13/0076 , B01F13/0077 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0415 , B03C5/026 , C12M33/00 , C12M47/04
摘要： A microsystem adapted for dielectrophoretic manipulation of particles in a suspension liquid wherein the microsystem has a channel with channel walls and a longitudinal extension. An electrode arrangement is present which has at least one microelectrode on at least one of the channel walls. This acts to generate a field barrier which crosses the channel at least partly. The microelectrode has a band-shape or has a multitude of straight electrode sections connected to each other. The band-shape has a predetermined curvature or the straight electrode sections are arranged with predetermined different angles so that the field barrier has a predetermined curvature relative to the longitudinal extension of the channel.
摘要翻译：一种适用于悬浮液中颗粒的介电电泳操作的微系统，其中微系统具有通道壁和纵向延伸的通道。存在在至少一个通道壁上具有至少一个微电极的电极布置。这用于产生至少部分穿过通道的场屏障。微电极具有带状或具有彼此连接的多个直电极部分。带状具有预定的曲率或直线电极部分以预定的不同角度布置，使得场屏障相对于通道的纵向延伸具有预定的曲率。

39. 发明授权

US5948328A Shaping of microparticles in electric-field cages 失效
标题翻译：电场笼中微粒的形成
公开(公告)号：US5948328A
公开(公告)日：1999-09-07
申请号：US700395
申请日：1996-08-23
申请人： Stefan Fiedler , Andreas Voigt , Thomas Schnelle , Guenter Fuhr , Torsten Mueller , Rolf Hagedorn , Jan Hornung , Henning Glasser , Bernd Wagner
发明人： Stefan Fiedler , Andreas Voigt , Thomas Schnelle , Guenter Fuhr , Torsten Mueller , Rolf Hagedorn , Jan Hornung , Henning Glasser , Bernd Wagner
IPC分类号： B01J2/00 , B01J13/02 , B01J19/08
CPC分类号： B01J13/02 , B01J19/087 , B01J2/00
摘要： In the method proposed, microparticles suspended in a liquid or droplets suspended in a liquid with which they are immiscible are shaped by high-frequency electric fields in a three-dimensional electrode array of a size in the micrometer or submicrometer range and subsequently consolidated by prior art chemical bonding procedures or by physical methods. The disposition, geometry and control of the electrodes determine the shape of the particles. The particles themselves must have a conductivity and/or relative dielectric constant lower than the solution surrounding them. For some, this can be achieved only at certain frequencies in the kHz and MHz band which are determined by the passive electrical properties of the particles and the surrounding solution. The particles or droplets are repelled by the electrodes so that they are shaped in the free solution without making contact with any surface and can then be consolidated. This makes it possible to shape micrometer and submicrometer size particles of the kind required in chromatography, affinity biochemistry and medicine, as well as for filter systems.
摘要翻译： PCT No.PCT / DE95 / 00237 Sec。 371日期：1996年8月23日 102（e）日期1996年8月23日PCT提交1995年2月23日PCT公布。 WO95 / 23020 PCT公开号日期1995年8月31日在所提出的方法中，悬浮在液体中的微粒悬浮在与其不混溶的液体中的微滴通过在微米或亚微米范围内的尺寸的三维电极阵列中的高频电场并随后通过现有技术的化学键合方法或通过物理方法进行固结。电极的布置，几何形状和控制决定了颗粒的形状。颗粒本身必须具有低于围绕它们的溶液的导电性和/或相对介电常数。对于一些，这只能在通过颗粒和周围溶液的被动电特性确定的kHz和MHz频带的某些频率下实现。颗粒或液滴被电极排斥，使得它们在游离溶液中成形，而不与任何表面接触，然后可以被固结。这使得可以形成色谱，亲和力生物化学和药物所需类型的微米和亚微米尺寸的颗粒，以及过滤系统。

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