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31. 发明专利

AR122018A1 PROTEÍNAS QUE SE UNEN A NKG2D, CD16 Y CLEC12A 未知
公开(公告)号：AR122018A1
公开(公告)日：2022-08-03
申请号：ARP210101229
申请日：2021-05-05
申请人： DRAGONFLY THERAPEUTICS INC
发明人： BARUAH HEMANTA , CHANG GREGORY P , CHEUNG ANN F , FALLON DANIEL , GRINBERG ASYA , JUO ZONG SEAN , MORGAN CHRISTOPHER RYAN
IPC分类号： C07K16/28 , A61K39/395
摘要： Aquí se describen proteínas de unión multiespecíficas que se unen al receptor NKG2D, CD16 y CLEC12A, composiciones farmacéuticas que comprenden las proteínas de unión multiespecíficas, y métodos terapéuticos útiles para el tratamiento del cáncer.

32. 发明专利

AR120223A1 PROTEÍNAS QUE UNEN NKG2D, CD16 Y FLT3 未知
公开(公告)号：AR120223A1
公开(公告)日：2022-02-02
申请号：ARP200102840
申请日：2020-10-14
申请人： DRAGONFLY THERAPEUTICS INC
发明人： BARUAH HEMANTA , CHANG GREGORY P , CHEUNG ANN F , GRINBERG ASYA , JUO ZONG SEAN , MQUADE THOMAS J
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C07K16/30 , C07K16/46
摘要： Proteínas de unión multiespecíficas que se unen al receptor NKG2D, CD16 y FLT3, así como composiciones farmacéuticas y métodos terapéuticos útiles para el tratamiento de enfermedades autoinmunes o cáncer.

33. 发明专利

MA53284A PROTÉINES DE LIAISON À NKG2D, À CD16 ET À UN ANTIGÈNE ASSOCIÉ À UNE TUMEUR 未知
公开(公告)号：MA53284A
公开(公告)日：2022-01-26
申请号：MA53284
申请日：2019-08-08
申请人： DRAGONFLY THERAPEUTICS INC
发明人： CHANG GREGORY P , CHEUNG ANN F , DU JINYAN , FALLON DANIEL , GRINBERG ASYA , HANEY WILLIAM , LUNDE BRADLEY M , O'NEIL STEVEN , PRINZ BIANKA , WEI RONNIE
IPC分类号： A61K39/00 , C07K16/28

34. 发明专利

PE20211224A1 DOMINIOS VARIABLES DE ANTICUERPO QUE SE DIRIGEN A CD33 Y SUS USOS 未知
公开(公告)号：PE20211224A1
公开(公告)日：2021-07-06
申请号：PE2020001434
申请日：2019-02-20
申请人： DRAGONFLY THERAPEUTICS INC
发明人： CHANG GREGORY P , CHEUNG ANN F , GRINBERG ASYA , SETHI DHRUV KAM , HANEY WILLIAM , PRINZ BIANKA
IPC分类号： A61K35/17 , A61K39/395 , A61K48/00
摘要： Se describen proteinas con dominios variables de cadena ligera y cadena pesada que se pueden emparejar para formar un sitio de union a antigenos dirigido a CD33 (Siglec-3) en una celula, composiciones farmaceuticas que comprenden dichas proteinas y metodos terapeuticos que usan dichas proteinas y composiciones farmaceuticas, inclusive para el tratamiento del cancer

35. 发明专利

CL2020003071A1 Proteínas de unión multiespecíficas y mejoras con estas 未知
公开(公告)号：CL2020003071A1
公开(公告)日：2021-05-24
申请号：CL2020003071
申请日：2020-11-26
申请人： DRAGONFLY THERAPEUTICS INC
发明人： PRINZ BIANKA , CHANG GREGORY P , CHEUNG ANN F , GRINBERG ASYA , HANEY WILLIAM , LUNDE BRADLEY M , DU JINYAN , FALLON DANIEL , O'NEIL STEVEN , WEI RONNIE
IPC分类号： C07K14/705 , C07K16/28
摘要： En la invención se proporcionan mejoras en anticuerpos de fragmentos variables monocatenarios (scFv), proteínas de unión multiespecíficas, composiciones farmacéuticas que comprenden dichas proteínas y métodos terapéuticos que utilizan dichas proteínas y composiciones farmacéuticas, incluso para el tratamiento del cáncer.

36. 发明专利

SG11202100883SA MULTI-SPECIFIC BINDING PROTEINS THAT BIND BCMA, NKG2D AND CD16, AND METHODS OF USE 未知
公开(公告)号：SG11202100883SA
公开(公告)日：2021-02-25
申请号：SG11202100883S
申请日：2019-08-08
申请人： DRAGONFLY THERAPEUTICS INC
发明人： BIGELOW MITCHELL , CHANG GREGORY P , CHEUNG ANN F , GRINBERG ASYA , HANEY WILLIAM , WAGTMANN NICOLAI , LUNDE BRADLEY M , PRINZ BIANKA
IPC分类号： A61K39/395 , C07K16/28
摘要： Multi-specific binding proteins that bind to and kill human cancer cells are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of cancer. The cancer can be B-cell maturation antigen (BCMA)-expressing cancer. The multi-specific binding proteins provided herein exhibit high potency and maximum lysis of target cells compared to anti-BCMA monoclonal antibodies.

