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31. 发明授权

US5198229A Self-retaining gastrointestinal delivery device 失效
标题翻译：自体胃肠输送装置
公开(公告)号：US5198229A
公开(公告)日：1993-03-30
申请号：US710607
申请日：1991-06-05
申请人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen
发明人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen
IPC分类号： A61K9/00
CPC分类号： A61K9/0065 , A61K9/0004
摘要： The present invention is directed to a fluid-imbibing drug delivery device having a first, low density such that it floats in the stomach contents for a predetermined prolonged period of time, during which prolonged period of time it dispenses a drug or other active agent to the stomach, and having a second, higher density such that the device exits the stomach at the end of the predetermined prolonged period of time.
摘要翻译：本发明涉及一种流体吸收药物递送装置，其具有第一低密度，使得其在胃内容物中漂浮预定的较长时间段，在此期间，其将药物或其它活性剂分配到胃，并且具有第二较高密度，使得装置在预定的较长时间段结束时离开胃。

32. 发明授权

US5006346A Delivery system 失效
标题翻译：输送系统
公开(公告)号：US5006346A
公开(公告)日：1991-04-09
申请号：US350482
申请日：1989-05-11
申请人： David E. Edgren , Felix Theeuwes
发明人： David E. Edgren , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/28 , A61K9/36
CPC分类号： A61K9/0004 , A61K9/2866 , A61K9/2886
摘要： A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.
摘要翻译：公开了包含围绕药物的外套的剂型。该涂层包括底涂层和外涂层热退火以在药物周围提供单一的单一涂层。

33. 发明授权

US4994031A Intravenous system for delivering a beneficial agent 失效
标题翻译：用于递送有益药物的静脉内系统
公开(公告)号：US4994031A
公开(公告)日：1991-02-19
申请号：US338691
申请日：1989-04-17
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
摘要翻译：公开了一种配制腔，其包括围绕包含用于递送有益剂的装置的内腔的壁。腔室具有用于允许流体进入腔室的入口和用于使药剂制剂离开腔室的出口。腔室适用于静脉输送系统，用于将药剂配制物递送给患者。

34. 发明授权

US4985016A Intravenous system for delivering a beneficial agent 失效
标题翻译：用于递送有益药物的静脉内系统
公开(公告)号：US4985016A
公开(公告)日：1991-01-15
申请号：US311905
申请日：1989-02-15
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
IPC分类号： A61M39/00 , A61M5/14
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a material which is permeable to the drug but which prevents convective loss of the IV fluid. A transdermal-type drug delivery device is adhered to the semipermeable/microporous wall portion. Drug is delivered by the delivery device through the wall portion and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the wall portion or a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the wall portion to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate.
摘要翻译：提供了用于静脉内给药组的药物制剂室。静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。室壁的一部分由药物可渗透的材料组成，但是防止IV流体的对流损失。透皮型药物输送装置粘附在半透膜/微孔壁部分上。药物由输送装置通过壁部分输送到流动的IV流体中。该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。从装置向IV流体的药物递送速率由药物递送装置中的壁部分或膜层控制。多个药物递送装置可以粘附到壁部分以递送多种药物或以更高的剂量率递送单一药物。

35. 发明授权

US4957494A Multi-layer delivery system 失效
标题翻译：多层交付系统
公开(公告)号：US4957494A
公开(公告)日：1990-09-18
申请号：US283631
申请日：1988-12-13
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
摘要翻译：一种在流体环境中使用的分配器，其能够以任何期望的输送模式或轮廓递送多个离散的含药层。分配器包括容纳多个药物层的刚性壳体，其可由无药物层分离。出口设在壳体的一端，并且流体驱动的驱动装置设置在壳体的另一端和药物层之间。壳体靠近驱动装置的部分对水具有受控的渗透性，因此当浸入流体环境中时，药物层朝着出口被驱动。可以通过适当选择药物和无药物层的比较和尺寸来实现各种递送模式。

