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31. 发明专利

CA2701435A1 REPAIR AND REGENERATION OF RENAL TISSUE USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS 未知
公开(公告)号：CA2701435A1
公开(公告)日：2009-04-09
申请号：CA2701435
申请日：2008-10-03
申请人： ETHICON INC
发明人： COLTER DAVID , GOSIEWSKA ANNA
IPC分类号： A61K35/44 , A61K35/12 , A61P13/12 , C12N5/073
摘要： Methods for treating a patient having a disease or damage to at least one kidney are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. When administered, the cells promote and support the repair and regeneration of the diseased or damaged kidney tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

32. 发明专利

CA2691361A1 TISSUE FRAGMENT COMPOSITIONS FOR THE TREATMENT OF INCONTINENCE 未知
公开(公告)号：CA2691361A1
公开(公告)日：2008-12-24
申请号：CA2691361
申请日：2008-06-05
申请人： ETHICON INC
发明人： GOSIEWSKA ANNA , SEYDA AGNIESZKA , BUENSUCESO CHARITO S , DHANARAJ SRIDEVI
IPC分类号： A61K35/34 , A61L27/38
摘要： Compositions for the treatment of incontinence are disclosed. More particularly, compositions of viable muscle tissue fragments and a carrier are disclosed. The compositions are useful in the treatment urinary and fecal incontinence.

33. 发明专利

ES2256420T3 MEDIO DE ANDAMIAJE TISULAR POROSO PARA LA REPARACION Y REGENERACION DE TEJIDO DERMICO. 未知
公开(公告)号：ES2256420T3
公开(公告)日：2006-07-16
申请号：ES02258231
申请日：2002-11-29
申请人： ETHICON INC
发明人： VYAKARNAM MURTY N , ZIMMERMAN MARK C , GOSIEWSKA ANNA
IPC分类号： A61L27/18 , A61L27/56 , C08L67/04
摘要： Un procedimiento para preparar espumas biomédicas absorbibles adecuadas para uso en la reparación y/o la regeneración de tejido dérmico, que comprende preparar una solución homogénea que comprende un copolímero sintético biocompatible bioabsorbible alifático elastomérico que comprende å-caprolactona y glicolida copolimerizadas a una relación molar de å- caprolactona:glicolida en el intervalo de 30:70 a 40:60 y un disolvente en el que el copolímero es soluble, en el que la solución homogénea comprende aproximadamente 5% en peso del copolímero y aproximadamente 95% en peso del disolvente, disponer la solución homogénea en un molde u otro dispositivo adecuado para preparar medios de andamiaje de tejido de espuma adecuado para uso en la reparación y la regeneración de tejido dérmico, enfriar la solución homogénea a una temperatura menor de la temperatura de congelación de la solución y a una velocidad de reducción de la temperatura en el intervalo de 2ºC/min a 50ºC/min, solidificar la soluciónpara formar un sólido; y eliminar el disolvente del sólido, proporcionando una espuma porosa biocompatible bioabsorbible adecuada para uso en la reparación y la regeneración de tejido dérmico.

34. 发明专利

AU2005322068A1 Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells 未知
公开(公告)号：AU2005322068A1
公开(公告)日：2006-07-06
申请号：AU2005322068
申请日：2005-12-22
申请人： ETHICON INC
发明人： KRAMER BRIAN C , MESSINA DARIN J , ROMANKO MICHAEL J , MISTRY SANJAY , GOSIEWSKA ANNA , HONG L S KLAUDYNE
IPC分类号： A61K35/44 , A61K35/30 , A61K35/50 , A61P9/10
摘要： Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.

35. 发明专利

DK1316322T3 未知
公开(公告)号：DK1316322T3
公开(公告)日：2006-04-18
申请号：DK02258231
申请日：2002-11-29
申请人： ETHICON INC
发明人： VYAKARNAM MURTY N , ZIMMERMAN MARK C , GOSIEWSKA ANNA
IPC分类号： A61L27/18 , A61L27/56 , C08L67/04
摘要： The present invention provides synthetic, biocompatible, bioabsorbable, porous foam tissue scaffolds possessing physicochemical properties suitable for use in the repair and regeneration of dermal tissue and to methods of preparing such foam scaffolds.

