专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

32. 发明专利

BRPI0708258A2 未知
公开(公告)号：BRPI0708258A2
公开(公告)日：2011-05-24
申请号：BRPI0708258
申请日：2007-02-16
申请人： ABBOTT LAB
发明人： COWART MARLON D , ZHAO CHEN , SUN MINGHUA , BLACK LAWRENCE A , ZHENG GUO ZHU , GREGG ROBERT J , ZHANG GEOFF G , SHEIKH AHMAD Y , LOU XIAOCHUN , HENRY RODGER F , BARNES DAVID M , KOLACZKOWSKI LAWRENCE , HAIGHT ANTHONY R , CHANG SOU-JEN , WITTENBERGER STEVEN J , FICKES MICHAEL G
IPC分类号： C07D487/04 , A61K31/407
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

33. 发明专利

CR10287A DERIVADOS DE OCTAHIDRO -PIRROLO [3,4-B]PIRROL 未知
公开(公告)号：CR10287A
公开(公告)日：2008-12-10
申请号：CR10287
申请日：2008-09-16
申请人： ABBOTT LAB
发明人： ZHENCOWART MARLON , ZHAO CHEN , SUN MINGHUA , BALCK LAWRANCE , ZHENG GUO ZHU , GREGG ROBERT J , ZHANG GEOFF G Z , SHEIKH AHMAD Y , LOU XIAOCHUN , HENRY RODGER F , BARNES DAVID M , KOLACZKOWSKI LAWRENCE , HAIGHT ANTHONY R , CHANG SOU-JEN , WITTENBERGER STEVEN J , FICKES MICHAEL G
IPC分类号： A61K31/407 , C07D487/04
摘要： Derivados de octahidro-pirrolo[3,4-b]pirrol utiles para tratar condiciones o trastornos que se previenen o mejoran con ligandos del receptor de histamina-3. En la presente se divulgan compuestos, composiciones para hacerlos, y procesos para preparar dichos compuestos.

34. 发明专利

MX2008010805A DERIVADOS DE OCTAHIDRO-PIRROLO[3,4-B]PIRROL Y SU USO COMO LIGANDOS DEL RECEPTOR DE HISTAMINA-3. 未知
公开(公告)号：MX2008010805A
公开(公告)日：2008-09-01
申请号：MX2008010805
申请日：2007-02-16
申请人： ABBOTT LAB
发明人： BARNES DAVID M , KOLACZKOWSKI LAWRENCE , CHANG SOU-JEN , BLACK LAWRENCE A , COWART MARLON D , GREGG ROBERT J , ZHENG GUO ZHU , SUN MINGHUA , ZHAO CHEN , WITTENBERGER STEVEN J , HENRY RODGER F , HAIGHT ANTHONY R , ZHANG GEOFF G Z , SHEIKH AHMAD Y , LOU XIAOCHUN , FICKES MICHAEL G
IPC分类号： C07D487/04 , A61K31/407
摘要： Se describen en la presente derivados de octahidropirrolo[3,4-b]pi rrol o una sal farmacéuticamente aceptable, éster, amida, profármaco, o forma radiomarcada del mismo, en donde R1 es alquilo, cicloalquilo de 03-05, o (cicloalquilo de 03- C5)metilo: R2a, R2, R2C, R2d, R2e y R2 son cada uno independientemente hidrógeno, metilo o fluorometilo; R3a, R3b, R3C y R3d son cada uno independientemente hidrógeno, alquilo, fluoroalquilo, fluoroalcoxi, alcoxi, tioalcoxi, halógeno, o nitrilo, con la condición de que cuando uno o más de R3, R3b, R3C y R3d son alquilo, entonces al menos uno de R3, R3b, R3° y R3d es fluoroalquilo, fluoroalcoxi, alcoxi, tioalcoxi, halógeno o nitrilo: L1 es un enlace, oxígeno, azufre, carbonilo, alquileno, alquilcarbonilo, alquilamino, -C(=N-Oalquilo)-, NR4, -C(=O)NR4-, o -NR4C(=O)-; o R4 es hidrógeno o alquilo; Cy1 es arilo, cicloalquilo, cicloalquenilo, heteroarilo, o heterociclo; Z es un sustituyente R6 o un grupo representado por -L3-0y3 R6 es hidrógeno, acilo, aciloxi, alquenilo, alcoxi, alcoxialcoxi, alcoxialq u ib, alcoxicarbonibo, alcoxi i mino, alcoxisulfon ib, alquilo, alquilcarbonibo, alquilsulfonibo, alquinilo, amido, carboxi, ciano, cicloalquibo, fluoroalcoxi, haloalcoxi, haboalquilo, halógeno, hidroxi, hidroxialquilo, mercapto, nitro, alquiltio, amino, NHR7, NR7R8, -N(R7)C(0)R9, -C(=O)NR7R8, o N(R7)S02(R10); [3 es un enlace, oxígeno, azufre, carbonilo, alquileno, alquilcarbonilo, alquilamino, -C(N-Oalquilo)-, NR11, C(=O)NR11-, o -NR11C(=O)-; Cy3 es arilo, cicloalquilo, cicloalquenilo, heteroarilo o heterociclo; R7, R8, R9, R1° y R11 en cada caso son independientemente hidrógeno, alquilo de C14, cicloalquilo de C34, o una (cicloalquilo de C3-C4)amina; son útiles en el tratamiento de condiciones o trastornos prevenidos por o mejorados por ligandos del receptor de histamina 3. También se describen compuesto de octahidro-pirrolo[3,4- b]pirrol, métodos para utilizar tales compuestos, composiciones para fabricarlos, y procesos para preparar tales compuestos.