37. 发明专利

SG11202011763YA MULTI-SPECIFIC BINDING PROTEINS AND IMPROVEMENTS THEREON 未知
公开(公告)号：SG11202011763YA
公开(公告)日：2020-12-30
申请号：SG11202011763Y
申请日：2019-05-28
申请人： DRAGONFLY THERAPEUTICS INC
发明人： CHANG GREGORY , CHEUNG ANN , DU JINYAN , FALLON DANIEL , GRINBERG ASYA , HANEY WILLIAM , O'NEIL STEVEN , WEI RONNIE , LUNDE BRADLEY , PRINZ BIANKA
IPC分类号： C07K14/705 , C07K16/28
摘要： The invention provides improvements on single-chain variable fragment (scFv) antibodies, multi-specific binding proteins, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer.

38. 发明专利

SG11202007945UA MULTI-SPECIFIC BINDING PROTEINS THAT BIND CD33, NKG2D, AND CD16, AND METHODS OF USE 未知
公开(公告)号：SG11202007945UA
公开(公告)日：2020-09-29
申请号：SG11202007945U
申请日：2019-02-20
申请人： DRAGONFLY THERAPEUTICS INC
发明人： CHANG GREGORY , CHEUNG ANN , GRINBERG ASYA , SETHI DHRUV , HANEY WILLIAM , PRINZ BIANKA , LUNDE BRADLEY M
IPC分类号： C07K16/28 , C07K16/32
摘要： Multi-specific binding proteins that bind to and kill human cancer cells expressing CD33 (Siglec-3) are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of CD33 expressing cancer. The invention relates to multi-specific binding proteins that bind to human cancer cells expressing CD33, and exhibit high potency and maximum lysis of target cells compared to anti-CD33 monoclonal antibodies.

39. 发明专利

SG11201907299XA MULTI-SPECIFIC BINDING PROTEINS FOR ACTIVATION OF NATURAL KILLER CELLS AND THERAPEUTIC USES THEREOF TO TREAT CANCER 未知
公开(公告)号：SG11201907299XA
公开(公告)日：2019-09-27
申请号：SG11201907299X
申请日：2018-02-08
申请人： DRAGONFLY THERAPEUTICS INC
发明人： CHANG GREGORY , CHEUNG ANN , HANEY WILLIAM , GRINBERG ASYA
IPC分类号： A61K35/17 , A61K38/17 , C07K16/18 , C07K16/28 , C07K16/30 , C07K19/00
摘要： WO 18/ 148 445 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 August 2018 (16.08.2018) WIPO I PCT o °nolo DID IIH momommornom oimIE (10) International Publication Number WO 2018/148445 Al (51) International Patent Classification: A61K 35/17 (2015.01) C07K 16/28 (2006.01) A61K 38/17 (2006.01) CO7K 16/30 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) (21) International Application Number: PCT/US2018/017470 (22) International Filing Date: 08 February 2018 (08.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/456,535 08 February 2017 (08.02.2017) US (71) Applicant: ADIMAB, LLC [US/US]; 7 Lucent Drive, Lebanon, NH 03766 (US). (72) Inventors: CHANG, Gregory, P.; 143 Saunders Street, Medford, MA 02155 (US). CHEUNG, Ann, F.; 25 Morn- ingside Lane, Lincoln, MA 01773 (US). HANEY, William; 61 Lincoln Road, Wayland, MA 01778 (US). GRINBERG, Asya; 37 Follen Road, Lexington, MA 02421 (US). (74) Agent: ASHRAF, Shovon et al.; Goodwin Procter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: MULTI-SPECIFIC BINDING PROTEINS FOR ACTIVATION OF NATURAL KILLER CELLS AND THERAPEUTIC USES THEREOF TO TREAT CANCER FIG. 1 (57) : Multi-specific binding proteins that bind a tumor associated antigen, the NKG2D receptor, and CD 16 are described, as well as pharmaceu- tical compositions and therapeutic methods useful for the treatment of cancer.

40. 发明专利

CA3091424A1 MULTI-SPECIFIC BINDING PROTEINS THAT BIND CD33, NKG2D, AND CD16, AND METHODS OF USE 未知
公开(公告)号：CA3091424A1
公开(公告)日：2019-08-29
申请号：CA3091424
申请日：2019-02-20
申请人： DRAGONFLY THERAPEUTICS INC
发明人： CHANG GREGORY P , CHEUNG ANN F , GRINBERG ASYA , SETHI DHRUV KAM , HANEY WILLIAM , PRINZ BIANKA , LUNDE BRADLEY M
IPC分类号： C07K16/28 , C07K16/32
摘要： Multi-specific binding proteins that bind to and kill human cancer cells expressing CD33 (Siglec-3) are described, as well as pharmaceutical compositions and therapeutic methods useful for the treatment of CD33 expressing cancer. The invention relates to multi - specific binding proteins that bind to human cancer cells expressing CD33, and exhibit high potency and maximum lysis of target cells compared to anti-CD33 monoclonal antibodies.

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