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31. 发明授权

US6115626A Systems and methods using annotated images for controlling the use of diagnostic or therapeutic instruments in instruments in interior body regions 失效
标题翻译：使用注释图像来控制在室内区域的仪器中使用诊断或治疗仪器的系统和方法
公开(公告)号：US6115626A
公开(公告)日：2000-09-05
申请号：US48376
申请日：1998-03-26
申请人： James G. Whayne , David K. Swanson , Dorin Panescu , Daniel A. Dupree
发明人： James G. Whayne , David K. Swanson , Dorin Panescu , Daniel A. Dupree
IPC分类号： A61B5/042 , A61B18/14 , A61B5/00
CPC分类号： A61B5/6858 , A61B5/0422 , A61B5/7435 , A61B5/7475 , A61B18/14 , A61B2018/00178 , A61B2562/0209 , A61B2562/043 , A61N1/3625
摘要： An interface, used in association with an electrode structure deployed in contact with heart tissue, generates a display comprising an image of the electrode structure at least partially while performing a therapeutic or diagnostic procedure. The interface annotates the image in response to procedure events.
摘要翻译：与部署为与心脏组织接触的电极结构相关联地使用的界面在进行治疗或诊断过程时至少部分地产生包括电极结构的图像的显示器。界面会根据过程事件注释图像。

32. 发明授权

US6106522A Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements 失效
公开(公告)号：US6106522A
公开(公告)日：2000-08-22
申请号：US763169
申请日：1996-12-10
申请人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
发明人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
IPC分类号： A61B18/04 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , A61M25/00 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B17/39
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , A61B18/1402 , A61B18/1815 , A61B2017/00084 , A61B2017/00088 , A61B2017/00092 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00577 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61M2025/09141 , A61M25/0041
摘要： Systems and associated methods position arrays of multiple emitters of ablating energy in straight or curvilinear positions in contact with tissue to form elongated lesion patterns. The elongated lesion patterns can continuous or interrupted, depending upon the orientation of the energy emitters.

33. 发明授权

US6101409A Systems and methods for analyzing biopotential morphologies in body tissue 失效
标题翻译：用于分析身体组织中生物电位形态的系统和方法
公开(公告)号：US6101409A
公开(公告)日：2000-08-08
申请号：US944110
申请日：1997-10-06
申请人： David K. Swanson , Dorin Panescu , James G. Whayne
发明人： David K. Swanson , Dorin Panescu , James G. Whayne
IPC分类号： A61B1/005 , A61B5/042 , A61B5/0452 , A61N1/05 , A61N1/40 , G06F17/00 , A61B5/0402 , A61N1/36
CPC分类号： A61N1/403 , A61B5/0422 , A61B5/04525 , A61B5/6855 , A61B5/6858 , A61N1/056 , A61B1/0051
摘要： Systems and methods analyze biopotential morphologies in body tissue. The systems and methods use a template of a biopotential event of known cause in body tissue. The systems and methods compare this template to a sample of a biopotential event externally triggered in body tissue. The systems and methods generate an output based upon the comparison. The systems and methods can be used to compare an event-specific template of a cardiac event of known diagnosis to a sample of a paced cardiac event. The comparison yields a matching coefficient indicating how alike the input sample is to the input template. The matching coefficient can be used by the physician, for example, to aid in the location of sites that are potentially appropriate for ablation.
摘要翻译：系统和方法分析身体组织中的生物电位形态。系统和方法使用身体组织中已知原因的生物潜在事件的模板。系统和方法将该模板与身体组织中外部触发的生物潜在事件的样本进行比较。系统和方法基于比较产生输出。系统和方法可用于将已知诊断的心脏事件的事件特定模板与起搏心脏事件的样本进行比较。比较产生一个表示输入样本与输入模板相似的匹配系数。例如，医生可以使用匹配系数来帮助可能适合于消融的部位的位置。

