专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20080032985A1 4-Substituted Quinoline Derivatives, Method and Intermediates for Their Preparation and Pharmaceutical Compositions Containing Them 审中-公开
标题翻译： 4-取代的喹啉衍生物，其制备方法和中间体以及含有它们的药物组合物
公开(公告)号：US20080032985A1
公开(公告)日：2008-02-07
申请号：US11571407
申请日：2005-06-24
申请人： Michel Tabart , Fabrice Viviani , Serge Mignani , Baptiste Ronan
发明人： Michel Tabart , Fabrice Viviani , Serge Mignani , Baptiste Ronan
IPC分类号： A61K31/47 , A61K31/4375 , A61K31/502 , A61K31/517 , A61P31/00 , C07D215/12 , C07D237/28 , C07D239/72 , C07D471/04
CPC分类号： C07D409/12 , C07D215/20
摘要： The present invention relates to 4-substituted quinoline derivatives of general formula I: which are active as antimicrobials. The invention also relates to the method and intermediates for their preparation and the pharmaceutical compositions containing them.
摘要翻译：本发明涉及通式I的4-取代喹啉衍生物：其作为抗微生物剂是有活性的。本发明还涉及其制备方法和中间体以及含有它们的药物组合物。

32. 发明申请

US20060270649A1 AZETIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM 审中-公开
标题翻译： AZETIDINE DERIVATIVES，他们的准备和药物包含他们
公开(公告)号：US20060270649A1
公开(公告)日：2006-11-30
申请号：US11420238
申请日：2006-05-25
申请人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
发明人： Daniel Achard , Herve Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
IPC分类号： A61K31/397
CPC分类号： C07D401/06 , C07D205/06 , C07D409/06 , C07D409/14 , C07D417/06
摘要： Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them.
摘要翻译：公开的是下式的氮杂环丁烷衍生物：它们的光学异构体，它们的盐，它们的制备物和含有它们的药物。

33. 发明授权

US06518264B2 Azetidine derivatives, their preparation and medicaments containing them 失效
标题翻译：氮杂环丁烷衍生物，其制备方法和含有它们的药物
公开(公告)号：US06518264B2
公开(公告)日：2003-02-11
申请号：US09803723
申请日：2001-03-09
申请人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
发明人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
IPC分类号： C07D20506
CPC分类号： C07D401/06 , C07D205/06 , C07D409/06 , C07D409/14 , C07D417/06
摘要： Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them.
摘要翻译：公开的是下式的氮杂环丁烷衍生物：它们的光学异构体，它们的盐，它们的制备物和含有它们的药物。

34. 发明授权

US5114949A Heterocyclic derivatives, their preparation and medicinal products containing them 失效
标题翻译：杂环衍生物，其制备和含有它们的药物
公开(公告)号：US5114949A
公开(公告)日：1992-05-19
申请号：US615670
申请日：1990-11-19
申请人： Claude Gueremy , Jean-Luc Malleron , Serge Mignani
发明人： Claude Gueremy , Jean-Luc Malleron , Serge Mignani
IPC分类号： C07D209/46 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/428 , A61K31/47 , A61K31/495 , A61K31/496 , A61P3/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , A61P43/00 , C07D209/92 , C07D235/26 , C07D275/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/06 , C07D513/04 , C07D513/06
CPC分类号： C07D403/06 , C07D403/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/06 , C07D513/04
摘要： Compounds are disclosed of formula:R.sub.1 --(CH.sub.2).sub.n --Hetin which R.sub.1 represents a residue of formula ##STR1## X represents a hydrogen atom or an alkyl radical, Y represents a hydrogen atom or an alkyl or alkoxy radical,Z represents an alkyl radical,n is equal to 2 or 3,Het represents a substituted piperidino (substituted at the 4-position with a 1-indenylidene, 1-indenyl or 1-indanyl radical or with a chain --(CH.sub.2).sub.m --R.sub.2 or .dbd.CH--R.sub.2), substituted 1,2,3,6-tetrahydro-1-pyridyl (substituted at the 4-position with a chain --(CH.sub.2).sub.m --R.sub.2),m is equal to 1 or 2, andR.sub.2 represents an optionally substituted 2- or 3-indolyl radical, a 1- or 2-indanyl, 1- or 2-indenyl, an optionally substituted 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-2-yl radical, a 1,2,3,4-tetrahydro-3-quinolyl radical, an optionally substituted 1,2,3,4-tetrahydro-2-naphthyl radical or a 1-indolyl radical, their preparation and medicinal products containing them.
摘要翻译：（C）＆gt;（C）＆lt; IMAGE＆gt;（D）＆lt; IMAGE＆gt;（D）＆lt; IMAGE＆gt; J）X表示氢原子或烷基，Y表示氢原子或烷基或烷氧基，Z表示烷基，n表示2或3，Het表示取代的哌啶子基（在4-位取代具有1-茚基，1-茚基或1-茚满基或与链 - （CH 2）m -R 2或= CH-R 2）取代的1,2,3,6-四氢-1-吡啶基（在具有链 - （CH 2）m -R 2）的4-位，m等于1或2，并且R 2表示任选取代的2-或3-吲哚基，1-或2-二氢茚基，1-或2- 茚基，任选取代的1,2,3,4-四氢-5H-吡啶并[4,3-b]吲哚-2-基，1,2,3,4-四氢-3-喹啉基，任选地取代的1,2,3,4-四氢-2-萘基或1-吲哚基，它们的制备方法和含有它们的药用产品。

