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31. 发明授权

US08840877B2 Polysaccharide-protein conjugates reversibly coupled via imine bonds 有权
标题翻译：多糖 - 蛋白质结合物通过亚胺键可逆地偶联
公开(公告)号：US08840877B2
公开(公告)日：2014-09-23
申请号：US12999076
申请日：2009-06-26
申请人： Gord Adamson , David Bell , Steven Brookes
发明人： Gord Adamson , David Bell , Steven Brookes
IPC分类号： A61K38/17 , A61K38/18 , A61K38/19 , A61K38/22 , A61K38/36 , A61K38/38 , A61K38/43 , A61K38/55 , A61K39/395 , A61K47/48 , A61K38/44 , A61K38/57 , C07K16/28 , A61K38/16 , A61K38/50 , A61K38/28 , A61K38/21 , A61K38/37 , A61K49/00
CPC分类号： A61K47/4823 , A61K38/166 , A61K38/193 , A61K38/212 , A61K38/28 , A61K38/37 , A61K38/385 , A61K38/44 , A61K38/48 , A61K38/50 , A61K38/57 , A61K39/3955 , A61K47/60 , A61K47/61 , A61K49/0017 , C07K16/2896 , C12Y107/03003 , C12Y305/01001
摘要： Method for preparing an oxidized polysaccharide-protein composition, by (a) oxidizing a polysaccharide with an oxidizing agent to form an oxidized polysaccharide where less than 20% of the oxidized units are comprised of alpha-hydroxy aldehyde units, (b) reacting the oxidized polysaccharide with a protein to form a composition comprising an oxidized polysaccharide-protein conjugate, and (c) maintaining the oxidized polysaccharide-protein conjugate composition by placing it in an environment where the temperature is less than 8° C. The oxidized polysaccharide and the protein are conjugated via one or more imine bonds, the oxidized polysaccharide-protein composition is soluble in aqueous solvent, and the composition is capable of releasing the protein.
摘要翻译：通过（a）用氧化剂氧化多糖以形成氧化多糖的方法，其中少于20％的氧化单元由α-羟基醛单元组成，（b）使氧化的多糖 - 蛋白质组合物多糖与蛋白质形成包含氧化多糖 - 蛋白质缀合物的组合物，和（c）通过将氧化的多糖 - 蛋白质缀合物组合物置于温度低于8℃的环境中来维持氧化多糖 - 蛋白质结合物组合物。氧化多糖和蛋白质通过一个或多个亚胺键共轭，氧化的多糖 - 蛋白质组合物可溶于含水溶剂，组合物能释放蛋白质。

32. 发明申请

US20140068688A1 APPARATUS AND METHODS FOR CONTROLLING DIGITAL VIDEO RECORDERS 有权
标题翻译：用于控制数字视频记录器的装置和方法
公开(公告)号：US20140068688A1
公开(公告)日：2014-03-06
申请号：US13596969
申请日：2012-08-28
申请人： George Sarosi , Chris Cholas , David Bell , William L. Helms
发明人： George Sarosi , Chris Cholas , David Bell , William L. Helms
IPC分类号： H04N21/47
CPC分类号： H04N21/6543 , H04N5/76 , H04N5/765 , H04N21/262 , H04N21/4135 , H04N21/4147 , H04N21/431 , H04N21/43622 , H04N21/458 , H04N21/47 , H04N21/47214 , H04N21/6587
摘要： A DVR controller in network communication with a digital video recorder receives an instruction from a user directing the digital video recorder to perform a function among a set of available functions. The set of available functions comprises a record function operative to cause the digital video recorder to record content and store that content on the digital video recorder, and a playback function operative to cause the digital video recorder to play back content stored on the digital video recorder. Subsequently, at least in part in response to the instructions from the user, the DVR controller issues a command to the digital video recorder to perform the function. The digital video recorder is operative to present content on a presentation device controlled by the user. The DVR controller, in turn, is remotely disposed from the digital video recorder in a facility of a content provider.
摘要翻译：与数字视频记录器进行网络通信的DVR控制器接收来自用户的指令，指示数字录像机在一组可用功能中执行功能。该组可用功能包括一个记录功能，可操作以使数字录像机记录内容并将该内容存储在数字视频录像机上，以及播放功能，该播放功能可使数字录像机播放存储在数字录像机上的内容。随后，至少部分地响应于来自用户的指令，DVR控制器向数字录像机发出命令以执行该功能。数字视频记录器可操作以在由用户控制的呈现设备上呈现内容。 DVR控制器又在内容提供商的设施中从数字录像机远程处理。

