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31. 发明授权

US4176186A Quaternary derivatives of noroxymorphone which relieve intestinal immobility 失效
标题翻译： noroxymorphone的第四纪衍生物可缓解肠道不动
公开(公告)号：US4176186A
公开(公告)日：1979-11-27
申请号：US928821
申请日：1978-07-28
申请人： Leon I. Goldberg , Herbert Merz , Klaus Stockhaus
发明人： Leon I. Goldberg , Herbert Merz , Klaus Stockhaus
IPC分类号： C07D489/08 , C07D489/00
CPC分类号： C07D489/08
摘要： Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, andX is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion;the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.
摘要翻译：其中R为烯丙基或相关基团如氯烯丙基，环丙基甲基或炔丙基，X为酸的阴离子，特别是氯离子，溴化物，碘化物或甲基硫酸根阴离子的式该化合物可预防或缓解麻醉止痛药的肠道迁移性抑制副作用，而不会影响麻醉止痛药的止痛活性。

32. 发明授权

US4100288A N-Tetrahydrofurfuryl-noroxymorphones, their salts, and analgesic compositions and methods employing them 失效
标题翻译： N-四氢糠基 - 去甲羟基苯甲酸，它们的盐和止痛剂组合物和使用它们的方法
公开(公告)号：US4100288A
公开(公告)日：1978-07-11
申请号：US714045
申请日：1976-08-13
申请人： Herbert Merz , Gerhard Walther , Adolf Langbein , Klaus Stockhaus , Helmut Wick
发明人： Herbert Merz , Gerhard Walther , Adolf Langbein , Klaus Stockhaus , Helmut Wick
IPC分类号： C07D489/02 , A61K31/47 , A61K31/485 , A61P25/04 , A61P25/30 , C07D489/08
CPC分类号： C07D489/08
摘要： Diastereoisomers of the compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof; the isomers as well as their salts are useful as analgesics and morphine-antagonists.
摘要翻译：式“化合物”的非对映异构体及其无毒的药学上可接受的酸加成盐; 异构体及其盐可用作镇痛药和吗啡拮抗剂。

33. 发明授权

US4087532A Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof 失效
标题翻译：止痛有用的2-四氢糠基-5-低级烷基-2-氧基-6,7-苯并吗啡及其盐
公开(公告)号：US4087532A
公开(公告)日：1978-05-02
申请号：US673116
申请日：1976-04-02
申请人： Herbert Merz , Adolf Langbein , Gerhard Walther , Klaus Stockhaus
发明人： Herbert Merz , Adolf Langbein , Gerhard Walther , Klaus Stockhaus
IPC分类号： C07D221/26 , A61K31/445
CPC分类号： C07D221/26
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl, andR.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.
摘要翻译：其中R 1是甲基，乙基或丙基，R 2是氢，甲基或乙基，R 3是氢或甲基，R 4是氢，1至4个碳原子的烷基或2至5个碳原子的烷酰基，和非毒性，药理学上可接受的酸添加量; 该化合物作为盐作为有用的方法。

34. 发明授权

US3987031A Acyl derivatives of proscillaridin A 失效
标题翻译：青蒿素A的ACYL衍生物
公开(公告)号：US3987031A
公开(公告)日：1976-10-19
申请号：US421751
申请日：1973-12-05
申请人： Walter Losel , Herbert Merz , Wolfgang Hoefke , Werner Traunecker
发明人： Walter Losel , Herbert Merz , Wolfgang Hoefke , Werner Traunecker
IPC分类号： C07J19/00
摘要： Compounds of the formula ##SPC1##Wherein R.sub.3 is hydrogen, methyl, cyclopropylcarbonyl, benzoyl or thenoyl, andWhen R.sub.3 is hydrogen, R.sub.2 is phenyl, phenethyl, phenyl-propyl, chloro-propyl, chloro-phenyl, fluoro-phenyl, cycloalkyl of 3 to 8 carbon atoms or (cycloalkyl of 5 to 6 carbon atoms)-methyl, orWhen R.sub.3 is other than hydrogen, R.sub.2 is methyl, ethyl, phenyl, cyclopropyl or chloropropyl; the compounds are useful as cardiotonics.

