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31. 发明授权

US06534508B2 Methods and compositions for treating infection using optically pure (S)-lomefloxacin 失效
公开(公告)号：US06534508B2
公开(公告)日：2003-03-18
申请号：US09996822
申请日：2001-11-30
申请人： James W. Young , A. K. Gunnar Aberg
发明人： James W. Young , A. K. Gunnar Aberg
IPC分类号： A61K31495
CPC分类号： A61K31/47 , A61K31/496 , Y02A50/475 , Y02A50/481
摘要： Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of Mycobacteria infection.

32. 发明授权

US06303632B1 Compositions for treating allergic and other disorders using norastemizole in combination with other active ingredients 失效
标题翻译：使用诺尔阿司咪唑与其他活性成分组合治疗过敏性和其它病症的组合物
公开(公告)号：US06303632B1
公开(公告)日：2001-10-16
申请号：US09835149
申请日：2001-04-16
申请人： Raymond L. Woosley , A. K. Gunnar Aberg
发明人： Raymond L. Woosley , A. K. Gunnar Aberg
IPC分类号： A61K31445
CPC分类号： A61K31/454 , A61K31/445 , A61K2300/00
摘要： Methods and compositions are disclosed utilizing metabolic derivatives of astemizole for the treatment of allergic disorders while avoiding the concomitant liability of adverse effects associated with the astemizole. The metabolic derivatives of astemizole are also useful for the treatment of retinopathy and other small vessel disorders associated with diabetes mellitus and such other conditions as may be related to the antihistamine activity of astemizole. For example, the metabolic derivatives of astemizole are useful for the treatment of asthma, motion sickness, and vertigo, without the concomitant liability of adverse effects associated with astemizole. Furthermore, the metabolic derivatives of astemizole, in combination with non-steroidal anti-inflammatory agents or other non-narcotic analgesics, or in combination with a decongestant, cough suppressant/antitussive or expectorant, are useful for the treatment of cough, cold, cold-like, and/or flu symptoms and the discomfort, headache, pain, fever, and general malaise associated therewith, without the concomitant liability of adverse effects associated with astemizole.
摘要翻译：公开了利用阿司咪唑的代谢衍生物治疗过敏性疾病的方法和组合物，同时避免与阿司咪唑相关的副作用的伴随的责任。阿司咪唑的代谢衍生物也可用于治疗与糖尿病相关的视网膜病变和其它小血管障碍以及可能与阿司咪唑的抗组织胺活性相关的其它病症。例如，阿司咪唑的代谢衍生物可用于治疗哮喘，晕车和眩晕，而不伴随与阿司咪唑有关的不良反应。此外，阿司咪唑的代谢衍生物与非甾体抗炎剂或其他非麻醉止痛剂组合，或与减充血剂，止咳剂/镇咳药或祛痰剂组合可用于治疗咳嗽，感冒，感冒类似，和/或流感症状以及与之相关的不适，头痛，疼痛，发烧和全身不适，而不伴随与阿司咪唑有关的不良反应。

33. 发明授权

US06268382B1 Methods and compositions for treating allergic disorders and other disorders using norastemizole in combination with other active ingredients 失效
公开(公告)号：US06268382B1
公开(公告)日：2001-07-31
申请号：US09650645
申请日：2000-08-30
申请人： Raymond L. Woosley , A. K. Gunnar Aberg
发明人： Raymond L. Woosley , A. K. Gunnar Aberg
IPC分类号： A61K31445
CPC分类号： A61K31/445 , A61K31/454 , A61K2300/00 , A61K31/00
摘要： Methods and compositions are disclosed utilizing metabolic derivatives of astemizole for the treatment of allergic disorders while avoiding the concomitant liability of adverse effects associated with the astemizole. The metabolic derivatives of astemizole are also useful for the treatment of retinopathy and other small vessel disorders associated with diabetes mellitus and such other conditions as may be related to the antihistamine activity of astemizole. For example, the metabolic derivatives of astemizole are useful for the treatment of asthma, motion sickness, and vertigo, without the concomitant liability of adverse effects associated with astemizole. Furthermore, the metabolic derivatives of astemizole, in combination with non-steroidal anti-inflammatory agents or other non-narcotic analgesics, or in combination with a decongestant, cough suppressant/antitussive or expectorant, are useful for the treatment of cough, cold, cold-like, and/or flu symptoms and the discomfort, headache, pain, fever, and general malaise associated therewith, without the concomitant liability of adverse effects associated with astemizole.

