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31. 发明申请

WO2006078444A1 DELIVERY OF THERAPEUTIC THROUGH MULTIPLE DELIVERY MEMBERS 审中-公开
标题翻译：通过多个交付成员交付治疗
公开(公告)号：WO2006078444A1
公开(公告)日：2006-07-27
申请号：PCT/US2006/000062
申请日：2006-01-03
申请人： BOSTON SCIENTIFIC SCIMED, INC. , FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy , SHAW, William, J.
发明人： FREYMAN, Toby , PALASIS, Maria , NAIMARK, Wendy , SHAW, William, J.
IPC分类号： A61M25/00 , A61M25/10 , A61M5/32
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/0071 , A61M25/0074 , A61M25/0084 , A61M25/10 , A61M2025/0058 , A61M2025/0076 , A61M2025/0079 , A61M2025/0085 , A61M2025/0681
摘要： Embodiments of the present application regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices (140) for the delivery of therapeutic or other substances. This apparatus may include a first catheter (120) ; a second catheter (130) in the first catheter and a multiple delivery member injection device (140) . This multiple delivery member may include an expandable member and a plurality of injection elements (220-224). A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes (230-234) connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic .
摘要翻译：本申请的实施方案涉及治疗的递送。一种这样的装置可以包括用于递送治疗剂或其它物质的多个独立激活的注射装置（140）。该装置可包括第一导管（120）; 第一导管中的第二导管（130）和多个递送部件注射装置（140）。该多个传送构件可以包括可扩张构件和多个注射元件（220-224）。第三导管可以定位在第二导管中。该第三导管可以具有连接到可扩张构件的壁的远端和连接到第三导管的远端的多个填充管（230-234）。在一些实施方案中，每个注射元件可以在释放治疗剂之前保持加压治疗。

32. 发明申请

WO2005097677A1 EMBOLIZATION 审中-公开
标题翻译：栓塞
公开(公告)号：WO2005097677A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/009851
申请日：2005-03-24
申请人： BOSTON SCIENTIFIC SCIMED, INC. , KAMATH, Kalpana , FREYMAN, Toby , MISHRA, Shubhang
发明人： KAMATH, Kalpana , FREYMAN, Toby , MISHRA, Shubhang
IPC分类号： C01B33/12
CPC分类号： A61L24/0089 , A61B17/12022 , A61B17/12109 , A61B17/12186 , A61K49/0002 , A61L24/001 , A61L31/128 , A61L31/14 , A61L31/18 , A61L2430/36 , C01B33/124
摘要： Embolization, as well as related particles, compositions and methods are disclosed. The particles are substantially spherical porous silica particles having a diameter of from about 100 µm to about 3000 µm.
摘要翻译：公开了栓塞，以及相关的颗粒，组合物和方法。颗粒是直径为约100μm至约3000μm的基本上球形的多孔二氧化硅颗粒。

33. 发明申请

WO2005091834A3 COATED MEDICAL DEVICE AND METHOD FOR MANUFACTURING THE SAME 审中-公开
公开(公告)号：WO2005091834A3
公开(公告)日：2005-10-06
申请号：PCT/US2005/004982
申请日：2005-02-17
申请人： BOSTON SCIENTIFIC LIMITED , AUSTIN, Michael , ROBINSON, Don , BOULAIS, Dennis, R. , KULKARNI, Praveen , FREYMAN, Toby , EPSTEIN, Samuel, J. , NAIMARK, Wendy , SCHWARZ, Marlene
发明人： AUSTIN, Michael , ROBINSON, Don , BOULAIS, Dennis, R. , KULKARNI, Praveen , FREYMAN, Toby , EPSTEIN, Samuel, J. , NAIMARK, Wendy , SCHWARZ, Marlene
IPC分类号： A61F2/06
摘要： A medical device in the form of a stent (10) having struts (11) is disclosed. The stent (10) includes an outermost portion (43) having plurality of depressions (45) on the struts (11). The depressions (45) occupy at least about 80% of the surface area of the surface. The depressions (45) contain a coating material (77) that preferably includes a biologically active material and/or polymer where the outermost portion (43) is free of coating material (77).