34. 发明授权

US6047218A Systems and methods for visualizing interior tissue regions 失效
标题翻译：用于可视化内部组织区域的系统和方法
公开(公告)号：US6047218A
公开(公告)日：2000-04-04
申请号：US298198
申请日：1999-04-23
申请人： James G. Whayne , David K. Swanson , Dorin Panescu , David McGee , Harm TenHoff
发明人： James G. Whayne , David K. Swanson , Dorin Panescu , David McGee , Harm TenHoff
IPC分类号： A61B1/005 , A61B1/01 , A61B1/04 , A61B1/12 , A61B5/042 , A61B5/0456 , A61B18/14 , A61N1/02 , A61B8/00
CPC分类号： A61B8/543 , A61B1/00082 , A61B1/00085 , A61B1/0016 , A61B1/00183 , A61B18/1492 , A61B5/0422 , A61B5/6853 , A61B5/6858 , A61B1/0051 , A61B2017/003 , A61B2018/00208 , A61B2018/00214 , A61B2018/00267 , A61B2018/00839 , A61B2018/1861 , A61B2090/3782 , A61B2562/0209 , A61B2562/043 , A61B5/0456 , A61B5/7285 , A61B6/541
摘要： An imaging element characterizes tissue morphology by analyzing perfusion patterns of a contrast media in tissue visualized by the imaging element, to identify infarcted tissue. In a preferred implementation, a catheter tube introduced into a heart region carries the imaging element, as well as a support structure spaced from the imaging element, which contacts endocardial tissue. The imaging element is moved as the imaging element visualizes tissue. A selected electrical event is sensed in surrounding myocardial tissue, which regulates movement of the imaging element. The support element stabilizes the moving imaging element as it visualizes tissue, providing resistance to dislodgment or disorientation despite the presence of dynamic forces.
摘要翻译：成像元件通过分析由成像元件可视化的组织中的造影剂的灌注图案来表征组织形态，以鉴定梗塞的组织。在优选的实施方案中，引入心脏区域的导管管携带成像元件以及与成像元件间隔开的与心内膜组织接触的支撑结构。当成像元件可视化组织时，成像元件移动。在周围的心肌组织中感测到选择的电事件，其调节成像元件的运动。支撑元件使运动的成像元件稳定，因为它可视化组织，提供抵抗移动或定向障碍，尽管存在动态力。

35. 发明授权

US5954662A Systems and methods for acquiring endocardially or epicardially paced electrocardiograms 失效
标题翻译：获得心内膜或心外膜心电图的系统和方法
公开(公告)号：US5954662A
公开(公告)日：1999-09-21
申请号：US955328
申请日：1997-10-21
申请人： David K. Swanson , James G. Whayne , Dorin Panescu
发明人： David K. Swanson , James G. Whayne , Dorin Panescu
IPC分类号： A61B1/005 , A61B5/042 , A61B5/0452 , A61B18/14 , A61N1/05 , G06F17/00 , G06F19/00 , A61B5/04 , A61N1/36
CPC分类号： G06F19/3406 , A61B5/0422 , A61B5/04525 , A61B5/6855 , A61B5/6858 , A61N1/056 , G06F19/3487 , A61B1/0051 , A61B18/1492
摘要： Systems and methods acquire electrocardiograms using a first electrode associated with a region of heart tissue and a second body surface electrode. An analog or digital processing element is coupled to the first and second electrodes for conditioning the first electrode to emit a pacing signal and for conditioning the second electrode to sense paced electrocardiograms occurring as a result of the pacing signal. The systems and methods also employ a template of an electrocardiogram of a cardiac event of known diagnosis; for example an arrhythmia that the physician seeks to treat. The systems and methods compare this event-specific template to a sample of a paced electrocardiogram. The comparison yields a matching coefficient indicating how alike the input sample is to the input template. The matching coefficient can be used by the physician, for example, to aid in the location of sites that are potentially appropriate for ablation.
摘要翻译：系统和方法使用与心脏组织区域和第二体表电极相关联的第一电极获取心电图。模拟或数字处理元件耦合到第一和第二电极，用于调节第一电极以发出起搏信号并调节第二电极以感测由于起搏信号而产生的起搏心电图。系统和方法还采用已知诊断的心脏事件的心电图的模板; 例如医师寻求治疗的心律失常。系统和方法将此事件特定的模板与起搏心电图的样本进行比较。比较产生一个表示输入样本与输入模板相似的匹配系数。例如，医生可以使用匹配系数来帮助可能适合于消融的部位的位置。