35. 发明专利

CA2641624A1 OCTAHYDRO-PYRROLO[3,4-B] PYRROLE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR LIGANDS 未知
公开(公告)号：CA2641624A1
公开(公告)日：2007-09-07
申请号：CA2641624
申请日：2007-02-16
申请人： ABBOTT LAB
发明人： ZHAO CHEN , ZHANG GEOFF G Z , SHEIKH AHMAD Y , GREGG ROBERT J , KOLACZKOWSKI LAWRENCE , LOU XIAOCHUN , COWART MARLON D , SUN MINGHUA , CHANG SOU-JEN , ZHENG GUO ZHU , HAIGHT ANTHONY R , BLACK LAWRENCE A , WITTENBERGER STEVEN J , FICKES MICHAEL G , BARNES DAVID M , HENRY RODGER F
IPC分类号： C07D487/04 , A61K31/407
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.

36. 发明专利

AU2014280939A1 Uracil or thymine derivative for treating hepatitis C 未知
公开(公告)号：AU2014280939A1
公开(公告)日：2015-01-22
申请号：AU2014280939
申请日：2014-12-24
申请人： ABBOTT LAB
发明人： KRUEGER ALLAN C , GAO YI , KOTECKI BRIAN J , FLENTGE CHARLES A , MOTTER CHRISTOPHER E , MARING CLARENCE J , LIU DACHUN , BETEBENNER DAVID A , DEGOEY DAVID A , BARNES DAVID M , HUTCHINSON DOUGLAS K , ZHANG GEOFF G Z , HENGEVELD JOHN E , PRATT JOHN K , RANDOLPH JOHN T , SARRIS KATHY , STEWART KENT D , LONGENECKER KENTON L , TUFANO MICHAEL D , DONNER PAMELA L , HUANG PEGGY P , HENRY RODGER F , WAGNER ROLF , CHEN SHUANG , FRANCZYK II THADDEUS S , ROCKWAY TODD W , KATI WARREN M , LOU XIAOCHUN , LIU YAYA , HAUGHT ANTHONY R
IPC分类号： C07D239/22 , A61K31/513 , A61P31/12 , C07D239/54 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2,4-dioxo-3,4 dihydropyrimidin-1(2H)-yl)-2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N (4(3-t-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxy-styryl phenyl)methanesulfonamide.

