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31. 发明专利

DE602004006379D1 未知
公开(公告)号：DE602004006379D1
公开(公告)日：2007-06-21
申请号：DE602004006379
申请日：2004-01-27
申请人： CYCLACEL LTD
发明人： MCINNES CAMPBELL , MEADES CHRISTOPHER , MEZNA MOKDAD , FISCHER PETER
IPC分类号： A61K31/428 , A61P35/00 , C07D277/68
摘要： The present invention relates to the use of a compound of formula I, or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , and R 4 are each independently H, NO 2 , CF 3 , SCF 3 , CN, halo, OH, OR 6 , NH 2 , NHR 6 , NR 6 R 7 , N + R 6 R 7 R 8 , COOH, COOR 6 , CONH 2 , CONHR 6 , CONR 6 R 7 , COH, COR 6 , SR 6 , SOR 6 , SO 2 R 6 , SO 2 OH, SO 2 OR 6 , SO 2 NH 2 , SO 2 NHR 6 , SO 2 NR 6 R 7 , alkyl, cycloalkyl, cycloheteroalkyl, aryl, or heteroaryl, with the proviso that at least one of R 1 , R 2 , R 3 , and R 4 is other than H; or R 1 and R 2 , R 2 and R 3 , or R 3 and R 4 , may together form part of a fused or unfused saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; R 5 is OH, OR 9 , CN, CONH 2 , CONHNH 2 , CONHOH, CONHR 9 , CONR 9 R 10 , NH 2 , NHR 9 , or NR 9 R 10 ; each R 6 , R 7 and R 8 is independently hydrocarbyl, or two of R 6 , R 7 and R 8 together form part of a saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; each R 9 and R 10 is independently hydrocarbyl, or R 9 and R 10 together form part of a saturated or unsaturated ring system, optionally containing up to two heteroatoms selected from N, O, and S; in the preparation of a medicament for treating a proliferative disorder.

32. 发明专利

BRPI0412363A 未知
公开(公告)号：BRPI0412363A
公开(公告)日：2006-09-05
申请号：BRPI0412363
申请日：2004-07-07
申请人： CYCLACEL LTD
发明人： MCINNES CAMPBELL , THOMAS MARK , WANG SHUDONG , MCINTYRE NEIL , WESTWOOD NICHOLAS , FISCHER PETER
IPC分类号： A61K31/519 , A61P25/00 , C07D413/04 , C07D513/04

33. 发明专利

BR0316152A 未知
公开(公告)号：BR0316152A
公开(公告)日：2005-09-27
申请号：BR0316152
申请日：2003-11-14
申请人： CYCLACEL LTD
发明人： WANG SHUDONG , MEADES CHRISTOPHER , WOOD GAVIN , O'BOYLE JANICE , MCINNES CAMPBELL , FISCHER PETER
IPC分类号： A61K31/506 , A61K31/513 , A61P35/00 , C07D417/04

34. 发明专利

CA2502190A1 PYRIMIDINE COMPOUNDS 未知
公开(公告)号：CA2502190A1
公开(公告)日：2004-05-27
申请号：CA2502190
申请日：2003-11-14
申请人： CYCLACEL LTD
发明人： MEADES CHRISTOPHER , O'BOYLE JANICE , WOOD GAVIN , MCINNES CAMPBELL , FISCHER PETER , WANG SHUDONG
IPC分类号： A61K31/506 , A61K31/513 , A61P35/00 , C07D417/04
摘要： The present invention relates to substituted pyrimidines of formula (I), the ir preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders and/or viral disorders.

35. 发明专利

AU1717101A Peptides 未知
公开(公告)号：AU1717101A
公开(公告)日：2001-06-12
申请号：AU1717101
申请日：2000-11-29
申请人： CYCLACEL LTD
发明人： ZHELEVA DANIELLA I , FISCHER PETER M , MCINNES CAMPBELL , ANDREWS MARTIN J I , CHAN WENG C , ATKINSON GAIL E
IPC分类号： A61K38/00 , A61P35/00 , C07K14/47

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