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31. 发明授权

US09611511B2 Complex miRNA sets as novel biomarkers for an acute coronary syndrome 有权
公开(公告)号：US09611511B2
公开(公告)日：2017-04-04
申请号：US13642321
申请日：2011-04-19
申请人： Andreas Keller , Peer F. Stähler , Markus Beier , Benjamin Meder , Hugo A. Katus , Wolfgang Rottbauer
发明人： Andreas Keller , Peer F. Stähler , Markus Beier , Benjamin Meder , Hugo A. Katus , Wolfgang Rottbauer
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to single polynucleotides or sets of polynucleotides for detecting single miRNAs or sets of miRNAs for diagnosing and/or prognosing of an acute coronary syndrome in a blood sample from a human. Further, the present invention relates to means for diagnosing and/or prognosing of an acute coronary syndrome comprising said polynucleotides or sets of polynucleotides. Furthermore, the present invention relates to a method for diagnosing and/or prognosing of an acute coronary syndrome based on the determination of expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome compared to a reference. In addition, the present invention relates to a kit for diagnosing and/or prognosing of an acute coronary syndrome comprising means for determining expression profiles of single miRNAs or sets of miRNAs representative for an acute coronary syndrome and at least one reference.

32. 发明授权

US08850715B2 Process and installation for drying articles 有权
标题翻译：干燥物品的处理和安装
公开(公告)号：US08850715B2
公开(公告)日：2014-10-07
申请号：US11899210
申请日：2007-09-04
申请人： Werner Swoboda , Andreas Keller
发明人： Werner Swoboda , Andreas Keller
IPC分类号： F26B3/04 , F26B21/14 , F26B25/00
CPC分类号： F26B21/14 , F26B25/006 , F26B2210/12
摘要： What is described is a process and an installation for drying articles, in particular painted vehicle bodies, in which the articles are moved through a drying zone in which they are hardened in an inert-gas atmosphere. Inert gas is taken from the drying zone constantly or intermittently and is first of all conducted along a first face which is at a first temperature at which higher-boiling contaminants condense out. The condensate that forms in the process is discharged. After that, the inert gas which has been pre-cleaned in this way is conducted along at least one second face which is at a lower temperature than the first face. Lower-boiling contaminants are precipitated at this point. These condensates, too, are then discharged. This process and installation work more favorably, energy-wise, and with higher cleaning efficiency than known processes and installations of a similar type.
摘要翻译：所描述的是用于干燥制品，特别是涂漆车体的方法和装置，其中制品通过其在惰性气体气氛中硬化的干燥区域移动。不断地或间歇地从干燥区取出惰性气体，首先沿着处于高沸点污染物浓缩的第一温度的第一面进行。在该过程中形成的冷凝物排出。此后，以这种方式预先清洁的惰性气体沿着比第一面低的至少一个第二面进行。此时较低沸点的污染物沉淀。然后，这些冷凝物也被排出。这种过程和安装工作比已知的相似类型的工艺和安装更有利于节能，并且具有更高的清洁效率。

33. 发明授权

US08492579B2 Method for producing astaxanthin dimethyldisuccinate 有权
标题翻译：虾青素二甲基琥珀酸盐的制备方法
公开(公告)号：US08492579B2
公开(公告)日：2013-07-23
申请号：US13021173
申请日：2011-02-04
申请人： Hansgeorg Ernst , Walter Dobler , Andreas Keller , Klaus Henrich
发明人： Hansgeorg Ernst , Walter Dobler , Andreas Keller , Klaus Henrich
IPC分类号： C07C403/24
CPC分类号： C07C403/24 , C07C2601/16
摘要： The present invention relates to an improved method for producing all-E astaxanthin dimethyldisuccinate of the formula I.
摘要翻译：本发明涉及一种生产式I的全-E虾青素二甲基丁二酸酯的改进方法。

34. 发明申请

US20120157337A1 miRNA FINGERPRINT IN THE DIAGNOSIS OF MULTIPLE SCLEROSIS 有权
标题翻译： miRNA指纹在多发性硬化症诊断中的应用
公开(公告)号：US20120157337A1
公开(公告)日：2012-06-21
申请号：US13376243
申请日：2010-06-07
申请人： Andreas Keller , Eckart Meese , Anne Borries , Peer Friedrich Staehler , Markus Beier
发明人： Andreas Keller , Eckart Meese , Anne Borries , Peer Friedrich Staehler , Markus Beier
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G06F19/20 , G06F19/24 , C12Q2525/207
摘要： The present invention provides novel methods for diagnosing diseases based on the determination of specific miR-NAs that have altered expression levels in disease states compared to healthy controls.
摘要翻译：本发明提供了基于与健康对照相比在疾病状态中改变表达水平的特异性miR-NAs的测定来诊断疾病的新方法。

