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31. 发明专利

AT298337T 未知
公开(公告)号：AT298337T
公开(公告)日：2005-07-15
申请号：AT00981994
申请日：2000-11-16
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , MULLEN GEORGE , PHILLIPS EIFION , SCHMIESING RICHARD
IPC分类号： A61K31/40 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/46 , A61P1/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00 , C07D451/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： Compounds of the general formula Iwherein A represents:D represents oxygen, or sulfur and R , R and R are as defined in the specification, enantiomers thereof, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

32. 发明专利

NZ518571A New use and novel N-azabicyclo-amide derivatives 未知
公开(公告)号：NZ518571A
公开(公告)日：2004-05-28
申请号：NZ51857100
申请日：2000-11-16
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , MULLEN GEORGE , PHILLIPS EIFION , SCHMIESING RICHARD
IPC分类号： A61K31/40 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/46 , A61P1/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00 , C07D451/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： A compound, an enantiomer or a pharmaceutically acceptable salt thereof has the formula (I) wherein: A is a group of formula (II) to (VI); D is oxygen, or sulphur; R1 is hydrogen or methyl; R2 is hydrogen, or alkyl; R3 is a group of formula (2) to (4); R4, R5, and R6 are independently hydrogen, halogen, alkyl, alkenyl, alkynyl, -CO2R7, -CN, -CF3, or Ar; Ar is an optionally substituted 5 or 6 membered aromatic or heteroaromatic ring containing 0 to 3 nitrogen, 0 or 1 oxygen and 0 or 1 sulphur or is a 8 to 10 membered fused aromatic or heteroaromatic ring system ring containing 0 to 4 nitrogen, 0 or 1 oxygen and 0 or 1 sulphur; R7 is as defined in the specification; With the proviso that Ar is not 2-, 3- or 4-pyridyl or optionally substituted phenyl, when A is a group of formula II or VI, R3 is a group of formula (2), D is oxygen, R2 and R5 is H and R6 is H, alkyl, phenyl or cyano and also provided that the compound is not N-(1-azabicyclo[2.2.2]oct-3-yl)-3-trifluoromethyl-cinnamamide, ethyl-3-[2-(3-quinclidinecarbamoyl)ethenyl]-4,6-dichloro-2-carboxylate or 2-N-butyl-N-(8-methyl-8-azabicyclo[3.2.1]-oct-3-yl)-3-phenyl-propenamide. The compound is useful for treatment or prophylaxis of human diseases or conditions in which activation of the a7 nicotinic acetylcholine receptor is beneficial such as Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Attention Deficit Hyperactivity Disorder, anxiety, schizophrenia, or mania or manic depression, Lewy Body Dementia, Parkinson's disease, Huntington's disease, Tourette's syndrome, neurodegenerative disorders in which there is loss of cholinergic synapse, jetlag, cessation of smoking, nicotine addiction including that resulting from exposure to products containing nicotine, pain, or ulcerative colitis.

33. 发明专利

HU0204245A2 NOVEL N-AZABICYCLO-AMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE 未知
公开(公告)号：HU0204245A2
公开(公告)日：2003-03-28
申请号：HU0204245
申请日：2000-11-16
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , MULLEN GEORGE , PHILLIPS EIFION , SCHMIESING RICHARD
IPC分类号： A61K31/40 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/46 , A61P1/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00 , C07D451/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： Compounds of the general formula Iwherein A represents:D represents oxygen, or sulfur and R , R and R are as defined in the specification, enantiomers thereof, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

34. 发明专利

BG106680A NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES 未知
公开(公告)号：BG106680A
公开(公告)日：2003-01-31
申请号：BG10668002
申请日：2002-05-09
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , MULLEN GEORGE , PHILLIPS EIFION , SCHMIESING RICHARD
IPC分类号： A61K31/40 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/46 , A61P1/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00 , C07D451/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： The invention relates to new use of a compound of general formula werein: A represents D represents oxygen, or sulfur; R1 represents hydrogen or methyl; R2 represents hydrogen, or C1-C4 alkyl; and R3 represents or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment of or prophylaxis of psychotic disorder and intellectual impairment disorders. 42 claims

