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31. 发明申请

US20070249526A1 PROCESS FOR THE PREPARATION OF CYCLIC PEPTIDES 审中-公开
标题翻译：制备循环肽的方法
公开(公告)号：US20070249526A1
公开(公告)日：2007-10-25
申请号：US11736517
申请日：2007-04-17
申请人： Giovanni Abbenante , David Fairlie , Robert Reid
发明人： Giovanni Abbenante , David Fairlie , Robert Reid
IPC分类号： A61K38/08 , C07K7/00
CPC分类号： C07K7/56 , A61K38/00
摘要： The present invention relates to a process for the preparation of cyclic peptides, in particular the preparation of Ac-Phe[Orn-Pro-D-Cha-Trp-Arg] known as 3D53 or PMX53 which is a macrocyclic peptidomimetic of the human plasma protein C5a and displays excellent anti-inflammatory activity.
摘要翻译：本发明涉及制备环肽的方法，特别是制备称为3D53的Ac-Phe [Orn-Pro-D-Cha-Trp-Arg]或PMX53，其是人血浆蛋白的大环肽模拟物 C5a并显示出优异的抗炎活性。

32. 发明申请

US20060225589A1 Doctoring apparatus 审中-公开
标题翻译：医疗器械
公开(公告)号：US20060225589A1
公开(公告)日：2006-10-12
申请号：US11100695
申请日：2005-04-07
申请人： Robert Johnson , Robert Reid , Allen Brauns
发明人： Robert Johnson , Robert Reid , Allen Brauns
IPC分类号： B41F9/10
CPC分类号： D21G3/005
摘要： A reciprocating doctor is provided for doctoring the cylindrical surface of a roll rotating about a first axis. The doctor includes a doctor back with a blade holder carrying a doctor blade. The doctor back has journals aligned on a second axis parallel to the first rotational axis of the roll. The journals are rotatably supported in sleeve bearings, and the sleeve bearings are in turn supported by diaphragms spaced along the second axis. The sleeve bearings are fixed axially on their respective journals, and the diaphragms have hub portions surrounding and fixed relative to the sleeve bearings, and peripheral portions surrounding the hub portions and fixed relative to a support structure. The diaphragms are configured to resiliently accommodate reciprocating movement of their hub portions and associated sleeve bearings relative to their peripheral portions and associated support structure. A first operating mechanism serves to rotate the doctor back about the second axis, and a second operating mechanism serves to impart reciprocating movement to the journals and their sleeve bearings along the second axis.
摘要翻译：提供往复式刮刀，用于对围绕第一轴线旋转的辊的圆柱形表面进行刮削。医生将医生带回带有刮刀的刀片架。医生背部具有在平行于辊的第一旋转轴线的第二轴上对准的轴颈。轴颈可旋转地支撑在套筒轴承中，并且套筒轴承又由沿着第二轴线隔开的隔膜支撑。套筒轴承在它们各自的轴颈上轴向固定，并且隔膜具有围绕套筒轴承包围和固定的轮毂部分，以及围绕轮毂部分并相对于支撑结构固定的周边部分。隔膜被构造成弹性地适应其轮毂部分和相关联的套筒轴承相对于其周边部分和相关联的支撑结构的往复运动。第一操作机构用于使刮刀围绕第二轴线旋转，并且第二操作机构用于沿着第二轴线向轴颈及其套筒轴承施加往复运动。

33. 发明申请

US20060029837A1 Humidifier bypass system and method for PEM fuel cell 审中-公开
标题翻译： PEM燃料电池加湿器旁路系统及方法
公开(公告)号：US20060029837A1
公开(公告)日：2006-02-09
申请号：US10912298
申请日：2004-08-05
申请人： Mohammed Sennoun , Robert Reid
发明人： Mohammed Sennoun , Robert Reid
IPC分类号： H01M8/00 , H01M2/02
CPC分类号： H01M8/04302 , H01M8/04126 , H01M8/04156 , H01M8/04223 , H01M8/04225
摘要： A humidifier bypass system for a fuel cell is disclosed. The humidifier bypass system includes a cathode and/or anode inlet conduits for carrying a cathode and/or anode inlet streams. A humidifier is provided in fluid communication with the cathode and/or anode inlet conduits for receiving and humidifying the cathode and/or anode inlet streams. A fuel cell is provided in fluid communication with the humidifier for receiving the cathode and/or anode inlet streams from the humidifier. A cathode and/or anode humidifier bypass conduits connects the cathode and/or anode inlet conduits to the fuel cell for selectively shunting the cathode and/or anode inlet streams around the humidifier to the fuel cell. A humidifier bypass method for a fuel cell is also disclosed.
摘要翻译：公开了一种用于燃料电池的加湿器旁路系统。加湿器旁路系统包括用于承载阴极和/或阳极入口流的阴极和/或阳极入口导管。提供加湿器与阴极和/或阳极入口导管流体连通，用于接收和加湿阴极和/或阳极入口流。燃料电池被设置成与加湿器流体连通，用于从加湿器接收阴极和/或阳极入口流。阴极和/或阳极加湿器旁路管道将阴极和/或阳极入口导管连接到燃料电池，用于选择性地将加湿器周围的阴极和/或阳极入口流分流到燃料电池。还公开了一种用于燃料电池的加湿器旁路方法。

