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31. 发明申请

US20080269842A1 Implantable medical device for treating neurological conditions with an initially disabled cardiac therapy port and leadless ECG sensing 有权
标题翻译：用于治疗神经病症的植入式医疗装置，其具有初始禁用的心脏治疗端口和无引导心电图感测
公开(公告)号：US20080269842A1
公开(公告)日：2008-10-30
申请号：US11796382
申请日：2007-04-27
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/36585 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译：可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。

32. 发明授权

US5778881A Method and apparatus for discriminating P and R waves 失效
标题翻译：用于辨别P波和R波的方法和装置
公开(公告)号：US5778881A
公开(公告)日：1998-07-14
申请号：US759494
申请日：1996-12-04
申请人： Weimin Sun , Eric J. Panken , William J. Combs
发明人： Weimin Sun , Eric J. Panken , William J. Combs
IPC分类号： A61B5/042 , A61B5/0464 , A61N5/0402
CPC分类号： A61B5/726 , A61B5/0422 , A61B5/0464 , A61B5/7203 , A61B5/7267 , A61B5/7225
摘要： This is a method and apparatus for the automated discrimination of cardiac events of interest, including P-waves, R-waves, T-waves, and specific arrhythmic sequences, in EGM signals for data storage in an implantable monitor or to control operations of an implantable cardiac stimulator through the use of Hidden Markov Modeling techniques and a reduced set of observations. The number of computations and computation time during a heart cycle is reduced by timing the frames of A-EGM samples to the detection of A-SENSE events by the atrial sense amplifier. The A-EGM sample frame is defined in a window preceding and following each A-SENSE event. The A-EGM sample frames are wavelet transformed, and a number of selected W.T. coefficients for each sample frame are saved in a buffer. Each set of saved W.T. coefficients therefore represents either a P-wave or an intrinsic or paced far field R-wave (including fusion beats) unless noise continuously causes A-SENSE events to occur. When the V-SENSE event occurs, an R-trigger is generated, and each set of saved W.T. coefficients is subjected to the HMM algorithm for a determination as to whether the preceding (and any concurrent) A-SENSE events from which the saved W.T. coefficients were derived are P-waves or R-waves. In addition, when the V-SENSE occurs, the HMM algorithm determines stochastically whether or not the successive sets of saved W.T. coefficients represent P-P sequences, far field R-R sequences or P-R sequences or the like.
摘要翻译：这是用于在可植入监视器中用于数据存储的EGM信号中自动辨别感兴趣的心脏事件（包括P波，R波，T波和特定心律失常序列）的方法和装置，或用于控制植入式心脏刺激器通过使用隐马尔可夫建模技术和一组减少的观察结果。通过将A-EGM样本的帧定位为由心房感觉放大器检测A-SENSE事件来减少心脏周期中的计算和计算时间的数量。 A-EGM采样帧在每个A-SENSE事件之前和之后的窗口中定义。 A-EGM采样帧被小波变换，并且每个采样帧的多个选定的W.T系数被保存在缓冲器中。因此，除非噪声连续地导致A-SENSE事件发生，所以每组保存的W.T.系数因此表示P波或固有或起搏的远场R波（包括融合节拍）。当V-SENSE事件发生时，产生R-触发，并且每一组保存的WT系数经受HMM算法以确定是否存在保存的WT的先前（和任何并发）A-SENSE事件导数系数是P波或R波。此外，当V-SENSE发生时，HMM算法随机确定保存的W.T.系数的连续组是否表示P-P序列，远场R-R序列或P-R序列等。

33. 发明授权

US08768446B2 Clustering with combined physiological signals 有权
标题翻译：组合生理信号
公开(公告)号：US08768446B2
公开(公告)日：2014-07-01
申请号：US11411712
申请日：2006-04-26
申请人： Touby A. Drew , Jonathan C. Werder , Jonathon E. Giftakis , Eric J. Panken
发明人： Touby A. Drew , Jonathan C. Werder , Jonathon E. Giftakis , Eric J. Panken
IPC分类号： A61B5/04
CPC分类号： A61B5/04 , A61B5/0006 , A61B5/0031 , A61B5/04001 , A61B5/04012 , A61B5/4094 , A61B5/7232 , A61N1/36135 , A61N1/36146 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , A61N1/3925 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63 , G16H50/70
摘要： Methods of generating an extended cluster are disclosed. A first cluster including data representative of a first signal indicative of an abnormal physiological symptom is generated. A second signal is detected as representing a second abnormal physiological symptom and the second abnormal physiological symptom continues after the first abnormal physiological symptom ends. An extended cluster including the data from the first signal and the second signal is generated that extends from the time when the first abnormal physiological symptom occurs to the time when the second abnormal physiological symptom ends. The first and the extended cluster may include data of both the first and second signals the entire period of the clusters. If desired, the first signal or the second signal may be provided from a sensor implanted in a patient's brain tissue.
摘要翻译：公开了生成扩展簇的方法。产生包括表示表示异常生理症状的第一信号的数据的第一群集。检测到第二信号表示第二异常生理症状，第二异常生理症状在第一异常生理症状终止后继续。产生包括来自第一信号和第二信号的数据的扩展簇，其从第一异常生理症状发生时到第二异常生理症状结束时延伸。第一和扩展簇可以包括簇的整个周期的第一和第二信号的数据。如果需要，可以从植入患者脑组织的传感器提供第一信号或第二信号。

