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31. 发明申请

US20080318983A1 A2B ADENOSINE RECEPTOR ANTAGONISTS 审中-公开
标题翻译： A2B腺苷受体拮抗剂
公开(公告)号：US20080318983A1
公开(公告)日：2008-12-25
申请号：US12147382
申请日：2008-06-26
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki , Dewan Zeng , Hongyan Zhong
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki , Dewan Zeng , Hongyan Zhong
IPC分类号： A61K31/522 , A61P35/00
CPC分类号： A61K31/522 , C07D473/06 , C07D473/08
摘要： Disclosed are methods for treating asthma, inflammatory gastrointestinal tract disorders, cancer, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis using A2B adenosine receptor antagonists having the structure of Formula I or Formula II:
摘要翻译：公开了使用具有式I或式II结构的A2B腺苷受体拮抗剂治疗哮喘，炎症性胃肠道疾病，癌症，心血管疾病，神经障碍和与不良血管发生相关的疾病的方法：

32. 发明申请

US20080085908A1 A2B ADENOSINE RECEPTOR ANTAGONISTS 有权
公开(公告)号：US20080085908A1
公开(公告)日：2008-04-10
申请号：US11950740
申请日：2007-12-05
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： A61K31/522
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.

33. 发明授权

US07317017B2 A2B adenosine receptor antagonists 有权
标题翻译： A2B腺苷受体拮抗剂
公开(公告)号：US07317017B2
公开(公告)日：2008-01-08
申请号：US11189202
申请日：2005-07-25
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： C07D473/12 , C07D473/06 , C07D473/04 , A61K51/522 , A61P11/06
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel A2B adenosine receptor antagonists having the structure of Formula I or Formula II The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis.
摘要翻译：公开了具有式I或式II结构的新型Aβ2 N 2腺苷受体拮抗剂。该化合物特别可用于治疗哮喘，炎症性胃肠道疾病，心血管疾病，神经障碍和与不期望的血管生成有关的疾病。

34. 发明申请

US20070066560A1 Partial and full agonists of A1 adenosine receptors 失效
公开(公告)号：US20070066560A1
公开(公告)日：2007-03-22
申请号：US11600523
申请日：2006-11-15
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
IPC分类号： A61K31/7076
CPC分类号： A61K31/7076 , C07D473/16 , C07H19/16
摘要： Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.

35. 发明授权

US07157440B2 Partial and full agonists of A1 adenosine receptors 失效
公开(公告)号：US07157440B2
公开(公告)日：2007-01-02
申请号：US10855471
申请日：2004-05-27
申请人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
发明人： Elfatih Elzein , Prabha Ibrahim , Venkata Palle , Vaibhav Varkhedkar , Jeff Zablocki
IPC分类号： A01N43/04 , A61K31/70 , C07H19/00 , C07H19/22
CPC分类号： A61K31/7076 , C07D473/16 , C07H19/16
摘要： Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infarction.

36. 发明授权

US07105665B2 A2B adenosine receptor antagonists 有权
标题翻译： A2B腺苷受体拮抗剂
公开(公告)号：US07105665B2
公开(公告)日：2006-09-12
申请号：US10947708
申请日：2004-09-23
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , A61K31/522 , A61P9/10
CPC分类号： C07D473/00 , C07D473/06 , C07D473/08
摘要： Disclosed are methods for making novel A2B adenosine receptor antagonists having the structure of formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis.
摘要翻译：公开的是制备具有式I或式II结构的新的Aβ2A腺苷受体拮抗剂的方法：该化合物特别可用于治疗哮喘，炎性胃肠道疾病，心血管疾病，神经障碍和疾病与不良血管生成有关。

37. 发明申请

US20050261316A1 A2B Adenosine receptor antagonists 有权
标题翻译： A2B腺苷受体拮抗剂
公开(公告)号：US20050261316A1
公开(公告)日：2005-11-24
申请号：US11189202
申请日：2005-07-25
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： A61K31/522 , C07D473/04 , C07D473/06
CPC分类号： C07D473/06 , A61K31/522 , C07D473/04
摘要： Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
摘要翻译：公开了可用于治疗各种疾病状态（包括哮喘和腹泻）的新颖化合物，其为Aβ2 N 2腺苷受体拮抗剂。