33. 发明授权

US08627127B2 Power-preserving communications architecture with long-polling persistent cloud channel for wireless network-connected thermostat 有权
标题翻译：功率保持通信架构，具有长时间轮询持续云通道，用于无线网络连接的恒温器
公开(公告)号：US08627127B2
公开(公告)日：2014-01-07
申请号：US13530901
申请日：2012-06-22
申请人： Andrea Mucignat , Oliver Steele , Senthil Supramaniam , Osborne Hardison , Richard J. Schultz , Daniel A. Warren , Hugo Fiennes , Jonathan A. Dutra , David Bell , Anthony M. Fadell , Matthew L. Rodgers , Ian C. Smith , Grant M. Erickson , Edwin H. Satterthwaite , Joseph E. Palmer
发明人： Andrea Mucignat , Oliver Steele , Senthil Supramaniam , Osborne Hardison , Richard J. Schultz , Daniel A. Warren , Hugo Fiennes , Jonathan A. Dutra , David Bell , Anthony M. Fadell , Matthew L. Rodgers , Ian C. Smith , Grant M. Erickson , Edwin H. Satterthwaite , Joseph E. Palmer
IPC分类号： G06F1/26 , G06F1/32
CPC分类号： G05D23/193 , F24F11/56 , F24F11/63 , F24F2140/60 , G05B15/02 , G05D23/1905 , G06F1/3296 , H04L12/2809 , H04L12/283 , H04L61/2514 , H04L61/2553 , H04L67/125 , H04L2012/2841
摘要： Provided according to one or more embodiments herein are methods, systems and related architectures for facilitating network communications between a wireless network-connected thermostat and a cloud-based management server in a manner that promotes reduced power usage and extended service life of a rechargeable battery of the thermostat, while at the same time accomplishing timely data transfer between the thermostat and the cloud-based management server for suitable and time-appropriate control of an HVAC system. The thermostat further comprises powering circuitry configured to: extract electrical power from one or more HVAC control wires in a manner that does not require a “common” wire; supply electrical power for thermostat operation; recharge the rechargeable battery (if needed) using any surplus extracted power; and discharge the rechargeable battery to assist in supplying electrical power for thermostat operation during intervals in which the extracted power alone is insufficient for thermostat operation.
摘要翻译：根据这里的一个或多个实施例提供的方法，系统和相关架构，用于促进无线网络连接的恒温器和基于云的管理服务器之间的网络通信，其方式是促进可再充电电池的减少的电力使用和延长的使用寿命恒温器，同时完成恒温器和基于云的管理服务器之间的及时数据传输，以适当和时间适当地控制HVAC系统。恒温器还包括供电电路，其配置为：以不需要“公共”导线的方式从一个或多个HVAC控制线提取电力; 为恒温器供电供电; 使用任何剩余的提取电力对可充电电池（如果需要）充电; 并且在仅提取的电力不足以用于恒温器操作的间隔期间，对可再充电电池进行放电以辅助供应用于恒温器操作的电力。

34. 发明授权

US08592639B2 Injection and hemostasis site 失效
标题翻译：注射止血部位
公开(公告)号：US08592639B2
公开(公告)日：2013-11-26
申请号：US11521203
申请日：2006-09-14
申请人： David S. Utterberg , William J. Schnell , David Bell
发明人： David S. Utterberg , William J. Schnell , David Bell
IPC分类号： A61F13/00
CPC分类号： A61F13/0203 , A61F2013/00417 , A61F2013/00468
摘要： A pad of elastomeric material having a softness of typically no more than about durometer 50 Shore 00. The pad may carry adhesive and/or a housing for adhering the pad to a surface, either manually, or by adhesive tape, or another strap. Such a pad exhibits hemostatic and leak prevention properties against needle puncture holes in the skin or the wall of a hollow medical device. Particularly, hemostasis may be prevented with low pressure application of the pad to the skin. The pad may be previously applied to the skin of the patient or a wall of a medical device such as tubing or a solution bag, and the needle may then penetrate both the pad and the skin or medical device wall, to make a resealable puncture with leakage reduction and hemostasis when the needle is withdrawn.
摘要翻译：具有通常不超过约硬度50 Shore 00的柔软度的弹性体材料垫。该垫可以携带粘合剂和/或用于将垫粘合到表面上的手套或粘合带或另一条带的壳体。这样的垫片对于中空医疗装置的皮肤或壁的针刺孔具有止血和防漏性能。特别地，可以通过将该垫低压施加到皮肤来防止止血。垫可以预先施加到患者的皮肤或医疗装置（例如管或溶液袋）的壁上，并且针可以然后穿过垫和皮肤或医疗装置壁两者进行可再密封穿刺，拔针时泄漏减少和止血。

