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31. 发明公开

EP1381306A1 METHOD FOR OPTICAL MEASUREMENTS OF TISSUE TO DETERMINE DISEASE STATE OR CONCENTRATION OF AN ANALYTE 审中-公开
标题翻译：用于组织的光学配置方法是一种疾病状态或分析物DETERMINE
公开(公告)号：EP1381306A1
公开(公告)日：2004-01-21
申请号：EP02725082.8
申请日：2002-03-07
申请人： ABBOTT LABORATORIES
发明人： KHALIL, Omar, S. , YEH, Shu-Jen , KANTOR, Stanislaw , HANNA, Charles, F. , SHAIN, Eric, B.
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1455 , A61B5/7264
摘要： A method for collecting optical data at two morphologically similar, substantially non-overlapping, and preferably adjacent, areas on the surface of a tissue, while the temperature in each area is being maintained or modulated according to a temperature program. The optical data obtained are inserted into a mathematical relationship, e.g., an algorithm, that can be used to predict a disease state (such as the diabetes mellitus disease state) or the concentration of an analyte for indicating a physical condition (such as blood glucose level). This invention can be used to differentiate between disease status, such as, for example, diabetic and non-diabetic. The method involves the generation of a calibration (or training) set that utilizes the relationship between optical signals emanating from the skin under different thermal stimuli and disease status, e.g., diabetic status, established clinically. This calibration set can be used to predict the disease state of other subjects. Structural changes, as well as circulatory changes, due to a disease state are determined at two morphologically similar, but substantially non-overlapping areas on the surface of human tissue, e.g., the skin of a forearm, with each area being subjected to different temperature modulation programs. In addition to determination of a disease state, this invention can also be used to determine the concentration of an analyte in the tissues. This invention also provides an apparatus for the determination of a disease state, such as diabetes, or concentration of an analyte, such as blood glucose level, by the method of this invention.

32. 发明公开

EP1035799A1 METHOD AND APPARATUS FOR OBTAINING INTERSTITIAL FLUID FOR DIAGNOSTIC TESTS 有权
标题翻译：装置脱除诊断检测组织间液
公开(公告)号：EP1035799A1
公开(公告)日：2000-09-20
申请号：EP98958113.7
申请日：1998-11-20
申请人： Abbott Laboratories
发明人： HENNING, Timothy, P. , HILTIBRAN, Robert, G. , CUNNINGHAM, David, D. , SHAIN, Eric, B. , TARKOWSKI, Brian, J. , YOUNG, Douglas, F.
IPC分类号： A61B5/103 , A61B5/14
CPC分类号： A61B5/14514 , A61B5/14532 , A61B10/0045 , A61B2010/008 , A61M2037/0007
摘要： Method and apparatus for obtaining a sample of interstitial fluid from a patient for subsequent diagnostic tests, e.g. glucose monitoring. In one aspect of the invention, the method comprises the steps of: (a) treating an area of the skin with vacuum or heat or both vacuum and heat to increase the availability of interstitial fluid at that area of the skin; (b) forming an opening in the treated area of the skin; and (c) extracting the sample of interstitial fluid from the opening in the skin, with the aid of vacuum and stretching of the skin. In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises: (a) a device for forming an unobstructed opening in an area of skin from which the sample is to be extracted, preferably a lancing assembly; and (b) a vacuum pump. Preferably, the apparatus also includes a housing.

33. 发明公开

EP0959765A1 CALIBRATION FOR SUBSEQUENT MONITORING OF BIOLOGICAL COMPOUNDS 失效
标题翻译：定标生物物质的后续监测
公开(公告)号：EP0959765A1
公开(公告)日：1999-12-01
申请号：EP97906739.0
申请日：1997-02-25
申请人： Abbott Laboratories
发明人： OOSTA, Gary, M. , ELSTROM, Tuan, A. , SHAIN, Eric, B. , SCHAPIRA, Thomas, G.
IPC分类号： A61B5 , G01N21
CPC分类号： A61B5/1495 , A61B5/0059 , A61B5/14532 , A61B5/1455 , A61B5/442 , A61B5/443
摘要： A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual using non-ionizing radiation is provided. The process includes determining the contribution of one or more skin parameters to the absorption and transmittance data and correcting the subsequent non-invasive measurement of the biological compound for the contribution of the parameter(s).