34. 发明授权

US06207684B1 Compounds with combined antihistaminic and mast cell stabilizing activities, intended for ophthalmic use 有权
标题翻译：具有组合抗组胺和肥大细胞稳定活性的化合物，用于眼科用途
公开(公告)号：US06207684B1
公开(公告)日：2001-03-27
申请号：US09445118
申请日：1999-12-02
申请人： A. K. Gunnar Aberg
发明人： A. K. Gunnar Aberg
IPC分类号： A61K31445
CPC分类号： A61K31/4535 , Y10S514/912
摘要： This invention relates to methods of treatment of ocular disease states, modulated by histaminergic and inflammatory mechanisms in a mammal using norketotifen, 10-OH-norketotifen and pharmaceutical compositions of those compounds. More particularly, this invention relates to methods of treating ocular diseases (such as, seasonal allergic conjunctivitis and other forms of conjunctivitis, keratitis, hyperemia, cellular infiltration, vascularization, fibroblastic proliferation, inflammatory cell degranulation), while avoiding certain side effects, such as local irriation, using compounds with combined antihistaminic and mast cell stabilizing activities.
摘要翻译：本发明涉及用诺卡托芬，10-OH-诺科托芬和那些化合物的药物组合物治疗哺乳动物中由组胺能和炎症机制调节的眼部疾病状态的方法。更具体地说，本发明涉及治疗眼部疾病（例如，季节性过敏性结膜炎和其他形式的结膜炎，角膜炎，充血，细胞浸润，血管形成，成纤维细胞增殖，炎性细胞脱粒）的方法，同时避免某些副作用，例如使用具有组合抗组胺和肥大细胞稳定活性的化合物进行局部抽搐。

35. 发明授权

US6124320A Methods for treating allergic disorders using norastemizole 失效
标题翻译：使用诺尔阿司咪唑治疗过敏性疾病的方法
公开(公告)号：US6124320A
公开(公告)日：2000-09-26
申请号：US766094
申请日：1996-12-16
申请人： Raymond L. Woosley , A. K. Gunnar Aberg
发明人： Raymond L. Woosley , A. K. Gunnar Aberg
IPC分类号： C07D401/12 , A61K31/4427 , A61K31/445 , A61K31/4523 , A61K31/454 , A61K45/00 , A61K45/06 , A61P3/08 , A61P3/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P31/12 , A61P37/08 , A61P43/00
CPC分类号： A61K31/445 , A61K31/454
摘要： Methods and compositions are disclosed utilizing metabolic derivatives of astemizole for the treatment of allergic disorders while avoiding the concomitant liability of adverse effects associated with the astemizole. The metabolic derivatives of astemizole are also useful for the treatment of retinopathy and other small vessel disorders associated with diabetes mellitus and such other conditions as may be related to the antihistamine activity of astemizole. For example, the metabolic derivatives of astemizole are useful for the treatment of asthma, motion sickness, and vertigo, without the concomitant liability of adverse effects associated with astemizole. Furthermore, the metabolic derivatives of astemizole, in combination with non-steroidal anti-inflammatory agents or other non-narcotic analgesics, or in combination with a decongestant, cough suppressant/antitussive or expectorant, are useful for the treatment of cough, cold, cold-like, and/or flu symptoms and the discomfort, headache, pain, fever, and general malaise associated therewith, without the concomitant liability of adverse effects associated with astemizole.
摘要翻译：公开了利用阿司咪唑的代谢衍生物治疗过敏性疾病的方法和组合物，同时避免与阿司咪唑相关的副作用的伴随的责任。阿司咪唑的代谢衍生物也可用于治疗与糖尿病相关的视网膜病变和其它小血管障碍以及可能与阿司咪唑的抗组织胺活性相关的其它病症。例如，阿司咪唑的代谢衍生物可用于治疗哮喘，晕车和眩晕，而不伴随与阿司咪唑有关的不良反应。此外，阿司咪唑的代谢衍生物与非甾体抗炎剂或其他非麻醉止痛剂组合，或与减充血剂，止咳剂/镇咳药或祛痰剂组合可用于治疗咳嗽，感冒，感冒类似，和/或流感症状以及与之相关的不适，头痛，疼痛，发烧和全身不适，而不伴随与阿司咪唑有关的不良反应。