35. 发明申请

US20130221117A1 POWER MANAGEMENT IN SINGLE CIRCUIT HVAC SYSTEMS AND IN MULTIPLE CIRCUIT HVAC SYSTEMS 有权
标题翻译：单电路暖通空调系统和多电路暖通空调系统的电源管理
公开(公告)号：US20130221117A1
公开(公告)日：2013-08-29
申请号：US13835860
申请日：2013-03-15
申请人： Daniel Adam Warren , Hugo Fiennes , Jonathan Alan Dutra , David Bell , Anthony Michael Fadell , Matthew Lee Rogers , Ian C. Smith , Edwin H. Satterthwaite, JR. , Grant M. Erickson , Andrea Mucignat , Joseph E. Palmer
发明人： Daniel Adam Warren , Hugo Fiennes , Jonathan Alan Dutra , David Bell , Anthony Michael Fadell , Matthew Lee Rogers , Ian C. Smith , Edwin H. Satterthwaite, JR. , Grant M. Erickson , Andrea Mucignat , Joseph E. Palmer
IPC分类号： G05D23/19
CPC分类号： G05D23/19 , F24D19/1015 , F24D19/1039 , F24D19/1048 , F24F11/30 , F24F11/56 , F24F11/61 , F24F2110/10 , F24F2120/14 , G05B2219/2614 , G05D23/1902
摘要： A thermostat includes a plurality of HVAC (heating, ventilation, and air conditioning) wire connectors for receiving a plurality of HVAC control wires corresponding to an HVAC system. The thermostat also includes a thermostat processing and control circuit operative to at least partially control the operation of the HVAC system and a powering circuit coupled to the HVAC wire connectors and configured to provide an electrical load power to the thermostat processing and control circuit. The thermostat includes circuitry and methods for maximizing efficiency of energy harvested from the HVAC system connected to the thermostat, and depending on which system is connected to the thermostat, different power schemes can be implemented in order to obtain power from the HVAC system.
摘要翻译：恒温器包括用于接收对应于HVAC系统的多个HVAC控制线的多个HVAC（加热，通风和空调）线连接器。恒温器还包括恒温器处理和控制电路，其操作以至少部分地控制HVAC系统的操作，以及耦合到HVAC线连接器并被配置为向恒温器处理和控制电路提供电负载功率的供电电路。恒温器包括用于最大化从连接到恒温器的HVAC系统收集的能量的效率的电路和方法，并且取决于哪个系统连接到恒温器，可以实现不同的电力方案以从HVAC系统获得电力。

