专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

US20070031951A1 Method for the production of resveratrol in a recombinant bacterial host cell 审中-公开
标题翻译：在重组细菌宿主细胞中生产白藜芦醇的方法
公开(公告)号：US20070031951A1
公开(公告)日：2007-02-08
申请号：US11436160
申请日：2006-05-17
申请人： Lixuan Huang , Zhixiong Xue , Quinn Zhu
发明人： Lixuan Huang , Zhixiong Xue , Quinn Zhu
IPC分类号： C12P7/22 , C12N9/88 , C12N1/21 , C12N15/74
CPC分类号： C12N9/1029 , C12P7/22
摘要： A method to produce resveratrol in a recombinant bacterial host cell is provided. Expression of a resveratrol synthase gene in combination with genes involved in the phenylpropanoid pathway enabled recombinant microbial production of resveratrol.
摘要翻译：提供了在重组细菌宿主细胞中产生白藜芦醇的方法。白藜芦醇合酶基因与参与苯丙素途径的基因组合的表达使白藜芦醇的重组微生物产生。

32. 发明申请

US20060115881A1 High eicosapentaenoic acid producing strains of Yarrowia lipolytica 有权
公开(公告)号：US20060115881A1
公开(公告)日：2006-06-01
申请号：US11265761
申请日：2005-11-02
申请人： Howard Damude , Peter Gillies , Daniel Macool , Stephen Picataggio , Dana Pollak , James Ragghianti , Zhixiong Xue , Narendra Yadav , Hongxiang Zhang , Quinn Zhu
发明人： Howard Damude , Peter Gillies , Daniel Macool , Stephen Picataggio , Dana Pollak , James Ragghianti , Zhixiong Xue , Narendra Yadav , Hongxiang Zhang , Quinn Zhu
IPC分类号： C12P7/64 , C07H21/04 , C12N9/04 , C12N1/18 , C12N15/74
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N1/16 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12N15/746 , C12N15/815 , C12P7/6472 , A23V2250/187 , A23V2200/30
摘要： Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.

33. 发明申请

US20060115506A1 Compositions and method of wood preservation 审中-公开
标题翻译：木材保鲜的组成和方法
公开(公告)号：US20060115506A1
公开(公告)日：2006-06-01
申请号：US11000162
申请日：2004-11-30
申请人： Mark Harmer , Weiming Qiu , Zhixiong Xue
发明人： Mark Harmer , Weiming Qiu , Zhixiong Xue
IPC分类号： A01N43/64 , A01N25/32 , A01N43/50
CPC分类号： A01N25/04 , B27K3/005 , B27K3/007 , B27K3/16 , B27K3/26 , B27K3/343 , B27K3/38 , B27K3/52 , A01N25/08 , A01N33/12 , A01N43/653 , A01N43/84 , A01N55/00
摘要： This invention provides a method for preserving wood by treating the wood with a composition comprising a dispersion of colloidal silica or colloidal alumina particles in a solvent and one or more organic biocides.
摘要翻译：本发明提供了一种通过用包含胶体二氧化硅或胶态氧化铝颗粒的分散体在溶剂和一种或多种有机杀生物剂中的组合物处理木材来保护木材的方法。

34. 发明申请

US20060094092A1 High arachidonic acid producing strains of Yarrowia lipolytica 有权
公开(公告)号：US20060094092A1
公开(公告)日：2006-05-04
申请号：US11264784
申请日：2005-11-01
申请人： Howard Damude , Peter Gillies , Daniel Macool , Stephen Picataggio , Dana Pollak , James Ragghianti , Zhixiong Xue , Narendra Yadav , Hongxiang Zhang , Quinn Zhu
发明人： Howard Damude , Peter Gillies , Daniel Macool , Stephen Picataggio , Dana Pollak , James Ragghianti , Zhixiong Xue , Narendra Yadav , Hongxiang Zhang , Quinn Zhu
IPC分类号： C12P7/64 , C12N15/74 , C12N1/18
CPC分类号： C12P7/6427 , A23D9/00 , A23K20/158 , A23L33/12 , A23V2002/00 , C12N1/16 , C12N9/0083 , C12N9/1029 , C12N15/52 , C12N15/746 , C12N15/815 , C12P7/6472 , A23V2250/187 , A23V2200/30
摘要： Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ω-6 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases, and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of ARA. Production host cells are claimed, as are methods for producing ARA within said host cells.

