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31. 发明申请

US20050167888A1 Compacted catheter balloon and method of incremental compaction 审中-公开
标题翻译：压实导管球囊和增量压实方法
公开(公告)号：US20050167888A1
公开(公告)日：2005-08-04
申请号：US11094025
申请日：2005-03-29
申请人： Timothy Owens , Florencia Lim
发明人： Timothy Owens , Florencia Lim
IPC分类号： A61M29/02 , B29C67/20
CPC分类号： A61M25/104 , A61M2025/1075 , Y10T428/1359
摘要： A catheter balloon or other expandable tubular medical device or component, having at least a first layer with a first section and a second section longitudinally compacted by more than the first section. In a presently preferred embodiment, the second section of the first layer extends at least in part along a central portion of the length of the first layer. The longitudinal compaction of the material of the first layer preferably results in a balloon or other expandable tubular medical device or component having improved performance characteristics such as compliance and dimensional stability. One aspect of the invention is directed to a method of longitudinally compacting a porous polymeric tube incrementally along the length of the tube, to compact sections of the tube.
摘要翻译：一种导管球囊或其它可扩张的管状医疗装置或部件，其至少具有第一部分和第二部分，该第一部分第一部分和第二部分被第一部分纵向压实。在目前优选的实施例中，第一层的第二部分至少部分地沿着第一层的长度的中心部分延伸。第一层的材料的纵向压实优选地导致具有改进的性能特征如柔顺性和尺寸稳定性的球囊或其它可扩展的管状医疗装置或部件。本发明的一个方面涉及一种沿管的长度逐渐压缩多孔聚合物管的方法，以压紧管的部分。

32. 发明申请

US20050089655A1 Surface modification of expanded ultra high molecular weight polyethylene (eUHMWPE) for improved bondability 有权
公开(公告)号：US20050089655A1
公开(公告)日：2005-04-28
申请号：US10990011
申请日：2004-11-16
申请人： Florencia Lim
发明人： Florencia Lim
IPC分类号： A61L29/08 , B65D1/00
CPC分类号： A61L29/085 , A61M2025/1075 , C08L23/06 , C08L75/04 , Y10T428/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/24479 , Y10T428/2495
摘要： A balloon catheter and a method of making the balloon catheter, having a balloon which is bonded to an elongated shaft, and which has a first layer and a second layer and an improved bond between the balloon and the shaft. One aspect of the invention is directed to a balloon in which the balloon first layer includes eUHMWPE and has at least a section that has been oxidized with a chromic acid solution to provide improved bondability.

33. 发明授权

US06841029B2 Surface modification of expanded ultra high molecular weight polyethylene (eUHMWPE) for improved bondability 失效
标题翻译：膨胀超高分子量聚乙烯（eUHMWPE）的表面改性，以提高粘结性
公开(公告)号：US06841029B2
公开(公告)日：2005-01-11
申请号：US10400809
申请日：2003-03-27
申请人： Florencia Lim
发明人： Florencia Lim
IPC分类号： A61L29/08 , C09J5/02 , B32B31/20 , B44C1/22 , C03C15/00 , C03C25/68
CPC分类号： A61L29/085 , A61M2025/1075 , C08L23/06 , C08L75/04 , Y10T428/13 , Y10T428/1334 , Y10T428/1352 , Y10T428/139 , Y10T428/1393 , Y10T428/24479 , Y10T428/2495
摘要： A balloon catheter and a method of making the balloon catheter, having a balloon which is bonded to an elongated shaft, and which has a first layer and a second layer and an improved bond between the balloon and the shaft. One aspect of the invention is directed to a balloon in which the balloon first layer includes eUHMWPE and has at least a section that has been oxidized with a chromic acid solution to provide improved bondability.
摘要翻译：气囊导管和制造气囊导管的方法，具有结合到细长轴的气球，并且具有第一层和第二层以及气囊和轴之间改进的结合。本发明的一个方面涉及一种球囊，其中球囊第一层包括eUHMWPE并且至少具有已经用铬酸溶液氧化以提供改善的粘合性的部分。

