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31. 发明申请

US20050045238A1 Micro valve device 审中-公开
标题翻译：微型阀门装置
公开(公告)号：US20050045238A1
公开(公告)日：2005-03-03
申请号：US10926976
申请日：2004-08-27
申请人： Jing-Tang Yang , Jia-Hui Chen , Ker-Jer Huang , Alex Chen
发明人： Jing-Tang Yang , Jia-Hui Chen , Ker-Jer Huang , Alex Chen
IPC分类号： F15C5/00 , F16K99/00 , F15C1/06
CPC分类号： F16K99/0001 , F15C5/00 , F16K99/0017 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , Y10T137/2224
摘要： The present invention discloses a novel micro valve device, comprising a micro fluidic channel, which is formed by combining two hydrophobic plates, and the micro/nano structure on the wall surfaces of the channel are used to manipulate the mobility of the fluid in the channel. The function of the micro/nano structure mentioned above is to alter the micro or nano surface pattern on the wall surfaces of the channel. According to the relation between the surface pattern and the surface tension, the textured areas on the wall surfaces can change the mobility of the fluid in the channel. This effect is used as a switch in new types of micro valve devices for biomedical tests. Methods of making the micro valve device are described and include generating a micro/nano structure on the surfaces of the channel. The temporal control of different valve resistances can be achieved with different lengths, shapes, depths and materials of the micro/nano structures.
摘要翻译：本发明公开了一种新颖的微阀装置，其包括通过组合两个疏水板形成的微流体通道，并且通道的壁表面上的微/纳米结构用于操纵流体在通道中的流动性。上述微/纳米结构的功能是改变通道壁表面上的微观或纳米表面图案。根据表面图案和表面张力之间的关系，壁表面上的纹理化区域可以改变通道中流体的流动性。这种效应用作用于生物医学测试的新型微型阀装置中的开关。描述制造微型阀装置的方法，包括在通道的表面上产生微/纳米结构。可以通过微/纳米结构的不同长度，形状，深度和材料实现不同阀阻的时间控制。

32. 发明申请

US20050032804A1 Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor 有权
标题翻译：二肽基肽酶-IV抑制剂的磷酸盐
公开(公告)号：US20050032804A1
公开(公告)日：2005-02-10
申请号：US10874992
申请日：2004-06-23
申请人： Stephen Cypes , Alex Chen , Russell Ferlita , Karl Hansen , Ivan Lee , Vicky Vydra , Robert Wenslow
发明人： Stephen Cypes , Alex Chen , Russell Ferlita , Karl Hansen , Ivan Lee , Vicky Vydra , Robert Wenslow
IPC分类号： A61K31/498 , A61P3/10 , C07D487/04
CPC分类号： C07D487/04
摘要： The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure.
摘要翻译： 4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪-7（8H） - 基] -1-（ 2,4,5-三氟苯基）丁-2-胺是二肽基肽酶-IV的有效抑制剂，可用于预防和/或治疗非胰岛素依赖性糖尿病，也称为2型糖尿病。本发明还涉及磷酸二氢盐的结晶一水合物及其制备方法，含有这种新型形式的药物组合物和用于治疗糖尿病，肥胖症和高血压的方法。

33. 发明授权

US06755100B1 Tool having quick release and positive locking device 失效
标题翻译：工具具有快速释放和正锁定装置
公开(公告)号：US06755100B1
公开(公告)日：2004-06-29
申请号：US10328691
申请日：2002-12-23
申请人： Alex Chen
发明人： Alex Chen
IPC分类号： B25B2316
CPC分类号： B25B23/0021 , B25B23/0035 , Y10T403/598
摘要： A tool device includes a diagonally disposed groove and a channel formed in one end and communicating each other, and a latch pin and a button slidably received in the groove and the channel of the tool device. A spring may bias one end of the latch pin out and to engage into a tool member, and to detachably lock the tool device to the tool member. The latch pin may be easily disengaged from the tool member by depressing the button into the tool device. The button has a notch formed between two legs for slidably receiving the latch pin.
摘要翻译：工具装置包括对角设置的沟槽和形成在一端并彼此连通的通道，以及可滑动地容纳在凹槽中的闩锁销和按钮以及工具装置的通道。弹簧可以将闩锁销的一端偏压并接合到工具构件中，并将工具装置可拆卸地锁定到工具构件上。通过将按钮按压到工具装置中，可以容易地将闩锁销从工具部件脱离。按钮具有形成在两个腿之间的切口，用于可滑动地接收闩锁销。

34. 发明授权

US4978047A Device for facilitating the hammering of nail 失效
标题翻译：用于促进钉子锤击的装置
公开(公告)号：US4978047A
公开(公告)日：1990-12-18
申请号：US419673
申请日：1989-10-11
申请人： Alex Chen
发明人： Alex Chen
IPC分类号： B25C1/02 , B25C3/00
CPC分类号： B25C3/008 , B25C1/02
摘要： A device for facilitating the hammering of a nail including a substantially cylindrical outer casing having a first open end and a second open end. A striking pin having a first end with a rounded head provided thereon disposed to be struck by a hammer or the like. An inner tube is received in the outer casing and attached to the striking pin at a first end thereof. The inner tube is longitudinally slidable in the outer casing. Two flexible holding strips each having a concave portion are disposed to be pressed outwardly for receiving a nail to be hammered therebetween. A hammering pin is attached to a second end of the inner tube at a first end thereof. A second end of the hammering pin is disposed to abut the head of the nail to be hammered which is held by the concave portions of the two holding strips before hammering. Two springs are provided for repositioning the hammering pin, the inner tube and the striking pin after the hammering of the nail is completed.
摘要翻译：一种用于促进钉子锤击的装置，其包括具有第一开口端和第二开口端的基本上圆柱形的外壳。具有设置在其上的具有圆形头部的第一端的撞击销设置成被锤子等撞击。内管容纳在外壳中并在其第一端附接到打击销。内管可在外壳中纵向滑动。每个具有凹部的两个柔性保持条被设置成向外挤压以接收钉在其间的钉子。锤头在其第一端附接到内管的第二端。锤击销的第二端设置成在锤击之前抵靠被锤击的钉的头部，其被两个保持条的凹部保持。提供两个弹簧，用于在钉子敲击完成之后重新定位锤击销，内管和打击销。

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