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31. 发明授权

US4479094A Differential amplifier 失效
标题翻译：差分放大器
公开(公告)号：US4479094A
公开(公告)日：1984-10-23
申请号：US382278
申请日：1982-05-26
申请人： David J. Harris
发明人： David J. Harris
IPC分类号： H03F1/52 , H03F3/30 , H03F3/45
CPC分类号： H03F1/52 , H03F3/3093 , H03F3/45071
摘要： A differential amplifier having a pair of common base transistors with emitter electrodes adapted for coupling to an input signal and collector electrodes coupled to a voltage source through a pair of resistors. A pair of clamping diodes is connected, in opposing polarity, across the collector electrodes to limit the differential voltages produced at such collector electrodes. A bias circuit is provided between the voltage source and the common base electrodes of the transistors to provide a bias voltage at the common base electrodes which is as close to the voltage of the voltage supply without biasing either one of such pair of transistors into saturation. The bias circuit includes a first resistor connected between the voltage source and the common base electrodes and, in parallel with such first resistor, second resistor and serially connected diode. The emitter electrodes of the pair of transistors is connected to a current source matched to a current source coupled to the bias circuit so that the voltage drop produced across the bias circuit is equal to the voltage drop produced between the voltage source and the collector electrodes of the pair of transistors. With such arrangement, such differential amplifiers may be used in a cascade connected multi-gain stage of a comparator circuit with level shifting provided therein with Zener connected transistors following the cascaded gain stages thereby reducing the effect of process created variations in the Zener connected transistors and the pair of clamping diodes on such comparator circuit.
摘要翻译：一种差分放大器，具有一对公共基极晶体管，其具有适于耦合到输入信号的发射极电极和通过一对电阻器耦合到电压源的集电极电极。一对钳位二极管以相反极性的方式连接在集电极上，以限制在这种集电极处产生的差分电压。在电压源和晶体管的公共基极之间提供偏置电路，以在公共基极处提供偏置电压，该偏置电压接近于电压源的电压，而不会使这种晶体管中的任一个偏置为饱和。偏置电路包括连接在电压源和公共基极之间并与第一电阻器并联的第二电阻器和串联二极管的第一电阻器。一对晶体管的发射电极连接到与耦合到偏置电路的电流源匹配的电流源，使得跨越偏置电路的电压降等于电压源和集电极之间产生的电压降一对晶体管。通过这样的布置，这种差分放大器可以用于比较器电路的级联连接的多增益级，其中提供电平移位，其中级联增益级之后具有齐纳连接的晶体管，从而减少齐纳连接晶体管产生的工艺变化的影响，该比较电路上的一对钳位二极管。

32. 发明授权

US09945192B2 Hydraulic draw works 有权
公开(公告)号：US09945192B2
公开(公告)日：2018-04-17
申请号：US14705779
申请日：2015-05-06
申请人： Wiley T. Brice , David J. Harris , Graham A. Hamshaw
发明人： Wiley T. Brice , David J. Harris , Graham A. Hamshaw
IPC分类号： E21B19/086
CPC分类号： E21B19/086
摘要： A hydraulic draw-works comprises several hydraulic cylinders of mixed orientation, such that some hydraulic cylinders actuate upwards and some hydraulic cylinders actuate downwards. These cylinders are connected by a plurality of braces mounted along a guide rail, and the drill head is mounted on a carriage along the guide rail and actuated by the upwards-oriented cylinders. The use of mixed orientation cylinders allows the effective vertical stroke length required to raise and lower the drill head to be halved. In a preferred embodiment, through-rod porting of the downwards-oriented cylinders supplies hydraulic fluid to the remainder through a manifold, and digitally controlled directional valves allow precise control of the drill head.

33. 发明申请

US20160032666A1 Hydraulic Draw Works 有权
标题翻译：液压牵引工程
公开(公告)号：US20160032666A1
公开(公告)日：2016-02-04
申请号：US14705779
申请日：2015-05-06
申请人： Wiley T. Brice , David J. Harris , Graham A. Hamshaw
发明人： Wiley T. Brice , David J. Harris , Graham A. Hamshaw
IPC分类号： E21B19/02
CPC分类号： E21B19/086
摘要： A hydraulic draw-works comprises several hydraulic cylinders of mixed orientation, such that some hydraulic cylinders actuate upwards and some hydraulic cylinders actuate downwards. These cylinders are connected by a plurality of braces mounted along a guide rail, and the drill head is mounted on a carriage along the guide rail and actuated by the upwards-oriented cylinders. The use of mixed orientation cylinders allows the effective vertical stroke length required to raise and lower the drill head to be halved. In a preferred embodiment, through-rod porting of the downwards-oriented cylinders supplies hydraulic fluid to the remainder through a manifold, and digitally controlled directional valves allow precise control of the drill head.
摘要翻译：液压牵引装置包括多个混合取向的液压缸，使得一些液压缸向上致动并且一些液压缸向下致动。这些气缸通过沿着导轨安装的多个支架连接，并且钻头沿着导轨安装在滑架上并由向上定向的气缸致动。使用混合定向气缸允许将钻头抬高和降低所需的有效垂直行程长度减半。在优选的实施例中，向下定向的气缸的通过杆移动通过歧管将液压流体提供给其余流体，并且数字控制的换向阀允许钻头的精确控制。

