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31. 发明授权

US06527763B2 Flow apparatus for the disruption of occlusions 失效
公开(公告)号：US06527763B2
公开(公告)日：2003-03-04
申请号：US09949443
申请日：2001-09-06
申请人： Victor C. Esch , Quang Q. Tran , R. Rox Anderson
发明人： Victor C. Esch , Quang Q. Tran , R. Rox Anderson
IPC分类号： A61B1818
CPC分类号： A61B18/26 , A61B18/245 , A61B2017/00176 , A61B2018/2211
摘要： The invention encompasses methods and apparatus for pumping fluid from one location to another through the repetitive expansion and collapse of bubbles generated as a result of the absorption of repetitive pulses of radiation in a fluid. This pumping phenomenon can be used to aid removal of a total or partial occlusion in a body passage by emulsifying the occlusion with acoustic shock and pressure waves or by causing mechanically disrupting the occlusive material.

32. 发明授权

US6120497A Method and apparatus for treating wrinkles in skin using radiation 有权
公开(公告)号：US6120497A
公开(公告)日：2000-09-19
申请号：US153052
申请日：1998-09-15
申请人： R. Rox Anderson , Edward Victor Ross, Jr. , James C. Hsia , Kathleen McMillan
发明人： R. Rox Anderson , Edward Victor Ross, Jr. , James C. Hsia , Kathleen McMillan
IPC分类号： A61B17/00 , A61B18/00 , A61B18/20 , A61N5/067 , A61B18/18
CPC分类号： A61B18/203 , A61B2017/00761 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452 , A61B2018/0047 , A61N2005/067
摘要： A method for treating wrinkles in skin involves the use of a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.

33. 发明授权

US6066130A Delivering laser energy 失效
标题翻译：提供激光能量
公开(公告)号：US6066130A
公开(公告)日：2000-05-23
申请号：US261838
申请日：1988-10-24
申请人： Kenton W. Gregory , R. Rox Anderson
发明人： Kenton W. Gregory , R. Rox Anderson
IPC分类号： A61B18/20 , A61B17/00 , A61B17/22 , A61B18/22 , A61B18/24 , A61B19/00 , A61D7/00 , A61F2/00 , G02B6/032 , A61N5/02
CPC分类号： G02B6/032 , A61B18/24 , A61B18/245 , A61B2017/00853 , A61B2017/22038 , A61B2017/22072 , A61B2018/206 , A61B2018/2261 , A61B2090/3933 , A61F2210/0019
摘要： A method for conducting laser energy to a site includes steps of bringing the proximal end of a flexible tube near the site, filling at least a proximal portion of the tube with a liquid by introducing the liquid into the tube, allowing a portion of the liquid to flow out from the proximal end of the tube toward the site, and directing laser energy from a laser energy source into the distal end of the tube, whereby a portion of the laser energy emerges from the proximal end of the tube at the site. Also, such a method in which the liquid is a radiographic contrast medium. Also, such a method for removing an obstruction from a blood vessel in an animal. Also, apparatus for delivering laser energy to a site includes a flexible tube, a liquid, the tube having an opening in a first end through which the liquid can pass, means for providing a flow of the liquid into the tube, and a source of laser energy operationally associated with a second end of the tube, wherein the tube and the liquid are adapted to cooperate, when the tube contains the liquid, to conduct laser energy from the source and to emit a portion of the laser energy from the first end of the liquid-containing tube.
摘要翻译：用于向现场进行激光能量的方法包括以下步骤：使柔性管的近端靠近现场，通过将液体引入管中来填充液体的至少近端部分，允许液体的一部分从管的近端向现场流出，并将来自激光能量源的激光能量引导到管的远端，由此一部分激光能量从位于管的近端处出现。此外，这种液体是射线照相造影剂的方法。此外，这种用于从动物的血管中除去阻塞物的方法。而且，向场地传递激光能量的装置包括柔性管，液体，该管在第一端具有液体可以通过的开口，用于提供液体流入管的装置和激光能量与管的第二端可操作地相关联，其中管和液体适于在管包含液体时协作以从源引入激光能量并从第一端发射一部分激光能量的含液管。

34. 发明授权

US5814041A Laser illuminator 失效
公开(公告)号：US5814041A
公开(公告)日：1998-09-29
申请号：US474698
申请日：1995-06-07
申请人： R. Rox Anderson , Nayantara Bhatta , Scott Prahl
发明人： R. Rox Anderson , Nayantara Bhatta , Scott Prahl
IPC分类号： A61B18/22 , A61N5/06 , A61B17/36
CPC分类号： A61N5/0601 , A61N5/062 , A61B2018/2261 , A61N2005/0611
摘要： An illuminator including a differential optical radiator and a laser fiber disposed within the differential optical radiator. The differential optical radiator includes a first region that has a first level of reflectivity and a first level of transmissivity and a second region that has a second, higher level of reflectivity and a second, lower level of transmissivity. The first and second regions are positioned such and their reflectivities and transmissivities are chosen such that the radiator produces a substantially uniform pattern of illumination from the first and second regions. In another embodiment, the illuminator includes an expandable radiator and a laser fiber disposed within the expandable radiator. The reflectivity of the expandable radiator is such that the illumination at the outer surface of the expandable radiator is substantially uniform.

