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31. 发明专利

AU2009200648A1 Viral inhibitors 未知
公开(公告)号：AU2009200648A1
公开(公告)日：2009-03-12
申请号：AU2009200648
申请日：2009-02-19
申请人： GILEAD SCIENCES INC , PURSTINGER GERHARD , LEUVEN K U RES & DEV
发明人： CLERCQ ERIK DE , PURSTINGER GERHARD , NEYTS JOHAN
IPC分类号： G01N33/50 , A61K31/437 , A61K31/444 , A61K31/7056 , A61K38/21 , A61K45/00 , A61P31/12 , A61P43/00 , C07D471/04 , G01N33/15
摘要： This invention relates to a class of imidazo[4,5-c]pyridine compounds which are useful for the treatment or prevention of a viral infection, and for inhibiting the replication of a virus of the family of the Flaviviridae or the Picornaviridae such as BVDV, HCV or Cocxsackie virus. This invention relates to a process for preparing this class of imidazo[4,5-c]pyridine compounds.

32. 发明专利

BR0312547A 未知
公开(公告)号：BR0312547A
公开(公告)日：2005-04-26
申请号：BR0312547
申请日：2003-07-03
申请人： LEUVEN K U RES & DEV , GILEAD SCIENCES INC , PURSTINGER GERHARD
发明人： NEYTS JOHAN , PURSTINGER GERHARD , CLERCQ ERIK DE
IPC分类号： G01N33/50 , A61K31/437 , A61K31/444 , A61K31/7056 , A61K38/21 , A61K45/00 , A61P31/12 , A61P43/00 , C07D471/04 , G01N33/15
摘要： This invention relates to a class of imidazo[4,5-c]pyridine compounds which are useful for the treatment or prevention of a viral infection, and for inhibiting the replication of a virus of the family of the Flaviviridae or the Picornaviridae such as BVDV, HCV or Cocxsackie virus. This invention relates to a process for preparing this class of imidazo[4,5-c]pyridine compounds.

33. 发明专利

ES2525483T3 Inhibidores virales 未知
公开(公告)号：ES2525483T3
公开(公告)日：2014-12-23
申请号：ES10182308
申请日：2003-07-03
申请人： LEUVEN K U RES & DEV , GILEAD SCIENCES INC , PÜRSTINGER GERHARD
发明人： PÜRSTINGER GERHARD , NEYTS JOHAN , DE CLERCQ ERIK
IPC分类号： C07D471/04 , G01N33/50 , A61K31/437 , A61K31/444 , A61K31/7056 , A61K38/21 , A61K45/00 , A61P31/12 , A61P43/00 , G01N33/15
摘要： Un proceso para preparar un compuesto de imidazo[4,5-c]piridina de fórmula (II):**Fórmula** en la que: - R1 se selecciona entre fenilo sustituido con 0-3 R6; anillo heterocíclico de 5 o 6 miembros que contiene 1-3 heteroátomos seleccionados entre el grupo de O, N, y S, sustituido con 0-2 R6; 1-naftilo sustituido con 0-3 R6; 2- naftilo sustituido con 0-3 R6; cicloalquilo C3-7; cicloalquenilo C5-7; - R2, R4 y R5 se seleccionan independientemente entre hidrógeno; alcoxi C1-6 lineal o ramificado; alquilo C1-6 lineal o ramificado; F; Cl; Br; I; OH; CN; NO2; NR7R8; OCF3; CF3; C(>=O)R9; fenilo; fenoxi; bencilo; hidroximetilo; - X se selecciona entre el grupo -CH2-; -CH(CH3)-; -CH2-CH2-; -CH2-CH2-CH2-; -CH2-CH2-CH2-CH2; -OCH2-CH2-; -SCH2-CH2-; -NR10 -CH2-CH2-; cicloalquilideno C3-7; -C(CH3)2; -CH2-CH(CH3)-CH2-; -CH(CH3)-CH2-CH2-; -CH2- CH2-CH(CH3)-; -CH>=CH-CH2-; - R3 se selecciona entre fenilo sustituido con 0-3 R17; anillo heterocíclico de 5 o 6 miembros aromático que contiene 1-3 heteroátomos seleccionados entre el grupo de O, N, y S, sustituido con 0-2 R17; 1-naftilo sustituido con 0-3 R17; 2-naftilo sustituido con 0-3 R17; cicloalquilo C3-7; cicloalquenilo C4-10 con la condición que el doble enlace no puede estar adyacente a un nitrógeno; - R6 y R17 se seleccionan independientemente entre H; alcoxi C1-6 lineal o ramificado; alquilo C1-6 lineal o ramificado; F; Cl; Br; I; OH; CN; NO2; NR13R14; OCF3; CF3; C(>=O)R18; fenilo; fenoxi; bencilo; hidroximetilo; - R7 y R8 se seleccionan independientemente entre H; alquilo C1-6 lineal o ramificado; fenilo; C(>=O)R12 o R7 y R8, junto con el nitrógeno al que están unidos, se combinan para formar un anillo de 5-6 miembros; - R9 y R18 se seleccionan independientemente entre H; OH; alquilo C1-6 lineal o ramificado; alcoxi C1-6 lineal o ramificado; NR15R16; fenilo; - R10 se selecciona entre el grupo H; alquilo C1-6 lineal o ramificado; fenilo; - R12 se selecciona entre el grupo H; alquilo C1-6 lineal o ramificado; fenilo; - R13 y R14 se seleccionan independientemente entre H; alquilo C1-6 lineal o ramificado; fenilo; C(>=O)R12; y - R15 y R16 se seleccionan independientemente entre el grupo H; alquilo C1-6 lineal o ramificado; fenilo; o una sal farmacéuticamente aceptable del mismo, comprendiendo dicho proceso hacer reaccionar una imidazo[4,5-c]piridina representada por la fórmula estructural (C) con un agente alquilante representado por la fórmula estructural R3 - X - R' (D) en la que R' es cloro o bromo, de acuerdo con el siguiente esquema:**Fórmula** en un disolvente apropiado con adición de base a temperatura ambiente.