34. 发明授权

US06939546B2 Model for testing immunogenicity of peptides 失效
标题翻译：用于测试肽免疫原性的模型
公开(公告)号：US06939546B2
公开(公告)日：2005-09-06
申请号：US09013077
申请日：1998-01-26
申请人： Jeffrey Nauss , Robert Reid , Marcia Kay Wolf , Scheberazade Sadegh-Nasseri
发明人： Jeffrey Nauss , Robert Reid , Marcia Kay Wolf , Scheberazade Sadegh-Nasseri
IPC分类号： A61K9/16 , A61K9/50 , A61K38/17 , A61K38/19 , A61K39/00 , A61K39/02 , A61K39/108 , A61K39/29 , G01N33/543
CPC分类号： A61K9/5031 , A61K9/1611 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/5026 , A61K39/00 , A61K39/0258 , Y02A50/474
摘要： Assay methods for determining whether a peptide is likely to be immunogenic are based on a computer modeling of binding to a Class II MHC DR1 receptor. This is confirmed by competitive inhibition binding assays. The peptides are useful for eliciting an immune response for vaccination or the production of antibodies or T-cells.
摘要翻译：用于确定肽是否可能是免疫原性的测定方法是基于与II类MHC DR1受体结合的计算机建模。这通过竞争性抑制结合测定来证实。这些肽可用于引发用于疫苗接种或产生抗体或T细胞的免疫应答。

35. 发明授权

US06838033B2 Decorative materials encased in a polymer with fragrance releasing characteristics 失效
标题翻译：装饰材料装在具有香味释放特性的聚合物中
公开(公告)号：US06838033B2
公开(公告)日：2005-01-04
申请号：US09947639
申请日：2001-09-06
申请人： Jerome I. Lindauer , Robert Reid , Lynn Iarossi , Andrea Lynn Meyer
发明人： Jerome I. Lindauer , Robert Reid , Lynn Iarossi , Andrea Lynn Meyer
IPC分类号： A61L9/04 , A61L9/12 , B29C39/10
CPC分类号： A61L9/12 , A61L9/042 , Y10S425/057 , Y10S428/905 , Y10T428/31663
摘要： The present invention provides a fragrant article that delivers fragrance over a period of time by an article comprising a polymer matrix, a fragrance and a decorative object. The decorative object is contained within a polymer matrix and in a preferred embodiment is the similar to the fragrance that is being released. The article is particularly well suited to be used as a room freshener, which because of its attractive appearance does not need to be hidden.
摘要翻译：本发明提供一种芳香制品，其通过包含聚合物基质，香料和装饰物品的物品在一段时间内递送香料。装饰物体包含在聚合物基质内，并且在优选实施方案中与被释放的香料相似。该文章特别适合用作室内清新剂，因为它的吸引人的外观不需要隐藏。

36. 发明授权

US6043357A HIV protease inhibitors 失效
标题翻译： HIV蛋白酶抑制剂
公开(公告)号：US6043357A
公开(公告)日：2000-03-28
申请号：US849599
申请日：1997-09-09
申请人： John Abbenante , Doug Bergman , Ross Brinkworth , Robert Dancer , Bronwyn Garnham , Peter Hunt , David Fairlie , Darren March , Jennifer Martin , Robert Reid
发明人： John Abbenante , Doug Bergman , Ross Brinkworth , Robert Dancer , Bronwyn Garnham , Peter Hunt , David Fairlie , Darren March , Jennifer Martin , Robert Reid
IPC分类号： A61K38/00 , C07D273/00 , C07D273/02 , C07D285/00 , C07D291/02 , C07D413/06 , C07K5/02 , C07K5/078 , C07K14/16 , C07D245/00
CPC分类号： C07D273/00 , C07D273/02 , C07D285/00 , C07D291/02 , C07D413/06 , C07K14/005 , C07K5/021 , C07K5/06139 , C07K5/06165 , A61K38/00 , C12N2740/16122
摘要： A HIV-1 protease inhibitor which includes a n-terminal cycle (A) or a C-terminal cycle (B) or both cycles (A) and (B) wherein Y is selected from side chains of Asn or Ilc or Val or Glu and alkyl of 1-6 carbon atoms inclusive of linear branched chains as well as cycloalkyl; and X is selected from (CH2)n where n=3-6, --CH(OH)--CH(OH)--CH2; CH(CO2H)--CH2--CH2; CH2CONHCHR where R=D or L amino acids and alkyl of 1-6 carbon atoms inclusive of linear or branched chains.
摘要翻译： PCT No.PCT / AU95 / 00817 Sec。 371日期1997年9月9日 102（e）1997年9月9日PCT 1995年12月4日PCT PCT。第WO96 / 16950号公报日期1996年6月6日包括n末端循环（A）或C末端循环（B）或两个循环（A）和（B）的HIV-1蛋白酶抑制剂，其中Y选自Asn的侧链或 Ilc或Val或Glu和1-6个碳原子的烷基，包括直链支链以及环烷基; 并且X选自（CH 2）n，其中n = 3-6，-CH（OH）-CH（OH）-CH 2; CH（CO 2 H）-CH 2 -CH 2; CH2CONHCHR其中R = D或L氨基酸和1-6个碳原子的烷基，包括直链或支链。