36. 发明授权

US5836874A Multi-function electrode structures for electrically analyzing and heating body tissue 失效
标题翻译：用于电分析和加热身体组织的多功能电极结构
公开(公告)号：US5836874A
公开(公告)日：1998-11-17
申请号：US629014
申请日：1996-04-08
申请人： David K. Swanson , Dorin Panescu , James G. Whayne , Jerome Jackson
发明人： David K. Swanson , Dorin Panescu , James G. Whayne , Jerome Jackson
IPC分类号： A61B18/14 , A61B5/04 , A61B17/39
CPC分类号： A61B18/1492 , A61B2018/00214
摘要： Systems and methods for heating body tissue place a multi-function structure having an exterior wall in contact with body tissue. The structure includes an array of electrically conducting electrode segments carried by the exterior wall. An electrically conductive network is coupled to the electrode segments, including at least one electrically conductive path individually coupled to each electrode segment. The systems and methods operate in a first mode during which the network is electrically conditioned to individually sense at each electrode segment local electrical events in tissue, such as electrical potentials, resistivity, or impedance. The systems and methods operate in a second mode during which the network is electrically conditioned, based at least in part upon local electrical events sensed by the electrode segments, to couple at least two electrode segments together to simultaneously transmit electrical energy to heat or ablate a region of body tissue.
摘要翻译：用于加热身体组织的系统和方法设置具有与身体组织接触的外壁的多功能结构。该结构包括由外壁承载的导电电极段的阵列。导电网络耦合到电极段，包括分别耦合到每个电极段的至少一个导电路径。系统和方法以第一模式操作，在该模式期间，网络经电气调节以在每个电极段处单独感测组织中的局部电气事件，例如电势，电阻率或阻抗。系统和方法在第二模式下操作，其中网络被电调节，至少部分地基于由电极段感测到的局部电气事件，以将至少两个电极段耦合在一起，以同时传输电能以加热或消融身体组织区域。

37. 发明授权

US5810802A Systems and methods for controlling tissue ablation using multiple temperature sensing elements 失效
公开(公告)号：US5810802A
公开(公告)日：1998-09-22
申请号：US788782
申请日：1997-01-24
申请人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
发明人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/20 , A61L29/14 , A61L31/10 , A61L31/14 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B17/36
CPC分类号： A61B5/0422 , A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61B5/6858 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , A61B18/20 , A61B2017/00088 , A61B2017/00092 , A61B2017/00154 , A61B2017/003 , A61B2018/00083 , A61B2018/00101 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00636 , A61B2018/0066 , A61B2018/0069 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00821 , A61B2018/124 , A61B2018/126 , A61B2018/128 , A61B2018/1435 , A61B2018/1467
摘要： Systems and associated methods place a temperature sensing element in an "edge region" between an energy transmitting electrode and a non-electrically conducting support body, where higher temperatures are likely to exist. Reliable temperature sensing, which is sensitive to variations in temperatures along the electrode, results.

38. 发明授权

US5752518A Systems and methods for visualizing interior regions of the body 失效
标题翻译：用于可视化身体内部区域的系统和方法
公开(公告)号：US5752518A
公开(公告)日：1998-05-19
申请号：US738822
申请日：1996-10-28
申请人： David McGee , David K. Swanson , Harm TenHoff , Dorin Panescu , James G. Whayne
发明人： David McGee , David K. Swanson , Harm TenHoff , Dorin Panescu , James G. Whayne
IPC分类号： A61B5/0408 , A61B1/00 , A61B5/00 , A61B5/0402 , A61B5/0478 , A61B5/0492 , A61B8/12 , A61B18/12 , A61B18/14 , A61M25/00 , A61B8/00
CPC分类号： A61B8/12 , A61B18/1492 , A61B8/4461 , A61B2018/00208 , A61B2018/00214 , A61B2018/1861 , A61B5/0066 , A61B5/0084 , A61B5/7285 , A61B6/541 , A61B8/4488 , A61B8/543
摘要： An imaging system for visualizing an interior body region comprises a catheter tube having a proximal end and a distal end adapted for introduction into the interior body region. The distal end carries an element that forms a three-dimensional support structure for contacting peripheral tissue in the interior body region. The three-dimensional support structure has an open interior. The distal end also carries an imaging element for visualizing the interior body region. The three-dimensional support structure peripherally surrounds the imaging element, thereby keeping peripheral tissue from contacting the imaging element. A steering mechanism on the proximal end of the catheter tube moves the imaging element within the open interior of the three-dimensional support structure. The system provides a stable platform through which accurate displays of interior body images can be created for viewing and analysis by the physician, so the appropriate treatment or therapy can be prescribed.
摘要翻译：用于可视化内部身体区域的成像系统包括具有适于引入到内部身体区域中的近端和远端的导管。远端携带形成用于接触内部身体区域中的外周组织的三维支撑结构的元件。三维支撑结构具有开放的内部结构。远端还携带用于使内部身体区域可视化的成像元件。三维支撑结构外围地围绕成像元件，从而保持外围组织不接触成像元件。在导管管的近端上的转向机构将成像元件移动到三维支撑结构的开放内部。该系统提供了一个稳定的平台，可以通过该平台创建内部身体图像的精确显示，以供医生观察和分析，因此可以规定适当的治疗或治疗。