35. 发明授权

US06858603B2 Acetindine derivatives, their preparation and medicaments containing them 失效
标题翻译：丙啶衍生物，其制剂和含有它们的药物
公开(公告)号：US06858603B2
公开(公告)日：2005-02-22
申请号：US10320344
申请日：2002-12-16
申请人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
发明人： Daniel Achard , Hervé Bouchard , Jean Bouquerel , Marc Capet , Serg Grisoni , Jean-Luc Malleron , Serge Mignani , Augustin Hittinger
IPC分类号： C07D205/04 , A61K31/397 , A61K31/4025 , A61K31/427 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4523 , A61K31/496 , A61K31/5355 , A61K31/541 , A61P1/00 , A61P1/08 , A61P3/04 , A61P5/00 , A61P9/00 , A61P9/02 , A61P11/06 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/06 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , C07D205/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/12 , C07D409/06 , C07D409/14 , C07D417/06 , C07D417/10 , C07D403/06
CPC分类号： C07D401/06 , C07D205/06 , C07D409/06 , C07D409/14 , C07D417/06
摘要： Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them.
摘要翻译：公开的是下式的氮杂环丁烷衍生物：它们的光学异构体，它们的盐，它们的制备物和含有它们的药物。

36. 发明授权

US5021420A Derivatives of (AZA)naphthalenesultam, their preparation and compositions containing them 失效
公开(公告)号：US5021420A
公开(公告)日：1991-06-04
申请号：US375934
申请日：1989-07-06
申请人： Marie-Iherese Comte , Claude Gueremy , Jean-Luc Malleron , Serge Mignani , Jean-Francois Peyronel , Alain Truchon
发明人： Marie-Iherese Comte , Claude Gueremy , Jean-Luc Malleron , Serge Mignani , Jean-Francois Peyronel , Alain Truchon
IPC分类号： A61K31/425 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61P9/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07D275/06 , C07D417/00 , C07D417/06 , C07D417/14 , C07D513/06
CPC分类号： C07D275/06 , C07D417/06 , C07D417/14 , C07D513/06
摘要： This invention relates to a compound ##STR1## in which R.sub.1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or alkoxy radical, (c) a 3-indolyl radical, (d) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (e) a 3-(5-hydroxyindolyl) radical.a 1-piperazinyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by an alkoxy, alkyl, hydroxy, nitro or amino radical or a halogen atom, (c) a 1,2-benzisothiazol-3-yl radical, (d) a 1,2-benzisoxazol-3-yl radical or (e) a 2-pyridyl radical.a piperidino radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or a hydroxy, alkyl or alkoxy radical, (c) two phenyl radicals, (d) a bis(4-fluorophenyl)methylene radical, (e) a 4-fluorobenzoyl radical, (f) a 2-oxo-1-benzimidazolinyl radical, (g) a 2-oxo-1-benzimidazolinyl radical substituted in the 3-position by an alkylcarbonyl or benzoyl radical, (b) a hydroxy radical and a phenyl radical optionally substituted with an alkyl, alkoxy or hydroxy radical or a halogen atom, (i) a 3-indolyl radical, (j) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (k) a 3-(5-hydroxyindolyl) radical.either:R.sub.2 and R.sub.3, which are identical, represent a hydrogen or halogen atom and R.sub.4 represents a hydrogen atom orR.sub.2 and R.sub.4 represent a hydrogen atom and R.sub.3 represents a halogen atom or an acetylamino radical orR.sub.2 and R.sub.3 represent a hydrogen atom and R.sub.4 represents a halogen atom and R.sub.5 represents a --CH.dbd. group.or R.sub.2, R.sub.3 and R.sub.4 represent a hydrogen atom and R.sub.5 represents a nitrogen atom.R.sub.6 represents an alkylene chain containing 2 to 4 carbon atoms or a propylene chain substituted in the 1- or 3-position by an alkyl radical or in the 2-position by an alkyl, alkoxy, hydroxy, dialkylamino, piperidino, morpholino or thiomorpholino radical,with the reservation that when R.sub.6 represents a propylene radical substituted in the 2-position by a dialkylamino, piperidino, morpholino or thiomorpholino radical, R.sub.1 cannot be a radical containing a hydroxy radical, and their salts, are useful in therapy for their ability to block serotonin receptors.

