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31. 发明专利

SK86693A3 NEW ISOBUTYLSUBSTITUTED AMIDS METANSULFONYL-QUINOLYLMETO- XYPHENYLCYCLOALKYLACETIC ACID 未知
公开(公告)号：SK86693A3
公开(公告)日：1994-09-07
申请号：SK86693
申请日：1993-08-10
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , MULLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61K31/47 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14
摘要： Isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides of the formula in which R stands for cyclohexyl in the form of the racemate and of the enantiomers and also the enantiomers when R stands for cyclopentyl or cycloheptyl and their salts. The isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides can be prepared by reaction of the corresponding racemic or enantiomeric acids with methanesulphonamide, it being possible to separate the racemic final products into the enantiomers by customary methods. The N-methanesulphonyl-2-[3-isobutyl-3-(quinolin-2-yl-methoxy)phenyl]-2-ay eloalkylacetamides can be employed as active compounds in pharmaceuticals. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

32. 发明专利

HUT65445A PROCESS FOR PREPARATION OF THIAZOLYL-SUBSTITUTED QUINOLINYL-METHOXY-PHENYL ACETIC ACID DERIVATIVES AND PHARMACEUTICALS CONTAINING THEM 未知
公开(公告)号：HUT65445A
公开(公告)日：1994-06-28
申请号：HU9203812
申请日：1992-12-02
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , MUELLER-PEDDINGHAUS REINER , MOHRS KLAUS-HELMUT , HATZELMANN ARMIN , MATZKE MICHAEL
IPC分类号： A61K31/47 , A61P43/00 , C07D215/14 , C07D417/12 , C07D521/00
摘要： Thiazolyl-substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of halogenoacetoacetic acid esters with quinolylmethoxyphenylacetic acid thioamides, which are obtainable from corresponding amides with Lawesson's reagent. The substances can be employed in medicaments as inhibitors of enzymatic reactions in the context of arachidonic acid metabolism.

33. 发明专利

PL300026A1 2-SUBSTITUTED DERIVATIVES OF QUINOLINOMETHOXY-PHENYLOACETIC ACID 未知
公开(公告)号：PL300026A1
公开(公告)日：1994-03-21
申请号：PL30002693
申请日：1993-08-10
申请人： BAYER AG
发明人： MATZKE MICHAEL , MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , FRUCHTMANN ROMANIS , MULLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61P7/02 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/04
摘要： 2-Substituted quinolylmethoxyphenylacetic acid derivatives of the general formula (I) in which A, B, D, E, G and L are identical or different and stand for hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or for straight-chain or branched alkyl or alkoxy in each case having up to 8 carbon atoms, or for aryl having 6 to 10 carbon atoms, which is optionally substituted by halogen, hydroxyl, nitro or cyano, R stands for halogen, cyano, nitro, azido, hydroxyl, carboxyl, trifluoromethyl, trifluoromethoxy or trifluoromethylthio, or for straight-chain or branched alkenyl or alkynyl in each case having up to 8 carbon atoms, each of which is optionally substituted by phenyl or cycloalkyl having 3 to 8 carbon atoms, or for cycloalkyl having 3 to 8 carbon atoms or phenyl, or for straight-chain or branched alkoxy or alkoxycarbonyl in each case having up to 6 carbon atoms, R stands for hydrogen or for straight-chain or branched alkyl having up to 6 carbon atoms, or for cycloalkyl having 3 to 12 carbon atoms, R stands for hydroxyl, for straight-chain or branched alkoxy having up to 8 carbon atoms or phenyl, or for a group of the formula -NR SO2R or -NR R , in which R , R and R are identical or different and denote hydrogen, straight-chain or branched alkyl having up to 6 carbon atoms, phenyl or benzyl, R denotes trifluoromethyl or phenyl which is optionally substituted by halogen, cyano, hydroxyl, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms, or denotes straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl which, for its part, can be substitued by halogen, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, hydroxyl or by straight-chain or branched alkyl or alkoxy in each case having up to 6 carbon atoms and their salts. 2-Substituted quinolylmethoxyphenylacetic acid derivatives are prepared by reaction of appropriately substituted phenols with quinolylmethyl halides or by reaction of unsubstituted phenols with quinolylmethyl halides and subsequent alkylation. The 2-substituted quinolylmethoxyphenylacetic acid derivatives can be employed as active compounds in medicaments. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

34. 发明专利

PL300025A1 NOVEL ISOBUTYL SUBSTITUTED QUINOLINOMETHOXYPHENYL-CYCLOALKYOACETIC METHANOSULFONYL AMIDES 未知
公开(公告)号：PL300025A1
公开(公告)日：1994-03-21
申请号：PL30002593
申请日：1993-08-10
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , MULLER-PEDDINGHAUS REINER , HATZELMANN ARMIN
IPC分类号： A61K31/47 , A61P1/16 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/04
摘要： Isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides of the formula in which R stands for cyclohexyl in the form of the racemate and of the enantiomers and also the enantiomers when R stands for cyclopentyl or cycloheptyl and their salts. The isobutyl-substituted methanesulphonylquinolylmethoxyphenylcycloalkylacetamides can be prepared by reaction of the corresponding racemic or enantiomeric acids with methanesulphonamide, it being possible to separate the racemic final products into the enantiomers by customary methods. The N-methanesulphonyl-2-[3-isobutyl-3-(quinolin-2-yl-methoxy)phenyl]-2-ay eloalkylacetamides can be employed as active compounds in pharmaceuticals. The substances can act as inhibitors of enzymatic reactions in arachidonic acid metabolism, in particular of lipoxygenase.