34. 发明申请

WO2005037444A1 METHOD FOR ROLL COATING MULTIPLE STENTS 审中-公开
标题翻译：用于多层涂层的方法
公开(公告)号：WO2005037444A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/030973
申请日：2004-09-22
申请人： SCIMED LIFE SYSTEMS, INC. , PALASIS, Maria , NAIMARK, Wendy , MICKLEY, Tim , FREYMAN, Toby
发明人： PALASIS, Maria , NAIMARK, Wendy , MICKLEY, Tim , FREYMAN, Toby
IPC分类号： B05B13/02
CPC分类号： B05D1/02 , A61L31/08 , B05B13/0235 , B05C3/10 , B05D1/002 , B05D2258/00
摘要： An improved method for high-volume production of coated stents with highly uniform stent coatings using a roll coating technique is provided. In a first embodiment, uncoated stents (8) are placed onto rotating stent holders with automated stent handling equipment. The holders are mounted on an endless conveyer belt (1) which advances the stents toward a stent coater. As the stents (8) advance through the coater (9), the holders (7) rotate, thereby rolling the stents (8) about their longitudinal axes as coating material is sprayed toward them, ensuring the stents (8) are uniformly coated on their exterior and interior surfaces. After the conveyer (1) turns to carry the coated stents (8) back toward the loading area, the rotating stents (8) pass again through the coating spray, downstream of the initial coating location, thereby increasing the efficient utilization of the coating material. The conveyer (1) then advances the coated stents to an unloading area for removal before the holders return to the stent loading area to receive new stents.
摘要翻译：提供了一种用于使用辊涂技术高度均匀的支架涂层的大量生产涂层支架的改进方法。在第一实施例中，将未涂覆的支架（8）放置在具有自动支架处理设备的旋转支架支架上。保持器安装在环形输送带（1）上，使得支架朝向支架式涂布机前进。当支架（8）通过涂布机（9）前进时，保持器（7）旋转，从而当涂覆材料向其喷射时，将支架（8）围绕其纵向轴线滚动，确保支架（8）均匀地涂覆在他们的外表和内表面。在输送器（1）转动后将涂覆的支架（8）运送回装载区域之后，旋转的支架（8）再次通过涂层喷涂，在初始涂覆位置的下游，从而增加涂层材料的有效利用。然后，输送机（1）将涂覆的支架前进到卸载区域以便在保持器返回到支架装载区域之前进行移除以接收新的支架。

35. 发明申请

WO2005018725A1 DEVICE AND METHOD FOR DIRECT DELIVERY OF A THERAPEUTIC USING NON-NEWTONIAN FLUIDS 审中-公开
标题翻译：使用非牛顿流体直接输送治疗药物的装置和方法
公开(公告)号：WO2005018725A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/025910
申请日：2004-08-12
申请人： SCIMED LIFE SYSTEMS, INC. , EPSTEIN, Samuel, J. , NAIMARK, Wendy , FREYMAN, Toby
发明人： EPSTEIN, Samuel, J. , NAIMARK, Wendy , FREYMAN, Toby
IPC分类号： A61M25/00
CPC分类号： A61M25/00 , A61M25/0023 , A61M25/0068 , A61M25/0074 , A61M25/0082 , A61M2025/0057 , A61M2025/0073
摘要： A device for direct delivery of a non-Newtonian fluid having therapeutic properties to a target site comprises a channel (11) having a proximal end (11a) and a distal end (11b) and a lumen (11c) extending therethrough, the channel containing a non Newtonian fluid to a viscosity adjuster (12).
摘要翻译：用于将具有治疗性质的非牛顿流体直接递送到目标部位的装置包括具有近端（11a）和远端（11b）的通道（11）和延伸穿过其中的内腔（11c），所述通道包含将非牛顿流体输送到粘度调节器（12）。