37. 发明专利

CA2699989C N-PHENYL-DIOXO-HYDRO PYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITOR 未知
公开(公告)号：CA2699989C
公开(公告)日：2014-03-25
申请号：CA2699989
申请日：2008-09-17
申请人： ABBOTT LAB
发明人： DONNER PAMELA L , RANDOLPH JOHN T , KRUEGER ALLAN C , BETEBENNER DAVID A , HUTCHINSON DOUGLAS K , LIU DACHUN , LIU YAYA , LONGENECKER KENTON L , MARING CLARENCE J , PRATT JOHN K , ROCKWAY TODD W , STEWART KENT D , WAGNER ROLF , BARNES DAVID M , CHEN SHUANG , FRANCZYK THADDEUS S II , GAO YI , HAIGHT ANTHONY R , HENGEVELD JOHN E , HENRY RODGER F , KOTECKI BRIAN J , LOU XIAOCHUN , ZHANG GEOFF G Z
IPC分类号： C07D239/22 , A61K31/506 , A61K31/513 , A61P31/14 , C07D239/54 , C07D239/553 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要： This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. The compounds are usefull in the treatment of hepatitis C and are of the following general structure: Formula (I)

38. 发明专利

SG188878A1 OCTAHYDRO-PYRROLO[3,4-B] PYRROLE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR LIGANDS 未知
公开(公告)号：SG188878A1
公开(公告)日：2013-04-30
申请号：SG2013017603
申请日：2007-02-16
申请人： ABBOTT LAB
发明人： COWART MARLON D , ZHAO CHEN , SUN MINGHUA , BLACK LAWRENCE A , ZHENG GUO ZHU , GREGG ROBERT J , ZHANG GEOFF G Z , SHEIKH AHMAD Y , LOU XIAOCHUN , HENRY RODGER F , BARNES DAVID M , KOLACZKOWSKI LAWRENCE , HAIGHT ANTHONY R , CHANG SOU-JEN , WITTENBERGER STEVEN J , FICKES MICHAEL G
摘要： Octahydro-pyrrolo[3,4-b]pyrrole derivatives are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Octahydro-pyrrolo[3,4-b]pyrrole compounds, methods for using such compounds, compositions for making them, and processes for preparing such compounds are disclosed herein.Figure 1

39. 发明专利

AU2013202002A1 Uracil or thymine derivative for treating hepatitis C 未知
公开(公告)号：AU2013202002A1
公开(公告)日：2013-04-18
申请号：AU2013202002
申请日：2013-03-26
申请人： ABBOTT LAB
发明人： KRUEGER ALLAN C , GAO YI , KOTECKI BRIAN J , FLENTGE CHARLES A , MOTTER CHRISTOPHER E , MARING CLARENCE J , LIU DACHUN , BETEBENNER DAVID A , DEGOEY DAVID A , BARNES DAVID M , HUTCHINSON DOUGLAS K , ZHANG GEOFF G Z , HENGEVELD JOHN E , PRATT JOHN K , RANDOLPH JOHN T , SARRIS KATHY , STEWART KENT D , LONGENECKER KENTON L , TUFANO MICHAEL D , DONNER PAMELA L , HUANG PEGGY P , HENRY RODGER F , WAGNER ROLF , CHEN SHUANG , FRANCZYK II THADDEUS S , ROCKWAY TODD W , KATI WARREN M , LOU XIAOCHUN , LIU YAYA , HAIGHT ANTHONY R
IPC分类号： C07D239/22 , A61K31/513 , A61P31/12 , C07D239/54 , C07D401/10 , C07D403/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： URACIL OR THYMINE DERIVATIVE FOR TREATING HEPATITIS C Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4 dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E) N-(4(3-t-butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1(2H)-yl)2-methoxy-styryl phenyl)methanesulfonamide.

40. 发明专利

SG175146A1 SALT OF ABT-263 AND SOLID-STATE FORMS THEREOF 未知
公开(公告)号：SG175146A1
公开(公告)日：2011-11-28
申请号：SG2011073632
申请日：2010-04-30
申请人： ABBOTT LAB
发明人： BORCHARDT THOMAS , BRACKEMYER PAUL , CATRON NATHANIEL , HENRY RODGER , LOU XIAOCHUN , RAVN MATTHEW , ZHANG GEOFF , ZHOU DELIANG
摘要： ABT-263 bis-HCl and crystalline polymorphs thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式