35. 发明申请

US20110178192A1 COATING FORMULATION FOR EXPANDABLE PARTICULATE STYRENE POLYMER 审中-公开
标题翻译：可涂性聚苯乙烯聚合物涂料配方
公开(公告)号：US20110178192A1
公开(公告)日：2011-07-21
申请号：US12672352
申请日：2008-08-08
申请人： Andreas Keller , Olaf Kriha , Wolfram Husemann , Klaus Hahn , Bernhard Schmied , Michael Riethues
发明人： Andreas Keller , Olaf Kriha , Wolfram Husemann , Klaus Hahn , Bernhard Schmied , Michael Riethues
IPC分类号： C08J9/224 , C08L25/06 , C08L91/00
CPC分类号： C08J9/224 , C08J2201/036 , C08J2325/06 , C08J2491/00
摘要： A coating formulation intended for expandable particulate styrene polymer and comprising (A) from 10 to 90% by weight of a tristearyl ester whose melting point is in the range from 60 to 65° C., (B) from 10 to 90% by weight of a triglyceride of a hydroxy-C16-C18 oleic acid whose melting point is in the range from 70 to 95° C., and also expandable particulate styrene polymer which has at least one coating composed of said coating-composition formulation.
摘要翻译：一种用于可膨胀的颗粒状苯乙烯聚合物的涂料制剂，其包含（A）10至90重量％的熔点为60至65℃的三硬脂酯，（B）10至90重量％的熔点在70至95℃范围内的羟基-C16-C18油酸甘油三酸酯，以及具有至少一种由所述涂料组合物制剂组成的涂层的可发性颗粒状苯乙烯聚合物。

36. 发明授权

US07378558B2 Method for producing carotenoids 失效
标题翻译：生产类胡萝卜素的方法
公开(公告)号：US07378558B2
公开(公告)日：2008-05-27
申请号：US10532207
申请日：2003-11-17
申请人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
发明人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
IPC分类号： C07C45/68 , C07C49/543 , C07C43/03 , C07C35/18 , C07C69/73
CPC分类号： C07C403/24 , C07C1/34 , C07C43/15 , C07C67/343 , C07C69/734 , C07C11/21
摘要： A process for preparing carotenoids, in which the process includes reacting a dialkoxy dialdehyde in a double Wittig condensation with a phosphonium salt of or in a double Wittig-Horner condensation with a phosphonate. The carotenoids include, for example, β-carotene, zeaxanthin, canthaxanthin, astaxathin, lycopene and croceptin, which are useful as nutraceuticals, food colorants, and feed additives.
摘要翻译：一种制备类胡萝卜素的方法，其中该方法包括使双维t嗪缩合中的二烷氧基二醛与双维维特 - 霍纳缩合的鏻盐与膦酸酯反应。类胡萝卜素包括例如β-胡萝卜素，玉米黄质，角黄素，虾青素，番茄红素和croceptin，其可用作营养制品，食品着色剂和饲料添加剂。

37. 发明申请

US20070244344A1 Method for Producing 2,7-Dimethyl-Octa-2,4,6-Trienedial 有权
标题翻译： 2,7-二甲基 - 八甲基-2,4,6-三烯酸的生产方法
公开(公告)号：US20070244344A1
公开(公告)日：2007-10-18
申请号：US10588683
申请日：2005-02-04
申请人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
发明人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
IPC分类号： C07C45/45
CPC分类号： C07C45/515 , C07C41/54 , C07C45/65 , C07C47/277 , C07C47/21 , C07C43/315
摘要： The present invention relates to an improved process for preparing 2,7-dimethylocta-2,4,6-trienedial of the formula I, by a) double enol ether condensation of a butenedial bisacetal of the formula II with an enol ether of the formula III, in the presence of a Lewis acid catalyst to give a condensation product of the formula IV, where the radicals R1 and R2 in formulae II to IV are independently of one another C1-C6-alkyl; b) hydrolysis of the acetal groups of IV by adding an aqueous acid to form the dialdehyde of the formula V; d) crystallization of I from the reaction mixture, Wherein process steps a) to d) are carried out in the presence of an inert, water-immiscible organic solvent.
摘要翻译：本发明涉及通过以下方式制备式I的2,7-二甲基辛-2,4,6-三烯酸的改进方法：a）式Ⅱ的丁二醛双缩醛与式II的烯醇醚的双烯醇醚缩合 III，在路易斯酸催化剂的存在下，得到式IV的缩合产物，其中式II至IV中的基团R 1和R 2与式另一个C 1 -C 6 - 烷基; b）通过加入酸水溶液来水解IV的缩醛基以形成式V的二醛; d）从反应混合物中结晶I，其中方法步骤a）至d）在惰性的与水不混溶的有机溶剂的存在下进行。