36. 发明申请

WO2005009497A1 DECELLULARIZED EXTRACELLULAR MATRIX OF CONDITIONED BODY TISSUES AND USES THEREOF 审中-公开
标题翻译：调节身体组织的细胞外细胞基质及其用途
公开(公告)号：WO2005009497A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/023187
申请日：2004-07-16
申请人： SCIMED LIFE SYSTEMS, INC. , FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
发明人： FREYMAN, Toby , NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61L27/38
CPC分类号： A61L27/3683 , A61K35/12 , A61L27/3633 , A61L2430/40 , C12N5/0679 , C12N2510/00
摘要： The present invention relates generally to decellularized extracellular matrix of conditioned body tissues. The decellularized extracellular matrix contains a biological material, preferably vascular endothelial growth factor (VEGF), produced by the conditioned body tissue that is in an amount different than the amount of the biological material that the body tissue would produce absent the conditioning. The invention also relates to methods of making and methods of using said decellularized extracellular matrix. Specifically, the invention relates to treating defective, diseased, damaged or ischemic cells, tissues or organs in a subject by administering, injecting or implanting the decellularized extracellular matrix of the invention into a subject in need thereof. The invention is further directed to a tissue regeneration scaffold for implantation into a subject inflicted with a disease or condition that requires tissue or organ repair, regeneration and/or strengthening. Additionally, the invention is directed to a medical device, preferably a stent or an artificial heart, having a surface coated or covered with the decellularized extracellular matrix of the invention or having a component comprising the decellularized extracellular matrix of the invention for implantation into a subject, preferably a human. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of conditioned body tissues are also provided.
摘要翻译：本发明一般涉及条件性身体组织的脱细胞细胞外基质。脱细胞的细胞外基质包含生物材料，优选血管内皮生长因子（VEGF），其由条件的身体组织产生，其量不同于身体组织在没有调理的情况下将产生的生物材料的量。本发明还涉及制备方法和使用所述脱细胞的细胞外基质的方法。具体地，本发明涉及通过将本发明的脱细胞的细胞外基质施用，注射或植入有需要的受试者来治疗受试者中的有缺陷，患病，损伤或缺血的细胞，组织或器官。本发明进一步涉及用于植入患有需要组织或器官修复，再生和/或加强的疾病或病症的受试者的组织再生支架。另外，本发明涉及一种医疗装置，优选支架或人造心脏，其具有被本发明的脱细胞细胞外基质包被或覆盖的表面，或者具有包含本发明的脱细胞的细胞外基质的组分用于植入受试者，优选人。还提供了用于制备组织再生支架的方法和用于制造具有包括经脱细胞的细胞外细胞外基质的组分的涂覆或覆盖的医疗装置的方法。

37. 发明申请

WO2005000381A1 DEVICE AND METHOD FOR DELIVERING MICRONIZED THERAPEUTIC AGENTS IN THE BODY 审中-公开
标题翻译：用于在体内递送微波治疗剂的装置和方法
公开(公告)号：WO2005000381A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/014956
申请日：2004-05-13
申请人： SCIMED LIFE SYSTEMS, INC. , PALASIS, Maria , NAIMARK, Wendy , FREYMAN, Toby , EPSTEIN, Samuel
发明人： PALASIS, Maria , NAIMARK, Wendy , FREYMAN, Toby , EPSTEIN, Samuel
IPC分类号： A61M5/00
CPC分类号： A61M11/06 , A61M25/0054 , A61M2025/0057
摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.
摘要翻译：本发明提供了一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。微粉化治疗剂以气溶胶形式或干粉形式递送。本发明还提供了一种通过将治疗剂置于导管中将微粉化治疗剂递送至靶部位的方法，将导管定位在靶部位，并将治疗剂暴露于足以产生超音速流动的激励机制将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