35. 发明专利

NO932031A 未知
公开(公告)号：NO932031A
公开(公告)日：1993-12-20
申请号：NO932031
申请日：1993-06-03
申请人： BAYER AG
发明人： MOHRS KLAS HELMUT , RADDATZ SIEGFRIED , MATZKE MICHAEL , FUGMANN BUCKHARD , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MUELLER PEDDINGHAUS REINER
IPC分类号： A61K31/425 , A61K31/428 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D241/42 , C07D241/44 , C07D277/42 , C07D277/64
CPC分类号： C07D241/42 , C07D277/64

36. 发明专利

FI932743A 未知
公开(公告)号：FI932743A
公开(公告)日：1993-12-18
申请号：FI932743
申请日：1993-06-15
申请人： BAYER AG
发明人： MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , MATZKE MICHAEL , FUGMANN BURKHARD , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MUELLER-PEDDINGHAUS REINER
IPC分类号： A61K31/425 , A61K31/428 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D241/42 , C07D241/44 , C07D277/42 , C07D277/64
摘要： Substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives are prepared either by reaction of heterocyclylmethyl-halogen compounds with corresponding phenoxy compounds, either directly or with subsequent alkylation, or by reaction of the heterocyclylmethyl-halogen compound with phenoxy compounds and subsequent reaction with suitable Grignard compounds. The substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives can be employed as active compounds in medicaments.

37. 发明专利

HU9301754D0 SUBSTITUTED BENZOTHIAZOLYL-PHENYL ACETIC ACID DERIVATIVES AND QUINOOXALYL-METHOXI ONES 未知
公开(公告)号：HU9301754D0
公开(公告)日：1993-09-28
申请号：HU9301754
申请日：1993-06-16
申请人： BAYER AG
发明人： MOHRS KLAUS-HELMUT , RADDATZ SIEGFRIED , MATZKE MICHAEL , FLUGMANN BURKHARD , HATZELMANN ARMIN , MUELLER-PEDDINGHAUS REINER
IPC分类号： A61K31/425 , A61K31/428 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , C07D241/42 , C07D241/44 , C07D277/42 , C07D277/64
摘要： Substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives are prepared either by reaction of heterocyclylmethyl-halogen compounds with corresponding phenoxy compounds, either directly or with subsequent alkylation, or by reaction of the heterocyclylmethyl-halogen compound with phenoxy compounds and subsequent reaction with suitable Grignard compounds. The substituted benzothiazolyl- and quinoxalyl-methoxyphenylacetic acid derivatives can be employed as active compounds in medicaments.

38. 发明专利

CA2084161A1 QUINOLYLMETHOXYPHENYLACETIC ACID ACYLAMIDES AND UREAS 未知
公开(公告)号：CA2084161A1
公开(公告)日：1993-06-04
申请号：CA2084161
申请日：1992-11-30
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MUELLER-PEDDINGHAUS REINER
IPC分类号： A61K31/47 , A61P9/00 , A61P11/00 , A61P37/08 , A61P43/00 , C07D215/14 , C07D215/16 , C07D215/48
摘要： Quinolylmethoxyphenylacetic acid acylamides and ureas A b s t r a c t Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The quinolylmethoxyphenylacetic acid acylamides or ureas can be used as active compounds in medicaments. Le A 28 781 - US

39. 发明专利

MX9206613A 未知
公开(公告)号：MX9206613A
公开(公告)日：1993-06-01
申请号：MX9206613
申请日：1992-11-17
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MULLER-PEDDINGHAUS REINER
IPC分类号： C07D417/12 , A61K31/00 , A61K31/165 , A61K31/47 , C07D20060101

40. 发明专利

MX9206612A 未知
公开(公告)号：MX9206612A
公开(公告)日：1993-06-01
申请号：MX9206612
申请日：1992-11-17
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED , MOHRS KLAUS-HELMUT , MATZKE MICHAEL , FRUCHTMANN ROMANIS , HATZELMANN ARMIN , MULLER-PEDDINGHAUS REINER
IPC分类号： A61K31/495 , A61K31/47 , A61K31/535 , A61P9/00 , A61P11/00 , A61P37/08 , C07D215/14 , C07D215/16 , C07D215/48 , A61K31/165
摘要： Quinolylmethoxyphenyl-acetamides of the formula: rogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl; R1 represents optionally substituted cycloalkyl; and R2 and R3 independently represent hydrogen, alkyl, benzyl, or optionally substituted cycloalkyl; or together represent piperidinyl, morpholino, or piperazinyl; show a high in vitro activity as leukotriene synthesis inhibitors and, therefore, are suitable for the treatment and prevention of inflammations.

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