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31. 发明授权

US06176004B1 Method of forming a sensor for sensing signals on conductors 失效
标题翻译：形成用于感测导体上的信号的传感器的方法
公开(公告)号：US06176004B1
公开(公告)日：2001-01-23
申请号：US09222224
申请日：1998-12-29
申请人： Robert L. Rainhart , Larry Davis , Charles M. Newton , Theodore R. Blumstein
发明人： Robert L. Rainhart , Larry Davis , Charles M. Newton , Theodore R. Blumstein
IPC分类号： H01P1100
CPC分类号： H01Q21/062 , G01R3/00 , G01R29/0878 , H01Q1/40 , H01Q9/30 , H01Q21/0087 , H01Q21/061 , H05K1/0219 , H05K1/0222 , H05K1/0306 , H05K1/115 , Y10T29/49002 , Y10T29/49016
摘要： A method of forming a sensor for sensing signals on conductors includes the step of forming a plurality of antenna element openings in a plurality of green tape ceramic sheets. Each antenna element opening includes a central opening and annular opening surrounding the central opening. The method includes the step of stacking successive green tape ceramic sheets so that central and annular openings are aligned with each other while also forming a planar sensor face that is to be placed adjacent the conductors to be sensed. The central openings and annular openings are filled with conductive paste. The stacked green tape ceramic sheets are heated to cure the green tape ceramic sheets and conductive paste. A signal processing integrated circuit is mounted on the side opposite the planar sensor face that is to be placed adjacent the conductors to be sensed. The method also includes the step of connecting the cured conductive paste filling central opening to the signal processing integrated circuit.
摘要翻译：形成用于感测导体上的信号的传感器的方法包括在多个生瓷带陶瓷片中形成多个天线元件开口的步骤。每个天线元件开口包括围绕中心开口的中心开口和环形开口。该方法包括堆叠连续的生瓷带陶瓷片的步骤，使得中心和环形开口彼此对准，同时还形成要邻近被感测导体放置的平面传感器面。中心开口和环形开口填充有导电膏。堆叠的绿色带状陶瓷片被加热以固化生胶带陶瓷片和导电膏。信号处理集成电路安装在与要被感测的导体相邻的平面传感器面相对的一侧。该方法还包括将固化的导电糊填充中心开口连接到信号处理集成电路的步骤。

32. 发明授权

US5519131A Synthesis of pyridooxazinyl-indoles 失效
标题翻译：吡啶并恶嗪基 - 吲哚的合成
公开(公告)号：US5519131A
公开(公告)日：1996-05-21
申请号：US138645
申请日：1993-10-20
申请人： Richard C. Effland , Larry Davis , Gordon E. Olsen
发明人： Richard C. Effland , Larry Davis , Gordon E. Olsen
IPC分类号： A61K31/535 , A61K31/5383 , A61K31/55 , A61P25/24 , A61P25/26 , A61P25/28 , C07D209/18 , C07D265/28 , C07D401/12 , C07D401/14 , C07D413/04 , C07D498/04
CPC分类号： C07D401/12
摘要： This application relates to a process for the preparation of indolylpyridooxazines of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification which comprises cyclizing compound of the formula ##STR2## in the presence of a strong base such as sodium hydride or potassium t-butoxide.
摘要翻译：本申请涉及一种制备式IMA的吲哚基吡啶并恶嗪的方法，其中R 1，R 2和R 3如说明书中所定义，其中包括在强碱如氢化钠存在下环化式IMAMA的化合物或叔丁醇钾。

