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31. 发明申请

WO2019213331A1 A METHOD FOR OPTIMIZING ANTIBODY EXPRESSION 审中-公开
公开(公告)号：WO2019213331A1
公开(公告)日：2019-11-07
申请号：PCT/US2019/030295
申请日：2019-05-01
申请人： AMBRX, INC.
发明人： RASHID, MD Harunur , SHIMAZU, Mark , TIAN, Feng
IPC分类号： C12N15/63 , C12N15/70 , C12N9/90 , C07K14/245 , C12N15/67 , C12N15/68
摘要： Disclosed herein are methods, compositions and components for optimizing or increasing expression of a protein, polypeptide or fragment therefrom.

32. 发明申请

WO2019191728A1 HUMANIZED ANTI-PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) ANTIBODY DRUG CONJUGATES 审中-公开
公开(公告)号：WO2019191728A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/025057
申请日：2019-03-29
申请人： AMBRX, INC.
发明人： BHOMIK, Shivarupam , WANG, Jianing , XIA, Jinming , BRADY, William , TIAN, Feng
IPC分类号： A61P35/00 , C07K16/30 , A61K47/68
摘要： The invention relates to prostate specific membrane antigen humanized antibodies (anti-PSMA) and anti-PSMA antibody drug conjugates. The invention also relates to methods and compositions for using anti-PSMA antibody drug conjugates in inhibiting, preventing or treating PSMA related diseases or cancers.

33. 发明申请

WO2018223108A1 METHODS AND COMPOSITIONS FOR PROMOTING NON-NATURAL AMINO ACID-CONTAINING PROTEIN PRODUCTION 审中-公开
公开(公告)号：WO2018223108A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035764
申请日：2018-06-02
申请人： AMBRX, INC.
发明人： CHEN, Sigeng , LU, Yingchun , TIAN, Feng
IPC分类号： C12N15/113 , C12N15/67 , A61K39/395
摘要： Disclosed herein are methods and compositions for generation of cell lines to promote unnatural amino acid- containing protein production using genome engineering technology.

34. 发明申请

WO2017079272A2 ANTI-CD3-FOLATE CONJUGATES AND THEIR USES 审中-公开
标题翻译：抗-CD3-叶酸缀合物及其用途
公开(公告)号：WO2017079272A2
公开(公告)日：2017-05-11
申请号：PCT/US2016/060087
申请日：2016-11-02
申请人： AMBRX, INC.
发明人： HARUN, Rashid , TIAN, Feng , GYMNOPOULOS, Marco
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/395 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2809 , C07K2317/55 , C07K2317/622 , C07K2317/92 , C07K2317/94
摘要： Described herein are novel anti-CD3 antibodies conjugated to folate and uses thereof treatment of diseases or conditions that would benefit from such conjugate are provided.
摘要翻译：本文描述了与叶酸结合的新型抗CD3抗体及其应用，其中提供了将从这样的缀合物受益的疾病或病症的治疗。

35. 发明申请

WO2013188740A1 ANTI-PSMA ANTIBODIES CONJUGATED TO NUCLEAR RECEPTOR LIGAND POLYPEPTIDES 审中-公开
标题翻译：抗核抗体联合核受体配体多肽的抗体
公开(公告)号：WO2013188740A1
公开(公告)日：2013-12-19
申请号：PCT/US2013/045834
申请日：2013-06-14
申请人： AMBRX, INC.
发明人： SUN, Ying , ZOU, Ning , HEWET, Amha , PINKSTAFF, Jason, K. , SRINAGESH, Shailaja , BARNETT, Richard, S. , TIAN, Feng , PUTNAM, Anna-Maria, A. Hays , GYMNOPOULOS, Marco , KNUDSEN, Nick , BECK, Andrew
IPC分类号： A61K47/48 , C07K16/30
CPC分类号： C07K16/3076 , A61K47/6869 , C07K16/3069
摘要： This invention relates to anti-prostate-specific membrane antigen antibodies (αPSMA) and αPSMA antibody - nuclear receptor ligand (NRL) conjugates comprising at least one non-naturally-encoded amino acid.
摘要翻译：本发明涉及包含至少一种非天然编码氨基酸的抗前列腺特异性膜抗原抗体（αPSMA）和αPSMA抗体 - 核受体配体（NRL）缀合物。

