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31. 发明授权

US08030278B2 Methods, compositions and articles of manufacture for contributing to the treatment of cancers 有权
标题翻译：用于治疗癌症的方法，组合物和制品
公开(公告)号：US08030278B2
公开(公告)日：2011-10-04
申请号：US12390376
申请日：2009-02-20
申请人： Anil Gulati , Guru Reddy , Luigi Lenaz
发明人： Anil Gulati , Guru Reddy , Luigi Lenaz
IPC分类号： A61K38/10 , A61P35/00
CPC分类号： A61K38/10 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7072 , A61K38/2013 , A61K38/21 , A61K38/2285 , A61K45/06 , A61K2300/00
摘要： Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.
摘要翻译：公开了用于治疗癌症（包括实体瘤）的方法，组合物和制品。方法，组合物和制品可以利用内皮素B激动剂（ETB）来增强化疗剂的递送和产生的功效。

32. 发明授权

US08026216B2 Methods and compositions for contributing to the treatment of cancers 有权
标题翻译：有助于治疗癌症的方法和组合物
公开(公告)号：US08026216B2
公开(公告)日：2011-09-27
申请号：US12101008
申请日：2008-04-10
申请人： Anil Gulati , Guru Reddy , Luigi Lenaz
发明人： Anil Gulati , Guru Reddy , Luigi Lenaz
IPC分类号： A61K38/10 , A61P35/00
CPC分类号： A61K38/10 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7072 , A61K33/24 , A61K38/1703 , A61K38/2013 , A61K38/21 , A61K38/2285 , A61K45/06 , A61K2300/00
摘要： Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of chemotherapeutic agent(s) (e.g., cisplatin and/or cyclophosphamide).
摘要翻译：公开了用于治疗癌症，特别是卵巢肿瘤的方法和组合物。所述方法和组合物利用内皮素B激动剂（ETB）来增强化学治疗剂（例如顺铂和/或环磷酰胺）的递送和所得功效。

33. 发明授权

US07976835B2 Methods and compositions for preventing and treating solid tumors 有权
标题翻译：用于预防和治疗实体瘤的方法和组合物
公开(公告)号：US07976835B2
公开(公告)日：2011-07-12
申请号：US11460202
申请日：2006-07-26
申请人： Anil Gulati
发明人： Anil Gulati
IPC分类号： A61K33/24 , A61K38/10 , A61K38/20 , A61K38/21 , A61K38/24
CPC分类号： A61K31/00 , A61K31/28 , A61K31/337 , A61K31/4745 , A61K31/519 , A61K31/704 , A61K33/24 , A61K35/60 , A61K38/05 , A61K38/2013 , A61K38/208 , A61K38/21 , A61K38/2285 , A61K41/0038 , A61K45/06 , A61N2005/1098 , A61K2300/00
摘要： Compositions and methods of preventing or treating a breast cancer are disclosed. The composition and method can utilize an endothelin B agonist and a chemotherapeutic agent as active ingredients to treat a solid tumor in mammals, including humans. Alternatively, the composition and method can utilize an endothelin B antagonist and an optional angiogenesis inhibitor to treat a solid tumor in mammals, including humans.
摘要翻译：公开了预防或治疗乳腺癌的组合物和方法。组合物和方法可以利用内皮素B激动剂和化学治疗剂作为活性成分来治疗包括人在内的哺乳动物的实体肿瘤。或者，组合物和方法可以利用内皮素B拮抗剂和任选的血管生成抑制剂来治疗包括人在内的哺乳动物的实体肿瘤。

34. 发明申请

US20100173872A1 Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin 审中-公开
标题翻译：治疗阿尔茨海默病和血管性原发性痴呆的方法和组成
公开(公告)号：US20100173872A1
公开(公告)日：2010-07-08
申请号：US12651647
申请日：2010-01-04
申请人： Anil Gulati
发明人： Anil Gulati
IPC分类号： A61K31/42 , A61P25/28 , A61K31/422 , A61K31/4365 , A61K31/675 , A61K31/505 , A61K31/36 , A61K31/5415 , A61K31/4025 , A61K31/4439 , A61K31/497 , A61K31/4965 , A61K31/4178 , A61K31/47 , A61K31/473 , A61K31/662 , A61K31/27 , A61K31/55 , A61K31/40 , A61K31/404
CPC分类号： A61K31/422 , A61K31/00 , A61K31/198 , A61K31/24 , A61K31/27 , A61K31/36 , A61K31/365 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/405 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/4355 , A61K31/4422 , A61K31/4439 , A61K31/4465 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/473 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/498 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/662 , A61K31/664 , A61K31/683 , A61K45/06 , A61K2300/00
摘要： A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.
摘要翻译：公开了治疗阿尔茨海默病或血管起源性痴呆的组合物和方法。组合物和方法利用内皮素拮抗剂作为活性剂来治疗哺乳动物（包括人）中的阿尔茨海默病或血管起源性痴呆。

