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31. 发明申请

US20130066391A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于选择信号传递站点和其他参数用于治疗衰竭和其他神经疾病的技术及相关系统和方法
公开(公告)号：US20130066391A1
公开(公告)日：2013-03-14
申请号：US13606906
申请日：2012-09-07
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is selected based in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍的信号递送部位和其它信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法包括获得对应于患者大脑第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。部分基于第二成像信息选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

32. 发明授权

US08090446B2 Methods and systems for establishing neural stimulation parameters and providing neural stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法和系统
公开(公告)号：US08090446B2
公开(公告)日：2012-01-03
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

33. 发明申请

US20100036453A1 TECHNIQUES FOR SELECTING SIGNAL DELIVERY SITES AND OTHER PARAMETERS FOR TREATING DEPRESSION AND OTHER NEUROLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS AND METHODS 有权
标题翻译：用于选择信号传递站点的技术和用于治疗衰竭和其他神经疾病的其他参数以及相关系统和方法
公开(公告)号：US20100036453A1
公开(公告)日：2010-02-11
申请号：US12395257
申请日：2009-02-27
申请人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
发明人： Justin Hulvershorn , Bradford E. Gliner , Brian Kopell
IPC分类号： A61N1/36 , A61B5/055
CPC分类号： A61B5/055 , A61B5/4064 , A61B6/501 , A61N1/0531 , A61N1/36082 , A61N2/004
摘要： The present disclosure is directed generally to techniques for selecting signal delivery sites and other signal delivery parameters for treating depression and other neurological disorders, and associated systems and methods. A method in accordance with a particular embodiment includes obtaining first imaging information corresponding to a first region of a patient's brain, the first imaging information being based at least in part on functional characteristics of the first region. The method further includes obtaining second imaging information corresponding to a second region of the patient's brain, the second region being a subset of the first region, the second imaging information being based at least in part on functional or structural characteristics of the second region. A target neural population is then selected based at least in part on the second imaging information. The method still further includes applying an electromagnetic signal to the target neural population to improve a patient function.
摘要翻译：本公开一般涉及用于选择用于治疗抑郁症和其他神经障碍以及相关系统和方法的信号传递部位和其他信号传递参数的技术。根据特定实施例的方法包括获得对应于患者大脑的第一区域的第一成像信息，第一成像信息至少部分地基于第一区域的功能特征。该方法还包括获得对应于患者大脑的第二区域的第二成像信息，第二区域是第一区域的子集，第二成像信息至少部分地基于第二区域的功能或结构特征。然后至少部分地基于第二成像信息来选择目标神经群体。该方法还包括将电磁信号应用于目标神经群体以改善患者功能。

34. 发明申请

US20090099622A1 Methods and Systems for Establishing Neural Stimulation Parameters and Providing Neural Stimulation 有权
标题翻译：建立神经刺激参数并提供神经刺激的方法与系统
公开(公告)号：US20090099622A1
公开(公告)日：2009-04-16
申请号：US12099415
申请日：2008-04-08
申请人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
发明人： Brad Fowler , Justin Hulvershorn , Bradford E. Gliner , Leif R. Sloan
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36025
摘要： Methods for providing electrical stimulation therapy to a cortex of a patient via a plurality of electrodes proximate to the cortex and a pulse generator implanted in the patient. One embodiment of a method in accordance with the invention comprises determining whether the current applied via the plurality of electrodes results in a sufficient current density in the cortex. The current density, for example, may need to be high enough to induce a response in the patient for determining the activation threshold of the specific stimulation site, or the current density may need to be high enough to perform a specific therapy. If the current density is not sufficient, the method continues by selecting a subset of the plurality of electrodes, and applying electrical current to the cortex via the subset of the electrodes. For example, if the current density is not sufficient when the current is applied to the full plurality of electrodes at approximately the maximum output of the pulse generator, then the current level from the pulse generator can be applied to only a subset of the electrodes to effectively increase the current density in the cortex at the active electrodes.
摘要翻译：用于通过靠近皮层的多个电极和植入患者中的脉冲发生器向患者的皮层提供电刺激治疗的方法。根据本发明的方法的一个实施例包括确定经由多个电极施加的电流是否导致皮层中的足够的电流密度。例如，电流密度可能需要足够高以在患者中诱导用于确定特定刺激部位的激活阈值的响应，或者电流密度可能需要足够高以执行特定治疗。如果电流密度不足，则该方法通过选择多个电极的子集，并且经由电极的子集将电流施加到皮质来继续。例如，如果电流密度在脉冲发生器的大致最大输出处施加到整个多个电极上时电流密度不足，则来自脉冲发生器的电流电平可以仅施加到电极的子集有效增加有源电极皮质中的电流密度。

35. 发明授权

US06356785B1 External defibrillator with CPR prompts and ACLS prompts and methods of use 有权
标题翻译：外部除颤器与CPR提示和ACLS提示和使用方法
公开(公告)号：US06356785B1
公开(公告)日：2002-03-12
申请号：US09331998
申请日：1999-08-18
申请人： Cecily Anne Snyder , Bradford E. Gliner , David E. Snyder
发明人： Cecily Anne Snyder , Bradford E. Gliner , David E. Snyder
IPC分类号： A61N139
CPC分类号： A61N1/39
摘要： This invention relates generally to defibrillators and, in particular, to a defibrillator with a built in CPR (“CPR”) prompt system. The invention also relates generally to a defibrillator with a built-in Advanced Cardiac Life Support (“ACLS”) prompt system. Defibrillators include manual defibrillator, automatic or semiautomatic external defibrillators (“AEDs”) and defibrillator trainers. More specifically, this invention is directed to a defibrillator system capable of generating audible prompts and/or visual prompts through an audible prompt generator and a visual prompt generator, wherein the defibrillator instructs a rescuer on performing CPR or ACLS. The instructions are controlled through a prompt generator and may be audible prompts or visual images, or a combination of the two. The prompts may be emitted at a predetermined rate and may be synchronized. This invention is also directed to a method for administering care comprising, providing instructions to a rescuer. The instructions are either CPR instructions, ACLS instructions, or a combination of the two. Both the ACLS and CPR systems are capable of providing instructions for treating both adults and pediatric patients.
摘要翻译：本发明一般涉及除颤器，特别涉及具有内置CPR（“CPR”）提示系统的除颤器。本发明一般涉及具有内置的高级心脏生命支持（“ACLS”）提示系统的除颤器。除颤器包括手动除颤器，自动或半自动外部除颤器（“AED”）和除颤器训练器。更具体地，本发明涉及一种能够通过声音提示发生器和视觉提示发生器产生听觉提示和/或视觉提示的除颤器系统，其中除颤器指示救援者执行CPR或ACLS。指令通过提示生成器进行控制，并且可以是可听见的提示或视觉图像，或两者的组合。提示可以以预定速率发射并且可以被同步。本发明还涉及一种用于治疗护理的方法，包括向救援者提供指示。指令是CPR指令，ACLS指令或两者的组合。 ACLS和CPR系统都能够提供治疗成人和儿科患者的指导。

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