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31. 发明申请

WO2005039486A3 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：WO2005039486A3
公开(公告)日：2006-03-16
申请号：PCT/US2004027997
申请日：2004-08-27
申请人： IRM LLC , DING QIANG , GRAY NATHANAEL SCHIANDER , LI BING , LIU YI , UNO TETSUO
发明人： DING QIANG , GRAY NATHANAEL SCHIANDER , LI BING , LIU YI , UNO TETSUO
IPC分类号： A61K20060101 , A61K31/4745 , A61K31/519 , A61K31/675 , C07D471/02 , C07D487/02 , C07D487/04 , C07D471/04 , A61K31/4355
CPC分类号： C07D487/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, CSK, TrkB, FGFR3, Fes, Lck, B-RAF, C-RAF, MKK6, SAPK2a and SAPK2ß kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，Bmx，CSK，TrkB，FGFR3，Fes，Lck，B-RAF，C-RAF，MKK6，SAPK2a和SAPK2β激酶。

32. 发明申请

WO2004086808A3 PORTABLE AUDIO SYSTEM 审中-公开
标题翻译：便携式音响系统
公开(公告)号：WO2004086808A3
公开(公告)日：2005-03-24
申请号：PCT/US2004008462
申请日：2004-03-19
申请人： LI BING
发明人： LI BING
IPC分类号： G11B5/012 , G11B31/00 , H04B1/08 , G06F13/00
CPC分类号： H04B1/082 , G11B5/012 , G11B31/003
摘要： A portable audio system includes a compact disc drive (12) and a control unit (14) communicable through a communication interface (18). The control unit (14) includes a user interface (20), a processing means (22), memory (24), and an audio output (26). The control unit (14) is detachable from the compact disc drive (12), and is operable while disconnected from the compact disc drive (12). The processing means (22) of the control unit is configured to read data from a compact disc within the compact disc drive (12). The processing means can encode the data into digitally formatted files, and store the files within the memory (24) of the control unit (14) while the control unit (14) is connected to the compact disc drive (12). The processing means (22) can read, encode, and store the data at a rate equal. to or faster than the normal rate of play of the data. The processing means (22) of the control unit can produce an audio signal representative of the data in one of the files stored within the memory regardless of whether the control unit (14) is connected to the compact disc drive (12).
摘要翻译：便携式音频系统包括可通过通信接口（18）通信的小型光盘驱动器（12）和控制单元（14）。控制单元（14）包括用户界面（20），处理装置（22），存储器（24）和音频输出（26）。控制单元（14）可从光盘驱动器（12）拆卸，并且在与光盘驱动器（12）断开连接的同时可操作。控制单元的处理装置（22）被配置为从光盘驱动器（12）内的光盘读取数据。处理装置可以将数据编码为数字格式的文件，并且在控制单元（14）连接到光盘驱动器（12）的同时将文件存储在控制单元（14）的存储器（24）内。处理装置（22）可以以相等的速率读取，编码和存储数据。达到或超过正常播放速率的数据。无论控制单元（14）连接到光盘驱动器（12），控制单元的处理装置（22）都可以产生代表存储在存储器内的一个文件中的数据的音频信号。

33. 发明申请

WO2004029204A3 SUBSTITUTED PYRIMIDINES 审中-公开
标题翻译：取代的嘧啶
公开(公告)号：WO2004029204A3
公开(公告)日：2004-06-17
申请号：PCT/US0330161
申请日：2003-09-23
申请人： MERCK & CO INC , KOPKA IHOR E , LI BING , HAGMANN WILLIAM K
发明人： KOPKA IHOR E , LI BING , HAGMANN WILLIAM K
IPC分类号： A61K31/505 , A61K31/513 , A61P25/18 , A61P25/28 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/56 , C07D401/12 , C07D487/08 , A61K31/506 , C07D239/36 , C07D239/47 , C07D239/48 , C07D239/58
CPC分类号： C07D239/28 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/54 , C07D239/56 , C07D401/12 , C07D487/08
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，并且可用于治疗，预防和抑制由CB1受体介导的疾病。本发明化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化症和格林 - 巴利综合征的神经炎症和病毒性脑炎的炎性后遗症，脑血管障碍事故和头部创伤，焦虑症，压力，癫痫，帕金森病，运动障碍和精神分裂症。该化合物还可用于治疗物质滥用障碍，肥胖或饮食失调的治疗，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

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