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31. 发明授权

US06426382B1 Polycationic polymer salts, their production and use 有权
标题翻译：聚阳离子聚合物盐，其生产和使用
公开(公告)号：US06426382B1
公开(公告)日：2002-07-30
申请号：US09720305
申请日：2000-12-21
申请人： John Farrar , Mark Graham , Andrew Jackson
发明人： John Farrar , Mark Graham , Andrew Jackson
IPC分类号： C08J303
CPC分类号： D21H17/56 , B41M5/508 , B41M5/5245 , C08G73/02 , C08G73/0226 , C09B23/148 , D21H21/30
摘要： Aqueous solutions of polycationic polymers (PAB) containing quaternary ammonium groups in salt form as heteroatomic chain members or ring members of the polymer, wherein a part of the counter-ions to the quaternary cationic groups are anionic groups of anionic optical brighteners, containing at least one anionic group, are valuable multi-functional agents in papermaking.
摘要翻译：含有盐形式的季铵基团的聚阳离子聚合物（PAB）的水溶液作为聚合物的杂原子链成员或环成员，其中与季阳离子基团的反离子的一部分为阴离子基团的阴离子荧光增白剂，至少含有一种阴离子基团是造纸中的有价值的多功能剂。

32. 发明申请

US20130215374A1 EYEWEAR DOCKING STATION AND ELECTRONIC MODULE 有权
公开(公告)号：US20130215374A1
公开(公告)日：2013-08-22
申请号：US13735887
申请日：2013-01-07
申请人： Ronald Blum , Yongping Wang , Mark Graham , William Kokonaski , Richard Clompus
发明人： Ronald Blum , Yongping Wang , Mark Graham , William Kokonaski , Richard Clompus
IPC分类号： G02C11/00 , G02C11/06 , G02C11/04 , G02C7/08
CPC分类号： G02C11/10 , A61F9/061 , G02C7/081 , G02C11/04 , G02C11/06 , G05B15/02 , G06K19/0715 , G06K19/07762
摘要： An eyewear system including an eyewear frame and an application module. The eyewear frame including a docking station, and an electronic connector including a first set of preconfigured application connection points. The application module adapted to be mounted to the docking station, and including an electronic device configured to perform a function, and a second set of preconfigured application connection points corresponding to at least some of the first set of preconfigured application connection points. The second set of preconfigured application connection points including at least two different sub-function connections used to support the function of the electronic device.

33. 发明申请

US20120270929A1 MODULATION OF TTC39 EXPRESSION TO INCREASE HDL 审中-公开
标题翻译： TTC39表达调控增加HDL
公开(公告)号：US20120270929A1
公开(公告)日：2012-10-25
申请号：US13498055
申请日：2010-09-24
申请人： Rosanne M. Crooke , Mark Graham , Thomas A. Bell
发明人： Rosanne M. Crooke , Mark Graham , Thomas A. Bell
IPC分类号： A61K31/7088 , A61P1/16 , A61P3/10 , A61P3/06 , A61P9/12 , A61P9/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a TTC39 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL and/or decreasing PCSK9 in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate cardiovascular disease, or a symptom thereof.
摘要翻译：本文提供了用于减少动物中TTC39mRNA和蛋白质表达的方法，化合物和组合物。本文还提供用于增加动物体内HDL和/或降低PCSK9的方法，化合物和组合物。这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或其症状。

34. 发明申请

US20120127423A1 ELECTRONIC SPECTACLE FRAMES 有权
标题翻译：电子麦克风框架
公开(公告)号：US20120127423A1
公开(公告)日：2012-05-24
申请号：US13298997
申请日：2011-11-17
申请人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C11/00
CPC分类号： G02C7/101 , G02C7/083
摘要： Embodiments may provide a first device that comprises eyeglasses, where the eyeglasses may further include a lens housing, a first temple and a second temple coupled to the lens housing, and a first and a second lens supported by the lens housing. The first device may further include a façade that covers the lens housing. The first device may further comprise an electronic component and at least one conductive path may be provided from the electronic component to the first lens having a portion that runs through the lens housing.
摘要翻译：实施例可以提供包括眼镜的第一装置，其中眼镜还可以包括透镜壳体，耦合到透镜壳体的第一镜腿和第二镜腿以及由透镜壳体支撑的第一和第二透镜。第一装置还可以包括覆盖透镜壳体的外墙。第一装置还可以包括电子部件，并且可以从电子部件到具有穿过透镜壳体的部分的第一透镜提供至少一个导电路径。

35. 发明申请

US20120002160A1 FRAME DESIGN FOR ELECTRONIC SPECTACLES 审中-公开
标题翻译：电子瞄准镜框架设计
公开(公告)号：US20120002160A1
公开(公告)日：2012-01-05
申请号：US13175634
申请日：2011-07-01
申请人： Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C5/14
CPC分类号： G02C11/10 , G02C5/146 , G02C7/081 , G02C7/101
摘要： A first device is provided. The first device comprises a frame, where the frame further comprises: a lens housing adapted to support a first lens and a second lens, a first temple coupled to the lens housing, and a second temple coupled to the lens housing. The first device further comprises a first conductive path provided by one or more frame elements from the first temple to the lens housing and a second conductive path provided by one or more frame elements from the first temple to the lens housing. The first conductive path is electrically isolated from the second conductive path.
摘要翻译：提供第一个设备。第一装置包括框架，其中框架还包括：适于支撑第一透镜和第二透镜的透镜壳体，耦合到透镜壳体的第一光阑以及耦合到透镜壳体的第二光阑。第一装置还包括由一个或多个框架元件从第一镜腿到透镜壳体提供的第一导电路径和由一个或多个框架元件从第一镜腿提供到镜片壳体的第二导电路径。第一导电路径与第二导电路径电绝缘。