34. 发明授权

US06527741B1 Angioplasty catheter system with adjustable balloon length 有权
公开(公告)号：US06527741B1
公开(公告)日：2003-03-04
申请号：US09469966
申请日：1999-12-21
申请人： Jeong S. Lee , Florencia Lim , Cheryl Stiger , Carolyn Voyles , Vincent Bavaro
发明人： Jeong S. Lee , Florencia Lim , Cheryl Stiger , Carolyn Voyles , Vincent Bavaro
IPC分类号： A61M2900
CPC分类号： B29C49/00 , A61M25/1027 , A61M2025/1031 , A61M2025/1059 , B29C43/10 , B29C43/36 , B29C55/28 , B29K2105/258 , B29L2022/025 , B29L2031/7542
摘要： A resizable inflatable balloon, primarily for use with balloon catheters. The resizable inflatable balloon comprises a first portion and an adjacent second portion. The first portion is inflatable to a working diameter at a first pressure while the second portion does not substantially expand at the first pressure. The second portion does expand to the working diameter at a second pressure greater than the first pressure, so that subsequent inflation at the first pressure inflates the first portion and the second portion to the working diameter. The methods of resizing the inflatable members include placing the inflatable balloon in a mold and supplying inflation fluid to expand the second member to the working diameter. In practice, a catheter having the resizable inflatable balloon is guided through a patient's vasculature until the inflatable balloon is positioned in a desired region. Inflation fluid is supplied at the first pressure to inflate the first portion to the working diameter. The catheter is withdraw and the inflatable balloon is resized as described above. The catheter is reintroduced to the patient's vasculature and inflation fluid is then supplied at the first pressure to inflate both the first and second portions.

35. 发明授权

US06344045B1 Sizing and therapeutic catheter with sheath 有权
标题翻译：护套尺寸和治疗导管
公开(公告)号：US06344045B1
公开(公告)日：2002-02-05
申请号：US09642961
申请日：2000-08-17
申请人： Florencia Lim , Christopher L. Haig , Vidya J. Nayak , Joann Heberer , Robert D. Ainsworth
发明人： Florencia Lim , Christopher L. Haig , Vidya J. Nayak , Joann Heberer , Robert D. Ainsworth
IPC分类号： A61F1100
CPC分类号： A61L29/049 , A61F2/958 , A61M25/1027 , A61M25/104 , A61M29/02 , B29C47/00 , B29C47/0023 , B29C47/065 , B29C55/24 , B29K2075/00 , B29L2022/022 , B29L2031/7542
摘要： The present invention is directed to a gauging system and method for using the same for determining the size of a lesion within a patient's body prior to stenting the lesion. In one embodiment the gauging system includes a catheter having an elongated shaft with proximal and distal ends, and an outer sheath formed of a compliant material and disposed about at least a portion of the catheter elongated shaft and being slidable over the same. In another embodiment, the gauging system further includes a radially expandable member formed of the same or different compliant material mounted on a distal section of the shaft and has an interior chamber in fluid communication with an inflation lumen extending within at least a portion of a distal shaft section to a location spaced proximally from the shaft distal end.
摘要翻译：本发明涉及一种测量系统和方法，用于在支架植入病变之前确定患者体内损伤的尺寸。在一个实施例中，测量系统包括具有细长轴的导管，其具有近端和远端，以及由柔性材料形成并且围绕导管细长轴的至少一部分设置并可在其上滑动的外护套。在另一个实施例中，测量系统还包括由安装在轴的远侧部分上的相同或不同顺应性材料形成的径向可扩张构件，并且具有与膨胀腔流体连通的内部腔室，所述内部腔室在至少一部分远端轴部分到距离轴远端近近距离的位置。

36. 发明授权

US09119787B2 Microparticles for the treatment of disease 有权
标题翻译：微粒治疗疾病
公开(公告)号：US09119787B2
公开(公告)日：2015-09-01
申请号：US12806790
申请日：2010-08-19
申请人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
发明人： Florencia Lim , Mikael Trollsas , Michael Ngo , Thierry Glauser , Jinping Wan
IPC分类号： A61K9/16 , A61K9/50 , A61K9/00
CPC分类号： A61K9/1647 , A61K9/0019 , A61K9/5031
摘要： Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.
摘要翻译：公开了用于局部治疗病变组织/器官的基于微粒 - 生物活性剂的治疗方法。