38. 发明申请

US20060106257A1 Method for producing carotenoids 失效
标题翻译：生产类胡萝卜素的方法
公开(公告)号：US20060106257A1
公开(公告)日：2006-05-18
申请号：US10532207
申请日：2003-11-17
申请人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
发明人： Hansgeorg Ernst , Klaus Henrich , Andreas Keller
IPC分类号： C07C45/45
CPC分类号： C07C403/24 , C07C1/34 , C07C43/15 , C07C67/343 , C07C69/734 , C07C11/21
摘要： A process for preparing carotenoids, in which the process includes reacting a dialkoxy dialdehyde in a double Wittig condensation with a phosphonium salt of or in a double Wittig-Horner condensation with a phosphonate. The carotenoids include, for example, β-carotene, zeaxanthin, canthaxanthin, astaxathin, lycopene and croceptin, which are useful as nutraceuticals, food colorants, and feed additives.
摘要翻译：一种制备类胡萝卜素的方法，其中该方法包括使双维t嗪缩合中的二烷氧基二醛与双维维特 - 霍纳缩合的鏻盐与膦酸酯反应。类胡萝卜素包括例如β-胡萝卜素，玉米黄质，角黄素，虾青素，番茄红素和croceptin，其可用作营养制品，食品着色剂和饲料添加剂。

39. 发明授权

US06254338B1 Water turbine or water pump 失效
标题翻译：水轮机或水泵
公开(公告)号：US06254338B1
公开(公告)日：2001-07-03
申请号：US09319783
申请日：1997-11-13
申请人： Andreas Keller
发明人： Andreas Keller
IPC分类号： F01D1712
CPC分类号： F03B3/126 , F03B3/123 , Y02E10/223
摘要： A water turbine or pump having a rotor (1) and a stator (2). The leading edges (13) and the trailing edges (14) at least of the rotor blades (6) form a bend (15) projecting in opposite relationship to the flow direction (12). That causes a flow force resulting in a self-cleaning effect being applied to impurities which are deposited at the leading edges (13). However the adjustment design providing for adjustability of the rotor blades remains substantially unchanged.
摘要翻译：一种具有转子（1）和定子（2）的水轮机或泵。至少转子叶片（6）的前缘（13）和后缘（14）形成与流动方向（12）成反向突出的弯曲部（15）。这导致流动力导致自清洁效应被施加到沉积在前缘（13）处的杂质。然而，提供转子叶片可调节性的调整设计基本上保持不变。

40. 发明授权

US4960521A Process for performing a dialysis operation using a magnetic weighted clamp 失效
标题翻译：使用磁加权夹具执行透析操作的过程
公开(公告)号：US4960521A
公开(公告)日：1990-10-02
申请号：US367338
申请日：1989-06-16
申请人： Andreas Keller
发明人： Andreas Keller
IPC分类号： B01D61/24 , B01D61/30 , B01D63/16
CPC分类号： B01D61/243 , B01D61/30 , B01D63/16 , Y10T24/15 , Y10T24/44752
摘要： An improved process for performing a dialysis operation and the magnetic weighted clamp used therewith. A dialysis sack is closed at one end with a weighted clamp which includes a magnetic bar. The closed sack is placed in a container filled with a dialysis buffer solution. The container is placed on a magnetic stir plate, and the clamp and dialysis sack are turned within the buffer solution so that the buffer at the surface of the dialysis sack is continuously renewed.
摘要翻译：用于进行透析操作的改进方法和与其一起使用的磁加权夹具。透析袋在一端用包括磁条的加重夹具封闭。将封闭的袋放在装有透析缓冲溶液的容器中。将容器放置在磁力搅拌板上，夹紧和透析袋在缓冲溶液内转动，使透析袋表面的缓冲液不断更新。

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