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    • 36. 发明公开
    • 대황 추출물, 이의 분획물 또는 스틸벤계 화합물을 포함하는 세포간접착인자-1로 매개되는 질환의 예방 또는 치료용 약학적 조성물
    • 一种包含由RHEI RHIZOMA或STILBENE化合物提取或分离的细胞间粘附分子-1介导的疾病的药物组合物
    • KR1020100094399A
    • 2010-08-26
    • KR1020100014074
    • 2010-02-17
    • 한국생명공학연구원
    • 노문철이우송이승웅박수진장종선류영배권형준
    • A61K36/708A61K31/05A61P19/02A61P11/06
    • Y02A50/411
    • PURPOSE: A pharmaceutical composition containing Rhei Rhizoma extract or fraction or stilbene compounds is provided to suppress binding between ICAM-1 and leukemia-associated antigen(LFA-1, CD11a/CD18). CONSTITUTION: A pharmaceutical composition for preventing or treating infectious diseases by rhinovirus, coxsackie virus, malaria, or HIV-1(human immunodeficiency virus type-1) contains Rhei Rhizoma extract or fraction as an active ingredient. The Rhei Rhizoma extract is isolated using water, low alcohol of 1-4 carbon atoms or mixture solvent thereof. The Rhei Rhizoma fraction is water fraction, n-hexane fraction, or chloroform fraction. A pharmaceutical composition for preventing or treating infectious diseases contains stilbene compounds of chemical formula 1 or 2 as an active ingredient. The stilbene compounds is isolated from Rhei Rhizoma, grape, grape wine, strawberry, raspberry, cranberry, mulberry, plum, cocoa, pine or peanut. The composition is an external use skin formulation.
    • 目的:提供含有Rhei Rhizoma提取物或级分或二苯乙烯化合物的药物组合物,以抑制ICAM-1与白血病相关抗原(LFA-1,CD11a / CD18)之间的结合。 构成:用于预防或治疗鼻病毒,柯萨奇病毒,疟疾或HIV-1(人类免疫缺陷病毒-1型)的传染病的药物组合物含有莱氏根提取物或级分作为活性成分。 使用水,1-4个碳原子的低级醇或其混合溶剂分离Rhei Rhizoma提取物。 Rhei Rhizoma馏分是水分,正己烷馏分或氯仿馏分。 用于预防或治疗感染性疾病的药物组合物含有化学式1或2的二苯乙烯化合物作为活性成分。 二苯乙烯化合物分离自Rhei Rhizoma,葡萄,葡萄酒,草莓,覆盆子,蔓越莓,桑树,李子,可可,松木或花生。 组合物是外用皮肤制剂。