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    • 32. 发明授权
    • Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
    • 用于与电力源一起递送治疗剂的内部医疗装置
    • US07850645B2
    • 2010-12-14
    • US11055930
    • 2005-02-11
    • Liliana AtanasoskaThomas J. HolmanJan WeberRobert WarnerScott Schewe
    • Liliana AtanasoskaThomas J. HolmanJan WeberRobert WarnerScott Schewe
    • A61M29/00
    • A61N1/325A61N1/05A61N1/306A61N1/327
    • The invention generally relates to internal (e.g., implantable, insertable, etc.) drug delivery devices which contain the following: (a) one or more sources of one or more therapeutic agents; (b) one or more first electrodes, (c) one or more second electrodes and (d) one or more power sources for applying voltages across the first and second electrodes. The power sources may be adapted, for example, to promote electrically assisted therapeutic agent delivery within a subject, including electroporation and/or iontophoresis. In one aspect of the invention, the first and second electrodes are adapted to have tissue of a subject positioned between them upon deployment of the medical device within the subject, such that an electric field may be generated, which is directed into the tissue. Furthermore, the therapeutic agent sources are adapted to introduce the therapeutic agents into the electric field. In another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of ion-conductive polymers and one or more types of charged therapeutic agents. In yet another aspect, the therapeutic agent sources are polymeric regions that contain one or more types of electrically conductive polymers and one or more types of charged therapeutic agents.
    • 本发明一般涉及含有以下物质的内部(例如,可植入,可插入等)药物递送装置:(a)一种或多种一种或多种治疗剂来源; (b)一个或多个第一电极,(c)一个或多个第二电极和(d)用于在第一和第二电极上施加电压的一个或多个电源。 电源可以适应于例如促进受试者内的电辅助治疗剂递送,包括电穿孔和/或离子电渗疗法。 在本发明的一个方面中,第一和第二电极适于在医疗装置在受试者内展开时使被检体的组织位于它们之间,使得可以产生被引导到组织中的电场。 此外,治疗剂源适于将治疗剂引入电场。 另一方面,治疗剂来源是含有一种或多种类型的离子导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。 在另一方面,治疗剂来源是含有一种或多种类型的导电聚合物和一种或多种类型的带电治疗剂的聚合物区域。
    • 40. 发明申请
    • Flexible and Durable Tip
    • 灵活和耐用的提示
    • US20080275426A1
    • 2008-11-06
    • US11743753
    • 2007-05-03
    • Thomas J. HOLMANTracee EidenschinkJohn J. ChenDaniel J. Horn
    • Thomas J. HOLMANTracee EidenschinkJohn J. ChenDaniel J. Horn
    • A61M25/16
    • A61M25/104A61M25/001A61M25/0069A61M25/1006A61M2025/1093
    • A method of making a flexible, durable catheter tip is achieved by providing a catheter tip, and in some embodiments, applying heat energy only to the distal portion of a catheter tip. In other embodiments, the method includes ablating a portion of the outer diameter of the proximal region material. In at least one embodiment, the method includes manufacturing a catheter tip with a layer of a harder material disposed about a first layer of a relatively softer material and then ablating at least a portion of the harder material. In some embodiments, the method includes dipping at least a portion of the distal region of the catheter tip into a chemical bath. In some embodiments, the method includes providing a catheter tip made of a tip material, adding a curable adhesive to at least a portion of the distal region, and then applying heat energy to cure the curable adhesive.
    • 通过提供导管尖端来实现制造柔性,耐久的导管尖端的方法,并且在一些实施例中,仅将热能施加到导管尖端的远端部分。 在其他实施例中,该方法包括烧蚀近端区域材料的外径的一部分。 在至少一个实施例中,该方法包括制造具有设置在相对较软材料的第一层周围的较硬材料层的导管末端,然后再烧蚀至少一部分较硬的材料。 在一些实施例中,该方法包括将导管尖端的远端区域的至少一部分浸入化学浴中。 在一些实施例中,该方法包括提供由尖端材料制成的导管末端,将可固化粘合剂添加到远侧区域的至少一部分,然后施加热能以固化可固化粘合剂。