36. 发明申请

US20120248211A1 THERMOSTAT WITH SELF-CONFIGURING CONNECTIONS TO FACILITATE DO-IT-YOURSELF INSTALLATION 有权
公开(公告)号：US20120248211A1
公开(公告)日：2012-10-04
申请号：US13467029
申请日：2012-05-08
申请人： DANIEL ADAM WARREN , Hugo Fiennes , Jonathan Alan Dutra , David Bell , Anthony Michael Fadell , Matthew Lee Rogers
发明人： DANIEL ADAM WARREN , Hugo Fiennes , Jonathan Alan Dutra , David Bell , Anthony Michael Fadell , Matthew Lee Rogers
IPC分类号： G05D23/19
CPC分类号： G05D23/19 , F24D19/1087 , F24F11/30 , F24F11/56 , F24F11/61 , F24F2110/10 , F24F2120/14 , G05B2219/2614 , G05B2219/2642 , G05D23/1902 , H01R43/26 , Y02T10/88 , Y10T29/49174 , Y10T29/49826 , Y10T307/258 , Y10T307/297 , Y10T307/766 , Y10T307/826
摘要： A thermostat is configured for automated compatibility with HVAC systems that are either single-HVAC-transformer systems or dual-HVAC-transformer systems. The compatibility is automated in that a manual jumper installation is not required for adaptation to either single-HVAC-transformer systems or dual-HVAC-transformer systems. The thermostat has a plurality of HVAC wire connectors including a first call relay wire connector, a first power return wire connector, a second call relay wire connector, and a second power return wire connector. The thermostat is configured such that if the first and second external wires have been inserted into the first and second power return wire connectors, respectively, then the first and second power return wire connectors are electrically isolated from each other. Otherwise, the first and second power return wire connectors are electrically shorted together.

37. 发明申请

US20120130338A1 DIAPHRAGM PRESSURE POD FOR MEDICAL FLUIDS 有权
标题翻译：医用液体压片POD
公开(公告)号：US20120130338A1
公开(公告)日：2012-05-24
申请号：US13299868
申请日：2011-11-18
申请人： WILLIAM J. SCHNELL , David Bell , Karen Wilson , David S. Utterberg
发明人： WILLIAM J. SCHNELL , David Bell , Karen Wilson , David S. Utterberg
IPC分类号： A61M1/36
CPC分类号： A61M1/3641 , A61M1/16 , A61M1/3627 , A61M1/3639 , A61M1/3655 , A61M39/00 , F16L29/005 , Y10T137/85978
摘要： A tubular medical fluid flow set comprises a pressure sensing chamber connected in flow-through relation to fluid flow tubing of the set. The pressure sensing chamber defines a movable, flexible, impermeable diaphragm dividing the chamber into two separate compartments. The fluid flow tubing communicates with one of the compartments and is isolated from the other of the compartments. A port is carried on the chamber, the port having a seal therein, and communicating with the other of the compartments. Thus, the other of the compartments is hermetically sealed until the port is opened for connection with a pressure measuring device, to keep the flexible diaphragm in a desired, initial position prior to opening of the seal.
摘要翻译：管状医疗流体流动装置包括与组件的流体流管连通的压力感测室。压力传感室限定了一个可移动的，柔性的，不可渗透的隔膜，将隔室分隔成两个独立的隔间。流体流动管道与隔室中的一个连通，并且与隔室中的另一个隔离。端口被承载在腔室上，该端口在其中具有密封，并且与另一个隔间连通。因此，隔室中的另一个被气密地密封，直到端口打开以与压力测量装置连接，以便在打开密封件之前将柔性隔膜保持在期望的初始位置。

38. 发明授权

US08151567B2 Adaptive learning system and method of vane position for a variable geometry turbocharger 有权
标题翻译：可变几何涡轮增压器的自适应学习系统和叶片位置的方法
公开(公告)号：US08151567B2
公开(公告)日：2012-04-10
申请号：US11754465
申请日：2007-05-29
申请人： John Eric Rollinger , David Bell , Michael John Cullen , Brien Lloyd Fulton
发明人： John Eric Rollinger , David Bell , Michael John Cullen , Brien Lloyd Fulton
IPC分类号： F02D23/00 , F02B33/44
CPC分类号： F02D41/0007 , F02B37/24 , F02D41/0055 , F02D41/1448 , F02D41/2438 , F02D41/2441 , F02D41/2464 , F02D2200/0406 , Y02T10/144 , Y02T10/47
摘要： A method of operation for an engine system having a variable geometry turbocharger with a vane is disclosed. In one example, an EGR valve is closed while vane position is adjusted. The method can reduce vane positioning errors during engine operation.
摘要翻译：公开了一种具有带叶片的可变几何涡轮增压器的发动机系统的操作方法。在一个示例中，在调节叶片位置时关闭EGR阀。该方法可以减少发动机运行期间的叶片定位误差。

