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31. 发明授权

US6097025A Light detection device having an optical-path switching mechanism 有权
标题翻译：具有光路切换机构的光检测装置
公开(公告)号：US6097025A
公开(公告)日：2000-08-01
申请号：US160533
申请日：1998-09-24
申请人： Douglas N. Modlin , Glenn R. Edwards , Michael T. Taylor , Samuel A. Marquiss , Amer El-Hage , Craig S. Barker , Lorne B. Bechtel , Rick V. Stellmacher , Philip A. Granieri, Jr. , Robert M. Lembi, Sr.
发明人： Douglas N. Modlin , Glenn R. Edwards , Michael T. Taylor , Samuel A. Marquiss , Amer El-Hage , Craig S. Barker , Lorne B. Bechtel , Rick V. Stellmacher , Philip A. Granieri, Jr. , Robert M. Lembi, Sr.
IPC分类号： G01J1/36 , G01N21/25 , G01N21/64 , G01N21/76
CPC分类号： G01N21/76 , G01N21/253 , G01N21/6445 , G01N21/6452 , G01N2021/6417 , G01N2021/6471
摘要： A high-throughput light detection instrument and method are described. In some embodiments, switch mechanisms and optical relay structures permit different light sources and/or detectors to be selected for different applications. In other embodiments, switch mechanisms and optical paths permit top/bottom illumination and/or top/bottom detection, or combinations thereof.
摘要翻译：描述了高通量光检测仪器和方法。在一些实施例中，开关机构和光学继电器结构允许为不同的应用选择不同的光源和/或检测器。在其他实施例中，开关机构和光路允许顶部/底部照明和/或顶部/底部检测或其组合。

32. 发明授权

US6033100A Floating head assembly 失效
标题翻译：浮头组件
公开(公告)号：US6033100A
公开(公告)日：2000-03-07
申请号：US118310
申请日：1998-07-16
申请人： Samuel A. Marquiss , Glenn R. Edwards , Douglas N. Modlin
发明人： Samuel A. Marquiss , Glenn R. Edwards , Douglas N. Modlin
IPC分类号： G01N21/64 , B01L9/00 , C40B60/14 , F21V21/18 , G01N21/03 , G01N21/17 , G01N21/21 , G01N21/27 , G01N21/76 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N21/76 , B01L9/523 , B82Y15/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00686 , B01J2219/00691 , B01J2219/00707 , B01L2300/0829 , C40B60/14 , Y10S436/807 , Y10S436/809 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/25
摘要： Devices and methods for transmitting light through an aperture in a surface substantially without leakage. In one embodiment, the device comprises an optical relay structure having an end configured to transmit light, and an opaque collar positioned around the end and configured to reorient to conform to the surface when the end and the aperture are aligned. In another embodiment, the device comprises an optical relay structure having an end configured to transmit light, and an opaque collar positioned around the end and spring-biased relative to the end, so that the opaque collar is forced against the surface when the end and the aperture are aligned. The devices further may include a stop mechanism for limiting movement of the opaque collar, a registration mechanism for aligning the end and the aperture, and a light source and/or a detector for generating or detecting light, among others.
摘要翻译：用于透过基本上没有泄漏的表面中的孔的光透射的装置和方法。在一个实施例中，该装置包括具有被配置为透射光的端部的光学继电器结构以及围绕该端部定位的不透明的环形，并且被配置为当端部和孔对准时重新定向以符合表面。在另一个实施例中，该装置包括具有被配置为透射光的端部的光学继电器结构以及围绕该端部设置并且相对于该端部具有弹簧偏置的不透明环圈，使得当端部和孔径对齐。这些装置还可以包括用于限制不透明环的运动的停止机构，用于对准端部和孔的对准机构，以及用于产生或检测光的光源和/或检测器等。

33. 发明申请

US20100173394A1 Droplet-based assay system 有权
标题翻译：基于液滴的测定系统
公开(公告)号：US20100173394A1
公开(公告)日：2010-07-08
申请号：US12586626
申请日：2009-09-23
申请人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, JR. , Phillip Belgrader
发明人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, JR. , Phillip Belgrader
IPC分类号： C12M1/00 , G01N33/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.
摘要翻译：用于进行测定的系统，包括装置和方法。这些系统可以包括通过将样品组分分成液滴或其它分隔，放大或以其他方式使液滴内的组分反应，检测放大的组分或其特征，和/或分析所得数据等来分离样品组分。

34. 发明授权

US06943034B1 Combinatorial strategies for polymer synthesis 失效
标题翻译：聚合物合成的组合策略
公开(公告)号：US06943034B1
公开(公告)日：2005-09-13
申请号：US09498554
申请日：2000-02-04
申请人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
发明人： James L. Winkler , Stephen P. A. Fodor , Christopher J. Buchko , Debra A. Ross , Lois Aldwin , Douglas N. Modlin
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/10 , G01N1/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00364 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00389 , B01J2219/00416 , B01J2219/0043 , B01J2219/00432 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00686 , B01J2219/00702 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C07K1/045 , C07K1/047 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1072 , Y10S436/809 , Y10T436/143333 , Y10T436/25 , Y10T436/255 , Y10T436/2575
摘要： A method for producing arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a compound in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm2 of the surface of the support, allowing the compound to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 ligands at a density of 1000 per cm2 or greater.
摘要翻译：一种通过将分配器与支撑体的表面间隔一定距离来产生阵列的方法，在单个耦合步骤中分配包含化合物的体积小于5nl以占据小于1cm 2的局部区域， SUP>，允许化合物直接或间接地结合到载体上并重复该步骤以产生密度为1000 / cm 2以上的至少100种配体的阵列。

