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    • 31. 发明申请
    • Photoacoustic Assay Method and Apparatus
    • 光声测定方法和装置
    • US20080194929A1
    • 2008-08-14
    • US10551543
    • 2004-03-29
    • Benny PesachGabriel BittonMichal Balberg
    • Benny PesachGabriel BittonMichal Balberg
    • A61B5/1455A61B8/00
    • A61B5/0066A61B5/0059A61B5/0095A61B5/14532A61B5/1455G01N21/1702G01N2021/1706
    • Apparatus (20, 100) for assaying a target analyte in a localized tissue region (22) that may include the target and other analytes comprising: a light source (34, 104) that illuminates the region with light at each of a plurality of wavelengths at which light is absorbed and/or scattered by tissue in the region wherein light at a least one of the wavelengths is absorbed or scattered by the target analyte; a signal generator (40) that generates signals responsive to intensity of the light from the light source (34, 104) at different locations in the localized region (22); and a controller (32, 102) that: receives the generated signals; processes the signals to determine an extinction coefficient for light in the localized region at each wavelength; and determines the concentration of the target analyte responsive to a solution of a set of simultaneous equations having as unknown variables concentrations of a plurality of analytes in the region (22), one of which is the target analyte, wherein each equation in the set expresses a relationship between the extinction coefficient, the absorption coefficient and/or the reduced scattering coefficient for light at a different one of the plurality of wavelengths and at least one of the equations expresses a relationship between the extinction coefficient and the reduced scattering coefficient.
    • 用于测定局部组织区域(22)中可能包括目标物和其它分析物的靶分析物的装置(20,100),包括:光源(34,104),其以多个波长中的每一个的光照射该区域 在该区域中的组织被光吸收和/或散射,其中至少一个波长的光被靶分析物吸收或散射; 信号发生器(40),其在所述局部区域(22)中的不同位置处产生响应于来自所述光源(34,104)的光的强度的信号; 以及控制器(32,102),其接收所生成的信号; 处理信号以确定每个波长处的局部区域中的光的消光系数; 并且确定目标分析物的浓度,其响应于在区域(22)中具有多个分析物浓度的未知变量的一组联立方程(其中一个是目标分析物)的溶液的溶液,其中集合中的每个方程表示 在多个波长中的不同一个波长处的光的消光系数,吸收系数和/或减小的散射系数之间的关系以及至少一个等式表示消光系数和降低的散射系数之间的关系。
    • 39. 发明申请
    • Wearable glucometer
    • 可戴式血糖仪
    • US20070085995A1
    • 2007-04-19
    • US10564127
    • 2004-07-09
    • Benny PesachGabriel BittonRon Nagar
    • Benny PesachGabriel BittonRon Nagar
    • G01N33/48
    • A61B5/14532A61B5/0053A61B5/1455A61B5/489A61B2562/0233A61B2562/0242A61B2562/046G01N33/66
    • Apparatus for assaying an analyte in blood in a blood vessel below a patient's skin comprising: at least one light source controllable to transmit light into tissue below the skin through at least one first region on the skin; at least one light detector that receives a portion of the transmitted light that reaches at least one second region on the skin after propagating through the blood vessel and generates signals responsive to the received light; and a controller; wherein the controller controls the at least one light source to transmit light at least one wavelength that interacts with blood and at least one wavelength that interacts with the analyte and uses the signals responsive to the light that interacts with the blood to determine a location for the blood vessel and the determined location and signals responsive to the light to assay the analyte.
    • 用于测定患者皮肤下面的血管中的分析物中的分析物的装置,包括:至少一个光源,其可通过皮肤上的至少一个第一区域将光透射到皮肤下方的组织; 至少一个光检测器,其在传播通过血管之后接收到达皮肤上的至少一个第二区域的透射光的一部分并响应于所接收的光产生信号; 和控制器; 其中所述控制器控制所述至少一个光源以发射与血液相互作用的至少一个波长的光和与分析物相互作用的至少一个波长,并使用响应于与血液相互作用的光的信号来确定 血管和确定的位置和响应于光的信号以测定分析物。