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    • 32. 发明申请
    • Shock Reduction Using Absolute Calibrated Tissue Oxygen Saturation and Total Hemoglobin Volume Fraction
    • 使用绝对校准的组织氧饱和度和总血红蛋白体积分数进行减震
    • US20100318149A1
    • 2010-12-16
    • US12797793
    • 2010-06-10
    • Jonathan L. KuhnCan CinbisDavid A. AndersonJames K. Carney
    • Jonathan L. KuhnCan CinbisDavid A. AndersonJames K. Carney
    • A61N1/365
    • A61N1/3622A61B5/02028A61B5/0215A61B5/042A61B5/1116A61B5/14542A61B5/1459A61N1/36557A61N1/3956
    • An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.
    • 一种可植入医疗装置,其包括:光学传感器,用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块,所述控制模块控制由所述光学传感器发射的光;监测模块,其接收光学传感器输出 信号和测量光衰减的组织电极,用于刺激血液灌注组织的体积的组织电极,耦合到组织电极的脉冲发生器,用于向血液灌注组织的体积输送电刺激;以及处理器,其耦合到心脏电极和监测 模块并且被配置为响应于去极化信号检测心律失常,计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激,并且检测血液动力学状态 响应于检测到的tis的速率中的至少一种的心律失常 检测氧合反应的下降和组织氧合恢复率。
    • 36. 发明申请
    • Adhesion system for rawhide & meat chew for dogs
    • 狗的生皮和肉咀嚼粘合系统
    • US20090004338A1
    • 2009-01-01
    • US12215082
    • 2008-06-25
    • David A. AndersonRichard L. Harpe
    • David A. AndersonRichard L. Harpe
    • A01K15/02
    • A01K15/026
    • A palatable and long lasting chew for dogs combines a rawhide fraction with meat, poultry or fish. The rawhide fraction is from rawhide splits die cut into desired shapes. The rawhide fraction is then dehydrated to approximately 6% moisture. The meat, poultry or fish fraction then attaches to the rawhide component. The meat fraction is held to the rawhide fraction utilizing a food grade adhesive from milk protein hydrolysate. The milk protein hydrolysate is solubilized in hot water to a solids level between 3% and 30%. The solution is then applied to the rawhide component where the meat fraction will contact the rawhide. The meat fraction is then deposited onto the coated rawhide surface and the chew is then dehydrated to laminate the meat fraction to the rawhide fraction. Alternatively, the food grade adhesive is blended with the meat fraction and deposited in the rawhide.
    • 狗的可口和持久的咀嚼将生皮部分与肉,家禽或鱼相结合。 生皮分数是从生皮分割成切割成所需的形状。 然后将生皮部分脱水至约6%的水分。 肉类,禽类或鱼类馏分然后附着在生皮成分上。 使用来自乳蛋白水解产物的食品级粘合剂将肉类部分保持在生皮部分。 将乳蛋白水解物溶于热水至3%至30%之间的固体含量。 然后将该溶液施加到生皮部分,其中肉分数将接触生皮。 然后将肉类部分沉积到涂覆的生皮表面上,然后将咀嚼物脱水以将肉类部分层压至生皮部分。 或者,将食品级粘合剂与肉类部分混合并沉积在生皮中。
    • 39. 发明授权
    • Method and apparatus for post-shock evaluation using tissue oxygenation measurements
    • 使用组织氧合测量进行休克后评估的方法和装置
    • US08918171B2
    • 2014-12-23
    • US12845843
    • 2010-07-29
    • Jonathan L. KuhnCan CinbisDavid A. AndersonWilliam J. Havel
    • Jonathan L. KuhnCan CinbisDavid A. AndersonWilliam J. Havel
    • A61N1/365A61N1/39A61B5/1455A61B5/00A61B5/1459
    • A61B5/14551A61B5/1459A61B5/6846A61B5/7285A61N1/36557A61N1/3925A61N1/3956
    • A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
    • 一种用于递送疗法的方法和装置,其包括用于感测心脏信号并递送治疗的电极,监测模块,响应于使用第一检测标准的所感测到的心脏信号检测心脏事件,发射光并检测由 与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;控制模块,耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射;以及控制器,耦合到所述监测模块,所述治疗递送模块 以及所述传感器,所述控制器被配置为响应于所述输出信号确定组织氧合测量,响应于组织氧合测量确定组织氧合趋势,响应于所确定的组织氧合趋势确定恢复指数,并且控制一个或两个 通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。
    • 40. 发明授权
    • Method and apparatus for post-shock evaluation using tissue oxygenation measurements
    • 使用组织氧合测量进行休克后评估的方法和装置
    • US08639332B2
    • 2014-01-28
    • US12845830
    • 2010-07-29
    • Jonathan L. KuhnCan CinbisDavid A. AndersonWilliam J. Havel
    • Jonathan L. KuhnCan CinbisDavid A. AndersonWilliam J. Havel
    • A61N1/365
    • A61B5/14551A61B5/1459A61B5/6846A61B5/7285A61N1/36557A61N1/3925A61N1/3956
    • A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
    • 一种用于递送治疗的方法和装置,其包括用于感测心脏信号并递送治疗的电极,治疗递送模块,其耦合到所述电极,以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近光学传感器的组织体积散射的光,以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块,以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器 模块和传感器,所述控制器被配置为响应于所述输出信号确定组织氧合测量,响应于所述组织氧合测量确定组织氧合趋势,并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能 趋势。