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31. 发明申请

US20050149875A1 Color quality and packet shaping features for displaying an application on various client devices 有权
标题翻译：颜色质量和数据包整形功能，用于在各种客户端设备上显示应用程序
公开(公告)号：US20050149875A1
公开(公告)日：2005-07-07
申请号：US11071499
申请日：2005-03-03
申请人： Andrew Shaw , Karl Burgess
发明人： Andrew Shaw , Karl Burgess
IPC分类号： H04L29/06 , H04L29/08 , G06F3/00 , G06F15/16
CPC分类号： H04L29/06 , H04L67/303 , H04L67/325 , H04L67/34 , H04L67/42 , H04L69/08 , H04L69/18 , H04L69/329
摘要： In a client-server architecture, data transmission performance enhancing features are described, including a color quality approach and a packet shaping approach. A method includes a color quality data transformation including: selecting a quality level to apply to a set of image data having a number of significant color bits defining an initial number of possible colors; applying a pixel mask to the set of image data, the initial number of possible colors reduced to a smaller number of possible colors as a function of the quality level; loading the set of image data into an output buffer; and sending the set of image data from the output buffer to a display engine. Another method includes a packet shaping data structure transformation including if i) a total network time, defined by a total time of requests in a pending request queue, is equal to or greater than a current round trip time, defined by twice a current latency, and ii) a total request time, defined by a sum of a total time of requests in the pending request queue and a total time of requests in a transmitted request queue, minus the total network time is equal to or less than half a preset limit, then forming a shaped packet by associating a first data portion with a second data portion and a header.
摘要翻译：在客户机 - 服务器架构中，描述了数据传输性能增强特征，包括颜色质量方法和分组整形方法。一种方法包括色彩质量数据变换，包括：选择质量水平以应用于具有限定可能颜色的初始数量的多个有效色彩位的图像数据集合; 将像素掩模应用于所述图像数据集合，所述可能颜色的初始数量减少到作为所述质量水平的函数的较小数量的可能颜色; 将该组图像数据加载到输出缓冲器中; 以及将所述一组图像数据从所述输出缓冲器发送到显示引擎。另一种方法包括分组整形数据结构变换，包括如果i）由等待请求队列中的请求的总时间定义的总网络时间等于或大于由当前等待时间的两倍定义的当前往返时间，以及ii）由等待请求队列中的请求的总时间与发送的请求队列中的请求的总时间减去总网络时间之和的总和定义的总请求时间等于或小于预设限制的一半，然后通过将第一数据部分与第二数据部分和报头相关联来形成成形分组。

32. 发明授权

US6104392A Method of displaying an application on a variety of client devices in a client/server network 失效
标题翻译：在客户机/服务器网络中的各种客户端设备上显示应用的方法
公开(公告)号：US6104392A
公开(公告)日：2000-08-15
申请号：US190757
申请日：1998-11-12
申请人： Andrew Shaw , Karl Richard Burgess , John Marcus Pullan , Peter Charles Cartwright
发明人： Andrew Shaw , Karl Richard Burgess , John Marcus Pullan , Peter Charles Cartwright
IPC分类号： H04L29/06 , H04L29/08 , G06F7/00
CPC分类号： H04L67/303 , H04L29/06 , H04L67/325 , H04L67/34 , H04L67/42 , H04L69/08 , H04L69/18 , H04L69/329
摘要： In a client-server architecture, an Adaptive Internet Protocol (AIP) system, comprised of a display engine operating on a server and a protocol engine operating on a server, provides means to support standard graphics based computer applications connected to clients of varying capability via a network of varying bandwidth and latency by automatically varying the type and number of graphic requests and their networking encoding to provide near optimum performance while maintaining the correct visual representation.
摘要翻译：在客户机 - 服务器架构中，由在服务器上操作的显示引擎和在服务器上操作的协议引擎组成的自适应互联网协议（AIP）系统提供了支持基于标准图形的计算机应用的方法，所述计算机应用连接到具有不同能力的客户端通过自动改变图形请求的类型和数量及其网络编码，提供不同带宽和延迟的网络，以提供接近最佳性能，同时保持正确的视觉表示。

