专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20100172919A1 NOVELTREATMENT FOR NEUROLOGICAL DISORDERS 审中-公开
标题翻译：神经病变的发展
公开(公告)号：US20100172919A1
公开(公告)日：2010-07-08
申请号：US12664540
申请日：2008-06-16
申请人： Jan Grimm , Roger Nitsch , Feng Chen
发明人： Jan Grimm , Roger Nitsch , Feng Chen
IPC分类号： A61K38/18 , C07K14/505 , A61K39/395 , A61P25/28 , G01N33/68
CPC分类号： A61K38/1816
摘要： Provided are novel drugs and methods in the treatment as well as diagnosis of neurological disorders such as Alzheimer's disease and amyloid-beta pathology/amyloidosis. More specifically, the use of erythropoietin and analogs thereof for the treatment of Aβ peptide related brain impairments is described. Furthermore, the use of claudin-5 and variants thereof as biomarker for Alzheimer's disease and for the progression of Alzheimer's disease, respectively, is provided.
摘要翻译：提供了治疗中的新型药物和方法以及诸如阿尔茨海默病和淀粉样蛋白β病理学/淀粉样变性之类的神经障碍的诊断。更具体地，促红细胞生成素及其类似物用于治疗A＆bgr; 描述了肽相关的脑损伤。此外，提供了分别使用claudin-5及其变体作为阿尔茨海默病的生物标志物和阿尔茨海默氏病的进展。

32. 发明申请

US20100048687A1 USE OF PHOSPHATASE INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：磷酸酯酶抑制剂用于治疗神经损伤性疾病的用途
公开(公告)号：US20100048687A1
公开(公告)日：2010-02-25
申请号：US12524011
申请日：2008-07-22
申请人： Roger Nitsch , Marlen Knobloch , Mélissa Farinelli , Isabelle Mansuy
发明人： Roger Nitsch , Marlen Knobloch , Mélissa Farinelli , Isabelle Mansuy
IPC分类号： A61K31/352 , C12Q1/68 , A61P25/00
CPC分类号： G01N33/6896 , A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/105 , A01K2267/0312 , A61K31/341 , C12N15/8509 , G01N2333/916 , G01N2800/2821
摘要： Provided are novel a target and drugs in the treatment of neurological disorders related to amyloid beta pathology/amyloidosis. More specifically, the use of phosphatase inhibitors for the treatment of brain impairments mediated by Aβ-oligomers is described.
摘要翻译：提供了一种靶向和药物治疗与淀粉样蛋白β病理学/淀粉样变性相关的神经障碍。更具体地说，描述了使用磷酸酶抑制剂来治疗由Aβ寡聚物介导的脑损伤。

33. 发明授权

US09370531B2 Method of providing patient specific immune response in amyloidoses and protein aggregation disorders 有权
标题翻译：在淀粉样变性和蛋白质聚集障碍中提供患者特异性免疫应答的方法
公开(公告)号：US09370531B2
公开(公告)日：2016-06-21
申请号：US12733437
申请日：2008-09-01
申请人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
发明人： Karsten Henco , Roger Nitsch , Jan Grimm , Anja Zeller , Marcel Maier
IPC分类号： A61K45/00 , A61K39/00 , C12N15/117 , A61K31/7088 , A61K39/39
CPC分类号： A61K39/0007 , A61K31/7088 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/575 , C12N15/117 , G01N33/6896 , G01N2333/4709 , Y02A50/41
摘要： A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are also described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.
摘要翻译：通过增强或维持针对主要针对存在于所述蛋白质或蛋白质复合物的致病形式的病理蛋白聚集体或新表位的抗体应答来提供治疗阿尔茨海默氏病和其它涉及蛋白质错误折叠或聚集的疾病。此外，还描述了将离体刺激的抗原选择的外周血淋巴细胞移植到同源供体中的治疗方法。