35. 发明授权

US3932626A Pharmaceutical compositions containing a carboxylic acyl derivative of digoxin and method of use 失效
标题翻译：含有地高辛的羧酰基衍生物的药物组合物及其使用方法
公开(公告)号：US3932626A
公开(公告)日：1976-01-13
申请号：US433663
申请日：1974-01-16
申请人： Walter Losel , Herbert Merz , Wolfgang Hoefke , Werner Traunecker
发明人： Walter Losel , Herbert Merz , Wolfgang Hoefke , Werner Traunecker
IPC分类号： A61K31/075 , A61K31/705
CPC分类号： A61K31/7048
摘要： Pharmaceutical dosage unit compositions containing as an active ingredient a compound of the formula ##SPC1##Wherein R.sub.1 is alkyl of 2 to 12 carbon atoms, halo-(alkyl of 1 to 4 carbon atoms), aryl-(alkyl of 1 to 4 carbon atoms), cycloalkyl-(alkyl of 1 to 4 carbon atoms) or cycloalkyl of 3 to 8 carbon atoms; and a method of using the same as cardiotonics.
摘要翻译：含有下式化合物的化合物的药物剂量单位组合物，其中R 1为2至12个碳原子的烷基，卤代（1至4个碳原子的烷基），芳基 - （1至4个碳原子的烷基），环烷基（1〜4个碳原子的烷基）或3〜8个碳原子的环烷基; 以及使用它们作为强心剂的方法。

36. 发明授权

US5326647A Abradable layer for a turbo-engine and a manufacturing process 失效
标题翻译：用于涡轮发动机的可磨损层和制造过程
公开(公告)号：US5326647A
公开(公告)日：1994-07-05
申请号：US64149
申请日：1993-05-17
申请人： Herbert Merz , Wolfgang Weiler
发明人： Herbert Merz , Wolfgang Weiler
IPC分类号： B22F7/06 , B22F8/00 , B32B15/01 , C23C26/00 , F01D5/28 , F01D11/02 , F01D11/08 , F01D11/12 , F16J15/447 , B32B5/02 , B22F3/26
CPC分类号： B32B15/018 , F01D11/02 , F01D11/125 , F01D5/288 , Y10T428/12424 , Y10T428/12444
摘要： An abradable layer for labyrinth seals of a turbo-engine, particularly a gas turbine is provided. The labyrinth is made of a layered composite material with a core and a shell and embedments. A process for the manufacturing of this abradable layer is provided. In this case, the core is made of a felted or three-dimensionally crosslinked fiber body made of iron base, nickel base or cobalt base alloys and the shell consists of one or several precious metals or precious-metal alloys. Each core is completely surrounded by the shell material, in which case the embedments consist of oxidation-stable sliding materials of the oxide, carbide or nitride group with a hexagonal crystal lattice layer structure.
摘要翻译： PCT No.PCT / EP92 / 01812 Sec。 371日期：1993年5月17日 102（e）日期1993年5月17日PCT提交1992年8月8日PCT公布。公开号WO93 / 06341 日期为1993年4月1日。提供涡轮发动机，特别是燃气轮机的迷宫式密封件的耐磨层。迷宫由具有芯和壳和嵌入物的分层复合材料制成。提供了制造这种可磨损层的方法。在这种情况下，芯由铁基，镍基或钴基合金制成的毡状或三维交联纤维体制成，壳由一种或几种贵金属或贵金属合金组成。每个芯完全被壳材料包围，在这种情况下，嵌入体由具有六方晶格子层结构的氧化物，碳化物或氮化物基团的氧化稳定的滑动材料组成。

37. 发明授权

US4966527A Composite blade construction for a propeller or rotor blade 失效
标题翻译：用于螺旋桨或转子叶片的复合叶片结构
公开(公告)号：US4966527A
公开(公告)日：1990-10-30
申请号：US389333
申请日：1989-08-03
申请人： Herbert Merz
发明人： Herbert Merz
IPC分类号： B64C11/20 , B29C70/06 , B29C70/20 , B29C70/30 , B29C70/86 , B29D99/00 , B29K103/04 , B29K105/08 , B29L31/08 , B63H1/26 , B64C11/26 , F01D5/30
CPC分类号： B29D99/0025 , B29C70/202 , B29C70/30 , B29C70/865 , B63H1/26 , B64C11/26 , F01D5/30 , F01D5/3053 , Y02T50/66 , Y02T50/672 , Y02T50/673
摘要： A composite propeller blade construction has fiber strands extending predominantly in a radial direction and looping around mounting hardware connecting a blade root to a rotor hub. The mounting hardware includes at least one bolt secured to the rotor hub or a shackle member secured to the hub by a mounting bolt and holding a tying bolt so that fiber strand loops forming the blade body loop around the shackle member and around free ends of the tying bolt. The radially extending fiber strands take up centrifugal forces and are enclosed by a jacket, the radially inner end of which is formed as mounting flanges screwed to a respective rim of the hub. The arrangement of the fiber loops is especially suitable for a fiber composite lightweight construction wherein the fibers form redundant load take-up paths and provide an advantageous centrifugal force and moment introduction into the structure.
摘要翻译：复合螺旋桨叶片结构具有主要在径向方向上延伸的纤维束，并围绕将叶片根部连接到转子毂的安装硬件。安装硬件包括固定到转子轮毂的至少一个螺栓或通过安装螺栓固定到轮毂的钩环构件，并且保持捆扎螺栓，使得形成叶片本体的纤维束回路环绕钩环构件环绕着钩环构件的自由端绑螺栓径向延伸的纤维束吸收离心力并且被套管包围，护套的径向内端形成为安装凸缘，该安装凸缘螺合到毂的相应边缘。纤维环的布置特别适合于纤维复合轻质结构，其中纤维形成冗余的载荷牵引路径并提供有利的离心力和力矩引入结构。