38. 发明授权

US06825349B2 A2B adenosine receptor antagonists 有权
标题翻译： A2B腺苷受体拮抗剂
公开(公告)号：US06825349B2
公开(公告)日：2004-11-30
申请号：US10290921
申请日：2002-11-08
申请人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
发明人： Rao Kalla , Thao Perry , Elfatih Elzein , Vaibhav Varkhedkar , Xiaofen Li , Prabha Ibrahim , Venkata Palle , Dengming Xiao , Jeff Zablocki
IPC分类号： C07D47312
CPC分类号： C07D473/00 , C07D473/06 , C07D473/08
摘要： Disclosed are novel A2B adenosine receptor antagonists compounds having the structure of Formula I or Formula II: The compounds are particularly useful for treating asthma, inflammatory gastrointestinal tract disorders, cardiovascular diseases, neurological disorders, and diseases related to undesirable angiogenesis.
摘要翻译：公开了具有式I或式II结构的新型A2B腺苷受体拮抗剂化合物：该化合物特别可用于治疗哮喘，炎症性胃肠道疾病，心血管疾病，神经障碍和与不期望的血管发生相关的疾病。

39. 发明授权

US07022681B2 Partial and full agonists of A1 adenosine receptors 失效
标题翻译： A1腺苷受体的部分和全部激动剂
公开(公告)号：US07022681B2
公开(公告)日：2006-04-04
申请号：US10641930
申请日：2003-08-15
申请人： Jeff Zablocki , Venkata Palle , Elfatih Elzein , Xiaofen Li
发明人： Jeff Zablocki , Venkata Palle , Elfatih Elzein , Xiaofen Li
IPC分类号： A61K31/70 , C07H19/167
CPC分类号： C07H19/16
摘要： Disclosed are A1 adenosine receptor agonists of the formula: wherein: R1 is optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl; R2 is hydrogen, halo, trifluoromethyl, or cyano; R3 is hydrogen, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl, R4 and R5 are independently hydrogen or optionally substituted acyl; X is a covalent bond or lower alkylene optionally substituted by cycloalkyl; X1 is a covalent bond or alkylene; Y is a covalent bond or lower alkylene optionally substituted by hedroxy or cycloalkyl; and Z is —C≡C—, —R6C═CR7—, or —CHR6CHR7—, in which R6 and R7 at each occurrence are hydrogen or lower alkyl.
摘要翻译：公开了下式的A 1 N 2腺苷受体激动剂：其中：R 1是任选取代的环烷基，任选取代的杂环基，任选取代的芳基或任选取代的杂芳基; R 2是氢，卤素，三氟甲基或氰基; R 3是氢，任选取代的环烷基，任选取代的芳基，任选取代的杂芳基或任选取代的杂环基，R 4和R 5独立地是氢或任选取代的酰基; X是共价键或任选被环烷基取代的低级亚烷基; X 1是共价键或亚烷基; Y是共价键或任选被羟基或环烷基取代的低级亚烷基; 并且Z是-C≡C-，-R 6 C-CR 7或-CHR 6 CHR 7，其中每次出现的R 6和R 7都是氢或低级烷基。

40. 发明申请

US20060135467A1 Partial and full agonists of A1 adenosine receptors 审中-公开
标题翻译： A1腺苷受体的部分和完全激动剂
公开(公告)号：US20060135467A1
公开(公告)日：2006-06-22
申请号：US11355656
申请日：2006-02-15
申请人： Jeff Zablocki , Venkata Palle , Elfatih Elzein , Xiaofen Li
发明人： Jeff Zablocki , Venkata Palle , Elfatih Elzein , Xiaofen Li
IPC分类号： A61K31/7076 , C07H19/16
CPC分类号： C07H19/16
摘要： Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular the supraventricular tachycardias, emesis, angina, myocardial infarction and hyperlipidemia.
摘要翻译：公开了可用于治疗各种疾病状态，特别是室上性心动过速，呕吐，心绞痛，心肌梗死和高脂血症的部分和全部A 1 N 2腺苷受体激动剂的新化合物。

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