34. 发明申请

US20100330075A1 MONOCLONAL HUMAN TUMOR-SPECIFIC ANTIBODY 有权
标题翻译：单克隆人肿瘤特异性抗体
公开(公告)号：US20100330075A1
公开(公告)日：2010-12-30
申请号：US12530764
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Alfred Zippelius , Dirk Jaeger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Goebels
发明人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Alfred Zippelius , Dirk Jaeger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Goebels
IPC分类号： A61K39/395 , C12P21/04 , C12N9/96 , C12N5/10 , C12N15/63 , G01N33/53 , C07K14/705 , C07K7/06 , C07K7/08 , C07K5/10 , C07K5/08 , C07K16/30 , C07H21/04 , A61P35/00 , A61P35/02
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.
摘要翻译：提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。

35. 发明申请

US20090023145A1 Methods of diagnosing or prognosing Alzheimer's disease 审中-公开
标题翻译：诊断或预后阿尔茨海默病的方法
公开(公告)号：US20090023145A1
公开(公告)日：2009-01-22
申请号：US11979234
申请日：2007-10-31
申请人： Roger Nitsch , John Growdon
发明人： Roger Nitsch , John Growdon
IPC分类号： C12Q1/68
CPC分类号： G01N33/6896 , G01N2333/8139 , G01N2800/2821
摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.
摘要翻译：一种用于诊断或预测受试者中的阿尔茨海默病的方法，或确定受试者是否处于发展中的阿尔茨海默氏病的风险增加的方法，其包括：确定转录产物和/或其他疾病的水平或活性，或所述水平和所述活性（i）半胱氨酸蛋白酶抑制剂C基因或（ii）来自所述受试者的样品中半胱氨酸蛋白酶抑制剂C基因的多态性变体的翻译产物; 以及将所述转录产物和/或所述翻译产物的所述水平或所述活性，或所述水平和所述活性两者进行比较，以代表已知疾病或健康状况的参考值，由此诊断或预测所述受试者的阿尔茨海默氏病，或确定所述受试者是否处于发展为阿尔茨海默氏病的风险增加。

36. 发明申请

US20060142194A1 Methods and compounds for treating brain amyloidosis 审中-公开
标题翻译：治疗脑淀粉样变性的方法和化合物
公开(公告)号：US20060142194A1
公开(公告)日：2006-06-29
申请号：US11274493
申请日：2005-11-16
申请人： Roger Nitsch , Johannes Pohlner , Axel Wollmer , Hasan Mohajeri
发明人： Roger Nitsch , Johannes Pohlner , Axel Wollmer , Hasan Mohajeri
IPC分类号： A61K38/17
CPC分类号： A61K38/1709
摘要： The present invention discloses the use of (i) a fragment of the amyloid precursor protein (APP); or, (ii) a derivative of (i); or, (iii) a functional mimetic of (i) or (ii), in the preparation of a medicament for modulating CNS levels and/or activity of a member of the neprilysin family.
摘要翻译：本发明公开了（i）淀粉样蛋白前体蛋白片段（APP）的用途; 或（ii）（i）的衍生物; 或（iii）（i）或（ii）的功能模拟物在制备调节neprilysin家族成员的CNS水平和/或活性的药物中的用途。

37. 发明申请

US20050239169A1 Methods of diagnosing or treating neurological diseases and cell degeneration 审中-公开
标题翻译：诊断或治疗神经系统疾病和细胞变性的方法
公开(公告)号：US20050239169A1
公开(公告)日：2005-10-27
申请号：US10910772
申请日：2004-08-04
申请人： Roger Nitsch , Isabell Greeve
发明人： Roger Nitsch , Isabell Greeve
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P11/00 , A61P15/00 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/68 , C07H21/04 , C12N9/99 , C12P21/04
CPC分类号： C07K14/4711 , G01N33/6896
摘要： The invention discloses an isolated nucleic acid molecule encoding a protein molecule, the function of which is to protect cells against degeneration and/or cell death, wherein the amino acid sequence of the protein comprises the sequence shown in SEQ ID NO. 2 or a functional variant thereof.
摘要翻译：本发明公开了编码蛋白质分子的分离的核酸分子，其功能是保护细胞免于变性和/或细胞死亡，其中蛋白质的氨基酸序列包含SEQ ID NO： 2或其功能变体。