39. 发明授权

US5740808A Systems and methods for guilding diagnostic or therapeutic devices in interior tissue regions 失效
标题翻译：用于指导内部组织区域的诊断或治疗装置的系统和方法
公开(公告)号：US5740808A
公开(公告)日：1998-04-21
申请号：US739508
申请日：1996-10-28
申请人： Dorin Panescu , David McGee , James G. Whayne , David K. Swanson
发明人： Dorin Panescu , David McGee , James G. Whayne , David K. Swanson
IPC分类号： A61B5/042 , A61B8/12 , A61B18/14
CPC分类号： A61B5/6853 , A61B18/1492 , A61B5/0066 , A61B5/0422 , A61B5/6858 , A61B8/12 , A61B8/4209 , A61B8/4461 , A61B2018/00148 , A61B2018/00214 , A61B2562/0209 , A61B2562/043 , A61B2562/046 , A61B2562/08 , A61B5/7285 , A61B6/541 , A61B8/445 , A61B8/4488 , A61B8/543
摘要： A catheter tube carries an operative element, such as, for example, an imaging element to visualize tissue. The catheter tube also carries a support structure, which surrounds the operative element. A steering element moves the operative element relative to the support structure. A guidance element generates an electric field within the support structure, while sensing spatial variations in the electric field during movement of the imaging element. The guidance element generates an output that locates the imaging element relative to the support structure based upon an analysis of the sensed spatial variations. The support structure preferably carries an identification code, which represents the specific spatial geometry of the support structure. The support structure outputs the identification code to the guidance element for consideration when generating the location-specific output.
摘要翻译：导管管承载操作元件，例如成像元件以使组织可视化。导管还具有围绕操作元件的支撑结构。操纵元件相对于支撑结构移动操作元件。引导元件在支撑结构内产生电场，同时在成像元件移动期间感测电场中的空间变化。引导元件基于感测的空间变化的分析生成相对于支撑结构定位成像元件的输出。支撑结构优选地携带代表支撑结构的特定空间几何的识别码。支持结构在生成位置特定输出时将识别码输出到引导元件以供考虑。

40. 发明授权

US5722402A Systems and methods for guiding movable electrode elements within multiple-electrode structures 失效
公开(公告)号：US5722402A
公开(公告)日：1998-03-03
申请号：US679156
申请日：1996-07-12
申请人： David K. Swanson , Dorin Panescu , James G. Whayne
发明人： David K. Swanson , Dorin Panescu , James G. Whayne
IPC分类号： A61B5/0408 , A61B5/0402 , A61B5/042 , A61B5/0478 , A61B5/0492 , A61B8/12 , A61B18/12 , A61B18/14 , A61N1/06 , A61B17/39 , A61N1/05
CPC分类号： A61B5/6858 , A61B18/1492 , A61B5/0422 , A61B8/12 , A61B8/4461 , A61N1/06 , A61B18/1815 , A61B2017/003 , A61B2018/0016 , A61B2018/00214 , A61B2018/0075 , A61B2018/00755 , A61B2018/00839 , A61B2018/00875 , A61B2090/3782 , A61B2562/0209 , A61B2562/043 , A61B5/7217
摘要： Systems and related methods guide a movable electrode within an array of multiple electrodes located within the body. The systems and methods employ the movable electrode or at least one of the multiple electrodes on the array to generate and then sense electrical or sonic energy in a predetermined fashion to generates an output that locates the movable electrode within the array.

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