35. 发明授权

US5810801A Method and apparatus for treating wrinkles in skin using radiation 失效
公开(公告)号：US5810801A
公开(公告)日：1998-09-22
申请号：US794876
申请日：1997-02-05
申请人： R. Rox Anderson , Edward Victor Ross, Jr. , James C. Hsia , Kathleen McMillan
发明人： R. Rox Anderson , Edward Victor Ross, Jr. , James C. Hsia , Kathleen McMillan
IPC分类号： A61B17/00 , A61B18/00 , A61B18/20 , A61N5/067 , A61B17/36
CPC分类号： A61B18/203 , A61B2017/00761 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452 , A61B2018/0047 , A61N2005/067
摘要： A method for treating wrinkles in skin involves the use of a beam of puls scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.

36. 发明授权

US5527308A Laser illuminator 失效
标题翻译：激光照明器
公开(公告)号：US5527308A
公开(公告)日：1996-06-18
申请号：US384345
申请日：1995-02-01
申请人： R. Rox Anderson , Nayantara Bhatta , Scott Prahl , Peter J. Dwyer
发明人： R. Rox Anderson , Nayantara Bhatta , Scott Prahl , Peter J. Dwyer
IPC分类号： A61B18/22 , A61N5/06 , A61B17/36
CPC分类号： A61N5/0601 , A61N5/062 , A61B2018/2261 , A61N2005/0611
摘要： An illuminator including a differential optical radiator and a laser fiber disposed within the differential optical radiator. The differential optical radiator includes a first region that has a first level of reflectivity and a first level of transmissivity and a second region that has a second, higher level of reflectivity and a second, lower level of transmissivity. The first and second regions are positioned such and their reflectivities and transmissivities are chosen such that the radiator produces a substantially uniform pattern of illumination from the first and second regions.In another embodiment, the illuminator includes an expandable radiator and a laser fiber disposed within the expandable radiator. The reflectivity of the expandable radiator is such that the illumination at the outer surface of the expandable radiator is substantially uniform.
摘要翻译：一种照明器，包括差分光学辐射器和设置在差分光学辐射器内的激光光纤。差分光学辐射器包括具有第一反射率和第一透射率水平的第一区域和具有第二较高水平的反射率的第二区域和第二较低的透射率水平。第一和第二区域被定位成这样，并且它们的反射率和透射率被选择为使得辐射体从第一和第二区域产生基本均匀的照明图案。在另一个实施例中，照明器包括可扩张辐射器和设置在可扩展散热器内的激光光纤。可膨胀散热器的反射率使得可扩张散热器的外表面处的照明基本上是均匀的。

37. 发明授权

US5300097A Fiber optic psoriasis treatment device 失效
标题翻译：光纤银屑病治疗装置
公开(公告)号：US5300097A
公开(公告)日：1994-04-05
申请号：US947893
申请日：1992-09-18
申请人： Ethan A. Lerner , R. Rox Anderson , Michael R. Lerner
发明人： Ethan A. Lerner , R. Rox Anderson , Michael R. Lerner
IPC分类号： A61N5/06 , G02B6/10 , G02B6/26 , G02B6/42 , A61M5/06
CPC分类号： A61N5/0617 , G02B6/102 , G02B6/262 , G02B6/4298 , A61N2005/0661 , A61N5/0616
摘要： Disclosed is a therapeutic device including an optical source including means for generating ultraviolet (UV) radiation, and a light delivery apparatus. The light delivery apparatus includes a body member and a plurality of optical fibers extending therefrom. Each of the optical fibers includes a proximal tip affixed to the body member, a distal tip at the end of the fiber opposite the proximal tip, and means for coupling the generated radiation from the proximal tips of the fibers through the fibers, and to the distal tips. The distal tips are characterized by a radius of curvature in the range 0.25 to 2.0 mm. The coupling means includes a flexible central core disposed within a flexible outer cladding. The central core has a diameter in the range of 0.1 mm to 1.0 mm, and the cladding has a refraction less than the index of refraction of the core.
摘要翻译：公开了一种治疗装置，其包括包括用于产生紫外线（UV）辐射的装置的光源和光输送装置。光输送装置包括主体部件和从其延伸的多根光纤。每个光纤包括固定到本体构件的近端，在与近端相反的端部处的远端，以及用于将所产生的辐射从纤维的近端通过纤维耦合的装置，以及远端提示。远端尖端的特征在于曲率半径在0.25至2.0mm的范围内。联接装置包括设置在柔性外包层内的柔性中心芯。中心芯的直径在0.1mm至1.0mm的范围内，并且包层的折射小于芯的折射率。