38. 发明授权

US08519106B2 Monoclonal human tumor-specific antibody 有权
标题翻译：单克隆人肿瘤特异性抗体
公开(公告)号：US08519106B2
公开(公告)日：2013-08-27
申请号：US12530764
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Künzle , Irene Abela , Alfred Zippelius , Dirk Jäger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Göbels
发明人： Christoph Esslinger , Sandra Künzle , Irene Abela , Alfred Zippelius , Dirk Jäger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Göbels
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.
摘要翻译：提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。

39. 发明申请

US20110182809A1 Method of Promoting Neurogenesis 审中-公开
标题翻译：促进神经发生的方法
公开(公告)号：US20110182809A1
公开(公告)日：2011-07-28
申请号：US13003245
申请日：2009-07-09
申请人： Roger Nitsch , Olle Lindvall , Barbara Biscaro , Christine Ekdahl
发明人： Roger Nitsch , Olle Lindvall , Barbara Biscaro , Christine Ekdahl
IPC分类号： A61K51/10 , A61K39/395 , A61P25/28 , A61P25/00 , A61P25/16
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74
摘要： The present description relates generally to methods of using Abeta binding molecules including, for example, antibodies and antibody fragments that recognize Abeta. The description provides methods of promoting neurogenesis, angiogenesis, synaptic activity and/or dendritic arborization using Abeta binding molecules. The description also provides methods of treating various diseases, disorder, injuries and conditions associated with amyloid plaques or the accumulation of Abeta.
摘要翻译：本说明书一般涉及使用Abeta结合分子的方法，包括例如识别Abeta的抗体和抗体片段。该描述提供了使用Abeta结合分子促进神经发生，血管生成，突触活性和/或树突状结构的方法。该描述还提供了治疗与淀粉样蛋白斑块相关的各种疾病，障碍，损伤和病症或Abeta的积累的方法。

40. 发明申请

US20110020220A1 HUMANIZED ANTIBODIES AGAINST THE BETA-AMYLOID PEPTIDE 失效
标题翻译：抗人Aβ抗体的抗体
公开(公告)号：US20110020220A1
公开(公告)日：2011-01-27
申请号：US12677732
申请日：2008-09-15
申请人： Stefan Ewert , Adrian Auf Der Maur , Susann Cattepoel , Roger Nitsch
发明人： Stefan Ewert , Adrian Auf Der Maur , Susann Cattepoel , Roger Nitsch
IPC分类号： A61K51/00 , A61K49/00 , A61K39/395 , A61K35/12 , C12N5/00 , C12N15/63 , A61K31/7088 , C07K16/18 , C07H21/04
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： The invention discloses an isolated antibody that selectively binds to the C-terminal part of Abeta and is humanized or fully human. The antibody of the invention is capable of preventing oligomerisation of Abeta. Furthermore, a method of diagnosis comprising the steps of: (i) Labelling an antibody; (ii) Administering an effective dose of said antibody intranasally or systemically to a subject; and (iii) Detecting the concentration and/or presence of the labelled antibody in body parts of the subject is disclosed.
摘要翻译：本发明公开了一种分离的抗体，其选择性地结合Abeta的C-末端部分并且是人源化的或完全人的。本发明的抗体能够防止Aβ的低聚。此外，诊断方法包括以下步骤：（i）标记抗体; （ii）向受试者鼻内或全身施用有效剂量的所述抗体; 并且（iii）公开了检测受试者体内部分标记的抗体的浓度和/或存在。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式