36. 发明授权

US5166143A Method for preventing onset of restenosis after angioplasty employing an ace inhibitor 失效
标题翻译：用ACE抑制剂预防血管成形术后再狭窄发作的方法
公开(公告)号：US5166143A
公开(公告)日：1992-11-24
申请号：US714479
申请日：1991-06-13
申请人： Miguel A. Ondetti , A. K. Gunnar Aberg , Patricia Ferrer
发明人： Miguel A. Ondetti , A. K. Gunnar Aberg , Patricia Ferrer
IPC分类号： A61K31/00 , A61K31/40 , A61K31/675 , A61K38/55
CPC分类号： A61K38/556 , A61K31/00 , A61K31/40 , A61K31/675
摘要： A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after angioplasty.
摘要翻译：提供了一种在血管成形术之前，期间和/或之后通过施用ACE抑制剂如福斯普利或考拉普利来预防或降低血管成形术后再狭窄的风险的方法。

37. 发明授权

US08741930B2 Treating xerophthalmia with norketotifen 有权
标题翻译：用诺卡芬治疗干眼症
公开(公告)号：US08741930B2
公开(公告)日：2014-06-03
申请号：US12317575
申请日：2008-12-24
申请人： A. K. Gunnar Aberg , Keith Johnson
发明人： A. K. Gunnar Aberg , Keith Johnson
IPC分类号： A61K31/4535
CPC分类号： A61K31/4535
摘要： Methods of using a cycloheptathiophene compound for the treatment of xerophthalmia are described, as are formulations and compositions for such treatment.
摘要翻译：描述了使用环庚噻吩化合物治疗干眼症的方法，以及用于这种治疗的制剂和组合物。

38. 发明授权

US08383685B2 Use of RR/SR-ractopamine 有权
公开(公告)号：US08383685B2
公开(公告)日：2013-02-26
申请号：US13227846
申请日：2011-09-08
申请人： A. K. Gunnar Aberg
发明人： A. K. Gunnar Aberg
IPC分类号： A61K31/135
CPC分类号： A61K31/137 , C07C211/27 , C07C211/36 , C07C215/60
摘要： A method of promoting or improving the feed efficiency and the muscle-to-fat ratio in animals by administering to the animals a therapeutically effective amount of a mixture of RR-ractopamine and SR-ractopamine is disclosed. Manufacturing methods for making RR/SR-ractopamine are presented.

39. 发明授权

US06413987B1 Dermal anesthetic agents 失效
标题翻译：皮肤麻醉剂
公开(公告)号：US06413987B1
公开(公告)日：2002-07-02
申请号：US09588582
申请日：2000-06-06
申请人： A. K. Gunnar Aberg , George E. Wright , Jan L. Chen
发明人： A. K. Gunnar Aberg , George E. Wright , Jan L. Chen
IPC分类号： A61K31445
CPC分类号： C07D211/34 , A61K31/136 , A61K31/165 , A61K31/445 , C07D211/26 , C07D401/12 , Y10S514/817 , Y10S514/818
摘要： The present invention relates to new aminoindane piperidine compounds, the method of using aminoindane compounds as local anesthetics, said compounds having particularly valuable properties as dermal and topical anesthetics in mammals, including man, as well as compositions containing said compounds.
摘要翻译：本发明涉及新的氨基茚满哌啶化合物，使用氨基茚满化合物作为局部麻醉剂的方法，所述化合物在哺乳动物（包括人）中具有特别有价值的性质，如皮肤和局部麻醉剂，以及含有所述化合物的组合物。

40. 发明授权

US06372799B1 Non-sedating diphenhydramine metabolites 失效
标题翻译：非镇静苯海拉明代谢物
公开(公告)号：US06372799B1
公开(公告)日：2002-04-16
申请号：US09744458
申请日：2001-02-08
申请人： A. K. Gunnar Aberg
发明人： A. K. Gunnar Aberg
IPC分类号： A61K31135
CPC分类号： A61K31/135 , A61K31/522 , A61K2300/00
摘要： Disclosed are N-substituted metabolites of diphenhydramine, which have been found to be potent and orally active antihistaminic compounds that are devoid of sedative side effects. Phamaceutically acceptable salts of the compounds, a complex with 8-chlorotheo-phylline, therapeutic use and compositions containing the compounds are also described.
摘要翻译：公开了苯海拉明的N-取代代谢物，其已被发现是没有镇静作用的有效和口服活性的抗组胺化合物。还描述了化合物的药学上可接受的盐，与8-氯代叶酸的复合物，治疗用途和含有该化合物的组合物。

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