38. 发明授权

US4699910A N-(3-trifluoromethyl-phenyl)-N'-propargyl-piperazine and salts thereof useful as analgesics 失效
标题翻译： N-（3-三氟甲基 - 苯基）-N'-炔丙基 - 哌嗪及其盐可用作止痛剂
公开(公告)号：US4699910A
公开(公告)日：1987-10-13
申请号：US800525
申请日：1985-11-22
申请人： Rolf Banholzer , Herbert Merz , Klaus Stockhaus , Hans M. Jennewein
发明人： Rolf Banholzer , Herbert Merz , Klaus Stockhaus , Hans M. Jennewein
IPC分类号： C07D295/02 , A61K31/495 , A61P25/04 , C07D241/08 , C07D295/04 , C07D295/06 , C07D295/073 , A61K31/505 , C07D241/04
CPC分类号： C07D295/073 , C07D241/08
摘要： The compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compound as well as its salts are useful as analgesics.
摘要翻译：式“IMAGE”的化合物及其无毒的药学上可接受的酸加成盐。该化合物及其盐可用作止痛剂。

39. 发明授权

US4575327A Enclosure for the hot-isostatic pressing of highly stressed workpieces of complex shape for turbomachines 失效
标题翻译：用于涡轮机的复杂形状的高应力工件的热等静压的外壳
公开(公告)号：US4575327A
公开(公告)日：1986-03-11
申请号：US465104
申请日：1983-02-09
申请人： Barbara Borchert , Herbert Schmid , Werner Huther , Herbert Merz
发明人： Barbara Borchert , Herbert Schmid , Werner Huther , Herbert Merz
IPC分类号： B22F3/12 , B22F5/04 , F01D5/28 , B22F3/14
CPC分类号： F01D5/28 , B22F3/1283 , B22F3/1291 , B22F5/04 , B22F2003/1046 , B22F2999/00
摘要： A mold comprising a core which is open at one end and has the negative contour of the workpiece and a sheet-metal outer container surrounding the core. High dimensional stability of the core, easy removability of the workpiece from the mold and a smoother surface of the workpiece are obtained by isostatic pressing of titanium powder in the spaces in the mold. The core consists, at least at its negative contour surface for the workpiece, of a high-temperature alloy, particularly one having a base of nickel or iron. This and the titanium powder material of the workpiece are neutral in chemical reaction and low in or free of diffusion with respect to each other upon the hot isostatic pressing. The core is in the form of a ring of segments surrounded by a solid holding ring.
摘要翻译：一种模具，其包括在一端开口且具有所述工件的负轮廓的芯，以及围绕所述芯的片金属外容器。通过在模具的空间中等压等压钛粉，获得了芯的高尺寸稳定性，工件从模具的易移除性和工件平滑的表面。核心至少在工件的负轮廓表面上包括高温合金，特别是具有镍或铁基体的高温合金。这和工件的钛粉末材料在化学反应中是中性的，并且在热等静压时相对于彼此低或不扩散。芯是由固体保持环包围的环形环的形式。

40. 发明授权

US4536127A Turbocompressor provided with an abradable coating 失效
标题翻译：涡轮压缩机配有耐磨涂层
公开(公告)号：US4536127A
公开(公告)日：1985-08-20
申请号：US605773
申请日：1984-05-01
申请人： Axel Rossmann , Herbert Merz
发明人： Axel Rossmann , Herbert Merz
IPC分类号： F01D11/12 , F16J15/16
CPC分类号： F01D11/122 , Y10S277/936
摘要： An improvement for a turbocompressor having a rotor, a stator and a casing, and an abradable coating provided between the rotor blades and the casing, or between the stator vanes and the rotor, such that the blades make initial contact with the coating to abrade the coating and produce a minimal clearance. The abradable coating is formed on a member having a first layer of carbon-fiber reinforced graphite adapted for attaching the coating member to the casing or rotor, and a second layer of graphite in the region in which the blade tips are intended to rub. The second layer may optionally contain, preferably radially oriented brush-type graphite-fiber reinforcements, or be entirely composed thereof.
摘要翻译：具有转子，定子和壳体的涡轮压缩机的改进以及设置在转子叶片和壳体之间或定子叶片和转子之间的可磨损涂层，使得叶片与涂层初始接触以磨损涂层并产生最小间隙。可磨损涂层形成在具有适于将涂层构件附接到壳体或转子的第一碳纤维增强石墨层的构件上，以及在叶片尖端要被摩擦的区域中的第二石墨层。第二层可以可选地包含优选径向定向的刷式石墨纤维增强件，或者完全由其构成。

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