37. 发明授权

US5563144A Antiserotonins, their preparation and pharmaceutical compositions containing them 失效
标题翻译：抗胰蛋白胨，它们的制剂和含有它们的药物组合物
公开(公告)号：US5563144A
公开(公告)日：1996-10-08
申请号：US470726
申请日：1995-06-06
申请人： Dominique Damour , Richard Labaudiniere , Jean-luc Malleron , Serge Mignani
发明人： Dominique Damour , Richard Labaudiniere , Jean-luc Malleron , Serge Mignani
IPC分类号： A61K31/425 , A61K31/428 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/505 , A61K31/517 , A61K31/54 , A61P7/02 , A61P9/12 , A61P11/00 , A61P25/04 , A61P25/18 , A61P37/08 , A61P43/00 , C07D217/24 , C07D239/70 , C07D275/06 , C07D401/06 , C07D417/06 , C07F7/08 , C07F7/10 , A61K31/445 , A61K31/55 , C07D401/04 , C07F7/02
CPC分类号： C07D275/06 , C07D217/24 , C07D239/70 , C07F7/0816
摘要： This invention relates to compounds having the formula R.sub.1 -(CH.sub.2).sub.n -Het wherein R.sub.1 is a residue having the formula (B), (C), (D); Het represents a radical phenyl-4 tetrahydro-1,2,3,6 pyridyl-1 whose phenyl cycle is optionally substituted by a halogen atom or an alkyl, alkoxy or hydroxy radical; a radical phenyl-4 piperazinyl-1 whose phenyl cycle is optionally substituted by a halogen atom or an alkyl, alkoxy or hydroxy radical; R.sub.3 is a hydrogen atom or a phenyl radical; R.sub.4 is a hydrogen or halogen atom or a residue Het; R.sub.5 is a carbonyl or sulfonyl radical; R.sub.6 is a radical Si(CH.sub.3).sub.2 or C(CH.sub.3).sub.2 ; n equals 1, 2, 3 or 4; excepting {[(phenyl-4 tetrahydro-1,2,3,6 pyridyl-1)-2 ethyl] amino}-3 benzisothiazol-1,2 dioxyde-1,1; their salts, their preparation and medicaments containing them.
摘要翻译：本发明涉及具有式R1-（CH2）n-Het的化合物，其中R1是具有式（B），（C），（D）的残基; Het表示苯基-4-四氢-1,2,3,6-吡啶基-1，其苯基周期任选被卤素原子或烷基，烷氧基或羟基取代; 其苯基周期任选被卤素原子或烷基，烷氧基或羟基取代的基团苯基-4-哌嗪基-1; R3是氢原子或苯基; R4是氢或卤素原子或残基Het; R5是羰基或磺酰基; R6是自由基的Si（CH3）2或C（CH3）2; n等于1,2,3或4; 除了{[（苯基-4四氢-1,2,3,6-吡啶基-1）-2-乙基]氨基} -3苯并异噻唑-1,2-二氧杂环己烷-1,1; 其盐，其制剂和含有它们的药物。

