专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明授权

US5792473A Granular product or tablet containing an effervescent system and an active pharmaceutical substance, as well as a method for its preparation 失效
标题翻译：含有泡腾系统和活性药物的粒状产品或片剂及其制备方法
公开(公告)号：US5792473A
公开(公告)日：1998-08-11
申请号：US620261
申请日：1996-03-22
申请人： Gehard Gergely , Thomas Gergely , Irmgard Gergely , Stefan Gergely
发明人： Gehard Gergely , Thomas Gergely , Irmgard Gergely , Stefan Gergely
IPC分类号： A61K9/46 , A61K9/16
CPC分类号： A61K9/0007
摘要： In accordance with this invention there is provided a granular product with an effervescent system which comprises acid-sensitive pharmaceutically active substances, such as, for example, betacarotene, cimetidine, ranitidine or cisapride, which is specially useful to prevent antacid action, having an acid-neutralizing capacity below about 5 meq, at a weight of about 1.6 to about 2.3 grams. The effervescent grains are made from carrier crystals of at least one solid, edible organic acid, preferably citric acid and/or tartaric acid, and are present as a granular product, separate from the pharmaceutically active substance, and are coated with at least one layer of a neutral substance which is soluble in water and/or alcohol and which is able to bring about a melting point depression of the acid grains at their surface, such as, for example, a water-soluble polymer, a polyalcohol, a carbohydrate and/or a hydrocolloid. A second coating contains at least a part of the alkali and/or alkaline earth carbonate or bicarbonate provided for the total dosage.
摘要翻译：根据本发明，提供了一种具有泡腾系统的颗粒产品，其包含酸敏感的药物活性物质，例如β-胡萝卜素，西咪替丁，雷尼替丁或西沙必利，其特别可用于防止抗酸作用，具有酸 - 中和容量低于约5meq，重量约1.6至约2.3克。泡腾颗粒由至少一种固体，可食用有机酸，优选柠檬酸和/或酒石酸的载体晶体制成，并且以与药物活性物质分开的粒状产物存在，并且涂覆有至少一层中性物质，其可溶于水和/或醇，并且能够在其表面产生酸晶粒的熔点下降，例如水溶性聚合物，多元醇，碳水化合物和 /或水胶体。第二涂层含有为总剂量提供的至少一部分碱金属和/或碱土金属碳酸盐或碳酸氢盐。

32. 发明授权

US07972623B2 Method for the production of effervescent granules in a vacuum 有权
标题翻译：在真空中生产泡腾颗粒的方法
公开(公告)号：US07972623B2
公开(公告)日：2011-07-05
申请号：US10568712
申请日：2004-08-07
申请人： Irmgard Gergely , Thomas Gergely , Stefan Gergely
发明人： Irmgard Gergely , Thomas Gergely , Stefan Gergely
IPC分类号： A61K9/46
CPC分类号： A61K9/0007 , A61K47/02 , A61K47/12 , Y10S514/951 , Y10T428/2982
摘要： The invention relates to a method for producing effervescent granules, in which the reaction partners edible, organic acid components and alkaline effervescent components separating carbon dioxide are reacted with each other in a vacuum under the effect of gas in a container that can be evacuated. The container is evacuated to a first vacuum value within a vacuum range of 200-900 mbar, whereupon the pressure inside the container is increased to a second vacuum value as a result of the gases produced during the reaction. The steps are cyclically repeated while the reaction continues. A maximum number of cycles, a maximum reaction time, and optionally, a maximum load for the stirring apparatus are defined before the reaction begins, and the reaction is terminated after reaching the first of the maximums. In an alternative embodiment, the invention also relates to a method for improving the shelf life of effervescent granules by a treatment with carbon dioxide during and/or following the production of the effervescent granules, and effervescent particles treated in this manner.
摘要翻译：本发明涉及一种生产泡腾颗粒的方法，其中反应配对物可食用，有机酸组分和分离二氧化碳的碱性泡腾成分在气体作用下在真空中彼此反应，在可抽出的容器中。容器在200-900mbar的真空范围内抽真空至第一真空值，由此在反应期间产生的气体，容器内的压力增加到第二真空度。反应继续时，循环重复步骤。在反应开始之前定义最大循环次数，最大反应时间和任选的搅拌装置的最大负荷，并且在达到第一个最大值后终止反应。在另一个实施方案中，本发明还涉及通过在生产泡腾颗粒期间和/或之后用二氧化碳处理来改善泡腾颗粒的保质期的方法，以及以这种方式处理的泡腾颗粒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式