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31. 发明专利

CA2556019A1 PROTEIN PHOSPHORYLATION IN C-SRC SIGNALING PATHWAYS 未知
公开(公告)号：CA2556019A1
公开(公告)日：2005-09-09
申请号：CA2556019
申请日：2004-08-12
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： RUSH JOHN , LEE KIMBERLY , POLAKIEWICZ ROBERTO , MORITZ ALBRECHT
IPC分类号： C12P21/06 , C12Q1/48 , C07K1/22 , C07K7/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , G01N33/68
摘要： The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/ Scaffold proteins, Actin Binding proteins, Cytoskeletal proteins, G protein/ GTPase Activating protein/Guanin e Nucleotide Exchange Factor proteins, Helicases, RNA Binding proteins, Transcription/Translation Factor or Initiation Complex proteins, Cellular Metabolism Enzymes, and Vesicle proteins.

32. 发明专利

AT419379T 未知
公开(公告)号：AT419379T
公开(公告)日：2009-01-15
申请号：AT04780956
申请日：2004-08-12
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： MORITZ ALBRECHT , LEE KIMBERLY , RUSH JOHN , POLAKIEWICZ ROBERTO
IPC分类号： C12P21/06 , C12Q1/48 , C07K1/22 , C07K7/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , G01N33/68
摘要： The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS 3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.

33. 发明专利

CA2601700A1 PROTEIN PHOSPHORYLATION IN EGFR-SIGNALING PATHWAYS 未知
公开(公告)号：CA2601700A1
公开(公告)日：2006-06-29
申请号：CA2601700
申请日：2004-12-21
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： MORITZ ALBRECHT , POLAKIEWICZ ROBERTO , LI YU , FARNSWORTH CHARLES , LEE KIMBERLY , RIKOVA KLARISA , GUO AILAN
IPC分类号： C12Q1/48 , C07K7/00 , C07K16/00 , G01N33/68

34. 发明专利

CA2556022A1 PROTEIN PHOSPHORYLATION IN T-CELL RECEPTOR SIGNALING PATHWAYS 未知
公开(公告)号：CA2556022A1
公开(公告)日：2005-09-09
申请号：CA2556022
申请日：2004-10-04
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： LEE KIMBERLY , MORITZ ALBRECHT , POLAKIEWICZ ROBERTO , RUSH JOHN
IPC分类号： C12P21/06 , G01N33/68 , C07K1/22 , C07K7/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , C12Q1/48
摘要： The invention discloses 95 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of the T-cell receptor, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagent s for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Adhesion proteins, Calcium-binding proteins, Cell Cycle Regulation or Channel proteins, Chaperones, Cofactor proteins, Cytoskeletal proteins, DNA Binding proteins, G protein or GTPase Activating proteins, Ligases, Lipid Kinases and Binding proteins, Oxidoreductases, Protein Kinases, Protein Phosphatases, Receptor proteins, RNA Binding proteins, Transcription Factor/Initiation Complex proteins, Transcription Coactivator/Corepressor proteins, Translation Initiation Complex proteins, Ubitquitin Conjugating System proteins, and Vesicle proteins.

35. 发明专利

AT417276T 未知
公开(公告)号：AT417276T
公开(公告)日：2008-12-15
申请号：AT04794025
申请日：2004-10-04
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： MORITZ ALBRECHT , LEE KIMBERLY , RUSH JOHN , POLAKIEWICZ ROBERTO
IPC分类号： C12P21/06 , G01N33/68 , C07K1/22 , C07K7/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , C12Q1/48
摘要： The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS 3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.

36. 发明专利

AT417273T 未知
公开(公告)号：AT417273T
公开(公告)日：2008-12-15
申请号：AT04777654
申请日：2004-07-07
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： MORITZ ALBRECHT , LEE KIMBERLY , RUSH JOHN , POLAKIEWICZ ROBERTO
IPC分类号： C12P21/06 , G01N33/574 , C07K1/22 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , C12Q1/48 , G01N33/68
摘要： The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS 3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.

37. 发明专利

ES2321197T3 FOSFORILACION DE PROTEINAS EN RUTAS DE SEÑALIZACION DE C-SRC. 未知
公开(公告)号：ES2321197T3
公开(公告)日：2009-06-03
申请号：ES04780956
申请日：2004-08-12
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： MORITZ ALBRECHT , LEE KIMBERLY , RUSH JOHN , POLAKIEWICZ ROBERTO
IPC分类号： C12P21/06 , C12Q1/48 , C07K1/22 , C07K7/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , G01N33/68
摘要： Un método para detectar o cuantificar una proteína de señalización que está fosforilada en tirosina en rutas de señalización de c-Src quinasa, comprendiendo dicho método la etapa de utilizar uno o más de los siguientes reactivos para detectar o cuantificar la proteína de señalización relacionada con c-Src para Rab 7 solamente cuando está fosforilada en la tirosina 183: (i) un anticuerpo específico de sitio de fosforilación aislado que se une específicamente a dicha proteína solamente cuando está fosforilada en la tirosina 183, comprendida dentro de la secuencia de sitio de fosforilación SEC ID Nº: 64, donde dicho anticuerpo no se une a dicha proteína cuando no está fosforilada en dicha tirosina; y/o (ii) un péptido marcado con isótopo pesado (péptido AQUA) para la cuantificación de dicha proteína, comprendiendo dicho péptido marcado la secuencia de sitio de fosforilación SEC ID Nº: 64, que comprende la tirosina fosforilada 183.