34. 发明授权

US08554325B2 Therapy control based on a patient movement state 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US08554325B2
公开(公告)日：2013-10-08
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/18
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

35. 发明授权

US08527039B2 Method and apparatus for detection of nervous system disorders 有权
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US08527039B2
公开(公告)日：2013-09-03
申请号：US13176890
申请日：2011-07-06
申请人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61B5/0476
CPC分类号： A61B5/02405 , A61B5/0456 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , A61N2/006 , G06F19/00 , G06K9/00543
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Further embodiments of the invention include preparing for the delivery of therapy by warming up therapy delivery components prior to the expected delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。本发明的其它实施方案包括通过在预期的治疗递送之前预热治疗递送成分来准备递送治疗。

36. 发明授权

US08214035B2 System and method for utilizing brain state information to modulate cardiac therapy 有权
公开(公告)号：US08214035B2
公开(公告)日：2012-07-03
申请号：US11796575
申请日：2007-04-27
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/00 , A61B5/00
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/0476 , A61B5/4094 , A61N1/365 , A61N1/37288
摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.

37. 发明申请

US20120116179A1 TECHNIQUES FOR DATA RETENTION UPON DETECTION OF AN EVENT IN AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：在可移植医疗设备中检测事件的数据保留技术
公开(公告)号：US20120116179A1
公开(公告)日：2012-05-10
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/00 , G06F12/02
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录，其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。

38. 发明申请

US20120108998A1 THERAPY CONTROL BASED ON A PATIENT MOVEMENT STATE 有权
标题翻译：基于患者运动状态的治疗控制
公开(公告)号：US20120108998A1
公开(公告)日：2012-05-03
申请号：US13345397
申请日：2012-01-06
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61B5/0476 , A61N1/36 , A61B5/048 , A61B5/0482
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译：基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。

39. 发明申请

US20110172567A1 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 有权
标题翻译：医疗器械的状态分类
公开(公告)号：US20110172567A1
公开(公告)日：2011-07-14
申请号：US12769484
申请日：2010-04-28
申请人： Eric J. Panken , Amanda Gaudreau
发明人： Eric J. Panken , Amanda Gaudreau
IPC分类号： A61B5/103 , G06F19/00
CPC分类号： A61B5/4839 , A61B5/021 , A61B5/024 , A61B5/0476 , A61B5/0488 , A61B5/1116 , A61B5/1118 , A61B5/14532 , A61B5/686 , A61B5/7264 , A61B5/7282 , A61B5/742 , A61B5/7475 , A61B2560/0223 , A61B2560/0475 , A61N1/36071 , A61N1/36535 , A61N1/37247 , G06F19/00 , G06F19/324 , G16H50/20
摘要： Techniques relate to operating a medical device in response to a detected posture state of a patient. A trigger event such as a request to modify how therapy is being delivered to the patient may cause a determination to be made as to whether the patient's posture state is stable. If the posture state is stable, an association is created between the posture state and one or more therapy parameter values. Over time, a library of such associations is created that may reflect any posture state in three dimensional space, wherein a posture state comprises at least one of a posture and an activity component. The library of associations may be used to automatically control therapy delivery. Similar ones of the associations may automatically be grouped into posture state regions to facilitate more efficient classification of the patient's posture state to control therapy delivery.
摘要翻译：技术涉及响应于患者的检测到的姿势状态来操作医疗装置。诸如要求修改治疗如何递送给患者的触发事件可能导致确定患者的姿势状态是否稳定。如果姿势状态稳定，则在姿势状态和一个或多个治疗参数值之间产生关联。随着时间的推移，创建了可以反映三维空间中的任何姿势状态的这种关联的库，其中姿势状态包括姿势和活动组件中的至少一个。协会图书馆可用于自动控制治疗传递。相似的关联可以自动地被分组到姿势状态区域中，以便于更有效地分类患者的姿态以控制治疗递送。

40. 发明申请

US20100292753A1 Method and Apparatus for Detection of Nervous System Disorders 审中-公开
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US20100292753A1
公开(公告)日：2010-11-18
申请号：US12816055
申请日：2010-06-15
申请人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L. Carlson , Eric J. Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61N1/36
CPC分类号： A61B5/0478 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , G16H20/30 , G16H40/63 , G16H40/67 , G16H50/20
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

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