35. 发明申请

US20060057690A1 Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast 有权
标题翻译：甘油-3-磷酸O-酰基转移酶启动子用于油质酵母中的基因表达
公开(公告)号：US20060057690A1
公开(公告)日：2006-03-16
申请号：US11225354
申请日：2005-09-13
申请人： Zhixiong Xue , Quinn Zhu
发明人： Zhixiong Xue , Quinn Zhu
IPC分类号： C12P7/64 , C12N1/18 , C12N15/74
CPC分类号： C12N15/815 , C12N9/1029 , C12P7/6427 , C12P21/02 , C12Y203/01015
摘要： The promoter region associated with the Yarrowia lipolytica glycerol-3-phosphate O-acyltransferase (gpat) gene has been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the instant invention have been shown to be suitable to drive high-level expression of genes involved in the production of ω-3 and ω-6 fatty acids.
摘要翻译：已经发现与解脂耶氏酵母甘油-3-磷酸O-酰基转移酶（gpat）基因相关的启动子区域在含油酵母中表达异源基因特别有效。已经显示本发明的启动子区域适合于驱动涉及ω-3和ω-6脂肪酸生产的基因的高水平表达。

36. 发明授权

US08969049B2 Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast 有权
标题翻译：酵母中用于基因表达的耶氏酵母双酰基甘油酰基转移酶启动子区
公开(公告)号：US08969049B2
公开(公告)日：2015-03-03
申请号：US13435246
申请日：2012-03-30
申请人： Quinn Qun Zhu , Zhixiong Xue
发明人： Quinn Qun Zhu , Zhixiong Xue
IPC分类号： C12P21/06 , C12P7/64 , C12N1/20 , C12N15/00 , C07H21/04 , C12N15/81 , C12N9/10
CPC分类号： C12N15/815 , C12N9/1029 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y203/0102
摘要： Promoter regions associated with the Yarrowia lipolytica diacylglycerol acyltransferase 2 (dgat2) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in yeast. These promoter regions will be useful for driving high-level expression of genes involved in the production of omega-3 and omega-6 fatty acids.
摘要翻译：公开了与解脂耶氏酵母双酰基甘油酰基转移酶2（dgat2）基因相关的启动子区域，并且已经发现其对酵母中异源基因的表达特别有效。这些启动子区域可用于驱动涉及ω-3和ω-6脂肪酸生产的基因的高水平表达。

37. 发明授权

US08865429B2 Increased oil content by increasing Yap1 transcription factor activity in oleaginous yeasts 有权
标题翻译：通过增加含油酵母中的Yap1转录因子活性来增加油含量
公开(公告)号：US08865429B2
公开(公告)日：2014-10-21
申请号：US13339461
申请日：2011-12-29
申请人： Seung-Pyo Hong , Zhixiong Xue , Quinn Qun Zhu
发明人： Seung-Pyo Hong , Zhixiong Xue , Quinn Qun Zhu
IPC分类号： C12P21/06 , C12N1/16 , C12P7/64 , C07K14/39
CPC分类号： C07K14/39 , C12P7/6409 , C12P7/6427 , C12P7/6463
摘要： Transgenic oleaginous yeast having increased oil content comprising increased Yap1 transcription factor activity, wherein the increased oil content is compared to the oil content of a non-transgenic oleaginous yeast, are described herein. The increased Yap1 transcription factor activity results from overexpressing a Yap1 transcription factor, by increasing the interaction between the transcription factor and a protein that is capable of activating the transcription factor, or by a combination thereof. Methods of using these yeast strains are also described.
摘要翻译：本文描述了具有增加的油含量的转基因含油酵母，其包含增加的Yap1转录因子活性，其中增加的油含量与非转基因油质酵母的油含量进行比较。通过增加转录因子与能够激活转录因子的蛋白质之间的相互作用，或通过其组合，Yap1转录因子活性的增加来自过表达Yap1转录因子。还描述了使用这些酵母菌株的方法。

38. 发明授权

US08685681B2 Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms 有权
标题翻译：用于改变多不饱和脂肪酸的二酰基甘油酰基转移酶和含油生物体中的油含量
公开(公告)号：US08685681B2
公开(公告)日：2014-04-01
申请号：US12338536
申请日：2008-12-18
申请人： Narendra S. Yadav , Zhixiong Xue , Hongxiang Zhang
发明人： Narendra S. Yadav , Zhixiong Xue , Hongxiang Zhang
IPC分类号： C12P7/64 , C12N9/10 , C12P21/06 , C12N1/20 , C12N1/16 , C12N1/12 , C07H21/04
CPC分类号： C12N9/1029 , C12P7/6463 , C12P7/6472
摘要： Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, genes encoding diacylglycerol acyltransferase (DGAT1) have been isolated from Y. lipolytica and Mortierella alpina. These genes encode enzymes that participate in the terminal step in oil biosynthesis in yeast. Each is expected to play a key role in altering the quantity of polyunsaturated fatty acids produced in oils of oleaginous yeasts.
摘要翻译：提供了酰基转移酶，适用于制造含油酵母（例如解脂耶氏酵母）富含ω脂肪酸的微生物油。具体来说，从解脂耶氏酵母和高山被孢霉中分离出编码二酰基甘油酰基转移酶（DGAT1）的基因。这些基因编码酵母中参与油生物合成的最终步骤的酶。预计每一种在改变油质酵母油中产生的多不饱和脂肪酸的量方面起关键作用。