38. 发明专利

DE602004018836D1 未知
公开(公告)号：DE602004018836D1
公开(公告)日：2009-02-12
申请号：DE602004018836
申请日：2004-08-12
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： MORITZ ALBRECHT , LEE KIMBERLY , RUSH JOHN , POLAKIEWICZ ROBERTO
IPC分类号： C12P21/06 , C12Q1/48 , C07K1/22 , C07K7/00 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/44 , C12P21/08 , C12Q1/25 , G01N33/68
摘要： The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more different proteins; (b) contacting the preparation with at least one immobilized modification-specific antibody; and (c) isolating at least one modified peptide specifically bound by the immobilized modification-specific antibody in step (b). The method may further comprise the step of (d) characterizing the modified peptide isolated in step (c) by mass spectrometry (MS), tandem mass spectrometry (MS-MS), and/or MS 3 analysis, or the step of (e) utilizing a search program to substantially match the spectra obtained for the modified peptide during the characterization of step (d) with the spectra for a known peptide sequence, thereby identifying the parent protein(s) of the modified peptide. Also provided are an immunoaffinity isolation device comprising a modification-specific antibody, and antibodies against novel UFD1 and PTN6 phosphorylation sites.

39. 发明申请

WO2008009002A3 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN SIGNALING PATHWAYS 审中-公开
标题翻译：在信号通路中检测蛋白质磷酸化的试剂
公开(公告)号：WO2008009002A3
公开(公告)日：2008-12-24
申请号：PCT/US2007073540
申请日：2007-07-13
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： HORNBECK PETER , GOSS VALERIE , LEE KIMBERLY , GU TING-LEI , MORITZ ALBRECHT
IPC分类号： G01N33/53 , C07K5/00 , C07K16/00
CPC分类号： C12Q1/485 , C07K16/18 , C07K16/40 , C07K16/44 , G01N33/68 , G01N33/6842 , G01N33/6845 , G01N33/6848 , G01N33/6872
摘要： The Invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor/scaffold proteins, adhesion/extracellular matrix protein, apoptosis proteins, calcium binding proteins, cell cycle regulation proteins, chaperone proteins, chromatin, DNA binding/repair/replication proteins, cytoskeletal proteins, endoplasmic reticulum or golgi proteins, enzyme proteins, G/regulator proteins, inhibitor proteins, motor/contractile proteins, phosphatase, protease, Ser/ Thr protein kinases, Protein kinase (Tyr)s, receptor/channel/cell suface proteins, RNA binding proteins, transcriptional regulators, tumor suppressor proteins, ubiquitan conjugating system proteins and proteins of unknown function.
摘要翻译：本发明公开了在信号转导蛋白和途径中鉴定的新的磷酸化位点，并提供用于选择性检测和定量这些磷酸化位点/蛋白质的磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），以及使用用于此目的的试剂。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：衔接子/支架蛋白，粘附/细胞外基质蛋白，凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，伴侣蛋白，染色质，DNA结合/修复/复制蛋白，细胞骨架蛋白，内质网或高尔基体蛋白，酶蛋白，G /调节蛋白，抑制蛋白，运动/收缩蛋白，磷酸酶，蛋白酶，Ser / Thr蛋白激酶，蛋白激酶（Tyr），受体/通道/细胞表面蛋白， RNA结合蛋白，转录调节物，肿瘤抑制蛋白，泛素偶联系统蛋白和功能未知的蛋白。

40. 发明公开

EP1872134A4 REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN CARCINOMA SIGNALING PATHWAYS 审中-公开
标题翻译：癌症信号通路中检测蛋白磷酸化的试剂
公开(公告)号：EP1872134A4
公开(公告)日：2010-09-01
申请号：EP06739581
申请日：2006-03-24
申请人： CELL SIGNALING TECHNOLOGY INC
发明人： GUO AILAN , RIKOVA KLARISA , MORITZ ALBRECHT , LI YU , FARNSWORTH CHARLES , LEE KIMBERLY , POLAKIEWICZ ROBERTO
IPC分类号： G01N33/53 , C07K7/00 , C07K16/00 , C07K16/44
CPC分类号： G01N33/57496 , C07K14/4748 , C07K16/44

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