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31. 发明授权

US5092339A Method and apparatus for electrically compensated measurement of cardiac output 失效
标题翻译：用于电补偿测量心输出量的方法和装置
公开(公告)号：US5092339A
公开(公告)日：1992-03-03
申请号：US557135
申请日：1990-07-23
申请人： Leslie A. Geddes , Joe D. Bourland , William D. Voorhees, III , Neal E. Fearnot , Anthony C. Raghep , Frederick J. Shipko
发明人： Leslie A. Geddes , Joe D. Bourland , William D. Voorhees, III , Neal E. Fearnot , Anthony C. Raghep , Frederick J. Shipko
IPC分类号： A61B5/0275 , A61B5/029
CPC分类号： A61B5/029 , A61B5/0275
摘要： Cardiac output is measured using an injected substance (indicator) that changes the conducting property (electrical resistivity) of blood, provided the indicator has a different resistivity from that of blood. A new type of electrically compensated tetrapolar conductivity cell located at the distal end of an intravascular catheter is disclosed. The conductivity cell consists of four electrodes arranged across the end of a catheter at its tip. The outer electrodes used for current injection are enlarged to reduce the electrode-electrolyte interface impedance. Capacitance compensation of the cather/tetrapolar conductivity cell provides reliable and repeatable blood resistivity measurements. The catheter further includes a calibration resistor thereby eliminating a calibration step previously necessary in using such a catheter for measuring cardiac output.
摘要翻译：使用改变血液的导电性（电阻率）的注射物质（指示剂）来测量心输出量，只要该指示器与血液具有不同的电阻率即可。公开了位于血管内导管远端的新型电补充四极导电电池。导电细胞由四个电极组成，四个电极在导管末端排列。用于电流注入的外部电极被放大以减少电极 - 电解质界面阻抗。电流/四极电导率电池的电容补偿提供可靠和可重复的血液电阻率测量。导管还包括校准电阻器，从而消除了使用这种导管测量心输出量所必需的校准步骤。

32. 发明授权

US08216268B2 Intragastric bag for treating obesity 有权
标题翻译：用于治疗肥胖的胃内袋
公开(公告)号：US08216268B2
公开(公告)日：2012-07-10
申请号：US11643436
申请日：2006-12-21
申请人： Frederick B. Haller , John A. Karpiel , Donagh O'Sullivan , Brian K. Rucker , Maximiliano Soetermans , William D. Voorhees, III
发明人： Frederick B. Haller , John A. Karpiel , Donagh O'Sullivan , Brian K. Rucker , Maximiliano Soetermans , William D. Voorhees, III
IPC分类号： A61M29/00
CPC分类号： A61F5/0003 , A61F5/0036
摘要： An apparatus and method comprising at least one intragastric member made of a digestive-resistant or substantially indigestible material that is introduced into a bag located in the gastric lumen of a mammal for the treatment of obesity. One or more intragastric members are loaded into a delivery tube in a partially compacted first configuration and delivered to an overtube. The overtube includes a proximal end, a distal end and a lumen configured to receive the intragastric members in the first configuration for delivery to the bag located in the gastric lumen wherein the intragastric member is expanded to a second configuration. The apparatus further comprises a constraining element engaged with the bag to secure the intragastric member upon delivery into the gastric lumen.
摘要翻译：一种装置和方法，包括至少一个由消化不良或基本上不可消化的材料制成的胃内部件，所述胃内部件被引入位于哺乳动物的胃腔中的用于治疗肥胖症的袋中。将一个或多个胃内部件以部分压实的第一构型装载到输送管中并输送到外套管。所述外套管包括近端，远端和构造成在所述第一构造中接收所述胃内构件的内腔，用于输送到位于胃腔内的囊，其中所述胃内构件被扩张至第二构型。所述装置还包括与所述袋接合的约束元件，以在输送到胃管腔中时固定胃内部件。

33. 发明授权

US07056274B2 Catheter with concentric balloons for radiogas delivery and booster radiosources for use therewith 有权
标题翻译：具有用于放射气体输送的同心气球的导管和用于其的增强放射源
公开(公告)号：US07056274B2
公开(公告)日：2006-06-06
申请号：US10195829
申请日：2002-07-12
申请人： Marc G. Apple , William D. Voorhees, III
发明人： Marc G. Apple , William D. Voorhees, III
IPC分类号： A61M29/00 , A61M5/32 , A61M25/00
CPC分类号： A61N5/1002 , A61N2005/1003 , A61N2005/1021
摘要： A catheter assembly for use in radiation therapy of a patient by insertion into a vessel, passageway or cavity to deliver radioactive material to a treatment site within the patient. The distal end of the catheter assembly (10) includes a noncompliant inner balloon (18) therearound that is inflatable with a non-radioactive fluid (such as CO2 or saline or contrast medium), and an outer balloon (16) therearound that is inflated with radioactive fluid (such as radiogas like xenon-133 ) and is noncompliant to conform the vessel wall to the balloon's shape at the treatment site for optimal distribution of dose. The inner balloon allows reduction in volume of the amount of radioactive fluid necessary to achieve a desired dose. The inner and outer balloons (112,108) may be affixed to inner and outer catheters (104,102), respectively. Further, a booster radioactive source, preferably removable from the catheter, may also be used to supplement the dose from the outer balloon, such as a radioactive line source (a wire or a seed train (118,234)) within the central catheter lumen (116,230) at the distal end, or a plurality of seeds (320) within flexible cylinders (318) spaced circumferentially around the inner balloon (308) but within the outer balloon (310), or a sleeve (402) around the inner balloon (406) that may be impregnated with iodine-125. A method of providing radiation therapy is disclosed.
摘要翻译：一种用于患者放射治疗的导管组件，其通过插入容器，通道或空腔中以将放射性物质输送到患者体内的治疗部位。导管组件（10）的远端包括不适合的内部球囊（18），其可与非放射性流体（例如CO 2或盐水或造影剂）充气，并且外部放射性液体（如像氙133这样的放射性气体）充气的气球（16），并且不符合在管理部位使血管壁与球囊的形状相符合，以达到最佳的剂量分布。内球囊允许减少实现所需剂量所需的放射性液体的体积。内部和外部气囊（112,108）可以分别固定到内部和外部导管（104,102）。此外，可以使用优选从导管除去的助推放射源来补充来自外部球囊的剂量，例如在中心导管内腔（116,230）内的放射线源（线或种子列（118,234）），或在围绕内球囊（308）周向但在外球囊（310）内周向间隔开的柔性圆柱体（318）内的多个种子（320），或围绕内球囊（406）的套筒（402））可以用碘-125浸渍。公开了一种提供放射治疗的方法。

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