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31. 发明授权

US07399816B2 Maleimidyl-containing material and production method thereof 失效
标题翻译：含马来酰亚胺基的材料及其制备方法
公开(公告)号：US07399816B2
公开(公告)日：2008-07-15
申请号：US11129851
申请日：2005-05-16
申请人： Chisato Urano , Yoshihiro Inaba , Hiroshi Yamamoto , Takako Kobayashi
发明人： Chisato Urano , Yoshihiro Inaba , Hiroshi Yamamoto , Takako Kobayashi
IPC分类号： C08F26/02
CPC分类号： C07K1/1077
摘要： The invention provides a maleimidyl-containing material having a substituent group defined by the following structural formula (1) containing a maleimidyl group (maleimido group): wherein A denotes a spacer containing an amino acid or a peptide spacer P. Also, the invention provides a production method of the above-mentioned maleimidyl-containing material involving a step of reacting a material containing an amino acid or a peptide chain with a compound containing a maleimido group.
摘要翻译：本发明提供具有由以下结构式（1）定义的含有马来酰亚胺基（马来酰亚胺基）的取代基的含马来酰亚胺基的物质：其中A表示含有氨基酸或肽间隔物P的间隔物。另外，本发明提供上述含有马来酰亚胺基的材料的制备方法包括使含有氨基酸或肽链的材料与含有马来酰亚胺基的化合物反应的步骤。

32. 发明授权

US07317059B2 Ligand immobilization support 有权
标题翻译：配体固定支架
公开(公告)号：US07317059B2
公开(公告)日：2008-01-08
申请号：US11057159
申请日：2005-02-15
申请人： Yoshihiro Inaba , Hiroshi Yamamoto , Takako Kobayashi , Chisato Urano
发明人： Yoshihiro Inaba , Hiroshi Yamamoto , Takako Kobayashi , Chisato Urano
IPC分类号： C08F26/06
CPC分类号： C08F220/18 , B01J20/26 , B01J20/261 , B01J20/265 , B01J20/285 , C08F212/08 , C08F220/36 , C08F2220/285
摘要： A polymer comprising a styrene-based monomer and t-butyl methacrylate, wherein a proportion of the styrene-based monomer in the polymer is 30% by mol to 90% by mol and the polymer has a functional group represented by the following formula (1) which includes a maleimidyl group: wherein in the formula (1), X represents —O— or —NH— and Q represents a spacer group. A ligand immobilization support comprising the polymer.
摘要翻译：一种包含苯乙烯基单体和甲基丙烯酸叔丁酯的聚合物，其中所述聚合物中苯乙烯类单体的比例为30摩尔％至90摩尔％，并且所述聚合物具有由下式（1 ），其中包括马来酰亚胺基：其中在式（1）中，X表示-O-或-NH-，Q表示间隔基。包含聚合物的配体固定载体。

33. 发明申请

US20060205905A1 Production method of hydroxyl-containing polymer 有权
标题翻译：含羟基聚合物的制备方法
公开(公告)号：US20060205905A1
公开(公告)日：2006-09-14
申请号：US11194722
申请日：2005-08-01
申请人： Yoshihiro Inaba , Takako Kobayashi , Hiroshi Yamamoto , Chisato Urano
发明人： Yoshihiro Inaba , Takako Kobayashi , Hiroshi Yamamoto , Chisato Urano
IPC分类号： C08F118/02
CPC分类号： C08F220/26 , C08F8/00 , C08F220/00
摘要： The present invention provides a production method of a hydroxyl-containing polymer including: protecting a hydroxyl group of a hydroxyl-containing monomer with a protecting group to make the monomer a protected monomer with decreased hydrophilicity; adding the protected monomer alone or together with a hydrophobic monomer to a water-based medium containing a salt and a dispersion stabilizer; adding a polymerization initiator to the mixture to carry out suspension polymerization; and de-protecting the obtained polymer having the protecting group to recover the hydroxyl group.
摘要翻译：本发明提供含羟基聚合物的制备方法，包括：用保护基保护含羟基单体的羟基，使单体成为亲水性降低的被保护单体; 将保护的单体单独或与疏水单体一起加入到含有盐和分散稳定剂的水性介质中; 向混合物中加入聚合引发剂进行悬浮聚合; 并将所得到的具有保护基的聚合物去保护以回收羟基。