35. 发明申请

US20100113396A1 Method and Composition for Potentiating an Opiate Analgesic 失效
标题翻译：增加阿片镇痛药的方法和组合
公开(公告)号：US20100113396A1
公开(公告)日：2010-05-06
申请号：US12611307
申请日：2009-11-03
申请人： Anil Gulati
发明人： Anil Gulati
IPC分类号： A61K31/675 , A61K31/485 , A61K31/445 , A61K31/42 , A61K31/4365 , A61K31/505 , A61K31/421 , A61K31/357 , A61K31/5415 , A61K31/497 , A61K31/47 , A61P25/36
CPC分类号： A61K31/485 , A61K38/17 , A61K2300/00
摘要： Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans.
摘要翻译：公开了治疗疼痛的组合物和方法以及降低或逆转对阿片镇痛药的耐受性。组合物和方法利用阿片止痛剂和内皮素拮抗剂作为治疗哺乳动物包括人类疼痛的活性剂。

36. 发明申请

US20090221490A1 Endothelin Receptors In Morphine Withdrawal 审中-公开
标题翻译：内皮素受体在吗啡戒断
公开(公告)号：US20090221490A1
公开(公告)日：2009-09-03
申请号：US12161200
申请日：2006-09-08
申请人： Anil Gulati , Shaifali Bhalla
发明人： Anil Gulati , Shaifali Bhalla
IPC分类号： A61K38/17 , G01N33/53
CPC分类号： A61K31/7076 , G01N33/9486
摘要： The present invention relates to compositions and methods for managing opioid tolerance and reducing opioid withdrawal. More specifically, the present invention provides for endothelin, endothelin receptors, and endothelin receptor antagonists and agonists as a means for managing G-protein activity in the context of opioid tolerance and withdrawal.
摘要翻译：本发明涉及用于治疗阿片样物质耐量和减少阿片样物质戒断的组合物和方法。更具体地，本发明提供内皮素，内皮素受体和内皮素受体拮抗剂和激动剂作为在阿片样物质耐受和戒断的背景下管理G蛋白活性的手段。

37. 发明授权

US06786047B2 Flashback resistant pre-mix burner for a gas turbine combustor 有权
标题翻译：用于燃气轮机燃烧器的防反冲预燃烧器
公开(公告)号：US06786047B2
公开(公告)日：2004-09-07
申请号：US10245768
申请日：2002-09-17
申请人： Robert Bland , Anil Gulati , John Battaglioli
发明人： Robert Bland , Anil Gulati , John Battaglioli
IPC分类号： F02C100
CPC分类号： F23D14/82 , F23D2900/00008 , F23D2900/14004 , F23R3/14 , F23R3/286
摘要： A pre-mixing burner (10) for a gas turbine engine having improved resistance to flashback. Fuel (32) is supplied to a pre-mixing chamber (24) of the burner from a plurality of fuel outlet openings (34) formed in fuel pegs (36) extending into the flow of air (30) passing through the chamber. The fuel outlet openings are formed to direct the fuel in a downstream direction at an angle (A) relative to the direction of the flow of air past the respective fuel peg. This angle imparts a downstream velocity vector (VD) for increasing the net velocity of the air and a normal velocity vector (VN) for directing the fuel away from the wake (44) formed downstream of the fuel peg. Alternate ones of the fuel outlet openings along a single fuel peg may be formed at respective positive (A) and negative (B) angles with respect to a plane (46) extending along the wake in order to minimize the size of the wake. The propensity of the burner to support upstream flame propagation and flashback is thus reduced by increasing the net air velocity, by minimizing the amount of fuel entrained in the wake, and by minimizing the size of the wake.
摘要翻译：一种用于燃气涡轮发动机的预混合燃烧器（10），其具有改进的抗回火性能。燃料（32）从形成在延伸进入通过该室的空气流（30）的燃料栓（36）中的多个燃料出口（34）供应到燃烧器的预混合室（24）。燃料出口开口形成为相对于通过相应的燃料栓的空气流的方向在下游方向上以相对于空气流的方向（A）引导燃料。该角度赋予用于增加空气净速度的下游速度矢量（VD）和用于引导燃料远离形成在燃料栓的下游的尾流（44）的正常速度矢量（VN）。沿着单个燃料栓的燃料出口开口中的替代燃料出口可相对于沿着尾流延伸的平面（46）以相对的正（A）和负（B）角度形成，以便最小化尾流的尺寸。燃烧器支持上游火焰传播和回火的倾向因此通过增加净空气速度来减少，通过最小化在尾流中夹带的燃料的量以及通过使尾流的尺寸最小化来实现。