38. 发明申请

US20080269733A1 METHOD AND APPARATUS FOR TREATING WRINKLES IN SKIN USING RADIATION 审中-公开
标题翻译：使用辐射处理皮肤皱纹的方法和装置
公开(公告)号：US20080269733A1
公开(公告)日：2008-10-30
申请号：US12167720
申请日：2008-07-03
申请人： R. Rox Anderson , Edward Victor Ross , James C. Hsia , Kathleen McMillan
发明人： R. Rox Anderson , Edward Victor Ross , James C. Hsia , Kathleen McMillan
IPC分类号： A61B18/28
CPC分类号： A61B18/203 , A61B2017/00761 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452 , A61B2018/0047 , A61N2005/067
摘要： A method for treating wrinkles in skin involves the use of a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.
摘要翻译：用于治疗皮肤皱纹的方法涉及使用脉冲，扫描或门控的连续波激光束或非相干辐射束。该方法包括产生辐射束，将辐射束引导到皮肤皱纹以下100微米至1.2毫米之间的目标皮肤区域，并且热损伤目标皮肤区域中的胶原蛋白。辐射束的波长在1.3和1.8微米之间。该方法可以包括冷却目标皮肤区域上方的皮肤区域，同时部分地使目标皮肤区域中的胶原变性。该方法还可以包括在热损伤目标皮肤区域中的胶原之前冷却目标皮肤区域之上的皮肤区域。

39. 发明授权

US06659999B1 Method and apparatus for treating wrinkles in skin using radiation 失效
标题翻译：使用辐射治疗皮肤皱纹的方法和装置
公开(公告)号：US06659999B1
公开(公告)日：2003-12-09
申请号：US09587156
申请日：2000-06-05
申请人： R. Rox Anderson , Edward Victor Ross, Jr. , James C. Hsia , Kathleen McMillan
发明人： R. Rox Anderson , Edward Victor Ross, Jr. , James C. Hsia , Kathleen McMillan
IPC分类号： A61B1818
CPC分类号： A61B18/203 , A61B2017/00761 , A61B2018/00023 , A61B2018/00029 , A61B2018/00452 , A61B2018/0047 , A61N2005/067
摘要： A method for treating wrinkles in skin involves the use of a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.
摘要翻译：用于治疗皮肤皱纹的方法涉及使用脉冲，扫描或门控的连续波激光束或非相干辐射束。该方法包括产生辐射束，将辐射束引导到皮肤皱纹以下100微米至1.2毫米之间的目标皮肤区域，并且热损伤目标皮肤区域中的胶原蛋白。辐射束的波长在1.3和1.8微米之间。该方法可以包括冷却目标皮肤区域上方的皮肤区域，同时部分地使目标皮肤区域中的胶原变性。该方法还可以包括在热损伤目标皮肤区域中的胶原之前冷却目标皮肤区域之上的皮肤区域。

40. 发明授权

US6129723A Apparatus and methods for laser-induced superficial alteration of a substrate 失效
标题翻译：用于激光诱导表面改变基底的装置和方法
公开(公告)号：US6129723A
公开(公告)日：2000-10-10
申请号：US563556
申请日：1995-11-28
申请人： R. Rox Anderson , Yacov Domankevitz
发明人： R. Rox Anderson , Yacov Domankevitz
IPC分类号： A61C1/00 , A61F9/01 , A61N5/06
CPC分类号： A61C1/0046 , A61F9/00804 , A61F2009/00872
摘要： An apparatus and method for superficially ablating and/or photochemically altering a substrate, e.g., a biological tissue, having a first refractive index, e.g., to a desired configuration, including a laser energy source which provides laser energy to an energy coupling wave generator which generates laser energy waves from the laser energy, the generator having a surface adapted to contact and form an interface with the substrate and having a second refractive index higher than the first refractive index, wherein laser energy entering the wave generator impinges on the surface at an angle of incidence greater than or equal to a critical angle for total internal reflection when the surface is not contacting the substrate, and wherein the wave generator couples the laser energy waves, e.g., refracted or evanescent waves, into the substrate at the interface to superficially ablate the substrate when contacting the substrate.
摘要翻译：一种用于表面烧蚀和/或光化学改变具有第一折射率的基底（例如生物组织）的设备和方法，所述生物组织具有第一折射率，例如到期望的配置，包括向能量耦合波发生器提供激光能量的激光能量源，从激光能量产生激光能量波，发生器具有适于接触并形成与衬底的界面并具有高于第一折射率的第二折射率的表面，其中进入波发生器的激光能量在当表面不接触衬底时，入射角大于或等于全内反射的临界角，并且其中波发生器将表面上的界面处的激光能量波例如折射或ev逝波耦合到衬底中在接触基底时烧蚀基底。

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