33. 发明授权

US5441960A 1-pyrimidinylacetamide human leukocyte elastate inhibitors 失效
标题翻译： 1-嘧啶基乙酰胺人类白细胞弹性蛋白酶抑制剂
公开(公告)号：US5441960A
公开(公告)日：1995-08-15
申请号：US44866
申请日：1993-04-08
申请人： Peter R. Bernstein , Philip D. Edwards , Andrew Shaw , Royston M. Thomas , Chris A. Veale , Peter Warner , Donald J. Wolanin
发明人： Peter R. Bernstein , Philip D. Edwards , Andrew Shaw , Royston M. Thomas , Chris A. Veale , Peter Warner , Donald J. Wolanin
IPC分类号： A61K38/55 , A61K38/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/08 , A61K31/505 , C07D239/22
CPC分类号： C07K5/0205 , C07K5/06191 , A61K38/00
摘要： The present invention relates to certain novel substituted ketones which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates ##STR2## useful in the synthesis of these substituted ketones processes for preparing the substituted ketones pharmaceutical compositions containing such substituted ketones and methods for their use.
摘要翻译：本发明涉及作为人白细胞弹性蛋白酶（HLE）抑制剂（也称为人嗜中性粒细胞弹性蛋白酶（HNE））的式I所示的1-嘧啶基乙酰胺衍生物的某些新的取代酮，其为如果需要这种抑制作用，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗中是有用的。本发明还包括可用于合成这些取代酮的中间体制备含取代酮的取代酮的药物组合物的方法及其使用方法。

34. 发明授权

US4771038A Hydroxamic acids 失效
标题翻译：羟肟酸
公开(公告)号：US4771038A
公开(公告)日：1988-09-13
申请号：US2814
申请日：1987-01-13
申请人： Donald J. Wolanin , Andrew Shaw
发明人： Donald J. Wolanin , Andrew Shaw
IPC分类号： A61K38/00 , C07K5/06 , C07K5/065 , C07K5/083 , A61K37/02 , C07K5/08
CPC分类号： C07K5/0808 , C07K5/06043 , C07K5/06052 , C07K5/06078 , A61K38/00
摘要： This invention provides a series of novel hydroxamic acids of formula I which are useful as inhibitors of metalloproteases such as endopeptidases.
摘要翻译：本发明提供了一系列新颖的式I异羟肟酸，其可用作金属蛋白酶如内肽酶的抑制剂。

35. 发明授权

US4046898A 6-Aryl-pyrrolo[1,2-a]Imidazole derivatives which possess anti-hypertensive activity 失效
标题翻译： 6-芳基吡咯并[8 1,2-a {9具有抗高血压活性的咪唑衍生物
公开(公告)号：US4046898A
公开(公告)日：1977-09-06
申请号：US652060
申请日：1976-01-26
申请人： Andrew Shaw
发明人： Andrew Shaw
IPC分类号： C07D487/04 , A61K31/33 , A61K31/415 , A61P9/12 , C07C205/04 , C07C205/09 , C07C205/26 , C07C205/53 , C07C205/56 , C07D207/22 , C07D207/26 , C07D207/277 , C07D209/96 , C07D233/20 , C07D233/26 , C07D303/08 , C07D307/33 , C07D333/12 , C07D333/22 , C07D333/24 , A61K31/44
CPC分类号： C07D207/26 , C07C205/04 , C07C205/09 , C07C205/26 , C07C205/53 , C07C205/56 , C07D207/22 , C07D207/277 , C07D209/96 , C07D233/20 , C07D233/26 , C07D303/08 , C07D307/33 , C07D333/12 , C07D333/22 , C07D333/24 , Y10S514/96
摘要： 6-Aryl-pyrrolo[1,2-a]imidazole derivatives, processes for their manufacture, pharmaceutical compositions containing them and a method of using them to lower blood pressure in warm-blooded animals. Representative of the compounds disclosed is 6-(2,6-dichlorophenyl)-2,3,6,7-tetrahydro-5H-pyrrolo[1,2-a]imidazole.
摘要翻译： 6-芳基 - 吡咯并[1,2-a]咪唑衍生物，其制备方法，含有它们的药物组合物和使用它们降低温血动物血压的方法。所公开的化合物的代表是6-（2,6-二氯苯基）-2,3,6,7-四氢-5H-吡咯并[1,2-a]咪唑。

36. 发明公开

US20230334389A1 SYSTEMS AND METHODS FOR INCREASED CORRECTIONAL FACILITY SAFETY 审中-公开
公开(公告)号：US20230334389A1
公开(公告)日：2023-10-19
申请号：US18136050
申请日：2023-04-18
申请人： Kenneth L. Dalley, JR. , Andrew Shaw , Gareth Miller , Adithi Deborah Chakravarthy
发明人： Kenneth L. Dalley, JR. , Andrew Shaw , Gareth Miller , Adithi Deborah Chakravarthy
IPC分类号： G06Q10/0631 , G06Q10/0639 , G06Q50/26
CPC分类号： G06Q10/063116 , G06Q10/06398 , G06Q50/265
摘要： Various embodiments monitor compliance with standards for conducting rounds within corrections facilities and assist in maintaining safe corrections facilities by identifying predictable rounds patterns and encouraging inmate monitoring through unpredictable rounds timing. Some embodiments generate scores indicative of randomness in conducting rounds by individuals, groups, and even an entire staff of corrections officers.

