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31. 发明申请

US20110081220A1 FASTENER AND METHOD OF PROLONGING USE OF A DRIVER BLADE IN A FASTENING TOOL 有权
标题翻译：紧固件和方法在驱动工具中使用驱动刀片
公开(公告)号：US20110081220A1
公开(公告)日：2011-04-07
申请号：US12881973
申请日：2010-09-14
申请人： William L. Gabriel , Christopher A. Horst , Donald E. Bergstrom
发明人： William L. Gabriel , Christopher A. Horst , Donald E. Bergstrom
IPC分类号： F16B15/00 , B05D3/02
CPC分类号： F16B33/06 , F16B15/06 , F16B2001/0021
摘要： A fastener and a method for reducing wear on a driver blade in a fastening tool includes applying a layer of solid-based lubricant between the head of a fastener and a driver blade end. The fastener is for use in a fastening tool and includes a head, a shank, and a layer of lubricant on the head of the fastener. The lubricant is graphite, molybdenum disulfide, tungsten disulfide, boron nitride, polytetrafluoroethylene (PTFE), nano-diamonds, calcium stearate, sodium stearate, oils, greases, waxes, thermoplastic polymers, or another lubricant that exhibits similar characteristics. Aromatic polyamides (such as Kevlar™), ultra-high molecular weight polyethylene, powdered glass, glass fibers, thermoplastic polymers, and thermoset polymers also are contemplate to provide a barrier to contact between the driver blade and fastener head. The lubricant is sprayed, rolled, brushed, blotted or otherwise applied between the head of the fastener and the driver blade end prior to firing the fastening tool.
摘要翻译：用于减少紧固工具中的驱动器叶片上的磨损的紧固件和方法包括在紧固件的头部和驱动器刀片端部之间施加一层固体润滑剂。紧固件用于紧固工具，并且在紧固件的头部上包括头部，柄部和润滑剂层。润滑剂是石墨，二硫化钼，二硫化钨，氮化硼，聚四氟乙烯（PTFE），纳米金刚石，硬脂酸钙，硬脂酸钠，油，油脂，蜡，热塑性聚合物或具有相似特性的其他润滑剂。芳族聚酰胺（例如Kevlar TM），超高分子量聚乙烯，玻璃粉末，玻璃纤维，热塑性聚合物和热固性聚合物也被设想为驱动器叶片和紧固件头之间的接触提供屏障。在点燃紧固工具之前，润滑剂被喷涂，滚动，拉丝，印迹或以其它方式施加在紧固件的头部和驱动器刀片端部之间。

32. 发明授权

US07819614B2 Deformed shank fastener 有权
标题翻译：变形的柄紧固件
公开(公告)号：US07819614B2
公开(公告)日：2010-10-26
申请号：US12138180
申请日：2008-06-12
申请人： Anthony M. Versino , Kenneth R. Levey , Jeffrey L. Trzaskus , Lawrence S. Shelton , Donald E. Bergstrom
发明人： Anthony M. Versino , Kenneth R. Levey , Jeffrey L. Trzaskus , Lawrence S. Shelton , Donald E. Bergstrom
IPC分类号： F16B15/08
CPC分类号： F16B15/06
摘要： A nail has a head, a penetrating tip and a shank extending from the head to the penetrating tip. The shank has a circumference and a longitudinal axis. A plurality of rows of deformations formed as teeth are formed in the shank extending outwardly of the shank. The rows are formed in a spiral pattern along the length of the shank from about the head to about the penetrating tip. The rows of teeth are formed parallel to one another and formed at an angle of at least 50 degrees relative to a cross-sectional plane perpendicular to a longitudinal axis of the nail.
摘要翻译：指甲具有头部，穿透尖端和从头部延伸至穿透尖端的柄部。柄具有圆周和纵向轴线。形成为齿的多排变形形成在柄上延伸到柄的外侧。这些排沿着柄的长度从螺旋形状形成为从头部到穿透尖端。齿排彼此平行地形成，并且相对于垂直于钉的纵向轴线的横截面为至少50度的角度形成。

