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31. 发明申请

US20120330409A1 Methods and Apparatus for Endovascularly Replacing a Patient's Heart Valve 审中-公开
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US20120330409A1
公开(公告)日：2012-12-27
申请号：US13591680
申请日：2012-08-22
申请人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
发明人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2230/0054 , A61F2250/0039
摘要： Methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an anchor to a vicinity of the heart valve, the anchor having a braid, and expanding the braid to a deployed configuration against the patient's tissue. The braid may be fabricated from a single strand of wire and/or may comprise at least one turn feature.
摘要翻译：血管内置换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和锚固件血管内输送到心脏瓣膜附近，锚具具有编织物，并且将编织物扩展到针对患者组织的展开构型。编织物可以由单股线制成和/或可以包括至少一个匝特征。

32. 发明授权

US08252052B2 Methods and apparatus for endovascularly replacing a patient's heart valve 有权
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US08252052B2
公开(公告)日：2012-08-28
申请号：US12028452
申请日：2008-02-08
申请人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn
发明人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2230/0054 , A61F2250/0039
摘要： Methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an anchor to a vicinity of the heart valve, the anchor having a braid, and expanding the braid to a deployed configuration against the patient's tissue. The braid may be fabricated from a single strand of wire and/or may comprise at least one turn feature.
摘要翻译：血管内置换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和锚固件血管内输送到心脏瓣膜附近，锚具具有编织物，并且将编织物扩展到针对患者组织的展开构型。编织物可以由单股线制成和/或可以包括至少一个匝特征。

33. 发明申请

US20120022642A1 Methods and Apparatus for Endovascularly Replacing a Patient's Heart Valve 审中-公开
公开(公告)号：US20120022642A1
公开(公告)日：2012-01-26
申请号：US13193312
申请日：2011-07-28
申请人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
发明人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2409 , A61F2/2415 , A61F2/2427 , A61F2/2436 , A61F2/2439 , A61F2210/0014 , A61F2230/0054 , A61F2230/0078 , A61F2250/0039
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an anchor having an expandable braid. In some embodiments, the expandable braid is fabricated from a single strand of wire. In some embodiments, the expandable braid comprises at least one turn feature. The anchor and the valve preferably are configured for endovascular delivery and deployment.

34. 发明授权

US08075614B2 Methods and apparatus for endovascularly replacing a patient's heart valve 有权
公开(公告)号：US08075614B2
公开(公告)日：2011-12-13
申请号：US11716123
申请日：2007-03-09
申请人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn
发明人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn
IPC分类号： A61F2/24
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an anchor having an expandable braid. In some embodiments, the expandable braid is fabricated from a single strand of wire. In some embodiments, the expandable braid comprises at least one turn feature. The anchor and the valve preferably are configured for endovascular delivery and deployment.

35. 发明申请

US20090264997A1 Everting Heart Valve 有权
标题翻译：永恒心脏瓣膜
公开(公告)号：US20090264997A1
公开(公告)日：2009-10-22
申请号：US12492512
申请日：2009-06-26
申请人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn , Kenneth J. Michlitsch
发明人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn , Kenneth J. Michlitsch
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.
摘要翻译：本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。在一些实施例中，替换阀不连接到锚的可膨胀部分。在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。在一些实施例中，锚固件包括由单股线制成的编织物。在一些实施例中，该装置包括被配置成保持锚固扩展的锁。本发明还包括用于血管内替代患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。

36. 发明申请

US20080125859A1 Methods and Apparatus for Endovascularly Replacing a Patient's Heart Valve 有权
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US20080125859A1
公开(公告)日：2008-05-29
申请号：US12028452
申请日：2008-02-08
申请人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn
发明人： Amr Salahieh , Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Dwight P. Morejohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2230/0054 , A61F2250/0039
摘要： Methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an anchor to a vicinity of the heart valve, the anchor having a braid, and expanding the braid to a deployed configuration against the patient's tissue. The braid may be fabricated from a single strand of wire and/or may comprise at least one turn feature.
摘要翻译：血管内置换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和锚固件血管内输送到心脏瓣膜附近，锚具具有编织物，并且将编织物扩展到针对患者组织的展开构型。编织物可以由单股线制成和/或可以包括至少一个匝特征。

