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31. 发明申请

US20060088917A1 IL-17 homologous polypeptides and therapeutic uses thereof 审中-公开
公开(公告)号：US20060088917A1
公开(公告)日：2006-04-27
申请号：US11311561
申请日：2005-12-20
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
IPC分类号： C07H21/04 , C12P21/02 , C07K14/54 , C07K16/24
CPC分类号： C07K14/54
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

32. 发明授权

US07189566B2 PRO347 nucleic acids 失效
标题翻译： PRO347核酸
公开(公告)号：US07189566B2
公开(公告)日：2007-03-13
申请号：US09944896
申请日：2001-08-31
申请人： David Botstein , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Margaret Ann Roy , William Wood
发明人： David Botstein , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Margaret Ann Roy , William Wood
IPC分类号： C12N5/10 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02
摘要： The present invention is directed to novel polypeptides having homology to cysteine-rich secretory protein-3 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cell comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及与富含半胱氨酸的分泌蛋白-3和编码这些多肽的核酸分子具有同源性的新型多肽。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

33. 发明申请

US20060073546A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060073546A1
公开(公告)日：2006-04-06
申请号：US10213535
申请日：2002-08-07
申请人： David Botstein , Luc Desnoyers , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Austin Gurney , James Pan , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood
发明人： David Botstein , Luc Desnoyers , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Austin Gurney , James Pan , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood
IPC分类号： C07H21/04 , C12P21/06 , C12N9/00 , C12N5/06 , C12N1/18
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

34. 发明申请

US20050176104A1 Compositions and methods for the treatment of tumor 审中-公开
标题翻译：用于治疗肿瘤的组合物和方法
公开(公告)号：US20050176104A1
公开(公告)日：2005-08-11
申请号：US11052503
申请日：2005-02-04
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Margaret Roy , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Margaret Roy , William Wood
IPC分类号： A61K39/395 , C07H21/04 , C07K14/82 , C07K16/30 , C07K16/40 , C12N5/06 , C12N5/16 , C12N15/00 , C12P21/02 , C12P21/04
CPC分类号： C07K16/30
摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与相同组织类型的正常细胞相比，与基因产物的过表达有关，并且有助于肿瘤发生。因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。本发明涉及新型多肽和编码那些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

35. 发明申请

US20070178539A1 Novel Cytokine Receptors and Nucleic Acids Encoding the Same 审中-公开
标题翻译：新型细胞因子受体和编码其的核酸
公开(公告)号：US20070178539A1
公开(公告)日：2007-08-02
申请号：US11697201
申请日：2007-04-05
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , Colin Watanabe , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , Colin Watanabe , William Wood
IPC分类号： G01N33/574 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/30
CPC分类号： G01N33/57492 , G01N33/6863
摘要： The present invention is directed to novel cytokine receptors having sequence similarity to AF18497_1 and to nucleic acid molecules encoding those cytokine receptors. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及与AF18497_1具有序列相似性的新型细胞因子受体以及编码这些细胞因子受体的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。

36. 发明申请

US20070136829A1 NOVEL TYPE-1 CYTOKINE RECEPTOR GLM-R 审中-公开
标题翻译：新型1型细胞因子受体GLM-R
公开(公告)号：US20070136829A1
公开(公告)日：2007-06-14
申请号：US11548639
申请日：2006-10-11
申请人： Nico Ghilardi , Frederic De Sauvage , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , William Wood
发明人： Nico Ghilardi , Frederic De Sauvage , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , William Wood
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/53 , G01N33/567 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C07K14/7158
摘要： The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.
摘要翻译：本发明涉及GLM-R多肽的新型多肽及其变体以及编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法发明。还提供了用于检测调节GLM-R的活性的试剂的方法。还提供了用于诊断和治疗特征在于单核细胞或巨噬细胞过度或不丰富的疾病的方法。

37. 发明申请

US20060088854A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060088854A1
公开(公告)日：2006-04-27
申请号：US11190075
申请日：2005-07-25
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C12Q1/68 , C12P21/06 , C12N9/00
CPC分类号： C07K14/47 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

38. 发明申请

US20060084084A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060084084A1
公开(公告)日：2006-04-20
申请号：US11150881
申请日：2005-06-09
申请人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Jian Chen , Luc Desnoyers , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Victoria Smith , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C12Q1/68 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

39. 发明申请

US20060074221A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060074221A1
公开(公告)日：2006-04-06
申请号：US10219064
申请日：2002-08-13
申请人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
发明人： Kevin Baker , Luc Desnoyers , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Victoria Smith , Jean-Philippe Stephan , Colin Watanabe , William Wood
IPC分类号： C07K14/47 , C07H21/04 , C12P21/06 , C12N9/00 , C07K16/18
CPC分类号： C07K14/705 , C07K14/47 , G01N33/574
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

40. 发明申请

US20060073547A1 Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
公开(公告)号：US20060073547A1
公开(公告)日：2006-04-06
申请号：US10226486
申请日：2002-08-22
申请人： Luc Desnoyers , Dan Eaton , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Timothy Stewart , Colin Watanabe , William Wood , Zemin Zhang
发明人： Luc Desnoyers , Dan Eaton , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Timothy Stewart , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： C07K14/47 , C07K16/18 , C07H21/04 , C12P21/06 , C12N9/00
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

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