38. 发明授权

US5129226A Flameholder for gas turbine engine afterburner 失效
标题翻译：燃烧器后燃气发动机的燃烧器
公开(公告)号：US5129226A
公开(公告)日：1992-07-14
申请号：US606247
申请日：1990-10-31
申请人： Elwin C. Bigelow , Anil Gulati
发明人： Elwin C. Bigelow , Anil Gulati
IPC分类号： F02C7/00 , F02C7/20 , F23R3/18
CPC分类号： F23R3/18 , F23D2206/10 , F23D2210/00
摘要： A V-shaped afterburner flameholder for a gas turbine engine has a plurality of rectangular tabs coextensive with and lying in the planes of the flameholder sidewalls. The tabs on opposing sidewalls alternate so as to introduce streamwise and spanwise (transverse) vortices in the flowing gas. The resultant streamwise vortices tend to reduce resonating vortex oscillations (screech) and the need for an acoustic liner to suppress such screech.
摘要翻译：用于燃气涡轮发动机的V形加力燃烧器火焰稳定器具有与火焰稳定器侧壁的平面共同延伸并位于其中的多个矩形突起。相对的侧壁上的突片交替，以便在流动气体中引入流动和横向（横向）涡流。所得到的流动涡流倾向于减少共鸣的涡流振荡（尖叫声），以及需要声学衬垫以抑制这种尖叫声。

39. 发明授权

US08440620B2 Methods, compositions and articles of manufacture for contributing to the treatment of cancers 有权
标题翻译：用于治疗癌症的方法，组合物和制品
公开(公告)号：US08440620B2
公开(公告)日：2013-05-14
申请号：US13220358
申请日：2011-08-29
申请人： Anil Gulati , Guru Reddy , Luigi Lenaz
发明人： Anil Gulati , Guru Reddy , Luigi Lenaz
IPC分类号： A61K38/10 , A61K38/20 , A61K38/21
CPC分类号： A61K38/10 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/704 , A61K31/7072 , A61K38/2013 , A61K38/21 , A61K38/2285 , A61K45/06 , A61K2300/00
摘要： Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.
摘要翻译：公开了用于治疗癌症（包括实体瘤）的方法，组合物和制品。方法，组合物和制品可以利用内皮素B激动剂（ETB）来增强化疗剂的递送和产生的功效。

40. 发明授权

US08217010B2 Methods, compositions and articles of manufacture for contributing to the treatment of solid tumors 有权
标题翻译：用于治疗实体瘤的方法，组合物和制品
公开(公告)号：US08217010B2
公开(公告)日：2012-07-10
申请号：US11360236
申请日：2006-02-22
申请人： Anil Gulati
发明人： Anil Gulati
IPC分类号： A61P35/00 , A61K38/00 , A61K38/21 , A61K33/24 , A61K38/04
CPC分类号： A61K31/337 , A61K45/06
摘要： Methods, compositions and articles of manufacture for contributing to the treatment of a solid cancerous tumor are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery of a chemotherapeutic agent to a solid tumor in mammals, including humans.
摘要翻译：公开了有助于治疗固体癌性肿瘤的方法，组合物和制品。方法，组合物和制品可以利用内皮素B激动剂（ETB）来增强哺乳动物（包括人）中化疗剂对实体肿瘤的递送。

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