37. 发明授权

US07329279B2 Methods and apparatus for endovascularly replacing a patient's heart valve 有权
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US07329279B2
公开(公告)日：2008-02-12
申请号：US10893143
申请日：2004-07-15
申请人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
发明人： Ulrich R. Haug , Hans F. Valencia , Robert A. Geshlider , Tom Saul , Amr Salahieh , Dwight P. Morejohn
IPC分类号： A61F2/24
CPC分类号： A61F2/2415 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2230/0054 , A61F2250/0039
摘要： Methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an anchor to a vicinity of the heart valve, the anchor having a braid, and expanding the braid to a deployed configuration against the patient's tissue. The braid may be fabricated from a single strand of wire and/or may comprise at least one the feature.
摘要翻译：血管内置换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和锚固件血管内输送到心脏瓣膜附近，锚具具有编织物，并且将编织物扩展到针对患者组织的展开构型。编织物可以由单股线制造和/或可以包括至少一个特征。

38. 发明授权

US07959666B2 Methods and apparatus for endovascularly replacing a heart valve 有权
标题翻译：血管内置换心脏瓣膜的方法和装置
公开(公告)号：US07959666B2
公开(公告)日：2011-06-14
申请号：US10982388
申请日：2004-11-05
申请人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
发明人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2439 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/90 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固体血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力，锚或锚的部分。本发明的另一方面提供了一种包括置换阀的装置; 锚点以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。

39. 发明申请

US20120016469A1 Methods and Apparatus for Endovascularly Replacing a Heart Valve 有权
标题翻译：血管内置换心脏瓣膜的方法和装置
公开(公告)号：US20120016469A1
公开(公告)日：2012-01-19
申请号：US13157733
申请日：2011-06-10
申请人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
发明人： Amr Salahieh , Jean-Pierre Dueri , Hans F. Valencia , Daniel Hildebrand , Brian D. Brandt , Dwight P. Morejohn , Claudio Argento , Tom Saul , Ulrich R. Haug
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2/2436 , A61F2/90 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固件血管内输送到心脏瓣膜附近的步骤; 以及在所述锚上施加外部非液压膨胀或非气动扩张的致动力以改变所述锚的形状，例如通过使用可释放的展开工具向所述锚上施加近端和/或远端定向的力，锚或锚的部分。本发明的另一方面提供了一种包括置换阀的装置; 锚点以及展开工具，其包括适于在锚上施加非液压膨胀或非气动膨胀的致动力的多个锚致动元件，以重构锚固件。

40. 发明授权

US07988724B2 Systems and methods for delivering a medical implant 有权
标题翻译：用于输送医疗植入物的系统和方法
公开(公告)号：US07988724B2
公开(公告)日：2011-08-02
申请号：US11706549
申请日：2007-02-14
申请人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
发明人： Amr Salahieh , Hans F. Valencia , Brian D. Brandt , Claudio Argento , Ulrich R. Haug , Jean-Pierre Dueri , Daniel Hildebrand , Dwight P. Morejohn , Tom Saul
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2427 , A61B17/0644 , A61B17/068 , A61B17/221 , A61B2017/22035 , A61B2017/2215 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2/90 , A61F2002/9534 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0078 , A61F2230/008 , A61F2250/001
摘要： The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.
摘要翻译：本发明涉及用于在患者的天然心脏瓣膜内和/或穿过患者的天然心脏瓣膜内血管内递送和释放假体（例如主动脉假体）的装置和方法，以下称为替换患者的心脏瓣膜。在一些实施例中，递送系统包括多个第一致动元件，其适于以第一构造接合多个第二元件以在输送系统内捕获植入物，并且其中多个第一可致动元件适于接合多个第二可动元件元件处于第二配置并且从输送系统释放植入物。

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