33. 发明申请

US20090155021A1 DEFORMED SHANK FASTENER 有权
标题翻译：变形山紧固件
公开(公告)号：US20090155021A1
公开(公告)日：2009-06-18
申请号：US12138180
申请日：2008-06-12
申请人： Anthony M. Versino , Kenneth R. Levey , Jeffrey L. Trzaskus , Lawrence S. Shelton , Donald E. Bergstrom
发明人： Anthony M. Versino , Kenneth R. Levey , Jeffrey L. Trzaskus , Lawrence S. Shelton , Donald E. Bergstrom
IPC分类号： F16B15/00
CPC分类号： F16B15/06
摘要： A nail has a head, a penetrating tip and a shank extending from the head to the penetrating tip. The shank has a circumference and a longitudinal axis. A plurality of rows of deformations formed as teeth are formed in the shank extending outwardly of the shank. The rows are formed in a spiral pattern along the length of the shank from about the head to about the penetrating tip. The rows of teeth are formed parallel to one another and formed at an angle of at least 50 degrees relative to a cross-sectional plane perpendicular to a longitudinal axis of the nail.
摘要翻译：指甲具有头部，穿透尖端和从头部延伸至穿透尖端的柄部。柄具有圆周和纵向轴线。形成为齿的多排变形形成在柄上延伸到柄的外侧。这些排沿着柄的长度从螺旋形状形成为从头部到穿透尖端。齿排彼此平行地形成，并且相对于垂直于钉的纵向轴线的横截面为至少50度的角度形成。

34. 发明申请

US20150209440A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE 审中-公开
标题翻译：结合物，颗粒，组合物及相关使用方法
公开(公告)号：US20150209440A1
公开(公告)日：2015-07-30
申请号：US14682749
申请日：2015-04-09
申请人： Scott Eliasof , Oliver S. Fetzer , Jungyeon Hwang , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Donald E. Bergstrom
发明人： Scott Eliasof , Oliver S. Fetzer , Jungyeon Hwang , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Donald E. Bergstrom
IPC分类号： A61K47/48 , C12N15/113 , A61K31/713
CPC分类号： A61K31/713 , A61K9/14 , A61K47/593 , A61K47/60 , A61K47/6921 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32 , Y10T428/2982
摘要： Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.
摘要翻译：用于递送核酸试剂的颗粒和共轭物。含有颗粒，共轭物或二者的组合物。使用颗粒，共轭物和组合物的方法。

35. 发明申请

US20120302622A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS 审中-公开
标题翻译：结合物，颗粒，成分及相关方法
公开(公告)号：US20120302622A1
公开(公告)日：2012-11-29
申请号：US13443765
申请日：2012-04-10
申请人： Scott Eliasof , Oliver S. Fetzer , Jungyeon Hwang , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Donald E. Bergstrom
发明人： Scott Eliasof , Oliver S. Fetzer , Jungyeon Hwang , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Donald E. Bergstrom
IPC分类号： A61K31/713 , C07H1/00 , C08F16/06 , C07H21/02
CPC分类号： A61K31/713 , A61K9/14 , A61K47/593 , A61K47/60 , A61K47/6921 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32 , Y10T428/2982
摘要： Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.
摘要翻译：用于递送核酸试剂的颗粒和共轭物。含有颗粒，共轭物或两者的组合物。使用颗粒，共轭物和组合物的方法。

36. 发明申请

US20120225129A1 CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS 审中-公开
公开(公告)号：US20120225129A1
公开(公告)日：2012-09-06
申请号：US13212951
申请日：2011-08-18
申请人： Scott Eliasof , Oliver S. Fetzer , Jungyeon Hwang , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Donald E. Bergstrom
发明人： Scott Eliasof , Oliver S. Fetzer , Jungyeon Hwang , Patrick Lim Soo , Pei-Sze Ng , Sonke Svenson , Donald E. Bergstrom
IPC分类号： A61K9/14 , A61K31/711 , C08F16/06 , C08F8/30 , C08G63/91 , A61K31/713 , B82Y5/00
CPC分类号： A61K31/713 , A61K9/14 , A61K47/593 , A61K47/60 , A61K47/6921 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , C12N2310/14 , C12N2310/351 , C12N2320/32 , Y10T428/2982
摘要： Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions.