36. 发明申请

WO2013068874A1 ANTIBODY-DRUG CONJUGATES 审中-公开
标题翻译：抗体药物联合用药
公开(公告)号：WO2013068874A1
公开(公告)日：2013-05-16
申请号：PCT/IB2012/055940
申请日：2012-10-27
申请人： PFIZER INC. , AMBRX INC.
发明人： DUSHIN, Russell , FEYFANT, Eric , SAPRA, Puja , TCHISTIAKOVA, Lioudmila, Gennadievna , TIAN, Feng
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/6851 , A61K47/6809
摘要： Disclosed are anti-5T4 antibody drug conjugates with an improved pharmacokinetic profile and methods for preparing and using the same. In one embodiment, the antibody-drug conjugate has the formula Ab-(D)p, wherein Ab is an anti-5T4 antibody comprising a non- natural amino acid; D is a dolastatin linker derivative; and p is from about 1 to about 8.
摘要翻译：公开了具有改善的药代动力学特征的抗5T4抗体药物偶联物及其制备和使用方法。在一个实施方案中，抗体 - 药物缀合物具有式Ab-（D）p，其中Ab是包含非天然氨基酸的抗5T4抗体; D是多拉司他汀接头衍生物; 且p为约1至约8。

37. 发明公开

EP3844188A1 ANTI-CD3 ANTIBODY FOLATE BIOCONJUGATES AND THEIR USES 审中-实审
公开(公告)号：EP3844188A1
公开(公告)日：2021-07-07
申请号：EP19773581.4
申请日：2019-08-28
申请人： Ambrx, Inc.
发明人： RASHID, Md Harunur , SUN, Ying , TIAN, Feng , MOON, Sung Ju
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61P35/00

38. 发明公开

EP3630977A1 METHODS AND COMPOSITIONS FOR PROMOTING NON-NATURAL AMINO ACID-CONTAINING PROTEIN PRODUCTION 有权
公开(公告)号：EP3630977A1
公开(公告)日：2020-04-08
申请号：EP18734359.5
申请日：2018-06-02
申请人： Ambrx, Inc.
发明人： CHEN, Sigeng , LU, Yingchun , TIAN, Feng
IPC分类号： C12N15/113 , C12N15/67 , A61K39/395

39. 发明授权

EP2858676B1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATES 有权
公开(公告)号：EP2858676B1
公开(公告)日：2019-03-13
申请号：EP13732008.1
申请日：2013-06-07
申请人： Ambrx, Inc.
发明人： BARNETT, Richard S. , TIAN, Feng , PUTNAM, Anna-Maria A. Hays , GYMNOPOULOS, Marco , KNUDSEN, Nick , BECK, Andrew , SUN, Ying
IPC分类号： A61K47/68 , C07K16/30

40. 发明公开

EP2858676A1 PROSTATE-SPECIFIC MEMBRANE ANTIGEN ANTIBODY DRUG CONJUGATES 有权
标题翻译：防盗报警器防盗报警器防盗报警器
公开(公告)号：EP2858676A1
公开(公告)日：2015-04-15
申请号：EP13732008.1
申请日：2013-06-07
申请人： Ambrx, Inc.
发明人： BARNETT, Richard S. , TIAN, Feng , PUTNAM, Anna-maria A. Hays , GYMNOPOULOS, Marco , KNUDSEN, Nick , BECK, Andrew , SUN, Ying
IPC分类号： A61K47/48
CPC分类号： C07K16/40 , A61K47/6817 , A61K47/6869 , C07K5/0205 , C07K16/3069
摘要： This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are αPSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the αPSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本发明涉及包含至少一种非天然编码氨基酸的前列腺特异性膜抗原（PSMA）抗体和抗体药物偶联物。本文公开了具有一种或多种非天然编码氨基酸的αPSMA抗体，并且还公开了抗体药物偶联物，其中本发明的αPSMA抗体与一种或多种毒素缀合。本文还公开了在翻译后进一步修饰的非天然氨基酸多拉司他汀类似物，用于实现这种修饰的方法，以及纯化这种多拉司他汀类似物的方法。通常，修饰的多拉司他汀类似物包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步公开的是使用这种非天然氨基酸抗体药物偶联物，多拉司他汀类似物和经修饰的非天然氨基酸多拉司他汀类似物的方法，包括治疗，诊断和其他生物技术用途。

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