39. 发明授权

US08637298B2 Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production 有权
标题翻译：优化的解脂耶氏酵母菌株用于高二十碳五烯酸生产
公开(公告)号：US08637298B2
公开(公告)日：2014-01-28
申请号：US12814815
申请日：2010-06-14
申请人： Seung-Pyo Hong , Pamela L. Sharpe , Zhixiong Xue , Narendra S. Yadav , Quinn Qun Zhu
发明人： Seung-Pyo Hong , Pamela L. Sharpe , Zhixiong Xue , Narendra S. Yadav , Quinn Qun Zhu
IPC分类号： C12N1/00
CPC分类号： C12N9/1029 , A21D2/165 , A23K20/158 , C12N9/00 , C12N9/13 , C12N9/93 , C12P7/6427 , C12P7/6472 , C12P7/6481
摘要： Described are engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing an oil comprising greater than 50 weight percent of eicosapentaenoic acid [“EPA”], an ω-3 polyunsaturated fatty acid, measured as a weight percent of total fatty acids [“% TFAs”] and having a ratio of at least 3.1 of EPA % TFAs, to linoleic acid, measured as % TFAs. These strains over-express at least one Δ9 elongase/Δ8 desaturase multizyme, in addition to other heterologous Δ9 elongases, Δ8 desaturases, Δ5 desaturases, Δ17 desaturases, Δ12 desaturases, C16/18 elongases, and optionally over-express diacylglycerol cholinephosphotransferases, malonyl CoA synthetases and/or acyl-CoA lysophospholipid acyltransferases. The expression of at least one peroxisome biogenesis factor protein is down-regulated. Methods for producing EPA within said host cells, oils obtained from the cells, and products therefrom are claimed.
摘要翻译：描述了能够产生包含大于50重量％的二十碳五烯酸[“EPA”]的油的油质酵母解脂耶氏酵母解脂耶氏酵母的工程菌株，其是以总脂肪酸的重量百分比测量的ω-3多不饱和脂肪酸[“％ TFAs“]，并且具有至少3.1％的EPA％TFA与比率为TFA的亚油酸的比率。除了其他异源Delta9延伸酶，Delta8去饱和酶，Δ5去饱和酶，Δ17去饱和酶，Δ12去饱和酶，C16 / 18延长酶和任选的过表达二酰基甘油胆碱磷酸转移酶，丙二酰辅酶A，这些菌株过表达至少一种Δ9延伸酶/Δδ去饱和酶多酶合成酶和/或酰基辅酶A溶血磷脂酰基转移酶。至少一种过氧化物酶体生物因子蛋白的表达下调。要求在所述宿主细胞内生产EPA的方法，从细胞获得的油及其产物。

40. 发明授权

US08119784B2 Delta-4 desaturase and its use in making polyunsaturated fatty acids 有权
标题翻译： Delta-4去饱和酶及其在制备多不饱和脂肪酸中的应用
公开(公告)号：US08119784B2
公开(公告)日：2012-02-21
申请号：US12408860
申请日：2009-03-23
申请人： Quinn Qun Zhu , Zhixiong Xue
发明人： Quinn Qun Zhu , Zhixiong Xue
IPC分类号： C07H21/04 , C12N1/20 , C12N5/10
CPC分类号： C12N9/0083
摘要： Described here are Δ4 desaturases that convert all-cis-7,10,13,16,19-docosapentaenoic acid [“DPA”; 22:5 ω-3] to docosahexaenoic acid [“DHA”; 22:6 ω-3], with secondary activity in converting docosatetraenoic acid [“DTA”; 22:4 ω-6] to all-cis-4,7,10,13,16-docosapentaenoic acid [“DPAn-6”; 22:5 ω-6]. Also, described here are isolated nuclei acid fragments and recombinant constructs comprising such fragments encoding Δ4 desaturases as well as methods of making long chain polyunsaturated fatty acids [“PUFAs”] using this Δ4 desaturase in oleaginous yeast.
摘要翻译：这里描述的是将全顺式-7,10,13,16,19-二十二碳五烯酸[“DPA”; 22：5ω-3]至二十二碳六烯酸[“DHA”; 22：6ω-3]，二次活性转化二十二碳四烯酸[“DTA”; 22：4ω-6]与全顺式-4,7,10,13,16-二十二碳五烯酸[“DPAn-6”; 22：5ω-6]。此外，这里描述的是分离的核酸片段和包含编码'Dgr。4去饱和酶的这种片段的重组构建体以及使用这种＆Dgr。4去饱和酶在含油酵母中制备长链多不饱和脂肪酸的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式