34. 发明专利

PT2332938E INIBIDORES VIRAIS 未知
公开(公告)号：PT2332938E
公开(公告)日：2014-12-12
申请号：PT10182308
申请日：2003-07-03
申请人： GILEAD SCIENCES INC , LEUVEN K U RES & DEV , PÜRSTINGER GERHARD
发明人： CLERCQ ERIK DE , PÜRSTINGER GERHARD , NEYTS JOHAN
IPC分类号： C07D471/04 , G01N33/50 , A61K31/437 , A61K31/444 , A61K31/7056 , A61K38/21 , A61K45/00 , A61P31/12 , A61P43/00 , G01N33/15

35. 发明专利

HK1161231A1 VIRAL INHIBITORS 未知
公开(公告)号：HK1161231A1
公开(公告)日：2012-08-24
申请号：HK11113246
申请日：2011-12-07
申请人： LEUVEN K U RES & DEV , GILEAD SCIENCES INC , PURSTINGER GERHARD
发明人： PRSTINGER GERHARD , NEYTS JOHAN , DE CLERCQ ERIK
IPC分类号： C07D20060101 , G01N33/50 , A61K20060101 , A61K31/437 , A61K31/444 , A61K31/7056 , A61K38/21 , A61K45/00 , A61P20060101 , A61P31/12 , A61P43/00 , C07D471/04 , G01N33/15
摘要： This invention relates to a class of imidazo[4,5-c]pyridine compounds which are useful for the treatment or prevention of a viral infection, and for inhibiting the replication of a virus of the family of the Flaviviridae or the Picornaviridae such as BVDV, HCV or Cocxsackie virus. This invention relates to a process for preparing this class of imidazo[4,5-c]pyridine compounds.

36. 发明专利

NZ553408A Imidazo[4,5-d]pyrimidines, their uses and methods of preparation 未知
公开(公告)号：NZ553408A
公开(公告)日：2010-10-29
申请号：NZ55340805
申请日：2005-07-26
申请人： GILEAD SCIENCES INC , LEUVEN K U RES & DEV , GERHARD PUERSTINGER
发明人： NEYTS JOHAN , OARE DAVID A , KIM CHOUNG U , PUERSTINGER GERHARD
IPC分类号： A61K31/52 , C07D471/04 , C07D473/00 , C07D519/00
摘要： Disclosed are imidazo[4,5-d]pyrimidine compounds of formula (A), wherein U is N and the remaining substituents are as defined in the specification, methods of preparation of said compounds and their uses in treating of viral infection such as HCV infection.