36. 发明授权

US07163518B1 Walking leg support 失效
标题翻译：步行支腿
公开(公告)号：US07163518B1
公开(公告)日：2007-01-16
申请号：US10824125
申请日：2004-04-14
申请人： Martin Roche , Mark Graham
发明人： Martin Roche , Mark Graham
IPC分类号： A61F5/00 , A43B7/24 , A63B25/08 , E04G1/00
CPC分类号： A61F5/0195 , A43B7/00 , A43B13/18
摘要： Apparatus attaches to the leg at or below the knee to take the shock of walking off the foot and ankle. The foot is encased in a boot. Two spaced-apart tubes extend upward from a subfloor mounted below the boot. The boot is mounted for sliding up and down on the tubes. A pair of parallel elongate rods are attached at their upper ends to the upper portion of the leg at or below the knee, such that the lower ends of the rods are in the tubes. A spring, preferably a gas compression spring, is inserted into each tube so that the lower end of each rod compresses the spring as body weight is put on the subfloor in walking. The subfloor moves toward the boot as the springs are compressed, reducing some of the shock of walking and transferring forces to the leg. The rods may be attached to the leg by a cast, brace or orthosis.
摘要翻译：装置附着在膝盖处或膝下的腿部，以消除脚部和脚踝上的冲击。脚被套在靴子里。两个间隔开的管子从安装在护罩下方的底板向上延伸。安装套管用于在管上滑动。一对平行的细长杆在其上端处连接到腿部的膝部上方或下方，使得杆的下端在管中。弹簧，优选气体压缩弹簧插入每个管中，使得每个杆的下端压缩弹簧，因为体重在步行时被放置在底层地板上。弹簧被压缩后，地板朝向靴子移动，减少了步行和将力传递到腿部的一些震动。杆可以通过铸造，支架或矫形器附接到腿部。

37. 发明申请

US20060024727A1 Antisense modulation of C-reactive protein expression 失效
公开(公告)号：US20060024727A1
公开(公告)日：2006-02-02
申请号：US11211803
申请日：2005-08-25
申请人： Rosanne Crooke , Mark Graham
发明人： Rosanne Crooke , Mark Graham
IPC分类号： C12Q1/68 , C07H21/02 , A61K48/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.

38. 发明申请

US20050009088A1 Antisense modulation of apolipoprotein B-expression 有权
标题翻译：载脂蛋白B表达的反义调节
公开(公告)号：US20050009088A1
公开(公告)日：2005-01-13
申请号：US10920612
申请日：2004-08-17
申请人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人： Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节载脂蛋白B的表达。组合物包含靶向编码载脂蛋白B的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节载脂蛋白B表达和治疗疾病的方法与载脂蛋白B的表达相关。

39. 发明授权

US08979259B2 Electro-active spectacle frames 有权
标题翻译：电活动眼镜架
公开(公告)号：US08979259B2
公开(公告)日：2015-03-17
申请号：US13179219
申请日：2011-07-08
申请人： Joshua N. Haddock , Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Joshua N. Haddock , Ronald D. Blum , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C1/00 , G02C11/00 , G02C5/22
CPC分类号： G02C11/10 , G02C5/2272
摘要： A first device is provided. The first device includes a lens comprising at least a first electrical contact and a lens housing holding the lens. The lens housing includes at least a second electrical contact. The first device further comprises a compliant conductive element disposed between the first and the second electrical contact. The compliant conductive element electrically connects the first and second electrical contacts.
摘要翻译：提供第一个设备。第一装置包括至少包括第一电触头和保持透镜的透镜壳体的透镜。透镜壳体至少包括第二电触点。第一装置还包括设置在第一和第二电触点之间的柔性导电元件。柔性导电元件电连接第一和第二电触点。

40. 发明授权

US08905541B2 Electronic spectacle frames 有权
标题翻译：电子眼镜架
公开(公告)号：US08905541B2
公开(公告)日：2014-12-09
申请号：US13298992
申请日：2011-11-17
申请人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
发明人： Ronald D. Blum , Joshua N. Haddock , Claudio Dalla Longa , Mark Graham , Yongping Wang
IPC分类号： G02C1/00 , G02C7/10 , G02C5/22 , G02C5/14 , G02C7/08 , G02C11/00
CPC分类号： G02C7/101 , G02C1/10 , G02C5/146 , G02C5/2236 , G02C7/081 , G02C11/10 , Y10T29/49826
摘要： Embodiments may provide a first device that includes a frame having a first temple and a second temple. The frame may also comprise a housing module coupled (e.g. attached) to a structural member. The first device may further include a first lens and a second lens coupled to the frame and an electronics module that may be located within the housing module. The electronics module may include at least any two of: a power source; a controller; and/or a sensing mechanism.
摘要翻译：实施例可以提供第一装置，其包括具有第一神庙和第二神殿的框架。框架还可以包括耦合（例如附接）到结构构件的壳体模块。第一装置还可以包括耦合到框架的第一透镜和第二透镜以及可以位于壳体模块内的电子模块。电子模块可以包括以下至少任意两个：电源; 控制器和/或感测机构。

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