37. 发明授权

US4750177A Digital data processor apparatus with pipelined fault tolerant bus protocol 失效
标题翻译：具有流水线容错总线协议的数字数据处理器
公开(公告)号：US4750177A
公开(公告)日：1988-06-07
申请号：US904827
申请日：1986-09-08
申请人： Gardner C. Hendrie , Kurt F. Baty , Ronald E. Dynneson , Daniel M. Falkoff , Robert Reid , Joseph E. Samson , Kenneth T. Wolff
发明人： Gardner C. Hendrie , Kurt F. Baty , Ronald E. Dynneson , Daniel M. Falkoff , Robert Reid , Joseph E. Samson , Kenneth T. Wolff
IPC分类号： G06F11/00 , G06F1/04 , G06F3/00 , G06F11/14 , G06F11/16 , G06F11/18 , G06F11/20 , G06F11/22 , G06F13/00
CPC分类号： G06F11/1625 , G06F11/1402 , G06F11/1604 , G06F11/2005 , G06F11/2007 , G06F11/2017 , G06F11/22 , G06F1/04 , G06F11/1629 , G06F11/1666 , G06F11/20
摘要： A fault-tolerant computer system provides information transfers between the units of a computing module, including a processor unit and a memory unit and one or more peripheral control units, on a bus structure common to all the units. Information-handling parts of the system, both in the bus structure and in each unit, can have a duplicate partner. Error detectors check the operation of the bus structure and of each system unit to provide information transfers only on fault-free bus conductors and between fault-free units. The computer system can operate in this manner essentially without interruption in the event of faults by using only fault-free conductors and functional units.Arbitration circuits of unusual speed and simplicity provide units of the computing module with access to the common bus structure according to the priority of each unit.The units of a module check incoming and outgoing signals for errors, signal other module units of a detected error, and disable the unit from sending potentially erroneous information onto the bus structure.
摘要翻译：容错计算机系统在计算模块的单元之间提供在所有单元共同的总线结构上的信息传输，包括处理器单元和存储器单元以及一个或多个外围控制单元。在总线结构和每个单元中，系统的信息处理部分可以具有重复的伙伴。错误检测器检查总线结构和每个系统单元的操作，仅在无故障总线导体和无故障单元之间提供信息传输。计算机系统可以通过仅使用无故障的导体和功能单元在基本上不发生故障的情况下以这种方式操作。具有异常速度和简单性的仲裁电路提供计算模块的单元根据每个单元的优先级访问公共总线结构。模块的单元检查输入和输出信号是否有错误，向其他模块单元发出检测到的错误信号，并禁止单元向总线结构发送潜在的错误信息。

38. 发明授权

US4162861A Structural joint 失效
标题翻译：结构接头
公开(公告)号：US4162861A
公开(公告)日：1979-07-31
申请号：US867289
申请日：1978-01-05
申请人： Robert Reid , Kaljo Lustvee
发明人： Robert Reid , Kaljo Lustvee
IPC分类号： F16B4/00 , E06C1/02 , E06C7/08 , F16B11/00 , F16B17/00 , B25G3/00 , F16B12/08 , F16B7/00 , F16L41/00
CPC分类号： E06C7/084 , E06C7/085 , F16B17/002 , F16B17/004 , Y10T29/49922 , Y10T29/49936 , Y10T403/4634
摘要： A structural joint for joining two elements comprises a malleable deformable flange on the first element and an elongate arcuate recess in the second element. The recess is adapted to receive the flange and allow the flange to be deformed therein into at least a portion of a coil where the entrance to the recess is less than the size of the formed coil. The recess is characterized in having a leg, the extremity of which defines one side of the recesses' entrance. The flange has next to it a tongue portion where a gap defined between the flange and tongue portion is of a size adapted to receive the leg of the recess in a manner to provide an interference fit between the tongue portion and the leg. The leg of the recess has an overturned part which overlies a portion of the coiled flange and has an abutment which abuts a side of the tongue portion. A method for making such structural joint is disclosed.
摘要翻译：用于连接两个元件的结构接头包括在第一元件上的可延展的可变形凸缘和第二元件中的细长的弓形凹部。该凹槽适于容纳凸缘，并允许凸缘在其中变形成线圈的至少一部分，其中凹部的入口小于形成的线圈的尺寸。凹槽的特征在于具有一个腿，其末端限定了凹部入口的一侧。凸缘旁边是一个舌部，其中限定在凸缘和舌部之间的间隙具有适于以提供舌部和腿之间的过盈配合的方式容纳凹部的腿的尺寸。凹部的腿部具有覆盖在盘绕法兰的一部分上的翻转部分，并且具有邻接舌部的一侧的抵接部。公开了一种制造这种结构接头的方法。

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