37. 发明专利

NZ595000A Imidazo[4,5-c]pyridine derivative for treating viral infections 未知
公开(公告)号：NZ595000A
公开(公告)日：2013-03-28
申请号：NZ59500004
申请日：2004-12-21
申请人： GILEAD SCIENCES INC , LEUVEN K U RES & DEV , GERHARD PUERSTINGER
发明人： BONDY STEVEN S , DOWDY ERIC DAVIS , KIM CHOUNG U , OARE DAVID A , NEYTS JOHAN , ZIA VAHID , PUERSTINGER GERHARD
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4745 , C07D471/02 , C07D519/00
摘要： Disclosed are imidazo[4,5-c]pyridine derivative compounds represented by structural formula (C), wherein the variables shown in formula (C) are as defined in the specification. Also disclosed is the use of the compound to treat viral infections such as the hepatitis-C virus, or an infection from a virus belonging to the family of the Flaviviridae or the Picomaviridae or a viral infection from a Coxsackie virus or Bovine Viral Diarrhea Virus.

38. 发明专利

AU2005287407A1 Imidazo(4,5-d)pyrimidines, their uses and methods of preparation 未知
公开(公告)号：AU2005287407A1
公开(公告)日：2006-03-30
申请号：AU2005287407
申请日：2005-07-26
申请人： GILEAD SCIENCES INC , LEUVEN K U RES & DEV
发明人： NEYTS JOHAN , OARE DAVID A , PUERSTINGER GERHARD , KIM CHOUNG U
IPC分类号： C07D473/00 , A61K31/52 , C07D471/04 , C07D519/00
摘要： The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one compound having the general formula (A): wherein U is N or C; X is selected from C1-C10 alkylene, C2-10 alkenylene or C2-10 alkynylene, where each may include one or more intrachain heteroatoms selected from O, S, or NR11, provided any such heteroatom is not adjacent to the N in the ring; R3 is selected from aryl, aryloxy, arylthio, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl-N(R10)—, or heterocycle, where each said substituent is optionally substituted with at least one R17, provided that for cycloalkenyl the double bond is not adjacent to a nitrogen; and the other substituents are described in the specification. The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula, their pharmaceutically acceptable formulations and their use as a medicine or to treat or prevent viral infections.

39. 发明申请

WO2010055164A3 ISOQUINOLONE DERIVATIVES AS INHIBITORS OF PLAVIVIRUS REPLICATION 审中-公开
标题翻译：作为PLAVIVIRUS复制抑制剂的异喹啉酮衍生物
公开(公告)号：WO2010055164A3
公开(公告)日：2010-07-08
申请号：PCT/EP2009065256
申请日：2009-11-16
申请人： UNIV LEUVEN KATH , BARDIOT DOROTHEE , BLANCHE EMILIE , CHALTIN PATRICK , KOUKNI MOHAMED , LEYSSEN PIETER , NEYTS JOHAN , MARCHAND ARNAUD , VLIEGEN INGE
发明人： BARDIOT DOROTHEE , BLANCHE EMILIE , CHALTIN PATRICK , KOUKNI MOHAMED , LEYSSEN PIETER , NEYTS JOHAN , MARCHAND ARNAUD , VLIEGEN INGE
IPC分类号： C07D217/24 , A61K31/472 , A61K31/4725 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： C07D409/04 , A61K31/472 , A61K31/4725 , A61K31/497 , C07D217/24 , C07D217/26 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to a series of Isoquinolone derivatives which are suitable to treat infections with viruses belonging to the family of the Flaviviridae and more preferably infections with Hepatitis C virus (HCV). The present invention also relates to Isoquinolone compounds for use as a medicine for the prevention or treatment of viral infections, preferably infections with viruses belonging to the family of the Flaviviridae.
摘要翻译：本发明涉及一系列适用于治疗属于黄病毒科病毒感染的异喹诺酮衍生物，更优选丙型肝炎病毒（HCV）感染。本发明还涉及用作预防或治疗病毒感染的药物的异喹诺酮化合物，优选为属于黄病毒科的病毒感染。

40. 发明专利

AU2011202214B2 Imidazo[4,5-C]Pyridine Compounds And Methods Of Antiviral Treatment 未知
公开(公告)号：AU2011202214B2
公开(公告)日：2012-12-20
申请号：AU2011202214
申请日：2011-05-13
申请人： GILEAD SCIENCES INC , K U LEUVEN RES & DEVELOPMENT , PUERSTINGER GERHARD
发明人： BONDY STEVEN S , DOWDY ERIC DAVIS , KIM CHOUNG U , OARE DAVID A , NEYTS JOHAN , ZIA VAHID , PUERSTINGER GERHARD
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4745 , C07D471/02 , C07D519/00
摘要： Au2011202214 IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT Abstract The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (C) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections. / Y -R 1 R 3 -X N N (C)

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