34. 发明申请

US20110197724A1 Apparatus and Method for Cutting a Cathode Ray Tube 审中-公开
标题翻译：用于切割阴极射线管的设备和方法
公开(公告)号：US20110197724A1
公开(公告)日：2011-08-18
申请号：US11816975
申请日：2006-06-02
申请人： David J. Harris , Neil R. Seacroft
发明人： David J. Harris , Neil R. Seacroft
IPC分类号： B26D7/01 , B26D3/00 , B26D5/02 , B26D7/18
CPC分类号： B26D5/20 , B26D7/01 , B26D7/1863 , C03B33/06 , H01J9/52 , Y02W30/828 , Y10T83/04 , Y10T83/051 , Y10T83/207 , Y10T83/536 , Y10T83/541 , Y10T83/865
摘要： An apparatus 12 for cutting a cathode ray tube 10 comprises a support means 14 for supporting the screen 16 of the cathode ray tube 10, first and second sensors 18,20 (shown in FIGS. 3 and 4) for determining the external dimensions of the screen 16, first and second spaced diamond cutting means 22,24, and displacement means 26 for moving the support means 14 relative to the diamond cutting means 22,24.
摘要翻译：用于切割阴极射线管10的装置12包括用于支撑阴极射线管10的屏幕16的支撑装置14，用于确定阴极射线管10的外部尺寸的第一和第二传感器18,20（图3和图4所示）屏幕16，第一和第二间隔金刚石切割装置22,24以及用于使支撑装置14相对于金刚石切割装置22,24移动的移位装置26。

35. 发明授权

US5948925A Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids 失效
标题翻译：含有源自中性或带正电氨基酸的连接体的阳离子两亲物
公开(公告)号：US5948925A
公开(公告)日：1999-09-07
申请号：US851917
申请日：1997-05-06
申请人： Mikaela N. Keynes , Craig S. Siegel , Edward R. Lee , David J. Harris
发明人： Mikaela N. Keynes , Craig S. Siegel , Edward R. Lee , David J. Harris
IPC分类号： C07J41/00 , C07J9/00 , C07J33/00
CPC分类号： C07J41/0055
摘要： Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
摘要翻译：提供阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。

36. 发明授权

US5939401A Cationic amphiphile compositions for intracellular delivery of therapeutic molecules 失效
标题翻译：用于细胞内递送治疗分子的阳离子两亲物组合物
公开(公告)号：US5939401A
公开(公告)日：1999-08-17
申请号：US680354
申请日：1996-07-15
申请人： John Marshall , David J. Harris , Edward R. Lee , Craig S. Siegel , Simon J. Eastman , Chau-Dung Chang , Ronald K. Scheule , Seng H. Cheng
发明人： John Marshall , David J. Harris , Edward R. Lee , Craig S. Siegel , Simon J. Eastman , Chau-Dung Chang , Ronald K. Scheule , Seng H. Cheng
IPC分类号： A61K47/48 , A61K9/127 , A61K31/70 , A61K47/28 , A61K48/00 , C07J41/00 , C07J43/00 , C12N15/87 , C12N15/88 , A61K38/00 , C07J9/00
CPC分类号： A61K9/1272 , A61K47/48038 , A61K47/48046 , A61K47/48123 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J43/003 , C12N15/88 , A61K48/00
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphiles; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。通过本发明，这种阳离子两亲物以其能够接受另外的质子即不完全质子化的状态使用。为了本发明的目的，阳离子两亲物可以被认为包括四个一般类别：（A）T型/类固醇基两亲物; （B）T型/非类固醇基两亲物; （C）非T型/类固醇基两亲物和（D）非T型/非类固醇基两亲物。

37. 发明授权

US5912239A Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules 失效
标题翻译：含咪唑的阳离子两亲物用于细胞内递送治疗分子
公开(公告)号：US5912239A
公开(公告)日：1999-06-15
申请号：US833370
申请日：1997-04-04
申请人： Craig S. Siegel , Edward R. Lee , David J. Harris
发明人： Craig S. Siegel , Edward R. Lee , David J. Harris
IPC分类号： A61K9/127 , C07J43/00 , A61K31/575
CPC分类号： A61K9/1272 , C07J43/003
摘要： Cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile.
摘要翻译：提供阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。