34. 发明授权

US07098272B2 Method for producing hydroxyl group-containing polymer particles 失效
标题翻译：制备含羟基聚合物颗粒的方法
公开(公告)号：US07098272B2
公开(公告)日：2006-08-29
申请号：US10784183
申请日：2004-02-24
申请人： Yoshihiro Inaba , Takako Kobayashi , Chisato Urano
发明人： Yoshihiro Inaba , Takako Kobayashi , Chisato Urano
IPC分类号： C08F8/32
CPC分类号： C08F8/00 , C08F2800/20 , C08F2220/1825
摘要： The present invention provides a method for producing hydroxyl group-containing polymer particles including causing cross-linked polymer particles containing a (meth)acrylate polymer to react in the presence of a metal-containing ester-exchange reaction catalyst with at least one compound selected from the group consisting of a compound including at least two hydroxyl groups and a compound including at least one primary amino group and at least one hydroxyl group, the cross-linked polymer particles comprising the (meth)acrylate polymer represented by the following formula (I): wherein R1 represents a hydrogen atom or a methyl group; R2 to R4 may be the same or different from each other, and each independently represents a substituted or non-substituted alkyl group or a substituted or non-substituted aryl group, any one of which has 1 to 12 carbon atoms; and n represents an integer of 1 or more.
摘要翻译：本发明提供一种含羟基聚合物颗粒的制造方法，其包括使含有（甲基）丙烯酸酯聚合物的交联聚合物颗粒在含金属的酯交换反应催化剂存在下与至少一种选自由包含至少两个羟基的化合物和包含至少一个伯氨基和至少一个羟基的化合物组成的组，所述交联聚合物颗粒包含由下式（I）表示的（甲基）丙烯酸酯聚合物，：其中R 1表示氢原子或甲基; R 2至R 4可以彼此相同或不同，并且各自独立地表示取代或未取代的烷基或取代或未取代的芳基，其中任何一个具有1至12个碳原子; n表示1以上的整数。

35. 发明授权

US07071265B2 Method of producing a non-crosslinked polymer particle 失效
标题翻译：制备非交联聚合物颗粒的方法
公开(公告)号：US07071265B2
公开(公告)日：2006-07-04
申请号：US10389916
申请日：2003-03-18
申请人： Chisato Urano , Yoshihiro Inaba , Masato Mikami , Takako Kobayashi
发明人： Chisato Urano , Yoshihiro Inaba , Masato Mikami , Takako Kobayashi
IPC分类号： C08F8/32 , C08F220/34
CPC分类号： C08F20/36
摘要： A method of producing a non-crosslinked polymer particle having in a side chain thereof a succinimidoxycarbonyl group represented by the following structural formula (1): the method comprising the step of using an initiator to polymerize a polymerizable monomer (A) containing a succinimidoxycarbonyl group represented by the above structural formula (1) and a polymerizable monomer (B) containing one polymerizable moiety in the monomer in a non-aqueous solvent in the presence of a macromolecular dispersion stabilizer. In this process the non-aqueous solvent is a solvent in which the polymerizable monomer (A) and the polymerizable monomer (B) are soluble and the non-crosslinked polymer particle is insoluble.
摘要翻译：一种在其侧链具有由下述结构式（1）表示的琥珀酰亚胺氧羰基的非交联聚合物颗粒的制备方法：包括使用引发剂使含有琥珀酰亚胺氧基羰基的可聚合单体（A）聚合的步骤的方法在上述结构式（1）表示的聚合性单体（B）和在高分子分散稳定剂的存在下，在非水溶剂中含有一个聚合性部分的聚合性单体（B）。在该方法中，非水溶剂是可聚合单体（A）和可聚合单体（B）可溶的溶剂，非交联聚合物颗粒是不溶的。

36. 发明申请

US20060051871A1 Method for determining the amount of the maleimidyl groups of a particle 失效
标题翻译：确定颗粒的马来酰亚胺基的量的方法
公开(公告)号：US20060051871A1
公开(公告)日：2006-03-09
申请号：US11052923
申请日：2005-02-09
申请人： Takako Kobayashi , Hiroshi Yamamoto , Chisato Urano , Yoshihiro Inaba
发明人： Takako Kobayashi , Hiroshi Yamamoto , Chisato Urano , Yoshihiro Inaba
IPC分类号： G01N33/44
CPC分类号： C08F8/34 , C08F8/30 , C08F2800/20 , C08F2810/20 , G01N15/1459 , G01N21/6428 , G01N21/77 , G01N33/442 , G01N2015/149 , G01N2021/7786 , Y10T436/17 , Y10T436/20 , C08F8/14 , C08F2220/1858
摘要： A method for quantitatively determining the amount of maleimidyl groups on a polymer fine particle containing at least maleimidyl groups, by allowing a fluorescent material having an SH group to react with the maleimidyl groups and determining the amount of maleimidyl groups by means of measuring the fluorescence of the fluorescent material.
摘要翻译：通过使具有SH基团的荧光体与马来酰亚胺基反应并通过测定马来酰亚胺基的量来测定马来酰亚胺基的量，定量测定含有至少马来酰亚胺基的聚合物微粒上的马来酰亚胺基的量的方法荧光材料。

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