35. 发明授权

US06576476B1 Chemiluminescence detection method and device 失效
标题翻译：化学发光检测方法及装置
公开(公告)号：US06576476B1
公开(公告)日：2003-06-10
申请号：US09302158
申请日：1999-04-29
申请人： Michael T. Taylor , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin
发明人： Michael T. Taylor , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin
IPC分类号： G01N2117
CPC分类号： G01N21/253 , G01N21/76 , Y10T436/114165
摘要： A device for detecting chemiluminescence from a sample. The device may include a stage for supporting a sample and one or more of the following elements: (1) an optics head, (2) an optical relay structure for transmitting chemiluminescence from the sample to a detector, (3) a drive mechanism, (4) a sensor for detecting proximity of the optical relay structure to the sample, (5) a mask structure for selecting an effective diameter of the optical relay structure, and (6) a baffle for blocking extraneous light from entering the optical relay structure.
摘要翻译：用于从样品中检测化学发光的装置。该装置可以包括用于支撑样品的台和以下元件中的一个或多个：（1）光学头，（2）用于将化学发光从样品传输到检测器的光中继结构，（3）驱动机构，（4）用于检测光继电器结构对样品的接近度的传感器，（5）用于选择光继电器结构的有效直径的掩模结构，以及（6）用于阻挡外来光进入光中继结构的挡板。

36. 发明授权

US06310687B1 Light detection device with means for tracking sample sites 失效
标题翻译：具有跟踪样品位置的装置的光检测装置
公开(公告)号：US06310687B1
公开(公告)日：2001-10-30
申请号：US09768765
申请日：2001-01-23
申请人： David P. Stumbo , Douglas N. Modlin
发明人： David P. Stumbo , Douglas N. Modlin
IPC分类号： G01N2164
CPC分类号： B01L3/50853 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00659 , B01J2219/00707 , C40B60/14 , G01N21/253 , G01N35/028 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462
摘要： Apparatus and methods for optical detection with improved read speed and/or signal-to-noise ratio. These apparatus and methods may involve among others moving an sample substrate (108) while simulataneously detecting light transmitted from one or more sample sites (110) on the substrate (108) by sequentially tracking the sample sites (110) as they move. A stage (101), movable in a first direction, supports the substrate (108). A detector (118) detects light emanating from an examination region (102) delimited by a detection initiation position (106a) and a detection termination position (106b). An optical relay structure (122) transmit light from the examination region (102) to the detector (118). A scanning mechanism (120) simultaneously moves the optical relay structure (122) and the substrate in the first direction. The optical relay structure (122) tracks the substrate (108) between the detection initiation position (106a) and the detection termination position (106b).
摘要翻译：用于具有改进的读取速度和/或信噪比的光学检测的装置和方法。这些装置和方法可以包括移动样品衬底（108），同时通过在样品位点（110）移动时顺序地跟踪样品位点（110）同时检测从衬底（108）上的一个或多个样品位点（110）传输的光。可沿第一方向移动的平台（101）支撑基板（108）。检测器（118）检测从由检测开始位置（106a）和检测终止位置（106b）限定的检查区域（102）发出的光。光学继电器结构（122）将来自检查区域（102）的光透射到检测器（118）。扫描机构（120）同时沿第一方向移动光学继电器结构（122）和基板。光继电器结构（122）在检测开始位置（106a）和检测终止位置（106b）之间跟踪基板（108）。

37. 发明授权

US6071748A Light detection device 失效
标题翻译：光检测装置
公开(公告)号：US6071748A
公开(公告)日：2000-06-06
申请号：US62472
申请日：1998-04-17
申请人： Douglas N. Modlin , Glenn R. Edwards , Michael T. Taylor , Samuel A. Marquiss
发明人： Douglas N. Modlin , Glenn R. Edwards , Michael T. Taylor , Samuel A. Marquiss
IPC分类号： G01N21/64 , B01L9/00 , C40B60/14 , F21V21/18 , G01N21/03 , G01N21/17 , G01N21/21 , G01N21/27 , G01N21/76 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G01N21/01
CPC分类号： G01N21/76 , B01L9/523 , B82Y15/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00686 , B01J2219/00691 , B01J2219/00707 , B01L2300/0829 , C40B60/14 , Y10S436/807 , Y10S436/809 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/25
摘要： A high-throughput light detection instrument and method are described. Confocal optics structure enables exclusive light detection from a sensed volume in a composition.
摘要翻译：描述了高通量光检测仪器和方法。共焦光学结构使组合物中感测体积的独特光检测成为可能。

38. 发明授权

US06025985A Moveable control unit for high-throughput analyzer 失效
标题翻译：可移动控制单元，用于高通量分析仪
公开(公告)号：US06025985A
公开(公告)日：2000-02-15
申请号：US118341
申请日：1998-07-16
申请人： Lev J. Leytes , William G. Burton , Yong Paik , Glenn R. Edwards , Douglas N. Modlin , Amer El-Hage
发明人： Lev J. Leytes , William G. Burton , Yong Paik , Glenn R. Edwards , Douglas N. Modlin , Amer El-Hage
IPC分类号： G01N21/64 , B01L9/00 , C40B60/14 , F21V21/18 , G01N21/03 , G01N21/17 , G01N21/21 , G01N21/27 , G01N21/76 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G06F1/16
CPC分类号： G01N21/76 , B01L9/523 , B82Y15/00 , B01J2219/00315 , B01J2219/00317 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00686 , B01J2219/00691 , B01J2219/00707 , B01L2300/0829 , C40B60/14 , Y10S436/807 , Y10S436/809 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/25
摘要： A moveable control unit for a high-throughput analyzer that can be operatively mounted at a plurality of locations on the analyzer housing.
摘要翻译：一种用于高通量分析仪的可移动控制单元，其可操作地安装在分析仪壳体上的多个位置处。

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