38. 发明授权

US5767099A Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules 失效
标题翻译：含有氨基酸或衍生化氨基酸基团的阳离子两亲物用于治疗分子的细胞内递送
公开(公告)号：US5767099A
公开(公告)日：1998-06-16
申请号：US546086
申请日：1995-10-20
申请人： David J. Harris , Edward R. Lee , Craig S. Siegel , Eric A. Rowe , Shirley C. Hubbard
发明人： David J. Harris , Edward R. Lee , Craig S. Siegel , Eric A. Rowe , Shirley C. Hubbard
IPC分类号： A61K9/127 , A61K47/48 , A61K48/00 , C07J41/00 , C07J43/00 , C12N15/88 , A61K31/70 , A61K31/56 , B61F17/28 , A61K17/28
CPC分类号： A61K9/1272 , A61K47/48023 , A61K47/48038 , A61K47/48046 , A61K47/48123 , A61K48/00 , C07J41/0005 , C07J41/0055 , C07J41/0061 , C07J43/003 , C12N15/88 , Y10S516/07 , Y10S516/915
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles with the therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, and polypeptides. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells. With respect to therapeutic compositions for gene therapy, the DNA is provided typically in the form of a plasmid for complexing with the cationic amphiphile. Novel and highly effective plasmid constructs are also disclosed, including those that are particularly effective at providing gene therapy for clinical conditions complicated by inflammation. Additionally, targeting of organs for gene therapy by intravenous administration of therapeutic compositions is described.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性（治疗性）分子进入细胞。两亲物含有衍生自类固醇的单亲或二烷基胺或烷基或酰基的亲脂基团; 和在生理pH下可质子化的阳离子基团，衍生自胺，烷基胺或多烷基胺。还提供了通常通过使一种或多种阳离子两亲物的分散体与治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA和多肽。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。关于基因治疗的治疗组合物，通常以与阳离子两亲物络合的质粒的形式提供DNA。还公开了新型和高效的质粒构建体，包括在为炎症复杂的临床病症提供基因治疗方面特别有效的质粒构建体。另外，描述了通过静脉内施用治疗组合物靶向用于基因治疗的器官。

39. 发明授权

US5650096A Cationic amphiphiles for intracellular delivery of therapeutic molecules 失效
标题翻译：阳离子两亲物用于细胞内递送治疗分子
公开(公告)号：US5650096A
公开(公告)日：1997-07-22
申请号：US352479
申请日：1994-12-09
申请人： David J. Harris , Edward R. Lee , Craig S. Siegel , Seng H. Cheng , Simon J. Eastman , John Marshall
发明人： David J. Harris , Edward R. Lee , Craig S. Siegel , Seng H. Cheng , Simon J. Eastman , John Marshall
IPC分类号： A61K9/127 , A61K48/00 , C07J41/00 , C07J43/00 , B01F17/16
CPC分类号： C07J43/003 , A61K47/48038 , A61K47/48046 , A61K47/48123 , A61K48/00 , A61K9/1272 , C07J41/0005 , C07J41/0055 , C07J41/0061 , Y10S514/975
摘要： Novel cationic amphiphiles are provided that facilitate transport of biologically active molecules into cells. Typically, the amphiphiles contain lipophilic groups derived from steroids or from mono or dialkylamines, and two cationic groups, protonatable at physiological pH, derived from amines, alkylamines or polyalkylamines. There are provided also therapeutic compositions prepared typically by contacting a dispersion of one or more cationic amphiphiles, with or without colipids, and therapeutic molecules. Therapeutic molecules that can be delivered into cells according to the practice of the invention include DNA, RNA, polypeptides and low molecular weight organic compounds. Representative uses of the therapeutic compositions of the invention include providing gene therapy, and delivery of antisense polynucleotides or biologically active polypeptides to cells.
摘要翻译：提供了新的阳离子两亲物，其促进生物活性分子进入细胞。通常，两亲物含有衍生自类固醇或单或二烷基胺的亲脂基团，以及两种阳离子基团，其在生理pH下可质子化，衍生自胺，烷基胺或多烷基胺。还提供了通常通过使一种或多种阳离子两亲物的分散体与或不与咔啉和治疗分子接触而制备的治疗组合物。根据本发明的实践可以递送到细胞中的治疗分子包括DNA，RNA，多肽和低分子量有机化合物。本发明治疗组合物的代表性用途包括提供基因治疗以及向细胞递送反义多核苷酸或生物活性多肽。

40. 发明授权

US5040233A Data compression by discarding portions of data 失效
标题翻译：通过丢弃部分数据进行数据压缩
公开(公告)号：US5040233A
公开(公告)日：1991-08-13
申请号：US462206
申请日：1990-01-09
申请人： Rex W. Davy , David J. Harris
发明人： Rex W. Davy , David J. Harris
IPC分类号： B41J5/30 , G06F3/12 , G06F5/00 , G06T9/00 , H04N1/41 , H04N1/411
CPC分类号： H04N1/411 , G06T9/00 , H04N1/41
摘要： A method of modifying a digital representation of an image in which digital data defines the content of pixels of the image. The method comprisesa) determining whether a predetermined degree of compression can be achieved if data defining a block of pixels is compressed by applying a predetermined compression algorithm; and, if not,b) discarding a portion of the data in the block, andrepeating steps a and b on the most recently modified block until the predetermined degree of compression is achieved, and generating a compressed version of the image.

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