36. 发明授权

US4915949A Dispenser with movable matrix comprising a plurality of tiny pills 失效
标题翻译：具有可移动矩阵的分配器，包括多个微小的药丸
公开(公告)号：US4915949A
公开(公告)日：1990-04-10
申请号：US312270
申请日：1989-02-21
申请人： Patrick S.-L. Wong , Felix Theeuwes , Richard Cortese , James B. Eckenhoff
发明人： Patrick S.-L. Wong , Felix Theeuwes , Richard Cortese , James B. Eckenhoff
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0068 , A61K9/0004
摘要： A dispenser is disclosed for delivering tiny pills to an environment of use. The dispenser comprising a wall that surrounds an internal space comprising a first mean in the dispenser for changing from a dispenser state to an environment of use state on leaving the dispenser, tiny pills in the first means, and a second means in the dispenser for aiding in displacing the first means for the dispenser.
摘要翻译：公开了用于将微小丸剂递送到使用环境的分配器。所述分配器包括围绕内部空间的壁，所述壁包括所述分配器中的第一平均值，用于在离开所述分配器时从分配器状态改变为使用状态，所述第一装置中的小丸和用于辅助的所述分配器中的第二装置在移动分配器的第一装置时。

37. 发明授权

US4871360A System for intravenous delivery of a beneficial drug at a regulated rates 失效
标题翻译：以有规律的速率静脉输送有益药物的系统
公开(公告)号：US4871360A
公开(公告)日：1989-10-03
申请号：US854452
申请日：1986-04-21
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A formulation chamber is disclosed comprising a wall surrounding a space containing a beneficial agent. The formulation chamber has an inlet for admitting a fluid into the chamber and an outlet for letting the fluid containing the agent leave the chamber. The chamber can additionally comprise a film for regulating the rate of release from the chamber, and optionally a filter. The chamber is adapted for use in an intraveous delivery system for delivering the fluid containing the agent to a patient. A method also is disclosed for using the formulation chamber.
摘要翻译：公开了一种配制腔，其包括围绕包含有益剂的空间的壁。制剂腔室具有用于将流体进入腔室的入口和用于使含有药剂的流体离开腔室的出口。该室还可以包括用于调节从室释放的速率的膜，以及可选的过滤器。该腔室适用于内部输送系统，用于将含有药剂的流体输送给患者。公开了一种使用制剂室的方法。

38. 发明授权

US4863744A Intestine drug delivery 失效
标题翻译：肠道给药
公开(公告)号：US4863744A
公开(公告)日：1989-09-05
申请号：US26236
申请日：1987-03-16
申请人： John Urquhart , Felix Theeuwes
发明人： John Urquhart , Felix Theeuwes
IPC分类号： A61K9/20
CPC分类号： A61K9/2081
摘要： A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.
摘要翻译：公开了用于将试剂递送到pH大于3.5的所选择的使用环境的递送系统。

39. 发明授权

US4857052A Intravenous system for delivering a beneficial agent 失效
标题翻译：用于递送有益药物的静脉内系统
公开(公告)号：US4857052A
公开(公告)日：1989-08-15
申请号：US45358
申请日：1987-05-04
申请人： Felix Theeuwes
发明人： Felix Theeuwes
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A formulation chamber is disclosed comprising a wall surrounding a lumen containing a device for delivering a beneficial agent. The chamber has an inlet for admitting a fluid into the chamber and an outlet for letting an agent formulation leave the chamber. The chamber is adapted for use in an intravenous delivery system for delivering an agent formulation to a patient.
摘要翻译：公开了一种配制腔，其包括围绕包含用于递送有益剂的装置的内腔的壁。腔室具有用于允许流体进入腔室的入口和用于使药剂制剂离开腔室的出口。腔室适用于静脉输送系统，用于将药剂配制物递送给患者。

40. 发明授权

US4814180A Agent dispenser comprising a semipermeable wall surrounding single-piece or two-piece container 失效
标题翻译：代理分配器包括围绕单件或两件式容器的半透壁
公开(公告)号：US4814180A
公开(公告)日：1989-03-21
申请号：US941971
申请日：1986-12-15
申请人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
发明人： James B. Eckenhoff , Felix Theeuwes , Joseph C. Deters
IPC分类号： A61K9/00 , A61K9/22 , A61M31/00 , A61K9/24 , A61K9/26 , A61K9/44
CPC分类号： A61K9/0004 , A61M31/002
摘要： A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.
摘要翻译：公开了一种用于将有益剂递送到使用环境的分配器。分配器包括围绕包含热响应组合物的隔室的半透壁和可膨胀组合物。墙壁上的通道将隔间与分配器的外部相连。

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