37. 发明授权

US08251686B1 Apparatus for making debris-free nail collation 有权
标题翻译：无碎屑指甲整理的装置
公开(公告)号：US08251686B1
公开(公告)日：2012-08-28
申请号：US12627866
申请日：2009-11-30
申请人： Isaac H. Heskel , Lawrence S. Shelton , Donald E. Bergstrom , Michael J. Christensen , Algis P. Suopys , Eldrige J. Presnell , Joseph J. Righter, Jr. , Richard W. Mrozik, Jr.
发明人： Isaac H. Heskel , Lawrence S. Shelton , Donald E. Bergstrom , Michael J. Christensen , Algis P. Suopys , Eldrige J. Presnell , Joseph J. Righter, Jr. , Richard W. Mrozik, Jr.
IPC分类号： B29C70/84
CPC分类号： B29C70/74 , B29B13/02 , B29C35/045 , B29C2035/0811 , B29C2035/1616 , B29C2035/1691
摘要： An apparatus for forming a plastic molded collated fastener assembly includes a conveyor for carrying a plurality of fasteners in a horizontal plane defining an upper surface and a lower surface, a preheater for preheating the plurality of nails and a plastic collation molding station. The molding station includes injection nozzles for applying molten plastic to the upper surface of the fasteners and to the lower surface of the fasteners. The station further includes forming wheels including a holding section to, in cooperation with the conveyor, secure the fasteners. The wheels include a forming section to mold the molten plastic to the fasteners to form a collation having a collar encircling the fasteners' shanks and a connecting portion extending between the collars. The apparatus includes at least one cooling spray nozzle to spray a cooling vapor onto the fasteners and collations and at least one cooling spray nozzle to spray a cooling vapor onto the forming wheels. An air chiller further cools the collations.
摘要翻译：一种用于形成塑料成型的整理的紧固件组件的装置包括用于在限定上表面和下表面的水平平面中承载多个紧固件的输送机，用于预热多个钉子的预热器和塑料整理成型台。成型站包括用于将熔融塑料施加到紧固件的上表面和紧固件的下表面的注射嘴。车站还包括形成轮，其包括保持部分，以与输送机协作，固定紧固件。车轮包括成形部分，用于将熔融塑料模制成紧固件以形成具有环绕紧固件柄部的轴环和在轴环之间延伸的连接部分的对准。该装置包括至少一个冷却喷嘴，用于将冷却蒸汽喷射到紧固件和排齐物上，以及至少一个冷却喷嘴以将冷却蒸汽喷射到成型轮上。空气冷却器进一步冷却排序。