39. 发明申请

US20120060445A1 PREVENTION OF AGGLOMERATION OF PARTICLES DURING STERILIZATION PROCESSES 有权
标题翻译：防止灭菌过程中颗粒聚集
公开(公告)号：US20120060445A1
公开(公告)日：2012-03-15
申请号：US12879611
申请日：2010-09-10
申请人： Chris Graham , Thaddeus Pesce , David Bell , Michael Abaskhroun , Mukesh Kasargode , Tak Man Lee , Galo Cadena
发明人： Chris Graham , Thaddeus Pesce , David Bell , Michael Abaskhroun , Mukesh Kasargode , Tak Man Lee , Galo Cadena
IPC分类号： B65B55/02 , B65B55/00
CPC分类号： B67C3/045 , A23L2/02 , A23L2/46 , A23L3/001 , A23L3/04 , A23L3/06 , B65B55/06 , B65B55/14
摘要： A method and an apparatus for hot-fill or cold fill sterilization of a container containing both a liquid and solid inclusions. The method and apparatus each prevent the inclusions from agglomerating in any area of the container, such as the container closure, thus allowing the liquid to contact the interior surfaces of the container for a time sufficient to achieve sterilization of the entire container. The filled container is subjected to an inversion sequence typically including alternating between inverting the container to an angle of about 60 degrees from vertical and an angle of about 140 degrees from vertical, over a time period of at least 30 seconds. The apparatus includes a means for conveying containers, configured to subject the containers to a series of angles as the containers are conveyed, as well as an enclosure for preventing the containers from falling off of the conveying means.
摘要翻译：一种用于对容纳液体和固体夹杂物的容器进行热灌装或冷灌灭菌的方法和装置。所述方法和装置均可防止夹杂物在容器的任何区域诸如容器封闭物之间聚集，从而允许液体接触容器的内表面足以实现整个容器的灭菌。填充的容器经受反转序列，通常包括在至少30秒的时间段内将容器翻转至与垂直方向成大约60度的角度和大约140度的垂直角度的交替。该装置包括用于输送容器的装置，其被构造成在容器被输送时使容器处于一系列角度，以及用于防止容器从输送装置脱落的外壳。

40. 发明申请

US20110104114A1 Polysaccharide-Protein Conjugates Reversibly Coupled Via Imine Bonds 有权
标题翻译：多糖 - 蛋白质缀合物通过亚胺键可逆地结合
公开(公告)号：US20110104114A1
公开(公告)日：2011-05-05
申请号：US12999076
申请日：2009-06-26
申请人： Gord Adamson , David Bell , Steven Brookes
发明人： Gord Adamson , David Bell , Steven Brookes
IPC分类号： A61K38/17 , A61K38/19 , A61K38/21 , A61K39/44 , A61K38/44 , A61K38/45 , A61K38/50 , A61K38/28 , A61K38/37 , C07K14/555 , C07K17/10 , C07K17/12 , A61P7/00 , A61P35/00 , A61P3/10 , A61P1/04 , A61P15/00 , A61P37/02 , A61P31/00 , C12N9/96
CPC分类号： A61K47/4823 , A61K38/166 , A61K38/193 , A61K38/212 , A61K38/28 , A61K38/37 , A61K38/385 , A61K38/44 , A61K38/48 , A61K38/50 , A61K38/57 , A61K39/3955 , A61K47/60 , A61K47/61 , A61K49/0017 , C07K16/2896 , C12Y107/03003 , C12Y305/01001
摘要： A method of preparing an oxidised polysaccharide-protein conjugate by oxidising a polysaccharide with an oxidising agent to form an oxidised polysaccharide and combining such oxidized polysaccharide with a protein. The oxidised polysaccharide is reacted with a protein to form a composition comprising a conjugate wherein the oxidised polysaccharide and the protein are conjugated via one or more imine bonds and wherein the oxidised polysaccharide comprises essentially no alpha-hydroxy aldehyde units. The conjugate may be used to provide sustained or latent activity of the protein.
摘要翻译：一种通过用氧化剂氧化多糖以形成氧化的多糖并将这种氧化的多糖与蛋白质组合来制备氧化的多糖 - 蛋白质结合物的方法。氧化的多糖与蛋白质反应以形成包含缀合物的组合物，其中氧化的多糖和蛋白质通过一个或多个亚胺键共轭，并且其中氧化的多糖基本上不含α-羟基醛单元。缀合物可用于提供蛋白质的持续或潜在活性。

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