34. 发明公开

EP0868144A1 DEVICE FOR THE DETECTION OF ANALYTE AND ADMINISTRATION OF A THERAPEUTIC SUBSTANCE 失效
标题翻译：设备中，用于分析物的检测，并给予AN治疗物质
公开(公告)号：EP0868144A1
公开(公告)日：1998-10-07
申请号：EP96942056.0
申请日：1996-11-26
申请人： Abbott Laboratories
发明人： HENNING, Timothy, P. , SHAIN, Eric, B. , KHALIL, Gamal , ELSTROM, Tuan, A.
IPC分类号： G01N27 , A61B5 , A61B10 , G01N21
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6848
摘要： The present invention relates to a device (10) for the sampling of blood or other body fluids which includes means (16) for the direct measurement of the analyte of interest within the fluid. Also disclosed is a 'closed-loop' device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.

35. 发明授权

EP1681571B8 Apparatus and method for handling fluids for analysis 有权
标题翻译：设备和方法处理流体分析
公开(公告)号：EP1681571B8
公开(公告)日：2010-06-23
申请号：EP06111128.2
申请日：2004-06-15
申请人： ABBOTT LABORATORIES
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： G01N35/00 , B03C1/253 , B03C1/288 , G01N35/0098 , G01N35/1065

36. 发明授权

EP1681571B1 Apparatus and method for handling fluids for analysis 有权
标题翻译：用于分析处理流体的设备和方法
公开(公告)号：EP1681571B1
公开(公告)日：2010-05-19
申请号：EP06111128.2
申请日：2004-06-15
申请人： ABBOTT LABORATORIES
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： G01N35/00 , B03C1/253 , B03C1/288 , G01N35/0098 , G01N35/1065

37. 发明公开

EP1706021A1 METHOD FOR DETECTING ARTIFACTS IN DATA 审中-公开
标题翻译：方法用于检测数据失真的
公开(公告)号：EP1706021A1
公开(公告)日：2006-10-04
申请号：EP04813356.5
申请日：2004-12-08
申请人： ABBOTT LABORATORIES
发明人： LOWERY, Michael, G. , SHAIN, Eric, B. , KHALIL, Omar, S.
IPC分类号： A61B5/00 , G01N21/35 , G01N33/487
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14535 , A61B5/7207 , G01N21/49
摘要： A method for identifying artifacts occurring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection oA method for identifying artifacts occuring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs temperature-controlled optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted at different wavelenghts, at different distances between the lht introduction site (s) and the light collection site (s), and at different temperatures are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection of data sets that contain these artifacts. The algorithm identifies sudden changes in the magnitude and direction in a sequence of collected signals.

38. 发明公开

EP1681571A2 Apparatus and method for handling fluids for analysis 有权
标题翻译：用于分析处理流体的设备和方法
公开(公告)号：EP1681571A2
公开(公告)日：2006-07-19
申请号：EP06111128.2
申请日：2004-06-15
申请人： ABBOTT LABORATORIES
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： G01N35/10 , B01L3/00
CPC分类号： G01N35/00 , B03C1/253 , B03C1/288 , G01N35/0098 , G01N35/1065
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
摘要翻译：具有底部排水口的反应容器通过流体的表面张力支撑选定的无压力流体头部。装置处理区域包括用于间隔排反应容器的支撑件，与支撑容器的排出口连通的通道以及用于选择性地通过排出口排出流体的压力源。通常水平条形磁体被支撑用于容器排之间的选定垂直运动。分配头具有可在X个选定的反应容器上选择性定位的X个排出口。计量泵机构选择性地计量X大量供应（其中X至少为4）的流体的选定量，并且选择性地将计量的选定量通过排放口泵送到选择的反应容器。还包括使用压力源从容器中抽取流体并移动磁体以形成分析物粒料的方法。

39. 发明公开

EP1638690A2 APPARATUS AND METHOD FOR HANDLING FLUIDS FOR ANALYSIS 审中-公开
标题翻译：装置和方法处理的油液用于分析
公开(公告)号：EP1638690A2
公开(公告)日：2006-03-29
申请号：EP04755308.6
申请日：2004-06-15
申请人： ABBOTT LABORATORIES
发明人： LOWREY, Michael , SAFAR, Scott , DUNN, Chadwick, M. , GALITZ, Charles, M. , TOTH, Julius, J. , KUKLA, Ronald, E. , HERCHENBACH, Stephen , SHAIN, Eric, B.
IPC分类号： B01L3/14
CPC分类号： G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
摘要： A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.

40. 发明公开

EP0880375A1 TRANSDERMAL TRANSPORT USING ULTRASONIC STANDING WAVES 失效
标题翻译：透皮运输工具常设超声波
公开(公告)号：EP0880375A1
公开(公告)日：1998-12-02
申请号：EP97905942.0
申请日：1997-02-14
申请人： Abbott Laboratories
发明人： ELSTROM, Tuan, A. , SHAIN, Eric, B. , HENNING, Timothy, P.
IPC分类号： A61B5 , A61M37
CPC分类号： A61B5/14514 , A61M37/0092 , A61M2037/0007
摘要： A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.

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