33. 发明授权

US5215984A Antihypertensive spiro(piperidine- pyrrolidine- or hexahydroazepinyl substituted) pyrrolo(2,1-c)(1,4)benzoxazepines) 失效
标题翻译：抗高血压螺（哌啶 - 吡咯烷或六氢氮杂环己基取代的）吡咯并（2,1-c）（1,4）苯并氧氮杂）
公开(公告)号：US5215984A
公开(公告)日：1993-06-01
申请号：US440947
申请日：1989-11-24
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D401/04 , C07D401/14 , C07D498/20
CPC分类号： C07D401/04 , C07D401/14
摘要： This invention relates to spiro-](piperidine-, pyrrolidine-, or -hexahydroazepinyl substituted) pyrrolo[2,1-c][1,4]-benzoxazepines] having the following formula ##STR1## wherein R is hydrogen, lower alkyl, arylloweralkyl, acyl, lower alkenyl, lower alkynyl, and loweralkylbenzisoxazole; X is hydrogen, halogen, loweralkoxy, and trifluoromethyl; Y is hydrogen; 2' or 3' acyl, formyl, carbinol of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are independently hydrogen, loweralkyl, arylloweralkyl, aryl, loweralkenyl, lower alkynyl and lower alkylbenzisoxazole; loweralkyl, loweralkenyl and halogen; and n is an integer of 1 to 3. The compounds of this invention display utility as analgesic and antihypertensive agents.
摘要翻译：本发明涉及具有下列结构式的螺 - - （哌啶 - ，吡咯烷 - 或六氢氮杂环己烷基取代的）吡咯并[2,1-c] [1,4] - 苯并恶唑[其中R是氢，低级烷基，芳基低级烷基，酰基，低级烯基，低级炔基和低级烷基苯并异恶唑; X是氢，卤素，低级烷氧基和三氟甲基; Y是氢; 其中R 1和R 2相同或不同并且独立地是氢，低级烷基，芳基低级烷基，芳基，低级烯基，低级炔基和低级烷基苯并异恶唑;式2'或3'酰基，甲酰基甲醇，低级烷基，低级烯基和卤素; 并且n为1至3的整数。本发明化合物显示出作为镇痛和抗高血压药物的用途。

34. 发明授权

US5155098A N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them 失效
标题翻译： N-杂芳基 - 嘌呤-6-胺，以及使用它们的药物组合物和方法
公开(公告)号：US5155098A
公开(公告)日：1992-10-13
申请号：US696472
申请日：1991-05-06
申请人： Richard C. Effland , Joseph T. Klein , Larry Davis , Gordon E. Olson
发明人： Richard C. Effland , Joseph T. Klein , Larry Davis , Gordon E. Olson
IPC分类号： C07D473/34 , C07H19/16
CPC分类号： C07H19/16 , C07D473/34
摘要： This invention relates to a N-heteroaryl-purin-6-amine of the formula ##STR1## where R.sub.1 is hydrogen, lower alkyl, and arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen, lower alkyl, or R.sub.4 and R.sub.5 taken together are aryl; R.sub.6 is hydrogen, lower alkyl, aryl, arylloweralkyl, ##STR2## where R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined above, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic and anitconvulsant agents.
摘要翻译：本发明涉及下式的N-杂芳基 - 嘌呤-6-胺：其中R 1是氢，低级烷基和芳基低级烷基; R2和R3独立地是氢，低级烷基或R2和R3一起是芳基; R4和R5独立地是氢，低级烷基或R4和R5一起是芳基; R 6是氢，低级烷基，芳基，芳基低级烷基，其中R 2，R 3，R 4和R 5如上定义，其药学上可接受的酸加成盐，以及适用的几何和旋光异构体及其外消旋混合物。本发明化合物显示出作为止痛剂和抗惊厥剂的用途。

35. 发明授权

US4983615A Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders 失效
标题翻译：可用于治疗皮肤病症的杂芳基氨基和杂芳基嘧啶胺化合物
公开(公告)号：US4983615A
公开(公告)日：1991-01-08
申请号：US496723
申请日：1990-03-21
申请人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis , Russell R. L. Hamer , Brian S. Freed
发明人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis , Russell R. L. Hamer , Brian S. Freed
IPC分类号： C07D213/63 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4427 , A61P17/00 , C07D213/74 , C07D213/75 , C07D213/89 , C07D401/12 , C07D403/12 , C07D417/12
CPC分类号： C07D213/74 , C07D213/89 , C07D401/12 , C07D403/12
摘要： There are described compounds of the formula ##STR1## where n is 0 or 1;X is O or NR.sub.2, R.sub.2 being hydrogen, loweralkyl or loweralkylcarbonyl;R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl; andR.sub.1 is ##STR2## wherein R.sub.3 is hydrogen, loweralkyl or loweralkylcarbonyl; m is 1 or 2; each R.sub.4 is independently hydrogen or loweralkyl; and Y is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl;which compounds are useful as topical antiinflammatory agents for the treatment of various dermatoses.