36. 发明专利

AU2003252886B2 Biocompatible scaffolds with tissue fragments 未知
公开(公告)号：AU2003252886B2
公开(公告)日：2005-10-27
申请号：AU2003252886
申请日：2003-10-09
申请人： ETHICON INC
发明人： BINETTE FRANCOIS , DHANARAJ SRIDEVI , HWANG JULIA , GOSIEWSKA ANNA
IPC分类号： A61L27/00 , A61F2/08 , A61F2/10 , A61F2/28 , A61F2/30 , A61L27/36 , A61L027/38 , G01N033/48 , A61L027/54 , A61L027/56
摘要： A biocompatible implant (I1) comprising a biocompatible scaffold, and at least one tissue fragment associated with at least a portion of the scaffold, is new. The tissue fragment includes viable cells that can migrate out of the tissue fragment and populate the scaffold. Independent claims are also included for: (1) a biocompatible implant (I2) comprising a biocompatible scaffold, a suspension containing at least one cartilage tissue fragment associated with at least a portion of the scaffold, and a retaining element (the tissue fragment contains viable cells that can migrate out of the tissue fragment and populate the scaffold); (2) a kit comprising a sterile container containing at least one biocompatible scaffold, and a harvesting tool for collecting at least one viable tissue sample from a subject; (3) preparing the tissue implant (I1) involving: (a) processing a tissue under aseptic conditions to form the tissue fragment and a physiological buffering solution; and (b) depositing the tissue fragment on the bioimplantable scaffold; and (4) measuring the effect of a substance on living tissue involving: (a) creating a tissue construct by processing the tissue sample to form the tissue fragment, depositing the tissue fragment on the biocompatible scaffold such that the tissue fragment is associated with the biocompatible scaffold; and incubating the tissue construct for a duration and under conditions effective to allow cells within the tissue fragment to populate the scaffold; (b) contacting the tissue construct with a substance; and (c) determining the effects of the substance on the tissue construct (the substance is selected from a drug, a pharmaceutical composition, a chemical, a microbe, an element, a cytokine, a growth factor, a hormone, an antibody, a peptide, a ligand and/or an antagonist of membrane-bound receptor). ACTIVITY : Osteopathic. MECHANISM OF ACTION : Tissue repair and/or regeneration inducer.

37. 发明专利

CA2530412A1 CARTILAGE AND BONE REPAIR AND REGENERATION USING POSTPARTUM-DERIVED CELLS 未知
公开(公告)号：CA2530412A1
公开(公告)日：2005-04-28
申请号：CA2530412
申请日：2004-06-25
申请人： ETHICON INC
发明人： HARRIS IAN ROSS , MESSINA DARIN J , WANG ZIWEI , DHANARAJ SRIDEVI , SEYDA AGNIESZKA , MISTRY SANJAY , YI CHIN-FENG , GOSIEWSKA ANNA , KIHM ANTHONY J , HARMON ALEXANDER M
IPC分类号： C12N5/073 , C12N5/074
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotyp e are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. T he postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilag e conditions.

38. 发明专利

AU2004281371A1 Cartilage and bone repair and regeneration using postpartum-derived cells 未知
公开(公告)号：AU2004281371A1
公开(公告)日：2005-04-28
申请号：AU2004281371
申请日：2004-06-25
申请人： ETHICON INC
发明人： HARRIS IAN ROSS , KIHM ANTHONY J , WANG ZIWEI , MISTRY SANJAY , YI CHIN-FENG , SEYDA AGNIESZKA , MESSINA DARIN J , DHANARAJ SRIDEVI , HARMON ALEXANDER M , GOSIEWSKA ANNA
IPC分类号： C12N5/073 , C12N5/074
摘要： Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeutically in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors.

39. 发明专利

AU2004254616A1 Postpartum cells derived from umbilical cord tissue, and methods of making and using the same 未知
公开(公告)号：AU2004254616A1
公开(公告)日：2005-01-13
申请号：AU2004254616
申请日：2004-06-25
申请人： ETHICON INC
发明人： SEYDA AGNIESZKA , HARRIS IAN ROSS , HARMON ALEXANDER M , MISTRY SANJAY , GOSIEWSKA ANNA , YI CHIN-FENG , MESSINA DARIN J , KIHM ANTHONY J
IPC分类号： C12N5/073 , C12N5/074
摘要： Cells derived from postpartum tissue are disclosed along with methods for their therapeutic use in diseases of the heart or circulatory system are disclosed. Cells may be used therapeutically in either differentiated or undifferentiated forms, in homogenous cultures, or as populations with other cells, and in conjunction with other bioactive factors.

40. 发明专利

AU740052B2 Anti-fibrotic agent assay 未知
公开(公告)号：AU740052B2
公开(公告)日：2001-10-25
申请号：AU6810798
申请日：1997-10-24
申请人： ETHICON INC
发明人： GEESIN JEFFREY C , GOSIEWSKA ANNA
IPC分类号： G01N33/50 , A61K38/00 , A61K38/27 , A61K38/30 , A61K45/00 , A61P43/00 , C07K14/47 , C07K14/495 , C07K14/65 , G01N33/15 , G01N33/68 , A61K38/16 , C07K5/00

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