38. 发明授权

US5036075A Derivatives of (AZA) naphthalensultam, their preparation and compositions containing them 失效
标题翻译：（AZA）萘磺酸的衍生物，它们的制备和含有它们的组合物
公开(公告)号：US5036075A
公开(公告)日：1991-07-30
申请号：US609506
申请日：1990-11-06
申请人： Marie-Therese Comte , Claude Gueremy , Jean-Luc Malleron , Serge Mignani , Jean-Francois Peyronel , Alain Truchon
发明人： Marie-Therese Comte , Claude Gueremy , Jean-Luc Malleron , Serge Mignani , Jean-Francois Peyronel , Alain Truchon
IPC分类号： A61K31/425 , A61K31/428 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61P9/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07D275/06 , C07D417/00 , C07D417/06 , C07D417/14 , C07D513/06
CPC分类号： C07D275/06 , C07D417/06 , C07D417/14 , C07D513/06
摘要： This invention relates to a compound of the formula: ##STR1## in which R.sub.1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position.a 1-piperazinyl radical substituted in the 4-position.a piperidino radical substituted in the 4-positioneither:R.sub.2 and R.sub.3, which are identical, represent a hydrogen or halogen atom and R.sub.4 represents a hydrogen atom orR.sub.2 and R.sub.4 represent a hydrogen atom and R.sub.3 represents a halogen atom or an acetylamino radical orR.sub.2 and R.sub.3 represent a hydrogen atom and R.sub.4 represents a halogen atom and R.sub.5 represents a --CH.dbd. group.or R.sub.2, R.sub.3 and R.sub.4 represent a hydrogen atom and R.sub.5 represents a nitrogen atom.R.sub.6 represents an alkylene chain containing 2 to 4 carbon atoms or a propylene chain substituted in the 1- or 3-position by an alkyl radical or in the 2-position by an alkyl, alkoxy, hydroxy, dialkylamino, piperidino, morpholino or thiomorpholino radical, and their salts, are useful in therapy for their ability to block serotonin receptors.

39. 发明授权

US08163768B2 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them 有权
标题翻译： 1,4-二氢吡啶稠合的杂环，其制备方法，用途和含有它们的组合物
公开(公告)号：US08163768B2
公开(公告)日：2012-04-24
申请号：US12014516
申请日：2008-01-15
申请人： Jacques Mauger , Anil Nair , Nina Ma , Kirsten Bjergarde , Bruno Filoche-Romme , Odile Angouillant-Boniface , Serge Mignani , Jean-Christophe Carry , Francois Clerc , Herve Minoux , Laurent Schio , Cecile Combeau
发明人： Jacques Mauger , Anil Nair , Nina Ma , Kirsten Bjergarde , Bruno Filoche-Romme , Odile Angouillant-Boniface , Serge Mignani , Jean-Christophe Carry , Francois Clerc , Herve Minoux , Laurent Schio , Cecile Combeau
IPC分类号： A61K31/437 , A61K31/4375 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.
摘要翻译：本发明涉及式（I）化合物，其用于制备这些化合物的方法，包含这些化合物的药物组合物，以及涉及治疗方法，包括施用这些化合物。

40. 发明授权

US07531663B2 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, preparation process, their use as medicaments, and pharmaceutical compositions comprising them 失效
公开(公告)号：US07531663B2
公开(公告)日：2009-05-12
申请号：US10749630
申请日：2003-12-31
申请人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
发明人： Heinz-Werner Kleemann , Jean-Christophe Carry , Pascal Desmazeau , Serge Mignani , Jean Bouquerel , Arielle Genevois-Borella , Baptiste Ronan
IPC分类号： C07D215/38
CPC分类号： C07D401/04 , C07D403/04
摘要： The present invention relates to 3-guanidinocarbonyl-1-heteroaryl-indole derivatives, pharmaceutical compositions comprising such derivatives, methods of treatment comprising administering such derivatives, and processes for their preparation.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式