36. 发明授权

US4983608A N-substituted-4-pyrimidinamines and pyrimidinediamines 失效
标题翻译： N-取代-4-嘧啶胺和嘧啶二胺
公开(公告)号：US4983608A
公开(公告)日：1991-01-08
申请号：US402415
申请日：1989-09-05
申请人： Richard C. Effland , Joseph T. Klein , Larry Davis , Gordon E. Olsen
发明人： Richard C. Effland , Joseph T. Klein , Larry Davis , Gordon E. Olsen
IPC分类号： A61K31/505 , A61P25/04 , A61P25/28 , C07D403/12 , C07D403/14
CPC分类号： C07D403/12 , C07D403/14
摘要： This invention relates to N-heteroaryl-4-pyrimidinamines of the formula ##STR1## where R.sub.1 is hydrogen, loweralkyl, aryl, or arylloweralkyl; R.sub.2 and R.sub.3 are independently hydrogen or loweralkyl, or R.sub.2 and R.sub.3 taken together are aryl; R.sub.4 and R.sub.5 are independently hydrogen or lowealkyl, or R.sub.4 and R.sub.5 taken together are aryl; X is hydrogen, halogen, cyano, nitro, amino, loweralkyl, loweralkoxy, trifluoromethyl or ##STR2## where Y is hydrogen, halogen or loweralkyl; m is an integer of 1 to 3; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometrical and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as memory enhancing agents and as analgesic agents.

37. 发明授权

US4959377A Phenoxypyridinamine compounds which are use as a dermatological composition 失效
标题翻译：用作皮肤病学组合物的苯氧吡啶胺化合物
公开(公告)号：US4959377A
公开(公告)日：1990-09-25
申请号：US372970
申请日：1989-06-29
申请人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis
发明人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61P17/00 , A61P29/00 , A61P37/08 , C07B41/04 , C07C39/02 , C07D213/68 , C07D213/73 , C07D213/75 , C07D213/89
CPC分类号： C07D213/73 , C07D213/68 , C07D213/75 , C07D213/89
摘要： There are described compounds of the formula ##STR1## where n is 0 or 1;X is hydrogen, loweralkyl, loweralkoxy, halogen, formyl, loweralkylcarbonyl, loweralkyoxycarbonyl, loweralkoxycarbonylloweralkyl or hydroxymethyl;Y is hydrogen or halogen;andR is hydrogen, loweralkyl arylloweralkyl or loweralkylcarbonyl,which compounds are useful as topical antiinflammatory agents for the treatment of various dermatoses.
摘要翻译：描述式为“IMAGE”的化合物，其中n为0或1; X是氢，低级烷基，低级烷氧基，卤素，甲酰基，低级烷基羰基，低级烷氧基羰基，低级烷氧基羰基低级烷基或羟甲基; Y是氢或卤素; R是氢，低级烷基芳基低级烷基或低级烷基羰基，该化合物可用作治疗各种皮肤病的局部抗炎剂。

38. 发明授权

US4931457A Naphthylamino-and naphthyloxy-pyridinamine comounds useful as topical antiinflammatory agents for the treatment of skin disorders 失效
标题翻译：可用作治疗皮肤疾病的局部抗炎剂的萘基氨基 - 和萘氧基 - 吡啶胺化合物
公开(公告)号：US4931457A
公开(公告)日：1990-06-05
申请号：US372508
申请日：1989-06-28
申请人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis
发明人： Richard C. Effland , Joseph T. Klein , Gordon E. Olsen , Larry Davis
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61P17/00 , A61P29/00 , A61P37/08 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/89
CPC分类号： C07D213/89 , C07D213/68 , C07D213/73
摘要： There are described compounds of the formula ##STR1## where R is hydrogen, loweralkyl, arylloweralkyl or loweralkylcarbonyl;X is O or NR.sub.1, R.sub.1 being hydrogen, loweralkyl or loweralkylcarbonyl; andY is hydrogen, loweralkyl, loweralkoxy, halogen or trifluoromethyl;which compounds are useful as topical antiinflammatory agents for the treatment of skin disorders.
摘要翻译：描述式为“IMAGE”的化合物，其中R是氢，低级烷基，芳基低级烷基或低级烷基羰基; X是O或NR 1，R 1是氢，低级烷基或低级烷基羰基; Y为氢，低级烷基，低级烷氧基，卤素或三氟甲基; 哪些化合物可用作治疗皮肤病症的局部抗炎药。