38. 发明申请

US20080282529A1 DEBRIS-FREE PLASTIC COLLATING STRIP FOR NAILS 有权
标题翻译：用于钉子的无破碎塑料收缩条
公开(公告)号：US20080282529A1
公开(公告)日：2008-11-20
申请号：US12176722
申请日：2008-07-21
申请人： Lawrence S. Shelton , Paul J. Storiz , Michael Starozhitzky , Algis P. Suopys , Donald E. Bergstrom
发明人： Lawrence S. Shelton , Paul J. Storiz , Michael Starozhitzky , Algis P. Suopys , Donald E. Bergstrom
IPC分类号： B22D11/128
CPC分类号： F16B15/08 , Y10T29/49982
摘要： A fastener assembly is configured for use in an associated fastener driving tool for driving a fastener from the assembly into an associated substrate. The assembly includes a row of fasteners, each having a shank, arranged substantially parallel to each other. A collation system is formed from a plastic material that is molded onto and adhered to the fasteners. The plastic material is molded to define a collar portion substantially encircling the fastener shank and a connecting portion extending between and connecting adjacent collar potions. The plastic material is formulated from an adhesive polymer. When the fastener is driven from the driving tool, the collar portion remains adhered to the fastener such that the collar portion penetrates the substrate with the fastener.
摘要翻译：紧固件组件被构造成用于相关联的紧固件驱动工具中，用于将紧固件从组件驱动到相关联的基底中。组件包括一排紧固件，每排紧固件具有基本上彼此平行布置的柄部。对照系统由塑料材料形成，该塑料材料被模制并粘附到紧固件上。塑料材料被模制以限定基本上环绕紧固件柄的套环部分和在相邻套环部分之间延伸并连接相邻套环部分的连接部分。塑料材料由粘合剂聚合物制成。当紧固件从驱动工具驱动时，套环部分保持粘附到紧固件上，使得套环部分用紧固件穿透衬底。

39. 发明授权

US07208528B1 Polyamine analogues as therapeutic and diagnostic agents 失效
标题翻译：多胺类似物作为治疗和诊断剂
公开(公告)号：US07208528B1
公开(公告)日：2007-04-24
申请号：US09396523
申请日：1999-09-15
申请人： Nicolaas M. J. Vermeulin , Christine L. O'Day , Heather K. Webb , Mark R. Burns , Donald E. Bergstrom
发明人： Nicolaas M. J. Vermeulin , Christine L. O'Day , Heather K. Webb , Mark R. Burns , Donald E. Bergstrom
IPC分类号： A61K31/47 , A61K31/425 , A61K31/42 , A61K31/17 , A61K31/16
CPC分类号： A61K31/16 , A61K31/17 , A61K31/42 , A61K31/425 , A61K31/47
摘要： Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinational polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.
摘要翻译：公开了具有比已知化合物低两个数量级的抑制常数的多胺转运的新型抑制剂。这些多胺类似物是治疗需要抑制多胺转运或其它多胺结合蛋白（例如癌症和血管成形术后损伤）的疾病的有用的药剂。公开了获得多胺类似物的新型化学合成方法，包括生产组合多胺文库。这些方法为诊断和研究测定和治疗产生了理想活动的类似物。本发明的测定法可用于在与多胺系统相互作用的药物的发现中靶向的高通量筛选。

40. 发明授权

US07160923B1 Polyamine analogues as therapeutic and diagnostic agents 有权
标题翻译：多胺类似物作为治疗和诊断剂
公开(公告)号：US07160923B1
公开(公告)日：2007-01-09
申请号：US09713512
申请日：2000-11-14
申请人： Nicolaas M. J. Vermeulin , Christine L. O'Day , Heather K. Webb , Mark R. Burns , Donald E. Bergstrom
发明人： Nicolaas M. J. Vermeulin , Christine L. O'Day , Heather K. Webb , Mark R. Burns , Donald E. Bergstrom
IPC分类号： A61K31/27 , A61K31/18 , A61K31/165 , A61K31/17 , A61K31/34
CPC分类号： C07C233/36 , A61K47/50 , C07C233/40 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/50 , C07C237/10 , C07C237/20 , C07C237/22 , C07C271/20 , C07C271/22 , G01N33/5308
摘要： Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatiorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.
摘要翻译：公开了具有比已知化合物低两个数量级的抑制常数的多胺转运的新型抑制剂。这些多胺类似物是治疗需要抑制多胺转运或其它多胺结合蛋白（例如癌症和血管成形术后损伤）的疾病的有用的药剂。公开了获得多胺类似物的新型化学合成方法，包括制备组合多胺文库。这些方法为诊断和研究测定和治疗产生了理想活动的类似物。本发明的测定法可用于在与多胺系统相互作用的药物的发现中靶向的高通量筛选。

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