37. 发明授权

US08697110B2 Polymers comprising amorphous terpolymers and semicrystalline blocks 有权
标题翻译：包含无定形三元共聚物和半结晶块的聚合物
公开(公告)号：US08697110B2
公开(公告)日：2014-04-15
申请号：US12466302
申请日：2009-05-14
申请人： Mikael Trollsas , Michael Ngo , Florencia Lim
发明人： Mikael Trollsas , Michael Ngo , Florencia Lim
IPC分类号： A61F2/00 , A61L31/10 , A61L31/06
CPC分类号： A61L31/041 , A61L31/06 , A61L31/10 , A61L31/16 , C08L67/04 , C08L77/12
摘要： The present invention provides an implantable article comprising an amorphous terpolymer and a semi-crystalline polymer. The amorphous terpolymer can be admixed with the semi-crystalline polymer or form a block copolymer with the semi-crystalline polymer.
摘要翻译：本发明提供一种包含无定形三元共聚物和半结晶聚合物的可植入制品。无定形三元共聚物可与半结晶聚合物混合，或与半结晶聚合物形成嵌段共聚物。

38. 发明授权

US08287840B2 Method of treating malignant solid tumors using transcatheter arterial chemoembolization (TACE) 有权
标题翻译：使用经导管动脉化学栓塞（TACE）治疗恶性实体瘤的方法
公开(公告)号：US08287840B2
公开(公告)日：2012-10-16
申请号：US12509338
申请日：2009-07-24
申请人： Liangxuan Zhang , Florencia Lim
发明人： Liangxuan Zhang , Florencia Lim
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K31/704 , A61K9/0019 , A61K9/5084 , A61K31/407 , A61K33/24 , A61K2300/00
摘要： This invention is directed to methods of treating solid tumor cancers, particularly refractory cancers by administration of two pluralities of microparticles, one comprising drug-carrying microparticles sized to lodge at the tumor preferably in the capillary bed of the tumor and the other comprising non-drug-carrying microparticles sized to lodge in the arterial system servicing the tumor so as to embolize the tumor.
摘要翻译：本发明涉及通过施用两个多个微粒来治疗实体肿瘤癌症，特别是难治性癌症的方法，一种包含药物载体微粒，其尺寸设置为优选在肿瘤的毛细血管床中提供肿瘤，另一种包括非药物携带的微粒尺寸设置在服务于肿瘤的动脉系统中以栓塞肿瘤。

39. 发明授权

US08128983B2 Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network 有权
标题翻译：包含聚（乙二醇） - 聚（丙交酯 - 乙交酯 - 己内酯）互穿网络的涂层
公开(公告)号：US08128983B2
公开(公告)日：2012-03-06
申请号：US12101866
申请日：2008-04-11
申请人： Mikael Trollsas , Florencia Lim , Syed F. A. Hossainy
发明人： Mikael Trollsas , Florencia Lim , Syed F. A. Hossainy
IPC分类号： A61L33/00
CPC分类号： A61L31/10 , Y10S623/926 , C08L71/02 , C08L67/04
摘要： Methods for fabricating coatings for implantable medical devices are disclosed. The method comprises forming a coating on an implantable device comprising an interpenetrating network or semi-interpenetrating network. The interpenetrating network or semi-interpenetrating network comprises poly(ethylene glycol) and an aliphatic polyester copolymer. It is also provided an implantable device and a method of using the implantable device.
摘要翻译：公开了用于制造可植入医疗装置的涂层的方法。该方法包括在包括互穿网络或半互穿网络的可植入装置上形成涂层。互穿网络或半互穿网络包括聚（乙二醇）和脂族聚酯共聚物。还提供了可植入装置和使用可植入装置的方法。

40. 发明申请

US20110229548A1 Implantable Medical Device With Poly(Vinylidene Fluoride-Co-Hexafluoropropylene)/Zotarolimus Drug Layer 审中-公开
标题翻译：具有聚（亚乙烯基氟化物 - 共 - 六氟丙烯）/佐他莫司药物层的可植入医疗器械
公开(公告)号：US20110229548A1
公开(公告)日：2011-09-22
申请号：US12727175
申请日：2010-03-18
申请人： Florencia Lim , Shawn Chin Quee , Mikael O. Trollsas
发明人： Florencia Lim , Shawn Chin Quee , Mikael O. Trollsas
IPC分类号： A61F2/82 , A61K31/436 , A61F2/06
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2420/08 , C08L27/20 , C08L27/16
摘要： This invention relates to an implantable medical device for and method of treating a vascular disease where the device is preferably a stent comprising a drug reservoir layer comprising poly(vinylidene fluoride-co-hexafluoropropylene) and zotarolimus.
摘要翻译：本发明涉及一种用于治疗血管疾病的可植入医疗装置及其方法，其中装置优选为支架，其包括含有聚（偏二氟乙烯 - 共 - 六氟丙烯）和佐他莫司的药物储存层。

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