35. 发明专利

BR0015624A 未知
公开(公告)号：BR0015624A
公开(公告)日：2002-07-30
申请号：BR0015624
申请日：2000-11-16
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , MULLEN GEORGE , PHILLIPS EIFION , SCHMIESING RICHARD
IPC分类号： A61K31/40 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/46 , A61P1/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00 , C07D451/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： Compounds of the general formula Iwherein A represents:D represents oxygen, or sulfur and R , R and R are as defined in the specification, enantiomers thereof, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

36. 发明专利

IS6385A Ný notkun og nýjar N-asabísýkló-amíð afleiður 未知
公开(公告)号：IS6385A
公开(公告)日：2002-05-15
申请号：IS6385
申请日：2002-05-15
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , MULLEN GEORGE , PHILLIPS EIFION , SCHMIESING RICHARD
IPC分类号： A61K31/40 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/46 , A61P1/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00 , C07D451/04 , C07D453/02 , C07D453/06 , C07D487/08

37. 发明专利

CA2389604A1 NEW USE AND NOVEL N-AZABICYCLO-AMIDE DERIVATIVES 未知
公开(公告)号：CA2389604A1
公开(公告)日：2001-05-25
申请号：CA2389604
申请日：2000-11-16
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , PHILLIPS EIFION , MULLEN GEORGE , SCHMIESING RICHARD
IPC分类号： A61K31/40 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/46 , A61P1/04 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/34 , A61P29/00 , A61P43/00 , C07D451/04 , C07D453/02 , C07D453/06 , C07D487/08
摘要： This invention relates to new use of a compound of general formula (I) wherein: A represents (II), (III), (IV), (V), (VI); D represents oxygen, or sulfur; R1 represents hydrogen or methyl; R2 represents hydrogen, or C1-C4 alkyl; and R3 represents (A), (B), (C), or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment of prophylaxis of psychotic disorders and intellectual impairment disorders.

38. 发明专利

DE69516524T2 未知
公开(公告)号：DE69516524T2
公开(公告)日：2001-01-18
申请号：DE69516524
申请日：1995-08-22
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , GORDON CHARLES , GRIFFITH CONRAD , MURRAY JOHN
IPC分类号： A61K31/42 , A61K31/424 , A61K31/439 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D20060101 , C07D453/02 , C07D487/08 , C07D498/20
摘要： There are provided new compounds of formula I: wherein R represents hydrogen or methyl; and n represents 1 or 2; or a pharmaceutically acceptable acid addition salt thereof, together with processes for preparing them, compositions containing them and their use in therapy. Compounds of formula I are expected to be useful in the treatment of psychotic disorders, intellectual impairment disorders and anxiety.

39. 发明专利

PT777671E 未知
公开(公告)号：PT777671E
公开(公告)日：2000-08-31
申请号：PT95930755
申请日：1995-08-22
申请人： ASTRAZENECA AB
发明人： BALESTRA MICHAEL , GORDON JOHN CHARLES , GRIFFITH RONALD CONRAD , MURRAY ROBERT JOHN
IPC分类号： A61K31/42 , A61K31/424 , A61K31/439 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D20060101 , C07D453/02 , C07D487/08 , C07D498/20
摘要： There are provided new compounds of formula I: wherein R represents hydrogen or methyl; and n represents 1 or 2; or a pharmaceutically acceptable acid addition salt thereof, together with processes for preparing them, compositions containing them and their use in therapy. Compounds of formula I are expected to be useful in the treatment of psychotic disorders, intellectual impairment disorders and anxiety.

40. 发明专利

ES2894903T3 Profármacos antagonistas de NMDA 未知
公开(公告)号：ES2894903T3
公开(公告)日：2022-02-16
申请号：ES19166031
申请日：2014-10-30
申请人： ASTRAZENECA AB
发明人： NORDVALL GUNNAR , HÖGDIN KATHARINA , MALMBORG PER JONAS , KERS ANNIKA , WEIGELT DIRK , BERNSTEIN PETER , QUIRK MICHAEL , BALESTRA MICHAEL
IPC分类号： C07D401/14 , A61K31/4402 , A61K31/4439 , A61P25/24 , C07D213/40 , C07D401/12
摘要： Una composición farmacéutica que comprende un compuesto de fórmula (I): **(Ver fórmula)** en la que R1 es **(Ver fórmula)** en la que AA es un aminoácido natural enlazado con enlaces peptídicos, o una sal farmacéuticamente aceptable del mismo, en asociación con un adyuvante,un diluyente o un vehículo farmacéuticamente aceptables.

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