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31. 发明公开

EP1592667A2 NEW MONO-ACYLATED O-PHENYLENDIAMINES DERIVATIVES 审中-公开
标题翻译：使用单苯乙烯邻苯二酚衍生物
公开(公告)号：EP1592667A2
公开(公告)日：2005-11-09
申请号：EP04708323.3
申请日：2004-02-05
申请人： F. HOFFMANN-LA ROCHE AG
发明人： FERTIG, Georg , HERTING, Frank , KUBBIES, Manfred , LIMBERG, Anja , REIFF, Ulrike , WEIDNER, Michael
IPC分类号： C07D213/90 , A61K31/381 , A61K31/44
CPC分类号： C07D213/82 , C07C233/80 , C07C2601/02 , C07D333/38
摘要： Objects of the present invention are new mono-acylated o-phenylendiamines derivatives of formula (A) wherein Ar is thiophen-2,5-diyl, pyridine-2,5-diyl, pyridine-5,2-diyl, pyridine-2,6-diyl, pyridine-2,4-diyl or 1,4-phenylene, R1, R2 independently from each other represent hydrogen, C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, C3-12-cycloalkyl, the alkyl, alkenyl, alkynyl and cycloalkyl groups being optionally mono or multiple substituted by hydroxy, halogen, C3-12-cycloalkyl, alkoxy, alkylsulfanyl, acyloxy, alkoxycarbonyl, acyl, C1-6-alkyl-NH-C(O)-, C1-6-alkyl-C(O)NH- or -NR3R4, or alternatively R1 is hydrogen, and R2 is hydroxyl, alkoxy, C2-C12-alkenyloxy or phenoxy, which phenoxy group is optionally substituted with methyl, methoxy, halogen, nitro, cyano, trifluoromethyl, ethenyl or -C(O)-O-CH3, provided that if R2 is hydroxy, Ar is not thiophen-2,5-diyl; and R3 and R4 independently from each other represent hydrogen or C1-6-alkyl, or wherein R3 and R4 together with the nitrogen-atom to which they are attached form a ring, which ring is monosubstituted by oxo and which ring may contain a further heteroatom, and pharmaceutically acceptable salts thereof, as well as processes for the manufacturing of these compounds, pharmaceutical compositions containing such compounds and their use in the manufacture of drugs for the treatment of diseases such as cancer.
摘要翻译：式A的单酰化邻苯二胺衍生物：其可用于治疗由组蛋白脱乙酰酶抑制如癌症介导的疾病。

32. 发明公开

EP2148861A1 ARYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译：芳基吡啶磺酰胺衍生物，它们的制造和用作药物制剂
公开(公告)号：EP2148861A1
公开(公告)日：2010-02-03
申请号：EP08758506.3
申请日：2008-05-14
申请人： F. Hoffmann-La Roche AG
发明人： BROOKFIELD, Frederick , KLING, Lothar , REIFF, Ulrike , VON DER SAAL, Wolfgang , VON HIRSCHHEYDT, Thomas
IPC分类号： C07D213/71 , A61K31/435 , A61P35/00
CPC分类号： C07D213/71
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式（I）化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在控制或预防诸如癌症之类的疾病。

33. 发明公开

EP1680417A1 1-'(E)-2-(PHENYL)ETHENYL-4-(ARYLALKOXY)-OXAZOLE OR -THIAZOLE COMPOUNDS AS HER-2 TYROSINE KINASES INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译： 1“ - （E）-2-（苯基）乙烯基-4-（芳基烷氧基）恶唑或-THIAZOLVERBINDUNGEN如HER-2酪氨酸激酶的抑制剂以及它们在癌症的治疗中使用
公开(公告)号：EP1680417A1
公开(公告)日：2006-07-19
申请号：EP04790740.7
申请日：2004-10-22
申请人： F. HOFFMANN-LA ROCHE AG
发明人： BOSSENMAIER, Birgit , FRIEBE, Walter-Gunar , REIFF, Ulrike , RUETH, Matthias , VOSS, Edgar
IPC分类号： C07D413/14 , C07D417/14 , A61K31/426 , A61K31/4192 , A61K31/422 , A61K31/4155 , A61P35/00
CPC分类号： C07D417/14 , C07D413/14
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

34. 发明公开

EP1656371A2 NOVEL OXAZOLES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS 审中-公开
标题翻译： NEW唑，生产和使用作为药剂
公开(公告)号：EP1656371A2
公开(公告)日：2006-05-17
申请号：EP04764040.4
申请日：2004-08-12
申请人： F. HOFFMANN-LA ROCHE AG
发明人： BOSSENMAIER, Birgit , FRIEBE, Walter-Gunar , REIFF, Ulrike , RUETH, Matthias , VOSS, Edgar
IPC分类号： C07D413/12 , A61K31/422
CPC分类号： C07D413/12
摘要： Objects of the present invention are compounds of formula (I) formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