38. 发明申请

WO2014152742A2 DELIVERY SYSTEM FOR IN SITU FORMING FOAMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：原位形成泡沫的输送系统及其使用方法
公开(公告)号：WO2014152742A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/027683
申请日：2014-03-14
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , BUSOLD, Rany , RAGO, Adam , ZUGATES, Gregory, T. , FREYMAN, Toby , MILLER, Lisette, Manrique
发明人： SHARMA, Upma , BUSOLD, Rany , RAGO, Adam , ZUGATES, Gregory, T. , FREYMAN, Toby , MILLER, Lisette, Manrique
IPC分类号： A61B17/00
CPC分类号： A61B17/00491 , A61B2017/00398 , A61B2017/00495 , A61B2017/00544 , A61B2017/00548 , A61B2017/8838 , A61C9/0026 , A61M5/1409 , A61M5/1452 , A61M5/16804 , A61M5/19 , A61M13/003 , A61M2205/103 , B01F3/04453 , B01F5/0602 , B01F5/0604 , B01F7/00558 , B01F7/00583 , B01F13/0023 , B01F15/00253 , B01F15/00525 , B01F15/0279 , B05B7/0037 , B05B7/2421 , B05B7/2472 , B05C17/00553 , B65D81/325
摘要： Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
摘要翻译：提供了原位形成泡沫配方的输送系统。这些装置可以包括各种致动机构并且可以以各种方式将空气带入流体制剂组分中，包括与空气混合并添加压缩气体。

39. 发明申请

WO2014004160A1 IN-SITU FORMING FOAMS FOR TREATMENT OF ANEURYSMS 审中-公开
标题翻译：治疗原发性疾病的现状
公开(公告)号：WO2014004160A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/046281
申请日：2013-06-18
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , ZUGATES, Gregory, T. , BUSOLD, Rany , FREYMAN, Toby
发明人： SHARMA, Upma , ZUGATES, Gregory, T. , BUSOLD, Rany , FREYMAN, Toby
IPC分类号： A61L31/06 , A61L31/14 , C08L75/02
CPC分类号： A61L24/0036 , A61L24/046 , A61L2430/36 , C08G18/7621 , C08G18/7664 , C08G2101/0083 , C08L75/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms are disclosed. The systems include an insertable medical device and an in-situ forming foam that is formed from a polymer that reacts in an aqueous environment. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译：公开了与用于治疗动脉瘤的原位形成聚合物泡沫有关的系统，方法和试剂盒。该系统包括可插入的医疗装置和由在水性环境中反应的聚合物形成的原位成形泡沫。当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。

40. 发明申请

WO2012027138A1 IN SITU FORMING HEMOSTATIC FOAM IMPLANTS 审中-公开
标题翻译：在现场形成HEMOSTATIC泡沫植入物
公开(公告)号：WO2012027138A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/047615
申请日：2011-08-12
申请人： ARSENAL MEDICAL, INC. , SHARMA, Upma , GITLIN, Irina , ZUGATES, Greg , RAGO, Adam , ZAMIRI, Parisa , BUSOLD, Rany , FREYMAN, Toby
发明人： SHARMA, Upma , GITLIN, Irina , ZUGATES, Greg , RAGO, Adam , ZAMIRI, Parisa , BUSOLD, Rany , FREYMAN, Toby
IPC分类号： A61B17/03
CPC分类号： A61L24/043 , A61L24/0036 , A61L2400/06 , A61M31/002 , C08L75/04 , C08L71/02
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
摘要翻译：通常描述与聚合物泡沫有关的系统和方法。一些实施方案涉及用于制备聚合物泡沫的组合物和方法，以及使用聚合物泡沫体的方法。聚合物泡沫可以施加到体腔并且与例如组织，损伤的组织，内部器官等接触。在一些实施例中，聚合物泡沫可以在体腔内形成（即，原位泡沫形成）。此外，发泡聚合物可能能够在体腔的内表面上施加压力，并且能够防止或限制体液（例如血液等）的移动。

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