37. 发明授权

US08232080B2 Variant Hyprocrea jecorina CBH1 cellulases 有权
标题翻译：变异Hyprocrea jecorina CBH1纤维素酶
公开(公告)号：US08232080B2
公开(公告)日：2012-07-31
申请号：US13107702
申请日：2011-05-13
申请人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
发明人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
IPC分类号： C12P19/02 , C12P19/00 , C12P21/06 , C12N9/42 , C12N1/20 , G01N33/53 , C07H21/04
CPC分类号： C12N9/2437 , C11D3/38645 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , D21C5/005 , Y02E50/16
摘要： Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
摘要翻译：本文描述的是H.jecorina CBH I，Cel7酶的变体。本发明提供了具有改善的热稳定性和可逆性的新型纤维二糖水解酶。

38. 发明授权

US08206960B1 Endoglucanases 有权
公开(公告)号：US08206960B1
公开(公告)日：2012-06-26
申请号：US13323724
申请日：2011-12-12
申请人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
发明人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
IPC分类号： C12N9/00
CPC分类号： C12N9/2437 , C07K2319/02 , C12N9/2445 , C12N15/75 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.

39. 发明申请

US20120021485A1 HYBRID ALPHA-AMYLASES 有权
标题翻译：混合阿尔法胺
公开(公告)号：US20120021485A1
公开(公告)日：2012-01-26
申请号：US13132881
申请日：2009-12-11
申请人： Scott D. Power , Andrew Shaw
发明人： Scott D. Power , Andrew Shaw
IPC分类号： C12N9/96 , G06G7/60 , C12N1/21 , C12N1/15 , C12N15/62 , C12N15/63
CPC分类号： C12N9/2417 , C07K2319/00 , G06F19/12 , G06F19/16
摘要： Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ? amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ? amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.
摘要翻译：提供杂交α-淀粉酶，其与野生型类戊酰样α-淀粉酶（例如芽孢杆菌淀粉酶）全部或部分共享保守的3D结构。在杂交体中，类戊酰样α-淀粉酶的N末端部分被来自古细菌的序列替代淀粉酶。两个淀粉酶序列之间的序列相似性可以小于60％。在杂交中保护野生型3D结构有助于获得酶活性淀粉酶。在一个实施方案中，一个或两个淀粉酶序列向B结构域贡献残基，导致特别有利的性质。例如，用具有古细菌的B结构域序列的Termamyl样α-淀粉酶的B结构域中的Ca 2+结合位点的替换不结合Ca2 +的淀粉酶可以产生在不存在Ca 2+的情况下完全活性的杂交体。

40. 发明申请

US20120009631A1 VARIANT ENDOGLUCANASES AND RELATED POLYNUCLEOTIDES 有权
标题翻译：各种内切酶和相关多核苷酸
公开(公告)号：US20120009631A1
公开(公告)日：2012-01-12
申请号：US13203909
申请日：2010-03-10
申请人： Jie Yang , Xiyun Zhang , Ish Kumar Dhawan , Andrew Shaw
发明人： Jie Yang , Xiyun Zhang , Ish Kumar Dhawan , Andrew Shaw
IPC分类号： C12P19/12 , C07H21/00 , C12N15/63 , C12P7/14 , C12P19/02 , C12P19/00 , C12P7/02 , C12N9/42 , C12N1/21
CPC分类号： C12N9/2408 , C12N9/2437 , C12P7/10 , C12P19/12 , C12P19/14 , C12Y302/01004 , C12Y302/01091 , Y02E50/16 , Y02E50/17 , Y02P20/52
摘要： The invention provides variants of the Clostridium thermocellum endoglucanase (CeIG) that have improved endoglucanase activity compared to the wild type enzyme. Also provided are related polynucleotides, compositions, vectors, host cells, and methods of use.
摘要翻译：本发明提供了与野生型酶相比具有改善的内切葡聚糖酶活性的热梭菌内切葡聚糖酶（CeIG）的变体。还提供了相关多核苷酸，组合物，载体，宿主细胞和使用方法。

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