35. 发明授权

EP2190834B1 PYRIDONEAMIDE DERIVATIVES AS FOCAL ADHESION KINASE (FAK) INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER 有权
标题翻译： PYRIDONAMIDDERIVATE ALS粘着斑激酶（FAK）抑制剂，及其用于治疗癌症的
公开(公告)号：EP2190834B1
公开(公告)日：2011-03-02
申请号：EP08785643.1
申请日：2008-08-20
申请人： F. Hoffmann-La Roche AG
发明人： GEORGES, Guy , KALUZA, Klaus , KOERNER, Matthias , REIFF, Ulrike , SCHEIBLICH, Stefan , VON DER SAAL, Wolfgang , WEIGAND, Stefan
IPC分类号： C07D401/12 , C07D213/82 , A61K31/444 , A61P35/00
CPC分类号： C07D213/82 , C07D401/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

36. 发明授权

EP2102173B1 PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS 有权
标题翻译： PYRIMIDYLDERIVATE ALS蛋白激酶抑制剂
公开(公告)号：EP2102173B1
公开(公告)日：2010-10-20
申请号：EP07856884.7
申请日：2007-12-19
申请人： F. Hoffmann-La Roche AG
发明人： GEORGES, Guy , KOERNER, Matthias , KOLM, Irene , REIFF, Ulrike , SCHAEFER, Wolfgang , VOSS, Edgar , WEIGAND, Stefan
IPC分类号： C07D239/47 , C07D405/12 , C07F7/08 , A61K31/505 , A61P35/00
CPC分类号： C07D239/47 , C07D405/12
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

37. 发明公开

EP1613622A1 OXIME DERIVATIVES AND THEIR USE AS PHARMACEUTICALLY ACTIVE AGENTS 审中-公开
标题翻译：肟衍生物及其作为药物的用途
公开(公告)号：EP1613622A1
公开(公告)日：2006-01-11
申请号：EP04725309.1
申请日：2004-04-02
申请人： F. HOFFMANN-LA ROCHE AG
发明人： FERTIG, Georg , HERTING, Frank , KUBBIES, Manfred , LIMBERG, Anja , REIFF, Ulrike , WEIDNER, Michael
IPC分类号： C07D409/12 , A61K31/38 , A61P35/00 , C07D333/38 , A61K31/44
CPC分类号： A61K31/38 , A61K31/44 , C07D333/38 , C07D409/12
摘要： Objects of the present invention are the compounds of formula I, their pharmaceutically acceptable salts as well as their enantiomeric forms, diastereoisomers and racemates; the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds as inhibitors of histone deacetylase ( HDAC ) and therefore in the control or prevention of illnesses and disorders as mentioned above, or in the manufacture of corresponding medicaments.

38. 发明公开

EP2190834A1 PYRIDONEAMIDE DERIVATIVES AS FOCAL ADHESION KINASE (FAK) INHIBITORS AND THEIR USE FOR THE TREATMENT OF CANCER 有权
标题翻译： PYRIDONAMIDDERIVATE ALS粘着斑激酶（FAK）抑制剂，及其用于治疗癌症的
公开(公告)号：EP2190834A1
公开(公告)日：2010-06-02
申请号：EP08785643.1
申请日：2008-08-20
申请人： F. Hoffmann-La Roche AG
发明人： GEORGES, Guy , KALUZA, Klaus , KOERNER, Matthias , REIFF, Ulrike , SCHEIBLICH, Stefan , VON DER SAAL, Wolfgang , WEIGAND, Stefan
IPC分类号： C07D401/12 , C07D213/82 , A61K31/444 , A61P35/00
CPC分类号： C07D213/82 , C07D401/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

39. 发明公开

EP2170859A1 BENZIMIDAZOLE AMIDO DERIVATIVES AS KINASE INHIBITORS 审中-公开
标题翻译：苯并咪唑胺衍生物ALS KINASEHEMMER
公开(公告)号：EP2170859A1
公开(公告)日：2010-04-07
申请号：EP08759319.0
申请日：2008-06-23
申请人： F. Hoffmann-La Roche AG
发明人： GEORGES, Guy , HOFFMANN, Eike , KALUZA, Klaus , KOERNER, Matthias , REIFF, Ulrike , WEIGAND, Stefan
IPC分类号： C07D401/04 , C07D401/14 , A61K31/435 , A61P35/00
CPC分类号： C07D401/14 , C07D401/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

40. 发明公开

EP2102173A1 PYRIMIDYL DERIVATIVES AS PROTEIN KINASE INHIBITORS 有权
标题翻译：吡啶衍生物ALS PROTEINKINASEINHIBITOREN
公开(公告)号：EP2102173A1
公开(公告)日：2009-09-23
申请号：EP07856884.7
申请日：2007-12-19
申请人： F. Hoffmann-La Roche AG
发明人： GEORGES, Guy , KOERNER, Matthias , KOLM, Irene , REIFF, Ulrike , SCHAEFER, Wolfgang , VOSS, Edgar , WEIGAND, Stefan
IPC分类号： C07D239/47 , C07D405/12 , C07F7/08 , A61K31/505 , A61P35/00
CPC分类号： C07D239/47 , C07D405/12
摘要： Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.

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