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31. 发明公开

EP2576510A1 PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER 有权
标题翻译： PIPERIDINONDERIVATE AS MDM2抑制剂用于癌症治疗
公开(公告)号：EP2576510A1
公开(公告)日：2013-04-10
申请号：EP11726581.9
申请日：2011-06-03
申请人： Amgen Inc.
发明人： BARTBERGER, Michael David , GONZALEZ BUENROSTRO, Ana , BECK, Hilary Plake , CHEN, Xiaoqi , CONNORS, Richard Victor , DEIGNAN, Jeffrey , DUQUETTE, Jason , EKSTEROWICZ, John , FISHER, Benjamin , FOX, Brian Matthew , FU, Jiasheng , FU, Zice , GONZALEZ LOPEZ DE TURISO, Felix , GRIBBLE, JR., Michael William , GUSTIN, Darin James , HEATH, Julie Anne , HUANG, Xin , JIAO, Xianyun , JOHNSON, Michael , KAYSER, Frank , KOPECKY, David John , LAI, Sujen , LI, Yihong , LI, Zhihong , LIU, Jiwen , LOW, Jonathan Dante , LUCAS, Brian Stuart , MA, Zhihua , MCGEE, Lawrence , MCINTOSH, Joel , MCMINN, Dustin , MEDINA, Julio Cesar , MIHALIC, Jeffrey Thomas , OLSON, Steven Howard , REW, Yosup , ROVETO, Philip Marley , SUN, Daqing , WANG, Xiaodong , WANG, Yingcai , YAN, Xuelei , YU, Ming , ZHU, Jiang
IPC分类号： C07D211/40 , C07D401/04 , C07D401/06 , C07D407/04 , C07D407/06 , C07D409/04 , C07D413/06 , C07D417/06 , C07D471/20 , C07D279/02 , C07D401/12 , C07D498/08 , C07D498/20 , A61K31/4412 , A61P35/00
CPC分类号： C07D211/76 , C07D221/20 , C07D279/02 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/08 , C07D491/153 , C07D498/08 , C07D498/14 , C07D498/20
摘要： The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

32. 发明公开

EP2513109A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：EP2513109A1
公开(公告)日：2012-10-24
申请号：EP10803182.4
申请日：2010-12-17
申请人： Amgen Inc.
发明人： CUSHING, Timothy D. , GONZALEZ LOPEZ DE TURISO, Felix , HAO, Xiaolin , SHIN, Youngsook
IPC分类号： C07D471/04 , C07D519/00 , A61K31/4375 , A61P1/04 , A61P3/10 , A61P9/10 , A61P17/06 , A61P19/02 , A61P35/00
CPC分类号： C07D519/00 , C07D471/04
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
摘要翻译：取代的双环杂芳基及其组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，包括但不限于（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏性病症的自身免疫性疾病。本发明还包括（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD）慢性粒细胞白血病（MPD）的治疗癌症的方法，所述方法用于治疗依赖于或关联于p110活性的癌症的方法包括但不限于白血病 C ML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤，如乳腺癌。

33. 发明公开

EP2137186A1 HETEROCYCLIC COMPOUNDS AND THEIR USES 有权
标题翻译：杂环化合物及其应用
公开(公告)号：EP2137186A1
公开(公告)日：2009-12-30
申请号：EP08727163.1
申请日：2008-03-24
申请人： Amgen Inc.
发明人： CHEN, Yi , CUSHING, Timothy D. , DUQUETTE, Jason A. , GONZALEZ LOPEZ DE TURISO, Felix , HAO, Xiaolin , HE, Xiao , LUCAS, Brian , McGEE, Lawrence R. , REICHELT, Andreas , RZASA, Robert M. , SEGANISH, Jennifer , SHIN, Youngsook , ZHANG, Dawei
IPC分类号： C07D473/30 , C07D473/34 , C07D487/04 , A61K31/519 , A61K31/52 , A61P29/00 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D473/30 , C07D473/34
摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on, or associated with p110 activity, including but not restricted to leukemias, such as acute myeloid leukaemia (AML), myelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD), chronic myeloid leukemia (CML), T-cell acute lymphoblastic leukaemia (T-ALL), B-cell acute lymphoblastic leukaemia (B-ALL), non Hodgkins lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.

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