39. 发明授权

US4794181A 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines 失效
标题翻译： 1-芳氧基-2,3,4,5-四氢-3-苯并吖庚因
公开(公告)号：US4794181A
公开(公告)日：1988-12-27
申请号：US819439
申请日：1986-01-16
申请人： Richard C. Effland , Joseph T. Klein , Larry Davis
发明人： Richard C. Effland , Joseph T. Klein , Larry Davis
IPC分类号： C07D223/16
CPC分类号： C07D223/16
摘要： The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3-benzazepines of the formula ##STR1## wherein Y is the same of different and is hydrogen and lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF.sub.3, NO.sub.2, CN and NH.sub.2 ; R is hydrogen, lower alkyl, cycloalkyllower alkyl, ##STR2## Ar lower alkyl of the formula ##STR3## where Z is hydrogen, lower alkyl, lower alkoxy, halogen CF.sub.3, NO.sub.2 and NH.sub.2 ; Aryloxy lower alkyl of the formula ##STR4## where Z is as previously defined; and an alkylene amine of the formula ##STR5## where R.sub.1 and R.sub.2 are the same or different and are hydrogen and lower alkyl, n is an integer of 1 or 2; and the pharmaceutically acceptable acid addition salts thereof.
摘要翻译：本发明涉及式（I）的1-芳氧基-2,3,4,5-四氢-3-苯并吖庚因，其中Y是不同的并且是氢和低级烷氧基; X是氢，卤素，低级烷基，低级烷氧基，CF 3，NO 2，CN和NH 2; R是氢，低级烷基，环烷基低级烷基，其中Z是氢，低级烷基，低级烷氧基，卤素，CF 3，NO 2和NH 2; 其中Z如前所定义的式“IMAGE”的芳氧基低级烷基; 和式“IMAGE”的亚烷基胺，其中R 1和R 2相同或不同，为氢和低级烷基，n为1或2的整数; 及其药学上可接受的酸加成盐。

40. 发明授权

US4681879A 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents 失效
标题翻译： 11-取代的5H，11H-吡咯并[2,1-c] [1,4]苯并氧杂吖庚因作为抗精神病药和镇痛药
公开(公告)号：US4681879A
公开(公告)日：1987-07-21
申请号：US713938
申请日：1985-03-20
申请人： Richard C. Effland , Larry Davis , Kevin J. Kapples
发明人： Richard C. Effland , Larry Davis , Kevin J. Kapples
IPC分类号： C07D401/06 , C07D498/04 , C07D413/04 , A61K31/40 , A61K31/445
CPC分类号： C07D401/06
摘要： There are described novel 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines of the general formula ##STR1## where m and n are each independently 0, 1 or 2 and m+n is 1 or 2, X and Y are each independently hydrogen, loweralkyl or halogen, and R is hydrogen, cyano, --C(NH.sub.2)NOH, ##STR2## unsubstituted loweralkyl, or substituted loweralkyl having one to three substituents each of which being independently cyano, hydroxy, cycloalkyl of 3-6 carbon atoms, furyl, thienyl, ##STR3## k being 1, 2 or 3, W being each indepentently hydrogen, halogen, hydroxy, loweralkyl, trifluoromethyl, loweralkoxy, nitro, amino, diloweralkylamino, phenoxy, or benzyloxy, and Z being hydrogen, loweralkyl or halogen, which are useful as antipsychotic and analgesic agents; novel intermediate compounds therefor; and methods of synthesizing the foregoing compounds.
摘要翻译：描述了通式（IMA）（I）的新颖的11取代的5H，11H-吡咯并[2,1-c] [1,4]苯并氧杂吖庚因，其中m和n各自独立地为0,1或2，m + n为1或2，X和Y各自独立地为氢，低级烷基或卤素，R为氢，氰基，-C（NH 2）NOH，未取代的低级烷基或具有一至三个取代基的取代的低级烷基，独立地是氰基，羟基，3-6个碳原子的环烷基，呋喃基，噻吩基，1,2或3个，各自独立地为氢，卤素，羟基，低级烷基，三氟甲基，低级烷氧基，硝基，氨基，二低级烷基氨基，苯氧基或苄氧基，Z为氢，低级烷基或卤素，可用作抗精神病药和镇痛药; 新型中间体化合物; 和上述化合物的合成方法。

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